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Article: Deciphering thyroid function and CIMT: a Mendelian randomization study of the U-shaped influence mediated by apolipoproteins.

Zhang, Ming-Zhu / Zhao, Cong / Xing, Xiao-Ming / Lv, Jie

2024 Volume 15, Page(s) 1345267

Abstract: Background: Carotid Intima-Media Thickness (CIMT) is a key marker for atherosclerosis, with its modulation being crucial for cardiovascular disease (CVD) risk assessment. While thyroid function's impact on cardiovascular health is recognized, the causal ...

Abstract	Background: Carotid Intima-Media Thickness (CIMT) is a key marker for atherosclerosis, with its modulation being crucial for cardiovascular disease (CVD) risk assessment. While thyroid function's impact on cardiovascular health is recognized, the causal relationship and underlying mechanisms influencing CIMT remain to be elucidated. Methods: In this study, Mendelian Randomization (MR) was employed to assess the causal relationship between thyroid function and CIMT. Thyroid hormone data were sourced from the Thyroidomics Consortium, while lipid traits and CIMT measurements were obtained from the UK Biobank. The primary analysis method was a two-sample MR using multiplicative random effects inverse variance weighting (IVW-MRE). Additionally, the study explored the influence of thyroid hormones on lipid profiles and assessed their potential mediating role in the thyroid function-CIMT relationship through multivariate MR analysis. Results: The study revealed that lower levels of Free Thyroxine (FT4) within the normal range are significantly associated with increased CIMT. This association was not observed with free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), or TPOAb. Additionally, mediation analysis suggested that apolipoprotein A-I and B are involved in the relationship between thyroid function and CIMT. The findings indicate a potential U-shaped curve relationship between FT4 levels and CIMT, with thyroid hormone supplementation in hypothyroid patients showing benefits in reducing CIMT. Conclusion: This research establishes a causal link between thyroid function and CIMT using MR methods, underscoring the importance of monitoring thyroid function for early cardiovascular risk assessment. The results advocate for the consideration of thyroid hormone supplementation in hypothyroid patients as a strategy to mitigate the risk of carotid atherosclerosis. These insights pave the way for more targeted approaches in managing patients with thyroid dysfunction to prevent cardiovascular complications.
MeSH term(s)	Humans ; Carotid Intima-Media Thickness ; Mendelian Randomization Analysis ; Hypothyroidism/genetics ; Hypothyroidism/complications ; Thyroid Hormones ; Apolipoproteins
Chemical Substances	Thyroid Hormones ; Apolipoproteins
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2024.1345267
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The mechanisms of ferroptosis in the pathogenesis of kidney diseases.

Liu, Jia / Chen, Jianheng / Lv, Jie / Gong, Yuhang / Song, Jie

Journal of nephrology

2024

Abstract: The pathological features of acute and chronic kidney diseases are closely associated with cell death in glomeruli and tubules. Ferroptosis is a form of programmed cell death characterized by iron overload-induced oxidative stress. Ferroptosis has ... ...

Abstract	The pathological features of acute and chronic kidney diseases are closely associated with cell death in glomeruli and tubules. Ferroptosis is a form of programmed cell death characterized by iron overload-induced oxidative stress. Ferroptosis has recently gained increasing attention as a pathogenic mechanism of kidney damage. Specifically, the ferroptosis signaling pathway has been found to be involved in the pathological process of acute and chronic kidney injury, potentially contributing to the development of both acute and chronic kidney diseases. This paper aims to elucidate the underlying mechanisms of ferroptosis and its role in the pathogenesis of kidney disease, highlighting its significance and proposing novel directions for its treatment.
Language	English
Publishing date	2024-05-04
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-024-01927-6
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Article ; Online: Application of dynamic firework algorithm considering variable neighborhood strategy in flexible job shop scheduling problem

Lv Jie / Zhang Fenqiang

E3S Web of Conferences, Vol 268, p

2021 Volume 01062

Abstract: Aiming at the flexible job shop scheduling problem, this paper constructs a dual-objective mathematical model to minimize the maximum completion time and the minimum total processing cost. The traditional firework algorithm introduces a variable ... ...

