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Article ; Online: Successful intraoperative ultrasound-guided retrieval of intracranial grass seed foreign body in a 4-month-old puppy.

Qin, Nancy / Lye, Gordon / Mathis, Karl / Stewart, Georgina

Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

2023 Volume 64, Issue 6, Page(s) E88–E92

Abstract: A 4-month-old female-entire Vizsla dog was referred for progressive seizure activity, vomiting, lethargy, inappetence, and neck pain. CT revealed focal inflammation, a calvarial osseous defect, a possible foreign body within the brain, and associated ... ...

Abstract	A 4-month-old female-entire Vizsla dog was referred for progressive seizure activity, vomiting, lethargy, inappetence, and neck pain. CT revealed focal inflammation, a calvarial osseous defect, a possible foreign body within the brain, and associated vasogenic edema. A cerebrospinal fluid tap revealed marked septic neutrophilic pleocytosis. MRI findings supported diagnosis of a 1.7 cm foreign body within the brain. A right rostrotentorial craniectomy was performed, and intraparenchymal grass seed was removed in its entirety via intraoperative ultrasound guidance. The patient was discharged 2 days postoperatively, and long-term follow-up revealed no abnormal neurological signs.
MeSH term(s)	Dogs ; Animals ; Female ; Poaceae ; Dog Diseases/diagnostic imaging ; Dog Diseases/surgery ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Foreign Bodies/veterinary ; Seeds ; Ultrasonography, Interventional/veterinary
Language	English
Publishing date	2023-10-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2142058-0
ISSN	1740-8261 ; 1058-8183
ISSN (online)	1740-8261
ISSN	1058-8183
DOI	10.1111/vru.13307
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Burns injuries from e-cigarettes kept in pockets.

Simpson, Laura J / Lye, George

BMJ (Clinical research ed.)

2019 Volume 364, Page(s) l554

MeSH term(s)	Accident Prevention ; Burns/epidemiology ; Burns/etiology ; Electronic Nicotine Delivery Systems/instrumentation ; Explosions/statistics & numerical data ; Health Behavior ; Humans ; Needs Assessment ; Risk Assessment ; United Kingdom
Language	English
Publishing date	2019-02-07
Publishing country	England
Document type	Letter
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.l554
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Article: Business as low carbon transformation driver?

Lye, Geoff

Carbon governance, climate change and business transformation , p. 55-79

2015 , Page(s) 55–79

Author's details	Geoff Lye
Language	English
Size	graph. Darst.
Publisher	Routledge
Publishing place	London [u.a.]
Document type	Article
ISBN	978-0-415-81690-8 ; 0-415-81690-4
Database	ECONomics Information System

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Article: Combination of Genome-Scale Models and Bioreactor Dynamics to Optimize the Production of Commodity Chemicals.

Lázaro, Jorge / Jansen, Giorgio / Yang, Yiheng / Torres-Acosta, Mario A / Lye, Gary / Oliver, Stephen G / Júlvez, Jorge

Frontiers in molecular biosciences

2022 Volume 9, Page(s) 855735

Abstract: The current production of a number of commodity chemicals relies on the exploitation of fossil fuels and hence has an irreversible impact on the environment. Biotechnological processes offer an attractive alternative by enabling the manufacturing of ... ...

Abstract	The current production of a number of commodity chemicals relies on the exploitation of fossil fuels and hence has an irreversible impact on the environment. Biotechnological processes offer an attractive alternative by enabling the manufacturing of chemicals by genetically modified microorganisms. However, this alternative approach poses some important technical challenges that must be tackled to make it competitive. On the one hand, the design of biotechnological processes is based on trial-and-error approaches, which are not only costly in terms of time and money, but also result in suboptimal designs. On the other hand, the manufacturing of chemicals by biological processes is almost exclusively carried out by batch or fed-batch cultures. Given that batch cultures are expensive and not easy to scale, technical means must be developed to make continuous cultures feasible and efficient. In order to address these challenges, we have developed a mathematical model able to integrate in a single model both the genome-scale metabolic model for the organism synthesizing the chemical of interest and the dynamics of the bioreactor in which the organism is cultured. Such a model is based on the use of Flexible Nets, a modeling formalism for dynamical systems. The integration of a microscopic (organism) and a macroscopic (bioreactor) model in a single net provides an overall view of the whole system and opens the door to global optimizations. As a case study, the production of citramalate with respect to the substrate consumed by
Language	English
Publishing date	2022-04-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2022.855735
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Article ; Online: Pharmacokinetics of subcutaneously administered doramectin in alpacas.

