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  1. Article ; Online: Preparation, Characterization, and In Vitro/In Vivo Evaluation of 3-O-β-D-Galactosylated Resveratrol-Loaded Polydopamine Nanoparticles.

    Wang, Beilei / Shan, Xiaoxiao / Lv, Shujie / Zha, Liqiong / Zhang, Caiyun / Dong, Qiannian / Chen, Weidong

    AAPS PharmSciTech

    2021  Volume 22, Issue 7, Page(s) 220

    Abstract: 3-O-β-D-galactosylated resveratrol (Gal-Res) was synthesized from resveratrol (Res) and 3-O-β-D-galactose (Gal) in our previous study. In order to improve the pH sensitivity and bioavailability of Gal-Res, Gal-Res nanoparticles (Gal-Res NPs) were ... ...

    Abstract 3-O-β-D-galactosylated resveratrol (Gal-Res) was synthesized from resveratrol (Res) and 3-O-β-D-galactose (Gal) in our previous study. In order to improve the pH sensitivity and bioavailability of Gal-Res, Gal-Res nanoparticles (Gal-Res NPs) were prepared using polydopamine (PDA) as a drug carrier. The drug loading (DL %) and entrapment efficiency (EE %) of Gal-Res NPs were 46.80% and 88.06%. The average particle size, polydispersity index (PDI), and Zeta potential of Gal-Res NPs were 179.38 ± 2.83 nm, 0.129 ± 0.013, and - 28.05 ± 0.36 mV, respectively. The transmission electron microscope (TEM) showed that Gal-Res NPs had uniform spherical morphology. Compared with the fast release of raw Gal-Res, the in vitro release of Gal-Res NPs was slow and pH-sensitive. The results of the blood vessel irritation and hemolysis test demonstrated that Gal-Res NPs had good hemocompatibility. The pharmacokinetics study in rats showed that area under the curve of plasma drug concentration time (AUC
    MeSH term(s) Drug Carriers ; Indoles/chemistry ; Nanoparticles ; Particle Size ; Polymers/chemistry ; Resveratrol ; Tissue Distribution
    Chemical Substances Drug Carriers ; Indoles ; Polymers ; polydopamine ; Resveratrol (Q369O8926L)
    Language English
    Publishing date 2021-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2052070-0
    ISSN 1530-9932 ; 1530-9932
    ISSN (online) 1530-9932
    ISSN 1530-9932
    DOI 10.1208/s12249-021-02079-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Classic Famous Prescription Kai-Xin-San Ameliorates Alzheimer's Disease via the Wnt/β-Catenin Signaling Pathway.

    Shan, Xiaoxiao / Lv, Shujie / Huang, Peng / Zhang, Wei / Jin, Chuanshan / Liu, Yuanxu / Li, Yangyang / Jia, Yong / Chu, Xiaoqin / Peng, Can / Zhang, Caiyun

    Molecular neurobiology

    2023  Volume 61, Issue 4, Page(s) 2297–2312

    Abstract: Kai-Xin-San (KXS) is a classic famous prescription composed of Polygalae Radix, Ginseng Radix et Rhizoma, Acori Tatarinowii Rhizoma, and Poria. Clinically, KXS is effective in treating amnesia and regulating cognitive dysfunction of Alzheimer's disease ( ... ...

    Abstract Kai-Xin-San (KXS) is a classic famous prescription composed of Polygalae Radix, Ginseng Radix et Rhizoma, Acori Tatarinowii Rhizoma, and Poria. Clinically, KXS is effective in treating amnesia and regulating cognitive dysfunction of Alzheimer's disease (AD), whereas its mechanism of action is still unclear. In this study, the AD model rats were established by combining intraperitoneal injection of D-galactose (150 mg/kg/day) and intracerebral injection of Aβ
    MeSH term(s) Rats ; Animals ; Alzheimer Disease/metabolism ; Caspase 3/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; beta Catenin/metabolism ; Wnt Signaling Pathway ; bcl-2-Associated X Protein ; Disease Models, Animal ; Drugs, Chinese Herbal
    Chemical Substances Kai-Xin-San ; Caspase 3 (EC 3.4.22.-) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; beta Catenin ; bcl-2-Associated X Protein ; Drugs, Chinese Herbal
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03707-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2411: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Identification and Analysis of Chemical Constituents and Rat Serum Metabolites in Gushuling Using UPLC-Q-TOF/MS Coupled with Novel Informatics UNIFI Platform.

