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Article ; Online: Clinical and genetic characteristics of the patients with hypertension and hypokalemia carrying a novel

Chen, Mengzi / Lv, Xi / Li, Jiwu / Guo, Manli / Ma, Shaogang

Scandinavian journal of clinical and laboratory investigation

2022 , Page(s) 1–5

Abstract: The objective of this study was to clinically and genetically characterize a pedigree with Liddle syndrome (LS). A LS pedigree comprising with one proband and seven family members was enrolled. The subjects' symptoms, laboratory results and genotypes ... ...

Abstract	The objective of this study was to clinically and genetically characterize a pedigree with Liddle syndrome (LS). A LS pedigree comprising with one proband and seven family members was enrolled. The subjects' symptoms, laboratory results and genotypes were analyzed. Peripheral venous samples were collected from the subjects, and genomic DNA was extracted. DNA library construction and exome capture were performed on an Illumina HiSeq 4000 platform. The selected variant sites were validated using Sanger sequencing. The mutation effects were investigated using prediction tools. The proband and her paternal male family members had mild hypertension, hypokalemia and muscle weakness, including the absence of low renin and low aldosterone. Genetic analysis revealed that the proband carried a compound heterozygous mutation in
Language	English
Publishing date	2022-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	3150-1
ISSN	1502-7686 ; 0036-5513
ISSN (online)	1502-7686
ISSN	0036-5513
DOI	10.1080/00365513.2022.2140454
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Article ; Online: Mycobacterium tuberculosis PE_PGRS1 promotes mycobacteria intracellular survival via reducing the concentration of intracellular free Ca2+ and suppressing endoplasmic reticulum stress

Yu, Xi / Huang, Yu / Li, Yuzhu / Li, Tongxin / Yan, Shuangquan / Ai, Xuefeng / Lv, Xi / Fan, Lin / Xie, Jianping

Molecular Immunology. 2023 Feb., v. 154 p.24-32

2023

Abstract: Mycobacterium tuberculosis (M. tuberculosis) is the causative agent of tuberculosis (TB). And the PE_PGRS family members of M. tuberculosis are closely associated with virulence and antigen presentation but with function largely elusive. PE_PGRS1(Rv0109) ...

Abstract	Mycobacterium tuberculosis (M. tuberculosis) is the causative agent of tuberculosis (TB). And the PE_PGRS family members of M. tuberculosis are closely associated with virulence and antigen presentation but with function largely elusive. PE_PGRS1(Rv0109) contained 7 Ca²⁺ binding domains of GGXGXD/NXUX (X is any amino acid), which can reduce intracellular Ca²⁺ surge. In addition, PE_PGRS1 can mitigate the activation of PERK branch in endoplasmic reticulum (ER) stress by down-regulating the expression of CHOP, Bip, p-PERK, p-eIF2α, and ATF4. Interestingly, we found that two splicing variations of Bax/Bcl-2, Baxβ, and Bcl-2α, were differentially expressed after infection with Ms_PE_PGRS1, and may be involved in the regulation of apoptosis. Hence, this study identified that PE_PGRS1 is a novel calcium-associated protein that can decrease intracellular Ca²⁺ levels and the PERK axis. And the weakening of the PERK-eIF2α-ATF4 axis reduces THP-1 macrophages apoptosis, promotes the survival of mycobacteria in macrophages.
Keywords	Mycobacterium tuberculosis ; amino acids ; antigen presentation ; apoptosis ; calcium ; endoplasmic reticulum ; endoplasmic reticulum stress ; etiological agents ; macrophages ; tuberculosis ; virulence ; ATF6 ; Bip ; CCK-8 ; CFU ; CHOP ; CLL ; E. coli DH5α ; eIF2α ; ER ; FBS ; Gen ; Glu ; H2O2 ; HABA ; Hyg ; IRE1α ; JNK ; LB ; LDH ; M. smegmatis ; M. tuberculosis ; MOI ; PBS ; PERK ; PGRS ; PI ; PS ; RT-PCR ; TB ; TLR ; Calcium-associated protein ; ER stress ; PERK axis ; Bax/Bcl-2 splice variation
Language	English
Dates of publication	2023-02
Size	p. 24-32.
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2022.12.007
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 166: Show issues

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Article: GC–MS Untargeted Analysis of Volatile Compounds in Four Red Grape Varieties (Vitis vinifera L. cv) at Different Maturity Stages near Harvest

Gu, Xiaobo / Zhang, Xue / Wang, Keqing / Lv, Xi / Li, Ruyi / Ma, Wen

Foods. 2022 Sept. 11, v. 11, no. 18

2022

Abstract: Grape volatile compounds directly determine the aroma quality of wines. Although the aroma profile of grapes evolved greatly at different maturity stages, there were less considerations for aroma status when determining grape harvest time. In the present ...