Abstract	Aiming at the flexible job shop scheduling problem, this paper constructs a dual-objective mathematical model to minimize the maximum completion time and the minimum total processing cost. The traditional firework algorithm introduces a variable neighborhood search strategy, which is generated during the explosion of the algorithm. On the basis of explosive spark and Gaussian spark, the algorithm is further avoided from falling into the dilemma of local optimization. The product of completion time and processing cost is used as the fitness value of the plan, so that the firework algorithm is suitable for solving the two objective scheduling problems in this paper, and the ratio of fitness value and congestion is used as a comprehensive index for the selection of the optimal plan . In this paper, the selected 5×6 calculation examples are solved, and the completion time of the optimal scheduling scheme is reduced by 12.9%, and the total production cost is reduced by 17.67%, which verifies the feasibility and efficiency of the method.
Keywords	variable neighborhood search ; firework algorithm ; fitness ; congestion ; Environmental sciences ; GE1-350
Subject code	670
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article: ZIF-67 Incorporated Sulfonated Poly (Aryl Ether Sulfone) Mixed Matrix Membranes for Pervaporation Separation of Methanol/Methyl Tert-Butyl Ether Mixture.

Han, Guanglu / Lv, Jie / Chen, Mohan

Membranes

2023 Volume 13, Issue 4

Abstract: Mixed matrix membranes (MMMs) with nano-fillers dispersed in polymer matrix have been proposed as alternative pervaporation membrane materials. They possess both promising selectivity benefiting from the fillers and economical processing capabilities of ... ...

Abstract	Mixed matrix membranes (MMMs) with nano-fillers dispersed in polymer matrix have been proposed as alternative pervaporation membrane materials. They possess both promising selectivity benefiting from the fillers and economical processing capabilities of polymers. ZIF-67 was synthesized and incorporated into the sulfonated poly (aryl ether sulfone) (SPES) matrix to prepare SPES/ZIF-67 mixed matrix membranes with different ZIF-67 mass fractions. The as-prepared membranes were used for pervaporation separation of methanol/methyl tert-butyl ether mixtures. X-ray diffraction (XRD), Scanning Electron Microscopy (SEM) and laser particle size analysis results show that ZIF-67 is successfully synthesized, and the particle size is mainly between 280 nm and 400 nm. The membranes were characterized by SEM, atomic force microscope (AFM), water contact angle, thermogravimetric analysis (TGA), mechanical property testing and positron annihilation technique (PAT), sorption and swelling experiments, and the pervaporation performance was also investigated. The results reveal that ZIF-67 particles disperse uniformly in the SPES matrix. The roughness and hydrophilicity are enhanced by ZIF-67 exposed on the membrane surface. The mixed matrix membrane has good thermal stability and mechanical properties, which can meet the requirements of pervaporation operation. The introduction of ZIF-67 effectively regulates the free volume parameters of the mixed matrix membrane. With increasing ZIF-67 mass fraction, the cavity radius and free volume fraction increase gradually. When the operating temperature is 40 °C, the flow rate is 50 L·h
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2614641-1
ISSN	2077-0375
ISSN	2077-0375
DOI	10.3390/membranes13040389
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Article ; Online: Research on air-water coordinated operation of water side free cooling system based on improved particle swarm optimization algorithm

Ma Keyan / Lv Jie / Zhang Jili

E3S Web of Conferences, Vol 356, p

2022 Volume 01057

Abstract: Water side free cooling is an important technology for cooling water system to use natural cooling source for energy saving, especially in the field of data center and industrial production. However, the operation regulation of water side free cooling ... ...

