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  1. Article ; Online: Electrochemical Synthesis of Selenosulfonates from Diselenides and Sulfonyl Hydrazides.

    Lv, Jin-Feng / Deng, Yang / Liang, Xin-Yi / Tan, Yu-Fang / He, Yan-Hong / Guan, Zhi

    The Journal of organic chemistry

    2024  Volume 89, Issue 6, Page(s) 3931–3940

    Abstract: The electrochemical oxidative radical-radical cross-coupling of sulfonyl hydrazides with diselenides for the synthesis of selenosulfonates was successfully accomplished. The method is applicable to a wide range of aromatic/aliphatic sulfonyl hydrazides ... ...

    Abstract The electrochemical oxidative radical-radical cross-coupling of sulfonyl hydrazides with diselenides for the synthesis of selenosulfonates was successfully accomplished. The method is applicable to a wide range of aromatic/aliphatic sulfonyl hydrazides and diselenides, providing products in good to excellent yields. Notably, this protocol stands out for its green and sustainable nature, as it does not rely on transition metals and oxidizing agents, and the starting materials are cost-effective and readily available.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4473: Show issues Location:
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  2. Article ; Online: Electrochemical Synthesis of β-Iodoesters by 1,2-Iodoesterization of Unactivated Alkenes with Carboxylic Acids and Tetrabutylammonium Iodide.

    Tan, Yu-Fang / Zhao, Ya-Nan / Yang, Dan / Lv, Jin-Feng / Guan, Zhi / He, Yan-Hong

    The Journal of organic chemistry

    2023  Volume 88, Issue 8, Page(s) 5161–5171

    Abstract: We report a novel and highly selective electrochemical method for the synthesis of β-iodoesters via difunctionalization of alkenes. The reaction is carried out in an undivided cell under constant current conditions without any additives, catalysts, ... ...

    Abstract We report a novel and highly selective electrochemical method for the synthesis of β-iodoesters via difunctionalization of alkenes. The reaction is carried out in an undivided cell under constant current conditions without any additives, catalysts, oxidants, and sacrificial reagents. Inexpensive and readily available tetrabutylammonium iodide not only acts as an electrolyte but also serves as an iodine source. The reaction shows high selectivity and good functional group tolerance, providing products in yields of up to 98%. This method is applicable not only to the iodofunctionalization of alkenes but also to the chloro- and bromofunctionalization of alkenes. The successful modification of drugs and natural products demonstrates the potential utility of this approach.
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c03020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4473: Show issues Location:
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  3. Article ; Online: Electrochemical C(sp

    Lv, Jin-Feng / Tan, Yu-Fang / Zhao, Ya-Nan / Yang, Dan / He, Yan-Hong / Guan, Zhi

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 42, Page(s) 8488–8493

    Abstract: The paper details an electrochemical method that couples olefins with benzotriazoles to form C( ... ...

    Abstract The paper details an electrochemical method that couples olefins with benzotriazoles to form C(sp
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob01300f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Polymorphisms in cytochrome P450 oxidoreductase and its effect on drug metabolism and efficacy.

    Gong, Liang / Zhang, Cong-Min / Lv, Jin-Feng / Zhou, Hong-Hao / Fan, Lan

    Pharmacogenetics and genomics

    2017  Volume 27, Issue 9, Page(s) 337–346

    Abstract: Cytochrome P450 oxidoreductase (POR) has played a potential role in the metabolism of drugs and steroids by supplying electrons to microsomal cytochrome P450 (CYP) enzymes. More than 200 different POR mutations and polymorphisms causing more than 130 ... ...

    Abstract Cytochrome P450 oxidoreductase (POR) has played a potential role in the metabolism of drugs and steroids by supplying electrons to microsomal cytochrome P450 (CYP) enzymes. More than 200 different POR mutations and polymorphisms causing more than 130 amino acid changes in the POR protein have been reported since 2004. A503V is a common amino acid sequence variant encoded by POR*28, whereas A287P and R457H are the most common disease-causing mutations in Europeans and Asians, respectively. Polymorphisms in the POR gene can affect POR activity, CYP-mediated drug metabolism activities, and the efficacy of several clinically used drugs. The effects of POR variants on CYP activities are substrate dependent. In this review, recent research on the effects of POR genetic polymorphisms on drug metabolism and therapy has been summarized and discussed, which can contribute to the rational use of drugs in clinic and the development of personalized medicine.
    Language English
    Publishing date 2017-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2175826-8
    ISSN 1744-6880 ; 0960-314X ; 1744-6872
    ISSN (online) 1744-6880
    ISSN 0960-314X ; 1744-6872
    DOI 10.1097/FPC.0000000000000297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3660: Show issues Location:
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  5. Article ; Online: Effect of NADPH-cytochrome P450 reductase on all-trans-retinoic acid efficacy and cytochrome P450 26A1 expression in human myeloid leukaemia HL-60 cells.

