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Article ; Online: The diagnostic value of transvaginal color Doppler ultrasonography plus serum β-HCG dynamic monitoring in intrauterine residue after medical abortion.

Liu, Yanbo / Lv, Wen

2023 Volume 102, Issue 5, Page(s) e31217

Abstract: To probe the diagnostic value of transvaginal color Doppler ultrasonography plus serum β-human chorionic gonadotropin (β-HCG) dynamic monitoring in intrauterine residue after medical abortion.In total, 200 pregnant women undergoing medical abortion in ... ...

Abstract	To probe the diagnostic value of transvaginal color Doppler ultrasonography plus serum β-human chorionic gonadotropin (β-HCG) dynamic monitoring in intrauterine residue after medical abortion.In total, 200 pregnant women undergoing medical abortion in our institution from January 2017 to December 2019 were picked, and assigned to either group A (n = 75, with residue) or group B (n = 125, without residue). We detected serum β-HCG, progesterone (P), follicle stimulating estrogen (FSH) levels and ultrasonic indicators endometrial thickness (ET), peak systolic velocity (PSV), resistance index (RI) values, dissected correlation of indicators using logistic linear regression analysis, and prospected the diagnostic value of relevant indicators in intrauterine residue after medical abortion utilizingreceiver operating characteristic curve.At 7 days after abortion (T3), total vaginal bleeding and visual analogue scalescore in group A were saliently higher in contrast to group B ( P < .05). At 72 hours after abortion (T2) and T3, serum β-HCG, P and FSH levels declined strikingly in both groups, but group B held plainly higher decrease rate than group A ( P HC.05). At T3, ET and PSV levels in both groups considerably waned, whereas RI levels notedly waxed, and group B owned markedly higher decrease/increase than group A ( P wa.05). At T3, serum β-HCG in group A possessed positive association with serum P, FSH, intrauterine ET, PSV levels separately ( P HC.05), whereas negative link with RI levels ( P , .05). The specificity and sensitivity of β-HCG, P, FSH, β-HCG/ET, β-HCG/PSV and β-HCG/RI in the diagnosis of intrauterine residue after medical abortion were high ( P < .05).Serum β-HCG dynamic monitoring plus transvaginal color Doppler ultrasonography is of great value in diagnosing intrauterine residue after medical abortion. Serum β-HCG, P, FSH levels can be combined with the results of intrauterine ET, PSV, RI values, so as to boost the diagnostic accuracy of the intrauterine residue after medical abortion.
MeSH term(s)	Female ; Humans ; Pregnancy ; Abortion, Induced/methods ; Chorionic Gonadotropin ; Chorionic Gonadotropin, beta Subunit, Human/blood ; Follicle Stimulating Hormone/blood ; Progesterone/blood ; Ultrasonography ; Ultrasonography, Doppler, Color ; Vagina/diagnostic imaging ; Uterus/diagnostic imaging ; Endometrium/diagnostic imaging
Chemical Substances	Chorionic Gonadotropin ; Chorionic Gonadotropin, beta Subunit, Human ; Follicle Stimulating Hormone (9002-68-0) ; Progesterone (4G7DS2Q64Y)
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000031217
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Article ; Online: Gene Editing of

Lv, Wen / Lu, Xinyao / Zhuge, Bin / Zong, Hong

ACS synthetic biology

2024 Volume 13, Issue 3, Page(s) 816–824

Abstract: ... Candida ... ...

Abstract	Candida glycerinogenes
MeSH term(s)	Gene Editing/methods ; Antitoxins/genetics ; Bacterial Toxins/genetics ; Phenylethyl Alcohol ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Pichia
Chemical Substances	Antitoxins ; Bacterial Toxins ; Phenylethyl Alcohol (ML9LGA7468)
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article
ISSN	2161-5063
ISSN (online)	2161-5063
DOI	10.1021/acssynbio.3c00640
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Article ; Online: A Novel Hypoxic-Angiogenesis-Immune-Related Gene Model for Prognostic and Therapeutic Effect Prediction in Hepatocellular Carcinoma Patients.

Lv, Wen / Yao, Qi

Disease markers

2022 Volume 2022, Page(s) 9428660

Abstract: Background: Hepatocellular carcinoma (HCC) is one of the most heterogeneous malignant tumors that have been discovered so far, which makes the prognostic prediction difficult. The hypoxia, angiogenesis, and immunity-related genes (HAIRGs) are closely ... ...

