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  1. Article ; Online: Implantation of Various Cell-Free Matrixes Does Not Contribute to the Restoration of Hyaline Cartilage within Full-Thickness Focal Defects.

    Ibragimova, Shabnam I / Medvedeva, Ekaterina V / Romanova, Irina A / Istranov, Leonid P / Istranova, Elena V / Lychagin, Aleksey V / Nedorubov, Andrey A / Timashev, Peter S / Telpukhov, Vladimir I / Chagin, Andrei S

    International journal of molecular sciences

    2021  Volume 23, Issue 1

    Abstract: Articular cartilage is a highly organized tissue that has a limited ability to heal. Tissue engineering is actively exploited for joint tissue reconstruction in numerous cases of articular cartilage degeneration associated with trauma, arthrosis, ... ...

    Abstract Articular cartilage is a highly organized tissue that has a limited ability to heal. Tissue engineering is actively exploited for joint tissue reconstruction in numerous cases of articular cartilage degeneration associated with trauma, arthrosis, rheumatoid arthritis, and osteoarthritis. However, the optimal scaffolds for cartilage repair are not yet identified. Here we have directly compared five various scaffolds, namely collagen-I membrane, collagen-II membrane, decellularized cartilage, a cellulose-based implant, and commercially available Chondro-Gide
    MeSH term(s) Animals ; Fibrillar Collagens/metabolism ; Hyaline Cartilage/pathology ; Knee Joint/pathology ; Male ; Osteogenesis ; Prosthesis Implantation ; Rats, Wistar ; SOX9 Transcription Factor/metabolism ; Tissue Scaffolds/chemistry ; Rats
    Chemical Substances Fibrillar Collagens ; SOX9 Transcription Factor
    Language English
    Publishing date 2021-12-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23010292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Repair of Damaged Articular Cartilage: Current Approaches and Future Directions.

    Medvedeva, Ekaterina V / Grebenik, Ekaterina A / Gornostaeva, Svetlana N / Telpuhov, Vladimir I / Lychagin, Aleksey V / Timashev, Peter S / Chagin, Andrei S

    International journal of molecular sciences

    2018  Volume 19, Issue 8

    Abstract: Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical and research efforts currently focus on the restoration of cartilage ... ...

    Abstract Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical and research efforts currently focus on the restoration of cartilage damaged in connection with osteoarthritis or trauma. Here, we discuss current clinical approaches for repairing cartilage, as well as research approaches which are currently developing, and those under translation into clinical practice. We also describe potential future directions in this area, including tissue engineering based on scaffolding and/or stem cells as well as a combination of gene and cell therapy. Particular focus is placed on cell-based approaches and the potential of recently characterized chondro-progenitors; progress with induced pluripotent stem cells is also discussed. In this context, we also consider the ability of different types of stem cell to restore hyaline cartilage and the importance of mimicking the environment in vivo during cell expansion and differentiation into mature chondrocytes.
    MeSH term(s) Animals ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Humans ; Joint Capsule/injuries ; Joint Capsule/metabolism ; Joint Capsule/pathology ; Osteoarthritis/metabolism ; Osteoarthritis/pathology ; Osteoarthritis/therapy ; Tissue Engineering/methods ; Tissue Engineering/trends ; Wounds and Injuries/metabolism ; Wounds and Injuries/pathology ; Wounds and Injuries/therapy
    Language English
    Publishing date 2018-08-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19082366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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