    Chang, Hong / Lv, Shujie / Yuan, Tengteng / Wu, Huan / Wang, Lei / Sang, Ran / Zhang, Caiyun / Chen, Weidong

    Evidence-based complementary and alternative medicine : eCAM

    2021  Volume 2021, Page(s) 2894306

    Abstract: Gushuling (GSL), a well-known hospital preparation composed of traditional Chinese medicine (TCM), has been widely used in the clinical treatment of osteoporosis (OP) for decades due to its remarkable therapeutic effect. However, the chemical ... ...

    Abstract Gushuling (GSL), a well-known hospital preparation composed of traditional Chinese medicine (TCM), has been widely used in the clinical treatment of osteoporosis (OP) for decades due to its remarkable therapeutic effect. However, the chemical constituents of GSL are still unclear so far, which limits the in-depth study of its pharmacodynamic material basis and further restricts its clinical application. In this study, we developed a strategy for qualitative analysis of the chemical constituents of GSL
    Language English
    Publishing date 2021-12-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2021/2894306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: PF-PLC micelles ameliorate cholestatic liver injury via regulating TLR4/MyD88/NF-κB and PXR/CAR/UGT1A1 signaling pathways in EE-induced rats.

    Yuan, Tengteng / Lv, Shujie / Zhang, Wei / Tang, Yanan / Chang, Hong / Hu, Zihan / Fang, Liang / Du, Jiaojiao / Wu, Sifan / Yang, Xinli / Guo, Yangfu / Guo, Ruihan / Ge, Zongrui / Wang, Lei / Zhang, Caiyun / Wang, Rulin / Chen, Weidong

    International journal of pharmaceutics

    2022  Volume 615, Page(s) 121480

    Abstract: Paeoniflorin (PF) has a certain therapeutic effect on cholestasis liver injury. To further improve the bioavailability of PF and play its pharmacological role in liver protection, PF-phospholipid complex micelles (PF-PLC micelles) were prepared based on ... ...

    Abstract Paeoniflorin (PF) has a certain therapeutic effect on cholestasis liver injury. To further improve the bioavailability of PF and play its pharmacological role in liver protection, PF-phospholipid complex micelles (PF-PLC micelles) were prepared based on our previous research on PF-PLC. The protective effects of PF and PF-PLC micelles on cholestasis liver injury induced by 17α-ethynylestradiol (EE) were compared, and the possible mechanisms were further explored. Herein, we showed that PF-PLC micelles effectively improved liver function, alleviated liver pathological damage, and localized infiltration of inflammatory cells. Mechanism studies indicated that PF-PLC micelles treatment could suppress the TLR4/MyD88/NF-κB pathway, and further reduce the levels of pro-inflammatory factors. Meanwhile, our experimental results demonstrated that the beneficial effect of PF-PLC micelles on EE-induced cholestasis may be achieved by the upregulation of nuclear receptors and metabolic enzymes (PXR/CAR/UGT1A1). All these results indicate that PF-PLC micelles have great potential in the treatment of cholestatic liver disease.
    MeSH term(s) Animals ; Cholestasis/chemically induced ; Cholestasis/drug therapy ; Glucosides/pharmacology ; Liver/drug effects ; Liver/metabolism ; Micelles ; Monoterpenes/pharmacology ; Rats ; Signal Transduction
    Chemical Substances Glucosides ; Micelles ; Monoterpenes ; peoniflorin (21AIQ4EV64)
    Language English
    Publishing date 2022-01-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2022.121480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Salidroside attenuates oxidized low‑density lipoprotein‑induced endothelial cell injury via promotion of the AMPK/SIRT1 pathway.