Abstract	Background: Hepatocellular carcinoma (HCC) is one of the most heterogeneous malignant tumors that have been discovered so far, which makes the prognostic prediction difficult. The hypoxia, angiogenesis, and immunity-related genes (HAIRGs) are closely related to the development of liver cancer. However, the prognostic and treatment effect of hypoxia, angiogenesis, and immunity-related genes in HCC continues to be further clarified. Methods: The gene expression quantification data and clinical information in patients with liver cancer were downloaded from the TCGA database, and HAIRG signature was built by using the least absolute shrinkage and selection operator (LASSO) technique. Patient from the ICGC database validated the model. Then, tumor immune dysfunction and exclusion (TIDE) algorithm was applied to estimate the clinical response to immunotherapy and the sensitivity of drugs was evaluated by the half-maximal inhibitory concentration (IC Result: The HAIRGs were identified between the HCC patients and normal patients in the TCGA database. In univariate Cox regression analysis, seventeen differentially expressed genes (DEGs) were associated with overall survival (OS). An eight HAIRG signature model was constructed and was used to divide the patients into two groups according to the median value of the risk score base on the TCGA dataset. Patients in the high-risk group had a significant reduction in OS compared to those in the low-risk group ( Conclusions: HAIRG signature can be utilized for prognostic prediction in HCC, while it can be considered a prediction model for clinical evaluation of immunotherapy response and chemotherapy sensitivity in HCC.
MeSH term(s)	Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/pathology ; Humans ; Hypoxia ; Liver Neoplasms/pathology ; Prognosis
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2022-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
DOI	10.1155/2022/9428660
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Article ; Online: Development and validation of machine learning-based models for prediction of adolescent idiopathic scoliosis: A retrospective study.

Lv, Zheng / Lv, Wen / Wang, Lei / Ou, Jiayuan

Medicine

2023 Volume 102, Issue 14, Page(s) e33441

Abstract: Adolescent idiopathic scoliosis (AIS) can cause abnormal body posture, which has a negative impact on the overall posture. Therefore, timely prevention and early treatment are extremely important. The purpose of this study is to build an early warning ... ...

Abstract	Adolescent idiopathic scoliosis (AIS) can cause abnormal body posture, which has a negative impact on the overall posture. Therefore, timely prevention and early treatment are extremely important. The purpose of this study is to build an early warning model of AIS risk, so as to provide guidance for accurately identifying early high-risk AIS children and adolescents. We conducted a retrospective study of 1732 children and adolescents with or without AIS who underwent physical examination in Longgang District Central Hospital of Shenzhen (LDCHS queue) from January 2019 to October 2022 and 1581 children and adolescents with or without AIS in Shenzhen People Hospital (January 2018 to December 2022) as external validation queues (SPH queue). The random forest model (RFM), support vector machine model, artificial neural network model (ANNM), decision tree model (DTM), and generalized linear model (GLM) were used to build AIS model for children and adolescents. The predictive efficacy of 5 machine learning models was evaluated by receiver operating characteristic curve and decision curve analysis. For screening candidate predictors of AIS, the ratio of sitting height to standing height (ROSHTSH), angle of lumbar rotation, scapular tilt (ST), shoulder-height difference (SHD), lumbar concave (LC), pelvic tilt (PT) and angle of thoracolumbar rotation (AOTR) can be used as a potential predictor of AIS. The effectiveness of the prediction model constructed by the 5 machine learning algorithms was between (area under the curve [AUC]: 0.767, 95% confidence interval [CI]: 0.710-0.824) and (AUC: 0.899, 95% CI: 0.842-0.956) in the training set and internal verification set, respectively. Among them, the ANNM was equipped with the best prediction effectiveness (training set: AUC: 0.899, 95% CI: 0.842-0.956) and (internal verification set: AUC: 0.897, 95% CI: 0.842-0.952). The prediction model of AIS based on machine learning algorithm can achieve satisfactory prediction efficiency, among which ANNM is the best, which can be used to guide clinicians in diagnosis and treatment and improve the prognosis of AIS children and adolescents.
MeSH term(s)	Child ; Humans ; Adolescent ; Scoliosis/diagnosis ; Retrospective Studies ; Kyphosis ; Prognosis ; Machine Learning
Language	English
Publishing date	2023-04-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033441
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Article ; Online: Missed Spontaneous Heterotopic Pregnancy: A Case Report of a Ruptured Tubal Pregnancy after Induced Abortion.

Yu, Shuqian / Lv, Wen / Li, Wu

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2023 Volume 33, Issue 7, Page(s) 829–830

Abstract: Null. ...

Abstract	Null.
MeSH term(s)	Pregnancy ; Female ; Humans ; Pregnancy, Heterotopic/diagnostic imaging ; Pregnancy, Heterotopic/surgery ; Pregnancy, Tubal/diagnostic imaging ; Pregnancy, Tubal/surgery ; Abortion, Induced/adverse effects ; Abortion, Spontaneous ; Rupture, Spontaneous
Language	English
Publishing date	2023-07-04
Publishing country	Pakistan
Document type	Case Reports ; Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2023.07.829
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Article ; Online: Starter molds and multi-enzyme catalysis in koji fermentation of soy sauce brewing: A review.