Abstract	Grape volatile compounds directly determine the aroma quality of wines. Although the aroma profile of grapes evolved greatly at different maturity stages, there were less considerations for aroma status when determining grape harvest time. In the present study, several maturation indicators, namely, sugars/acids ratio, free volatile compounds, bound volatile compounds and IBMP (3-isobutyl-2-methoxypyrazine) content were monitored in four red wine grape varieties (Vitis vinifera L. cv Cabernet Sauvignon, Cabernet Gernischet, Cabernet Franc and Merlot) near harvest time (42 days) in Ningxia, China. The results showed that the highest sugars/acids ratio was reached on day 21 and day 28 for Merlot and the other three varieties, respectively. For both free and bound volatile compounds, the content of carbonyl compounds decreased continuously in the process of ripening. The contents of free alcohols, esters and terpenes increased in the ripening stage and decreased in the stage of over-ripening. The accumulation of favorable bound aroma compounds peaked at day 35. The content of IBMP presenting a green smell in all four varieties descended continuously and kept steady from day 28. Therefore, the present findings revealed that the best aroma maturity time of four studied grape varieties was later than the sugars/acids ratio in Ningxia region. Aroma maturity should be taken into account during harvest time determination.
Keywords	Vitis vinifera ; harvest date ; odors ; red wines ; smell ; terpenoids ; wine grapes ; China
Language	English
Dates of publication	2022-0911
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11182804
Database	NAL-Catalogue (AGRICOLA)

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Article: GC-MS Untargeted Analysis of Volatile Compounds in Four Red Grape Varieties (

Gu, Xiaobo / Zhang, Xue / Wang, Keqing / Lv, Xi / Li, Ruyi / Ma, Wen

Foods (Basel, Switzerland)

2022 Volume 11, Issue 18

Abstract	Grape volatile compounds directly determine the aroma quality of wines. Although the aroma profile of grapes evolved greatly at different maturity stages, there were less considerations for aroma status when determining grape harvest time. In the present study, several maturation indicators, namely, sugars/acids ratio, free volatile compounds, bound volatile compounds and IBMP (3-isobutyl-2-methoxypyrazine) content were monitored in four red wine grape varieties (Vitis vinifera L. cv Cabernet Sauvignon, Cabernet Gernischet, Cabernet Franc and Merlot) near harvest time (42 days) in Ningxia, China. The results showed that the highest sugars/acids ratio was reached on day 21 and day 28 for Merlot and the other three varieties, respectively. For both free and bound volatile compounds, the content of carbonyl compounds decreased continuously in the process of ripening. The contents of free alcohols, esters and terpenes increased in the ripening stage and decreased in the stage of over-ripening. The accumulation of favorable bound aroma compounds peaked at day 35. The content of IBMP presenting a green smell in all four varieties descended continuously and kept steady from day 28. Therefore, the present findings revealed that the best aroma maturity time of four studied grape varieties was later than the sugars/acids ratio in Ningxia region. Aroma maturity should be taken into account during harvest time determination.
Language	English
Publishing date	2022-09-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11182804
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Article ; Online: The application of peripapillary vessel density in the diagnosis of primary glaucoma by optical coherence tomography angiography.

Ma, Feiyan / Lv, Xi / Liang, Shuang / Liu, Xiaoli / Duan, Jialiang / Zhang, Bin / Liu, Danyan

Minerva surgery

2022

Language	English
Publishing date	2022-01-28
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3067899-7
ISSN	2724-5438
ISSN (online)	2724-5438
DOI	10.23736/S2724-5691.21.09287-X
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Zs.A 25: Show issues

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Article ; Online: Modification and validation of the simultaneous detection of 38 pesticide residues method by ultra-high-performance liquid chromatography/tandem mass spectrometry with QuEChERS extraction in different oil crops and products.

Lv, Xi / Wang, Fengzhong / Cui, Ying / Fan, Bei / Kong, Zhiqiang / Yan, Tingcai / Li, Minmin

Rapid communications in mass spectrometry : RCM

2022 Volume 36, Issue 12, Page(s) e9284

Abstract: Rationale: Oil crops and products are important food materials in daily life. Pesticide residues in food could directly and indirectly endanger human health. However, the method for detecting multiple pesticides simultaneously is limited. In this study, ...