Abstract	Water side free cooling is an important technology for cooling water system to use natural cooling source for energy saving, especially in the field of data center and industrial production. However, the operation regulation of water side free cooling system was lack of scientific basis. This process involves the two-phase circulation of air and cooling water, which requires the coordinated operation of air and water to further optimize the energy consumption. The coordinated operation of air and water includes the coordination of air and water flow in each cooling tower and the matching of the operating numbers of equipment in the system. Firstly, based on the characteristics of the cooling tower, the key equipment in the water side free cooling system, the air-water two-phase heat transfer model in the cooling tower was established. Then, according to the heat transfer model and power model of each equipment in the system, the optimization objectives and constraints are established. An improved particle swarm optimization (PSO) algorithm was proposed to solve the problem of wind water collaborative optimization of water side free cooling system. Finally, this paper takes a small data center cooling water system as an example to analyze the optimization performance of the improved particle swarm optimization algorithm. The simulation results showed that the excellent rate obtained by the improved algorithm can be increased by 36.9%, which is more energy-saving. This method can provide a reference for the energy-saving optimization of water side free cooling system.
Keywords	Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Retrieval of Aerosol Optical Depth Based on MODIS

Lv Jie / Mao Xianglai

E3S Web of Conferences, Vol 206, p

2020 Volume 02018

Abstract: Aerosol plays an important role in global climate effect, and Aerosol Optical Depth (AOD), as one of its important parameters, can not only monitor the turbidity of the atmosphere, but also is an important index of atmospheric correction quality in ... ...

Abstract	Aerosol plays an important role in global climate effect, and Aerosol Optical Depth (AOD), as one of its important parameters, can not only monitor the turbidity of the atmosphere, but also is an important index of atmospheric correction quality in remote sensing. Urban agglomeration in the middle reaches of the Yangtze River is a key national-level urban agglomerations in China, and its rapid urbanization leads to the aggravation of urban diseases such as disorderly development of cities, waste of resources and environmental pollution, and the research on ecological environment problems of urban agglomerations is also the current key project.In view of the above problems, this paper studies the AOD inversion and its spatial and temporal distribution in the middle reaches of the Yangtze River, in order to provide important scientific materials for environmental monitoring and satellite atmospheric correction quality inspection.
Keywords	Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A glimpse into novel acylations and their emerging role in regulating cancer metastasis.

Shi, Huifang / Cui, Weigang / Qin, Yan / Chen, Lei / Yu, Tao / Lv, Jie

Cellular and molecular life sciences : CMLS

2024 Volume 81, Issue 1, Page(s) 76

Abstract: Metastatic cancer is a major cause of cancer-related mortality; however, the complex regulation process remains to be further elucidated. A large amount of preliminary investigations focus on the role of epigenetic mechanisms in cancer metastasis. ... ...

Abstract	Metastatic cancer is a major cause of cancer-related mortality; however, the complex regulation process remains to be further elucidated. A large amount of preliminary investigations focus on the role of epigenetic mechanisms in cancer metastasis. Notably, the posttranslational modifications were found to be critically involved in malignancy, thus attracting considerable attention. Beyond acetylation, novel forms of acylation have been recently identified following advances in mass spectrometry, proteomics technologies, and bioinformatics, such as propionylation, butyrylation, malonylation, succinylation, crotonylation, 2-hydroxyisobutyrylation, lactylation, among others. These novel acylations play pivotal roles in regulating different aspects of energy mechanism and mediating signal transduction by covalently modifying histone or nonhistone proteins. Furthermore, these acylations and their modifying enzymes show promise regarding the diagnosis and treatment of tumors, especially tumor metastasis. Here, we comprehensively review the identification and characterization of 11 novel acylations, and the corresponding modifying enzymes, highlighting their significance for tumor metastasis. We also focus on their potential application as clinical therapeutic targets and diagnostic predictors, discussing the current obstacles and future research prospects.
MeSH term(s)	Humans ; Acylation ; Histones/metabolism ; Acetylation ; Protein Processing, Post-Translational ; Neoplasms/genetics
Chemical Substances	Histones
Language	English
Publishing date	2024-02-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-023-05104-z
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Zs.A 195: Show issues

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Article: Axillary management in patients with clinical node-negative early breast cancer and positive sentinel lymph node: a systematic review and meta-analysis.

Li, Changzai / Zhang, Pan / Lv, Jie / Dong, Wei / Hu, Baoshan / Zhang, Jinji / Zhu, Hongcheng

Frontiers in oncology

2024 Volume 13, Page(s) 1320867

Abstract: Background: The omission of axillary lymph node dissection (ALND) or axillary radiation (AxRT) remains controversial in patients with clinical node-negative early breast cancer and a positive sentinel lymph node.: Methods: We conducted a ... ...

