Article ; Online: Both LTA and LTB Subunits Are Equally Important to Heat-Labile Enterotoxin (LT)-Enhanced Bacterial Adherence.
International journal of molecular sciences
2023 Volume 24, Issue 2
Abstract: There is increasing evidence indicating that the production of heat-labile enterotoxin (LT) enhances bacterial adherence within in vitro and in vivo models. However, which subunit plays the main role, and the precise regulatory mechanisms remain unclear. ...
Abstract | There is increasing evidence indicating that the production of heat-labile enterotoxin (LT) enhances bacterial adherence within in vitro and in vivo models. However, which subunit plays the main role, and the precise regulatory mechanisms remain unclear. To further elucidate the contribution of the A subunit of LT (LTA) and the B subunit of LT (LTB) in LT-enhanced bacterial adherence, we generated several LT mutants where their ADP-ribosylation activity or GM1 binding ability was impaired and evaluated their abilities to enhance the two LT-deficient |
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MeSH term(s) | Enterotoxins/genetics ; Enterotoxins/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Bacterial Toxins/genetics ; Bacterial Toxins/metabolism ; Hot Temperature ; G(M1) Ganglioside ; Escherichia coli Proteins/genetics |
Chemical Substances | Enterotoxins ; Bacterial Toxins ; G(M1) Ganglioside (37758-47-7) ; Escherichia coli Proteins |
Language | English |
Publishing date | 2023-01-08 |
Publishing country | Switzerland |
Document type | Journal Article |
ZDB-ID | 2019364-6 |
ISSN | 1422-0067 ; 1422-0067 ; 1661-6596 |
ISSN (online) | 1422-0067 |
ISSN | 1422-0067 ; 1661-6596 |
DOI | 10.3390/ijms24021245 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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