Lye, Gordon / Jacob, Anthony / Pomroy, William / Stafford, Kevin / Singh, Preet

Journal of veterinary pharmacology and therapeutics

2019 Volume 43, Issue 2, Page(s) 123–128

Abstract: The objective of this research was to evaluate comparative pharmacokinetics of doramectin in alpacas, after subcutaneous administration of 0.2 mg/kg dose. Six healthy adult alpacas, mean age of 5 years ± 1, (three female and three gelded males) of mean ... ...

Abstract	The objective of this research was to evaluate comparative pharmacokinetics of doramectin in alpacas, after subcutaneous administration of 0.2 mg/kg dose. Six healthy adult alpacas, mean age of 5 years ± 1, (three female and three gelded males) of mean bodyweight of 62 kg ± 16 kg with an average body condition scored 2.8 ± 1 out of five, were used in this study. Serial blood samples were collected from the jugular vein before the administration until day 21 afterwards to establish the pharmacokinetics of doramectin after its subcutaneous administration at 0.2 mg/kg dose. The blood samples were analysed using high-performance liquid chromatography (HPLC), fluorescence detection method with precolumn derivatisation, validated for alpacas. The pharmacokinetic parameters were calculated using a noncompartmental model, and results showed Cmax (6.05 ± 5.34 ng/ml), Tmax (3.83 ± 2.48 days), AUC (62.12 ± 18.86 ng/ml × d), terminal half-life (6.2 ± 4.9 days) and MRT (11.56 ± 4.43 days). The results of this study showed that the Cmax and AUC were much lower than in cattle and sheep at the same dosage. Tmax remained similar to cattle and sheep. This study presents valuable information about pharmacokinetics of doramectin in alpacas, which can be utilised in its future efficacy studies.
MeSH term(s)	Animals ; Anthelmintics/administration & dosage ; Anthelmintics/pharmacokinetics ; Area Under Curve ; Camelids, New World/blood ; Female ; Half-Life ; Injections, Subcutaneous/veterinary ; Ivermectin/administration & dosage ; Ivermectin/analogs & derivatives ; Ivermectin/pharmacokinetics ; Male
Chemical Substances	Anthelmintics ; Ivermectin (70288-86-7) ; doramectin (KGD7A54H5P)
Language	English
Publishing date	2019-10-29
Publishing country	England
Document type	Clinical Trial, Veterinary ; Journal Article
ZDB-ID	435216-6
ISSN	1365-2885 ; 0140-7783
ISSN (online)	1365-2885
ISSN	0140-7783
DOI	10.1111/jvp.12821
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Article: Pharmacokinetics of subcutaneously administered doramectin in alpacas

Lye, Gordon / Jacob, Anthony / Pomroy, William / Stafford, Kevin / Singh, Preet

Journal of veterinary pharmacology and therapeutics. 2020 Mar., v. 43, no. 2

2020

Abstract	The objective of this research was to evaluate comparative pharmacokinetics of doramectin in alpacas, after subcutaneous administration of 0.2 mg/kg dose. Six healthy adult alpacas, mean age of 5 years ± 1, (three female and three gelded males) of mean bodyweight of 62 kg ± 16 kg with an average body condition scored 2.8 ± 1 out of five, were used in this study. Serial blood samples were collected from the jugular vein before the administration until day 21 afterwards to establish the pharmacokinetics of doramectin after its subcutaneous administration at 0.2 mg/kg dose. The blood samples were analysed using high‐performance liquid chromatography (HPLC), fluorescence detection method with precolumn derivatisation, validated for alpacas. The pharmacokinetic parameters were calculated using a noncompartmental model, and results showed Cmax (6.05 ± 5.34 ng/ml), Tmax (3.83 ± 2.48 days), AUC (62.12 ± 18.86 ng/ml × d), terminal half‐life (6.2 ± 4.9 days) and MRT (11.56 ± 4.43 days). The results of this study showed that the Cmax and AUC were much lower than in cattle and sheep at the same dosage. Tmax remained similar to cattle and sheep. This study presents valuable information about pharmacokinetics of doramectin in alpacas, which can be utilised in its future efficacy studies.
Keywords	adults ; alpacas ; blood sampling ; body condition ; body weight ; cattle ; derivatization ; doramectin ; females ; fluorescence ; half life ; high performance liquid chromatography ; jugular vein ; males ; models ; pharmacokinetics ; sheep ; subcutaneous injection
Language	English
Dates of publication	2020-03
Size	p. 123-128.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	435216-6
ISSN	1365-2885 ; 0140-7783
ISSN (online)	1365-2885
ISSN	0140-7783
DOI	10.1111/jvp.12821
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Selective fractionation of Sugar Beet Pulp for release of fermentation and chemical feedstocks; optimisation of thermo-chemical pre-treatment.