    Zhao, Dongming / Sun, Xinyi / Lv, Shujie / Sun, Miying / Guo, Huatao / Zhai, Yujia / Wang, Zhi / Dai, Peng / Zheng, Lina / Ye, Mingzhe / Wang, Xinpeng

    International journal of molecular medicine

    2019  Volume 43, Issue 6, Page(s) 2279–2290

    Abstract: Oxidized low‑density lipoprotein (ox‑LDL)‑induced endothelial damage contributes to the initiation and pathogenesis of atherosclerosis. Salidroside can alleviate atherosclerosis and attenuate endothelial cell injury induced by ox‑LDL. However, the ... ...

    Abstract Oxidized low‑density lipoprotein (ox‑LDL)‑induced endothelial damage contributes to the initiation and pathogenesis of atherosclerosis. Salidroside can alleviate atherosclerosis and attenuate endothelial cell injury induced by ox‑LDL. However, the mechanisms involved in this process are not fully understood. Therefore, the purpose of the present study was to investigate the role of the adenosine monophosphate‑activated protein kinase (AMPK)/sirtuin (SIRT)1 pathway in the protection of salidroside against ox‑LDL‑induced human umbilical vein endothelial cells (HUVECs) injuries. The results revealed that salidroside reverses ox‑LDL‑induced HUVECs injury as demonstrated by the upregulation of cell viability and downregulation of LDH release. In addition, salidroside increased the expression of the SIRT1 protein in ox‑LDL‑treated HUVECs. Next, it was demonstrated that SIRT1 knockdown induced by transfection with small interfering (si)RNA targeting SIRT1 (siSRT1) abolished the protection of salidroside against ox‑LDL‑induced HUVECs injuries. This was illustrated by a decrease in cell viability and an increase in LDH release, caspase‑3 activity and apoptosis rate. Furthermore, salidroside mitigated ox‑LDL‑induced reactive oxygen species production, upregulated malondialdehyde content and NADPH oxidase 2 expression and decreased superoxide dismutase and glutathione peroxidase activities, while these effects were also reversed by siSIRT1 transfection. In addition, it was demonstrated that salidroside suppressed ox‑LDL‑induced mitochondrial dysfunction as demonstrated by the increase in mitochondrial membrane potential and decreases in cytochrome c expression, and Bax/Bcl‑2 reductions. However, these effects were eliminated by SIRT1 knockdown. Finally, it was demonstrated that salidroside significantly upregulated the phosphorylated‑AMPK expression in ox‑LDL‑treated HUVECs and AMPK knockdown induced by transfection with AMPK siRNA (siAMPK) leads to elimination of the salidroside‑induced increase in cell viability and the decrease in LDH release. Notably, siAMPK transfection further decreased the expression of SIRT1. In conclusion, these results suggested that salidroside protects HUVECs against ox‑LDL injury through inhibiting oxidative stress and improving mitochondrial dysfunction, which were dependent on activating the AMPK/SIRT1 pathway.
    MeSH term(s) AMP-Activated Protein Kinases/metabolism ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Cell Survival/drug effects ; Cytoprotection/drug effects ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Glucosides/chemistry ; Glucosides/pharmacology ; Human Umbilical Vein Endothelial Cells ; Humans ; Lipoproteins, LDL/metabolism ; Oxidative Stress/drug effects ; Phenols/chemistry ; Phenols/pharmacology ; Reactive Oxygen Species/metabolism ; Rhodiola/chemistry ; Signal Transduction/drug effects ; Sirtuin 1/metabolism
    Chemical Substances Antioxidants ; Glucosides ; Lipoproteins, LDL ; Phenols ; Reactive Oxygen Species ; oxidized low density lipoprotein ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; SIRT1 protein, human (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-) ; rhodioloside (M983H6N1S9)
    Language English
    Publishing date 2019-04-01
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1444428-8
    ISSN 1791-244X ; 1107-3756
    ISSN (online) 1791-244X
    ISSN 1107-3756
    DOI 10.3892/ijmm.2019.4153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4942: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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