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  1. Article: Heat shock protein: a double-edged sword linking innate immunity and hepatitis B virus infection.

    Dai, Wen-Ying / Yao, Guo-Qing / Deng, Xi-Chuan / Zang, Guang-Chao / Liu, Jia / Zhang, Guang-Yuan / Chen, Yu-Meng / Lv, Ming-Qi / Chen, Ting-Ting

    Journal of virus eradication

    2023  Volume 9, Issue 1, Page(s) 100322

    Abstract: Heat shock proteins (HSPs), which have a variety of functions, are one of the stress protein families. In recent years, They have been reported to play a dual role in hepatitis B virus (HBV) which as persistent infection which is associated with, ... ...

    Abstract Heat shock proteins (HSPs), which have a variety of functions, are one of the stress protein families. In recent years, They have been reported to play a dual role in hepatitis B virus (HBV) which as persistent infection which is associated with, cirrhosis and liver cancer. In this article, we have summarized the regulatory mechanisms between HSPs and viruses, especially HBV and associated diseases based on HSP biological functions of in response to viral infections. In view of their potential as broad-spectrum antiviral targets, we have also discuss current progress and challenges in drug development based on HSPs, as well as the potential applications of agents that have been evaluated clinically in HBV treatment.
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2868549-0
    ISSN 2055-6659 ; 2055-6640
    ISSN (online) 2055-6659
    ISSN 2055-6640
    DOI 10.1016/j.jve.2023.100322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Photocrosslinking silver nanoparticles-aloe vera-silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds.

    Liu, Yangkun / Fan, JinChuan / Lv, MingQi / She, Kepeng / Sun, Jiale / Lu, Qingqing / Han, Changhao / Ding, SongTao / Zhao, Shuang / Wang, GuiXue / Zhang, YuChan / Zang, GuangChao

    Regenerative biomaterials

    2021  Volume 8, Issue 6, Page(s) rbab048

    Abstract: Damage to the skin causes physiological and functional issues. The most effective treatment approach is the use of wound dressings. Silk fibroin (SF) is a promising candidate biomaterial for regulating wound healing; however, its antibacterial properties ...

    Abstract Damage to the skin causes physiological and functional issues. The most effective treatment approach is the use of wound dressings. Silk fibroin (SF) is a promising candidate biomaterial for regulating wound healing; however, its antibacterial properties and biological activity must be further improved. In this study, a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds. The composite hydrogel (Ag-AV-SF hydrogel) was prepared by introducing the silver nanoparticles (AgNPs) and aloe vera (AV) as the modifiers.
    Language English
    Publishing date 2021-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2799042-4
    ISSN 2056-3426 ; 2056-3418
    ISSN (online) 2056-3426
    ISSN 2056-3418
    DOI 10.1093/rb/rbab048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Multicenter randomized, double-blind, placebo-controlled trial of prostaglandin E1 cream for female sexual arousal disorder].

    Zhang, Miao / Liao, Qin-ping / Yao, Chen / Geng, Li / Wang, Xiang-ping / Song, Xue-hong / Zhao, Jian / Lv, Tao / Lv, Ming-qi / Chen, Lei / Yao, Yan-jun / Xia, Bei / Zhang, Hai-zhen / Wang, Qiu-xi / Lu, Jun-li

    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

    2010  Volume 42, Issue 6, Page(s) 727–733

    Abstract: Objective: To investigate the efficacy and safety of alprostadil cream in management of female sexual arouse disorder (FSAD), and its appropriate dose for clinical prescription.: Methods: The volunteers were assigned randomly to four groups which ... ...

    Abstract Objective: To investigate the efficacy and safety of alprostadil cream in management of female sexual arouse disorder (FSAD), and its appropriate dose for clinical prescription.
    Methods: The volunteers were assigned randomly to four groups which received alprostadil cream in different dosage (500 μg, 700 μg and 900 μg) or placebo cream, respectively. The cream was applied to the clitoris and G-spot before coitus. The efficacy was assessed by comparing the satisfactory rate of sexual arousal, the score of female sexual function index (FSFI) and female sex disorder scale (FSDS) and the general appraised question (GAQ) before and after the treatment. The safety was evaluated by the adverse effects that appeared including symptoms, physical and biochemical examination.
    Results: Totally, 400 women enrolled in this study with 374 assigned to the group for efficacy evaluation and 387 cases to the group for safety analysis. No significant difference was found among the four groups in the demographic characters and sexual baseline. The increase of satisfactory percentage of sexual arousal in the four groups (placebo, 500 μg, 700 μg and 900 μg) was 22.63%, 36.67%, 34.01%, and 44.29%, respectively (P<0.05), and the increase was statistically higher in the 900 μg group than in the placebo group (P<0.0167). The elevated FSFI score above the baseline in the treatment groups (900 μg 22.89, 700 μg 21.69, and 500 μg 20.71) were higher than that in the placebo group (14.68, P<0.05), while the reduced FSDS score below the baseline (900 μg 25.97, 700 μg 21.98, and 500 μg 20.27) were higher than that of the placebo (17.60, P<0.05). No significant difference was found in the four groups in GAQ (P=0.054). The main common adverse effect was topical stimulation. No adverse effect was reported in physical and biochemical examination, electrocardiogram (ECG) or Thinprep cytologic test (TCT).
    Conclusion: Alprostadil cream can treat female sexual arousal disorder effectively with the maximum effect at the dose of 900 μg and without significant adverse effect except for mild topical stimulation.
    MeSH term(s) Administration, Cutaneous ; Alprostadil/administration & dosage ; Alprostadil/adverse effects ; Double-Blind Method ; Female ; Humans ; Patient Satisfaction ; Sexual Dysfunctions, Psychological/drug therapy ; Treatment Outcome ; Vaginal Creams, Foams, and Jellies ; Vulva/drug effects
    Chemical Substances Vaginal Creams, Foams, and Jellies ; Alprostadil (F5TD010360)
    Language Chinese
    Publishing date 2010-12-18
    Publishing country China
    Document type English Abstract ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ISSN 1671-167X
    ISSN 1671-167X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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