Abstract	Rationale: Oil crops and products are important food materials in daily life. Pesticide residues in food could directly and indirectly endanger human health. However, the method for detecting multiple pesticides simultaneously is limited. In this study, an easy and efficient method for the simultaneous determination of 38 pesticides in oil crops and products was established and validated. Methods: All samples were treated with a modified QuEChERS procedure followed by ultra-high-performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS) analysis. Mass spectrometry was performed in positive and negative ion electrospray ionization mode. The mobile phase consisted of 0.1% formic acid in water and 0.1% formic acid in acetonitrile. The column used was a Poroshell 120 EC-C18 and the flow rate was 0.3 mL/min. Results: The method was validated so that the calibration curves for all pesticides had good linearity in the concentration range of 10-1000 μg/L with correlation coefficients (R Conclusions: The method proved to be accurate, sensitive, and stable. It can be used for rapid screening and confirmation of 38 pesticide residues in oil crops and products which takes 10 min for sample extraction and clean-up with less requirement of solvents. This study provides a technical basis for regulatory analysis and quality supervision of foods.
MeSH term(s)	Chromatography, High Pressure Liquid ; Humans ; Pesticide Residues/analysis ; Pesticides/analysis ; Solid Phase Extraction ; Tandem Mass Spectrometry
Chemical Substances	Pesticide Residues ; Pesticides
Language	English
Publishing date	2022-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	58731-x
ISSN	1097-0231 ; 0951-4198
ISSN (online)	1097-0231
ISSN	0951-4198
DOI	10.1002/rcm.9284
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Zs.A 3461: Show issues

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Article ; Online: Phenothiazines Inhibit SARS-CoV-2 Entry through Targeting Spike Protein.

Liang, Taizhen / Xiao, Shiqi / Wu, Ziyao / Lv, Xi / Liu, Sen / Hu, Meilin / Li, Guojie / Li, Peiwen / Ma, Xiancai

Viruses

2023 Volume 15, Issue 8

Abstract: Novel coronavirus disease 2019 (COVID-19), a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought an unprecedented public health crisis and continues to threaten humanity due to the persistent emergence ... ...

Abstract	Novel coronavirus disease 2019 (COVID-19), a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought an unprecedented public health crisis and continues to threaten humanity due to the persistent emergence of new variants. Therefore, developing more effective and broad-spectrum therapeutic and prophylactic drugs against infection by SARS-CoV-2 and its variants, as well as future emerging CoVs, is urgently needed. In this study, we screened several US FDA-approved drugs and identified phenothiazine derivatives with the ability to potently inhibit the infection of pseudotyped SARS-CoV-2 and distinct variants of concern (VOCs), including B.1.617.2 (Delta) and currently circulating Omicron sublineages XBB and BQ.1.1, as well as pseudotyped SARS-CoV and MERS-CoV. Mechanistic studies suggested that phenothiazines predominantly inhibited SARS-CoV-2 pseudovirus (PsV) infection at the early stage and potentially bound to the spike (S) protein of SARS-CoV-2, which may prevent the proteolytic cleavage of the S protein, thereby exhibiting inhibitory activity against SARS-CoV-2 infection. In summary, our findings suggest that phenothiazines can serve as a potential broad-spectrum therapeutic drug for the treatment of SARS-CoV-2 infection as well as the infection of future emerging human coronaviruses (HCoVs).
MeSH term(s)	Humans ; SARS-CoV-2 ; Phenothiazines/pharmacology ; COVID-19 ; Spike Glycoprotein, Coronavirus
Chemical Substances	Phenothiazines ; spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
Language	English
Publishing date	2023-07-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15081666
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Article ; Online: A Potential Nontraditional Approach To Combat

Wang, Xiaoming / Liu, Ting / Lv, Xi / Sun, Naiyan / Li, Fan / Luo, Lei / Zhuge, Xiangkai / Huang, Jinhu / Wang, Liping

Antimicrobial agents and chemotherapy

2023 Volume 67, Issue 7, Page(s) e0004723

Abstract: The emergence of TMexCD1-TOprJ1, a novel transferable resistance-nodulation-division (RND)-type efflux pump conferring resistance to tigecycline, is now a serious public health issue in the world. Here, we found that melatonin synergistically enhanced ... ...

Abstract	The emergence of TMexCD1-TOprJ1, a novel transferable resistance-nodulation-division (RND)-type efflux pump conferring resistance to tigecycline, is now a serious public health issue in the world. Here, we found that melatonin synergistically enhanced the antibacterial efficacy of tigecycline against
MeSH term(s)	Animals ; Mice ; Tigecycline/pharmacology ; Melatonin/pharmacology ; Melatonin/metabolism ; Minocycline/pharmacology ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology ; Drug Resistance, Bacterial/genetics ; Membrane Transport Proteins/genetics ; Anti-Bacterial Agents/therapeutic use ; Adjuvants, Immunologic ; Adjuvants, Pharmaceutic ; Microbial Sensitivity Tests ; Klebsiella pneumoniae/genetics ; Klebsiella pneumoniae/metabolism
Chemical Substances	Tigecycline (70JE2N95KR) ; Melatonin (JL5DK93RCL) ; Minocycline (FYY3R43WGO) ; Membrane Transport Proteins ; Anti-Bacterial Agents ; Adjuvants, Immunologic ; Adjuvants, Pharmaceutic
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.00047-23
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Restraint stress promotes monobenzone-induced depigmentation in mice via the activation of glucocorticoid receptor/macrophage migration inhibitory factor signaling pathway.

