Article ; Online: Clonorchis sinensis on the prognosis of patients with spontaneous rupture of Hepatocellular Carcinoma: An inverse probability of treatment weighting analysis.
PLoS neglected tropical diseases
2024 Volume 18, Issue 2, Page(s) e0011987
Abstract: Background: We examined the impact of the Clonorchis sinensis (C. sinensis) infection on the survival outcomes of spontaneous rupture Hepatocellular Carcinoma (srHCC) patients undergoing hepatectomy.: Methods: Between May 2013 and December 2021, 157 ... ...
| Abstract | Background: We examined the impact of the Clonorchis sinensis (C. sinensis) infection on the survival outcomes of spontaneous rupture Hepatocellular Carcinoma (srHCC) patients undergoing hepatectomy. Methods: Between May 2013 and December 2021, 157 consecutive srHCC patients who underwent hepatectomy were divided into an no C. sinensis group (n = 126) and C. sinensis group (n = 31). To adjust for differences in preoperative characteristics an inverse probability of treatment weighting (IPTW) analysis was done, using propensity scores. Overall survival (OS) and recurrence-free survival (RFS) were compared before and after IPTW. Multivariate Cox regression analysis was performed to determine whether the C. sinensis infection was an independent prognostic factor after IPTW. Results: In original cohort, the no C. sinensis group did not show a survival advantage over the C. sinensis group. After IPTW adjustment, the median OS for the C. sinensis group was 9 months, compared to 29 months for the no C. sinensis group. C. sinensis group have worse OS than no C. sinensis group (p = 0.024), while it did not differ in RFS(p = 0.065). The multivariate Cox regression analysis showed that C. sinensis infection and lower age were associated with worse OS. Conclusions: The C. sinensis infection has an adverse impact on os in srHCC patients who underwent hepatectomy. |
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| MeSH term(s) | Humans ; Animals ; Carcinoma, Hepatocellular/surgery ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/surgery ; Liver Neoplasms/pathology ; Clonorchis sinensis ; Rupture, Spontaneous/surgery ; Rupture, Spontaneous/complications ; Prognosis ; Propensity Score ; Clonorchiasis/complications ; Clonorchiasis/surgery ; Retrospective Studies |
| Language | English |
| Publishing date | 2024-02-21 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2429704-5 |
| ISSN | 1935-2735 ; 1935-2735 |
| ISSN (online) | 1935-2735 |
| ISSN | 1935-2735 |
| DOI | 10.1371/journal.pntd.0011987 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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