Liu, Yihao / Sun, Guangru / Li, Jingyao / Cheng, Peng / Song, Qian / Lv, Wen / Wang, Chunling

Food research international (Ottawa, Ont.)

2024 Volume 184, Page(s) 114273

Abstract: Soy sauce is a traditional fermented food produced from soybean and wheat under the action of microorganisms. The soy sauce brewing process mainly involves two steps, namely koji fermentation and moromi fermentation. In the koji fermentation process, ... ...

Abstract	Soy sauce is a traditional fermented food produced from soybean and wheat under the action of microorganisms. The soy sauce brewing process mainly involves two steps, namely koji fermentation and moromi fermentation. In the koji fermentation process, enzymes from starter molds, such as protease, aminopeptidase, carboxypeptidase, l-glutaminase, amylase, and cellulase, hydrolyze the protein and starch in the raw ingredients to produce short-chain substances. However, the enzymatic reactions may be diminished after being subjected to moromi fermentation due to its high NaCl concentration. These enzymatically hydrolyzed products are further metabolized by lactic acid bacteria and yeasts during the moromi fermentation process into organic acids and aromatic compounds, giving soy sauce a unique flavor. Thus, the starter molds, such as Aspergillus oryzae, Aspergillus sojae, and Aspergillus niger, and their secreted enzymes play crucial roles in soy sauce brewing. This review comprehensively covers the characteristics of the starter molds mainly used in soy sauce brewing, the enzymes produced by starter molds, and the roles of enzymes in the degradation of raw material. We also enumerate current problems in the production of soy sauce, aiming to offer some directions for the improvement of soy sauce taste.
MeSH term(s)	Soy Foods ; Fermentation ; Peptide Hydrolases ; Aspergillus niger ; Catalysis
Chemical Substances	Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2024-03-23
Publishing country	Canada
Document type	Journal Article ; Review
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2024.114273
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Article ; Online: AEBP1 upregulation contributes to cervical cancer progression by facilitating cell proliferation, migration, and invasion.

Liu, Songjun / Gu, Yanpin / Shi, Yin / Yu, Shuqian / Li, Wu / Lv, Wen

The journal of obstetrics and gynaecology research

2024

Abstract: Background: Aberrant expression of adipocyte enhancer-binding protein 1 (AEBP1) has been demonstrated to be involved in the tumorigenesis and progression of numerous cancers. This study was aimed to investigate the mechanism of AEBP1 in the development ... ...

Abstract	Background: Aberrant expression of adipocyte enhancer-binding protein 1 (AEBP1) has been demonstrated to be involved in the tumorigenesis and progression of numerous cancers. This study was aimed to investigate the mechanism of AEBP1 in the development of cervical cancer. Methods: The expression of AEBP1 in cervical cancer was assessed by immunohistochemistry. The function of AEBP1 on cell proliferation, migration, and invasion was determined by methyl thiazolyl tetrazolium assay, colony formation, and transwell assay. The activation of related signaling pathway was determined by western blot. The bioinformatics analysis was performed by Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Results: Higher protein expression of AEBP1 was observed in patients with cervical cancer. Overexpressed AEBP1 promoted cell proliferation, migration, and invasion abilities in cervical cancer cells. Moreover, the research manifested that AEBP1 activated the phosphorylation of STAT3. GO and KEGG analysis showed that genes positively related to AEBP1 were highly enriched in functions like epithelial cell proliferation, muscle cell migration, myoblast migration, smooth muscle tissue development, ECM-receptor interaction, transcriptional misregulation in cancer, and proteoglycans in cancer. While genes negatively related to AEBP1 were associated with immunity, including inflammatory response, external-stimulus response, neutrophil, granulocyte, and macrophage chemotaxis. Conclusions: This study suggested that AEBP1 acts as an oncogened and might be a potential therapeutic target for the treatment of cervical cancer.
Language	English
Publishing date	2024-04-29
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.15959
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Article: From predator to protector:

Han, Jian / Dong, Zhiming / Ji, Wenbo / Lv, Wen / Luo, Ming / Fu, Benzhong

Frontiers in microbiology

2024 Volume 15, Page(s) 1378288

Abstract: Fire blight, caused by the Gram-negative ... ...

Abstract	Fire blight, caused by the Gram-negative bacterium
Language	English
Publishing date	2024-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2024.1378288
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Article ; Online: Renal pelvis mucosal artery hemorrhage after percutaneous nephrolithotomy: a rare case report and literature review.