    Hu, Lei / Lv, Jin-Feng / Zhuo, Wei / Zhang, Cong-Min / Zhou, Hong-Hao / Fan, Lan

    The Journal of pharmacy and pharmacology

    2016  Volume 68, Issue 9, Page(s) 1193–1202

    Abstract: Objectives: All-trans-retinoic acid (ATRA), a naturally occurring metabolite of vitamin A, has been shown to have great potential as an antitumorigenic drug to treat acute leukaemia by promoting cancer cell differentiation. Cytochrome P450 ... ...

    Abstract Objectives: All-trans-retinoic acid (ATRA), a naturally occurring metabolite of vitamin A, has been shown to have great potential as an antitumorigenic drug to treat acute leukaemia by promoting cancer cell differentiation. Cytochrome P450 oxidoreductase (POR) is the only obligate electron donor for all of the microsomal cytochrome P450 enzymes including CYP26A1 which is highly specific for ATRA metabolism and efficacy in human myeloid leukaemia cells. In this study, we aimed to investigate the effect of POR on ATRA efficacy and CYP26A1 expression in human myeloid leukaemia HL-60 cells.
    Methods: Stably expressed POR and POR-RNAi HL-60 cell lines were established by transfecting POR overexpression or RNAi (RNA interference) vectors mediated by lentivirus. The protein expression of POR and CYP26A1 was examined by Western blot. The potential roles of POR on ATRA efficacy in HL-60 cells were explored by cell viability assay, cell cycle distribution, cellular differentiation and apoptosis analysis.
    Key findings: All-trans-retinoic acid treatment caused the expression of POR upregulation and CYP26A1 downregulation in dose- and time-dependent manners. POR overexpression decreased CYP26A1 expression in HL-60 cells. When POR gene was interfered, the downregulation of CYP26A1 expression by ATRA was abolished. In addition, POR overexpression in HL-60 cells significantly compromised ATRA-induced cell proliferation inhibition, cell cycle arrest, differentiation and apoptosis, whereas downregulation of POR significantly potentiated ATRA effects.
    Conclusions: Our study therefore suggested that POR played an important role in regulating ATRA efficacy and CYP26A1 expression in HL-60 cells.
    MeSH term(s) Apoptosis ; Cell Cycle Checkpoints ; Cell Differentiation ; Cell Proliferation ; Cytochrome P-450 Enzyme System/metabolism ; HL-60 Cells ; Humans ; Inactivation, Metabolic ; Leukemia, Myeloid/drug therapy ; NADPH-Ferrihemoprotein Reductase/metabolism ; Retinoic Acid 4-Hydroxylase/metabolism ; Tretinoin/metabolism ; Tretinoin/pharmacokinetics ; Tretinoin/pharmacology ; Tretinoin/therapeutic use
    Chemical Substances Tretinoin (5688UTC01R) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Retinoic Acid 4-Hydroxylase (EC 1.14.14.1) ; NADPH-Ferrihemoprotein Reductase (EC 1.6.2.4)
    Language English
    Publishing date 2016-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 3107-0
    ISSN 2042-7158 ; 0022-3573 ; 0373-1022
    ISSN (online) 2042-7158
    ISSN 0022-3573 ; 0373-1022
    DOI 10.1111/jphp.12591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uf I Zs.149: Show issues Location:
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  6. Article ; Online: Epigenetic alternations and cancer chemotherapy response.

    Lv, Jin-Feng / Hu, Lei / Zhuo, Wei / Zhang, Cong-Min / Zhou, Hong-Hao / Fan, Lan

    Cancer chemotherapy and pharmacology

    2016  Volume 77, Issue 4, Page(s) 673–684

    Abstract: Epigenetics, referring to alterations in gene expression without a change in nucleotide sequence in eukaryotes, mainly includes DNA methylation, miRNA and histone modification. In recent years, accumulating evidences have shown that epigenetic ... ...