Tang, Nan / Liu, Xiao-Ting / Wen, Wei-Lun / Liang, Tian-Shan / Lv, Xi-Ting / Li, Qi-Lin / Wang, Guo-En / Wu, Yan-Hua

Molecular immunology

2023 Volume 161, Page(s) 33–43

Abstract: Psychological stress triggers onset and development of vitiligo in humans. However, the mechanism of psychological stress on vitiligo remains unclear. The study aims to investigate whether psychological stress promotes vitiligo and explore the underlying ...

Abstract	Psychological stress triggers onset and development of vitiligo in humans. However, the mechanism of psychological stress on vitiligo remains unclear. The study aims to investigate whether psychological stress promotes vitiligo and explore the underlying mechanism. A depigmentation mouse model induced by applying a skin-bleaching reagent monobenzone to dorsal skin and an in vitro HaCaT keratinocyte death model induced by monobenzone were employed to explore the effect of restraint stress, which mimics psychological stress, on depigmentation. The results indicated that restraint stress promoted vitiligo-related depigmentation, vacuolisation, spongiosis, CD8
MeSH term(s)	Animals ; Mice ; Hypopigmentation ; Macrophage Migration-Inhibitory Factors ; NLR Family, Pyrin Domain-Containing 3 Protein ; Receptors, Glucocorticoid ; Signal Transduction ; Vitiligo/chemically induced ; Vitiligo/metabolism
Chemical Substances	Macrophage Migration-Inhibitory Factors ; monobenzone (9L2KA76MG5) ; NLR Family, Pyrin Domain-Containing 3 Protein ; Receptors, Glucocorticoid
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2023.07.007
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Zs.A 166: Show issues

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Article ; Online: Restraint stress promotes nonalcoholic steatohepatitis by regulating the farnesoid X receptor/NLRP3 signaling pathway.

Yang, Fan / Lv, Xi-Ting / Lin, Xiao-Li / Wang, Ruo-Hong / Wang, Shu-Mei / Wang, Guo-En

Acta biochimica et biophysica Sinica

2023 Volume 55, Issue 12, Page(s) 1961–1971

Abstract: Psychological stress promotes nonalcoholic steatohepatitis (NASH) development. However, the pathogenesis of psychological stress-induced NASH remains unclear. This study aims to explore the underlying mechanism of restraint stress-induced NASH, which ... ...

Abstract	Psychological stress promotes nonalcoholic steatohepatitis (NASH) development. However, the pathogenesis of psychological stress-induced NASH remains unclear. This study aims to explore the underlying mechanism of restraint stress-induced NASH, which mimics psychological stress, and to discover potential NASH candidates. Methionine choline deficient diet- and high fat diet-induced hepatosteatotic mice are subjected to restraint stress to induce NASH. The mice are administrated with Xiaoyaosan granules, NOD-like receptor family pyrin domain containing 3 (NLRP3) inhibitors, farnesoid X receptor (FXR) agonists, or macrophage scavengers. Pathological changes and NLRP3 signaling in the liver are determined. These results demonstrate that restraint stress promotes hepatic inflammation and fibrosis in hepatosteatotic mice. Restraint stress increases the expressions of NLRP3, Caspase-1, Gasdermin D, interleukin-1β, cholesterol 7α-hydroxylase, and sterol 12α-hydroxylase and decreases the expression of FXR in NASH mice. Xiaoyaosan granules reverse hepatic inflammation and fibrosis and target FXR and NLRP3 signals. In addition, inhibition of NLRP3 reduces the NLRP3 inflammasome and liver damage in mice with restraint stress-induced NASH. Elimination of macrophages and activation of FXR also attenuate inflammation and fibrosis by inhibiting NLRP3 signaling. However, NLRP3 inhibitors or macrophage scavengers fail to affect the expression of FXR. In conclusion, restraint stress promotes NASH-related inflammation and fibrosis by regulating the FXR/NLRP3 signaling pathway. Xiaoyaosan granules, NLRP3 inhibitors, FXR agonists, and macrophage scavengers are potential candidates for the treatment of psychological stress-related NASH.
MeSH term(s)	Mice ; Animals ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Liver/metabolism ; Inflammasomes/metabolism ; Signal Transduction ; Inflammation/metabolism ; Fibrosis ; Mice, Inbred C57BL
Chemical Substances	NLR Family, Pyrin Domain-Containing 3 Protein ; Inflammasomes
Language	English
Publishing date	2023-11-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2175256-4
ISSN	1745-7270 ; 0582-9879 ; 1672-9145
ISSN (online)	1745-7270
ISSN	0582-9879 ; 1672-9145
DOI	10.3724/abbs.2023240
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