Zhang, Lv Wen / Fei, Xiang / Song, Yan

BMC urology

2022 Volume 22, Issue 1, Page(s) 100

Abstract: Background: Following a percutaneous nephrolithotomy (PCNL) procedure, the most common complications are considered to be intraoperative and postoperative bleeding. Many patients with postoperative bleeding can be treated conservatively, causing the ... ...

Abstract	Background: Following a percutaneous nephrolithotomy (PCNL) procedure, the most common complications are considered to be intraoperative and postoperative bleeding. Many patients with postoperative bleeding can be treated conservatively, causing the perirenal hematoma to resolve spontaneously. The major causes of severe postoperative bleeding are pseudoaneurysms, arteriovenous fistula, and segmental arterial injury. Typically, the first choice of treatment to manage severe bleeding complications is selective angioembolization (SAE) because of the very high success rate associated with this procedure. Case presentation: This clinical case involves a 56-year-old man who underwent dual-channel PCNL treatment after diagnosing a left kidney staghorn stone and urinary tract infection. The operation was successful, with no apparent signs of bleeding. Tests revealed continued decreasing hemoglobin levels following the procedure. After the conservative treatment failed, renal angiography was performed immediately, indicating renal pelvis mucosal artery hemorrhage. In the three hours post-surgery, the SAE still failed to prevent bleeding. Further discussions led to formulating a new surgical plan using a nephroscope to enter the initial channel where hemostasis began. The hemostasis origin was found precisely in the mucosal artery next to the channel during the operation and was successfully controlled. Conclusions: This case reveals there is poor communication and inadequate discussions about the potential failures of an SAE procedure. Swift clinical decision-making is imperative when dealing with high-level renal trauma to prevent delays in surgery that can threaten the safety of patients.
MeSH term(s)	Arteries ; Humans ; Kidney Diseases/complications ; Kidney Pelvis ; Male ; Middle Aged ; Nephrolithotomy, Percutaneous/adverse effects ; Nephrostomy, Percutaneous/adverse effects ; Nephrostomy, Percutaneous/methods ; Postoperative Hemorrhage/diagnostic imaging ; Postoperative Hemorrhage/etiology ; Postoperative Hemorrhage/therapy
Language	English
Publishing date	2022-07-11
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-022-01049-w
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Article ; Online: Predicting the malignancy of extremity soft-tissue tumors by an ultrasound-based radiomics signature.

Li, Ao / Hu, Yu / Cui, Xin-Wu / Ye, Xin-Hua / Peng, Xiao-Jing / Lv, Wen-Zhi / Zhao, Chong-Ke

Acta radiologica (Stockholm, Sweden : 1987)

2024 , Page(s) 2841851231217227

Abstract: Background: Accurate differentiation of extremity soft-tissue tumors (ESTTs) is important for treatment planning.: Purpose: To develop and validate an ultrasound (US) image-based radiomics signature to predict ESTTs malignancy.: Material and ... ...

Abstract	Background: Accurate differentiation of extremity soft-tissue tumors (ESTTs) is important for treatment planning. Purpose: To develop and validate an ultrasound (US) image-based radiomics signature to predict ESTTs malignancy. Material and methods: A dataset of US images from 108 ESTTs were retrospectively enrolled and divided into the training cohort (78 ESTTs) and validation cohort (30 ESTTs). A total of 1037 radiomics features were extracted from each US image. The most useful predictive radiomics features were selected by the maximum relevance and minimum redundancy method, least absolute shrinkage, and selection operator algorithm in the training cohort. A US-based radiomics signature was built based on these selected radiomics features. In addition, a conventional radiologic model based on the US features from the interpretation of two experienced radiologists was developed by a multivariate logistic regression algorithm. The diagnostic performances of the selected radiomics features, the US-based radiomics signature, and the conventional radiologic model for differentiating ESTTs were evaluated and compared in the validation cohort. Results: In the validation cohort, the area under the curve (AUC), sensitivity, and specificity of the US-based radiomics signature for predicting ESTTs malignancy were 0.866, 84.2%, and 81.8%, respectively. The US-based radiomics signature had better diagnostic predictability for predicting ESTT malignancy than the best single radiomics feature and the conventional radiologic model (AUC = 0.866 vs. 0.719 vs. 0.681 for the validation cohort, all Conclusion: The US-based radiomics signature could provide a potential imaging biomarker to accurately predict ESTT malignancy.
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	105-3
ISSN	1600-0455 ; 0284-1851 ; 0349-652X
ISSN (online)	1600-0455
ISSN	0284-1851 ; 0349-652X
DOI	10.1177/02841851231217227
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