    Abstract Epigenetics, referring to alterations in gene expression without a change in nucleotide sequence in eukaryotes, mainly includes DNA methylation, miRNA and histone modification. In recent years, accumulating evidences have shown that epigenetic aberrations not only play important roles in the initiation and development of human cancers but also affect cancer chemotherapy response by altering the expression of key genes involved in the absorption, distribution, metabolism and excretion of drugs or those correlated with progression or severity of cancers. These epigenetic alterations, along with advanced detecting techniques, have great potential to be used as predictive and prognostic biomarkers for personalized therapy, especially in the field of cancer treatment. Here we provide an overview of recent findings on epigenetic alterations involved in cancer chemotherapy response, with the aim of promoting rational use of chemotherapy drugs in the clinic.
    MeSH term(s) Acetylation ; Antineoplastic Agents/therapeutic use ; DNA Methylation ; Epigenesis, Genetic ; Histones/metabolism ; Humans ; MicroRNAs/physiology ; Neoplasms/drug therapy ; Neoplasms/genetics ; Polymorphism, Single Nucleotide
    Chemical Substances Antineoplastic Agents ; Histones ; MicroRNAs
    Language English
    Publishing date 2016-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 6820-2
    ISSN 1432-0843 ; 0344-5704 ; 0943-9404
    ISSN (online) 1432-0843
    ISSN 0344-5704 ; 0943-9404
    DOI 10.1007/s00280-015-2951-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1420: Show issues Location:
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  7. Article: Effects of immuno-related gene polymorphisms on a bispecific antibody targeting colorectal cancer cell.

    Zhang, Cong-Min / Yu, Lin-Yu / Lv, Jin-Feng / Gong, Liang / Zhou, Hong-Hao / Chen, Xiao-Ping / Fan, Lan

    Personalized medicine

    2018  Volume 15, Issue 3, Page(s) 167–179

    Abstract: Background: Colorectal cancer (CRC) represents the third most common type of cancer and the third leading cause of death from cancer around the world. M701 is a CD3/EpCAM bispecific antibody that shows promising cytotoxicity toward CRC cells.: Aim: ... ...

    Abstract Background: Colorectal cancer (CRC) represents the third most common type of cancer and the third leading cause of death from cancer around the world. M701 is a CD3/EpCAM bispecific antibody that shows promising cytotoxicity toward CRC cells.
    Aim: To investigate the influence of immuno-related gene polymorphisms on M701 mediated cytotoxicity to CRC cell HCT116.
    Method: We analyzed the influence of the effect of M701 on the activation and cytotoxicity of peripheral mononuclear blood cells from 129 healthy volunteers with different genotypes.
    Result: When incubated with M701, peripheral mononuclear blood cells from CD247 rs2949655 AA homozygotes showed significantly lower cytotoxicity than those from AG/GG heterozygotes.
    Conclusion: CD247 rs2949655 was significantly associated with the cytotoxicity of M701 to HCT116, which might contribute to personalized medicine of M701.
    MeSH term(s) Antibodies, Bispecific/pharmacology ; CD3 Complex/genetics ; CD3 Complex/immunology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Epithelial Cell Adhesion Molecule/immunology ; Genotype ; HCT116 Cells ; Healthy Volunteers ; Humans ; Pharmacogenomic Variants ; Precision Medicine
    Chemical Substances Antibodies, Bispecific ; CD3 Complex ; EPCAM protein, human ; Epithelial Cell Adhesion Molecule
    Language English
    Publishing date 2018-05-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2299146-3
    ISSN 1744-828X ; 1741-0541
    ISSN (online) 1744-828X
    ISSN 1741-0541
    DOI 10.2217/pme-2017-0071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer.

    Zhang, Cong-Min / Lv, Jin-Feng / Gong, Liang / Yu, Lin-Yu / Chen, Xiao-Ping / Zhou, Hong-Hao / Fan, Lan

    International journal of environmental research and public health

    2016  Volume 13, Issue 9

    Abstract: Colorectal cancer (CRC) represents the third most common type of cancer in developed countries and one of the leading causes of cancer deaths worldwide. Personalized management of CRC has gained increasing attention since there are large inter-individual ...

    Abstract Colorectal cancer (CRC) represents the third most common type of cancer in developed countries and one of the leading causes of cancer deaths worldwide. Personalized management of CRC has gained increasing attention since there are large inter-individual variations in the prognosis and response to drugs used to treat CRC owing to molecular heterogeneity. Approximately 15% of CRCs are caused by deficient mismatch repair (dMMR) characterized by microsatellite instability (MSI) phenotype. The present review is aimed at highlighting the role of MMR status in informing prognosis and personalized treatment of CRC including adjuvant chemotherapy, targeted therapy, and immune checkpoint inhibitor therapy to guide the individualized therapy of CRC.
    MeSH term(s) Animals ; Antineoplastic Agents/therapeutic use ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; DNA Mismatch Repair ; Humans ; Microsatellite Instability ; Precision Medicine ; Prognosis
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2016-09-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph13090892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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