Abstract	Background: The omission of axillary lymph node dissection (ALND) or axillary radiation (AxRT) remains controversial in patients with clinical node-negative early breast cancer and a positive sentinel lymph node. Methods: We conducted a comprehensive review by searching PubMed, Embase, Web of Science, and Cochrane databases (up to November 2023). Our primary outcomes were overall survival (OS), disease-free survival (DFS), locoregional recurrence (LRR), and axillary recurrence (AR). Results: We included 26 studies encompassing 145,548 women with clinical node-negative early breast cancer and positive sentinel lymph node. Pooled data revealed no significant differences between ALND and sentinel lymph node biopsy (SLNB) alone in terms of OS (hazard ratio [HR]0.99, 95% confidence interval [CI] 0.91-1.08, Conclusion: Our findings suggest that survival and recurrence rates are not inferior in patients with clinical node-negative early breast cancer and a positive sentinel lymph node who receive SLNB alone compared to those undergoing ALND or AxRT.
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1320867
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Article: Autologous stem cell transplant for refractory and relapsed peripheral T-cell lymphoma: a retrospective study in China.

Zhang, Chen / Lv, Jie / Deng, Jili / Liu, Weiping / Wang, Xiaopei / Song, Yuqin / Zhu, Jun

Journal of Cancer

2024 Volume 15, Issue 2, Page(s) 539–544

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2024-01-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.89404
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of esketamine on postpartum depression after labor analgesia and potential mechanisms: a randomized, double-blinded controlled trial.

Wang, Wei / Ling, Bin / Zhao, Haibo / He, Jing / Xu, Hua / Lv, Jie / Wang, Qi

BMC anesthesiology

2024 Volume 24, Issue 1, Page(s) 4

Abstract: Background: To evaluate the effect of esketamine combined with ropivacaine hydrochloride on the occurrence of postpartum depression (PPD) after labor analgesia under epidural analgesia pump and explore the possible mechanisms.: Methods: A total of ... ...

Abstract	Background: To evaluate the effect of esketamine combined with ropivacaine hydrochloride on the occurrence of postpartum depression (PPD) after labor analgesia under epidural analgesia pump and explore the possible mechanisms. Methods: A total of 120 women aged 24 to 36 years old who underwent labor analgesia by epidural analgesia pump, with American Society of Anesthesiologists (ASA) physical status II were enrolled. According to the formula of epidural analgesia pump, all participants were randomly divided into two groups: esketamine group (Group E) and control group (Group C). Epidural anaesthesia were operated in all women between L Results: Compared with Group C, the VAS score at T Conclusion: Esketamine combined with ropivacaine hydrochloride used in labor analgesia can significantly reduce the incidence of postpartum depression after delivering without increasing related side effects, which may be related to the regulation of leptin, norepinephrine, and epinephrine in the serum. Trial registration: The trial was registered at the Chinese Clinical Trial Registry on 30/05/2022 (CTRI registration number-ChiCTR2200060387). URL of registry: https://www.chictr.org.cn/bin/home .
MeSH term(s)	Pregnancy ; Female ; Humans ; Young Adult ; Adult ; Ropivacaine ; Leptin ; Postpartum Hemorrhage/drug therapy ; Depression, Postpartum/drug therapy ; Analgesics/therapeutic use ; Analgesia, Epidural ; Analgesia, Obstetrical ; Epinephrine ; Norepinephrine ; Anesthetics, Local/therapeutic use
Chemical Substances	Ropivacaine (7IO5LYA57N) ; Esketamine (50LFG02TXD) ; Leptin ; Analgesics ; Epinephrine (YKH834O4BH) ; Norepinephrine (X4W3ENH1CV) ; Anesthetics, Local
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2091252-3
ISSN	1471-2253 ; 1471-2253
ISSN (online)	1471-2253
ISSN	1471-2253
DOI	10.1186/s12871-023-02377-6
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