Hamley-Bennett, C / Lye, G J / Leak, D J

Bioresource technology

2016 Volume 209, Page(s) 259–264

Abstract: The effect of time and pressure on the selective extraction of sugar beet pectin using steam pre-treatment on unprocessed Sugar Beet Pulp was evaluated using a design of experiments approach. This process gave the highest solubilisation of pectin ... ...

Abstract	The effect of time and pressure on the selective extraction of sugar beet pectin using steam pre-treatment on unprocessed Sugar Beet Pulp was evaluated using a design of experiments approach. This process gave the highest solubilisation of pectin oligomers at a relatively low pressure and longer time (5Bar, 24min), whilst leaving the majority of the cellulose fraction intact. This method of steam pre-treatment fits into the concept of a sugar beet biorefinery as it valorises an existing waste stream without requiring any further physical processing such as milling or dilution with water. The residual cellulose fraction was enriched in cellulose and could be effectively fermented into ethanol by yeast after enzymatic digestion, producing 0.48g ethanol per gram of glucose.
MeSH term(s)	Arabinose/analysis ; Beta vulgaris/chemistry ; Bioreactors ; Carbohydrates/analysis ; Chemical Fractionation/methods ; Chromatography, High Pressure Liquid ; Ethanol/metabolism ; Fermentation ; Hydrolysis ; Models, Theoretical ; Proteins/isolation & purification ; Reproducibility of Results ; Saccharomyces cerevisiae/metabolism ; Solubility ; Temperature
Chemical Substances	Carbohydrates ; Proteins ; Ethanol (3K9958V90M) ; Arabinose (B40ROO395Z)
Language	English
Publishing date	2016-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2016.02.131
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Article: Computed Tomographic Diagnosis of Traumatic Atlanto-occipital Rotatory Luxation and Successful Closed Reduction in a Dog

Lye, Gordon / Mathis, Karl / Hill, Sarah / Cattin, Ryan / Hartman, Angela

VCOT Open

2020 Volume 03, Issue 02, Page(s) e164–e169

Abstract: A 12-year-old, female spayed crossbred dog was presented for traumatic injuries sustained after being hit by a car. The dog was non-ambulatory with a right-sided head tilt on presentation, neurological deficits and signs of external trauma centred on the ...

Abstract	A 12-year-old, female spayed crossbred dog was presented for traumatic injuries sustained after being hit by a car. The dog was non-ambulatory with a right-sided head tilt on presentation, neurological deficits and signs of external trauma centred on the head. A trauma computed tomography was performed which revealed an atlanto-occipital luxation with narrowing of the vertebral canal. This was treated successfully via closed reduction and confirmed with a repeat computed tomography scan. The dog recovered well following the atlanto-occipital luxation reduction, and was ambulatory the day after the reduction, and neurological signs resolved within 2 days.
Keywords	atlanto-occipital luxation ; dog ; cervical vertebrae trauma ; closed reduction
Language	English
Publishing date	2020-07-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2934191-7
ISSN	2625-2325 ; 2625-2325
ISSN (online)	2625-2325
ISSN	2625-2325
DOI	10.1055/s-0040-1721031
Database	Thieme publisher's database

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Article ; Online: A Single Stage Composite Cleft Septorhinoplasty for Correction of the Mature Unilateral Cleft Nose Deformity - The Gujrat Technique.

Othman, Diaa / Gorman, Mark / Abbas Khan, Muhammad Adil / Ma, Yangmyung / Bhatti, Dujanah Siddique / Rafiq, Sadia / Shami, Hussan Berkhez / Lye, George / McBride, Michael / Riaz, Muhammad

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2022 Volume 60, Issue 7, Page(s) 823–832

Abstract: Objective: To evaluate the results of a single stage composite cleft septorhinoplasty procedure ("The Gujrat Technique") to correct the exaggerated cleft nose deformity after completion of nasal growth in an adult patient cohort.: Methods: Adult ... ...

Abstract	Objective: To evaluate the results of a single stage composite cleft septorhinoplasty procedure ("The Gujrat Technique") to correct the exaggerated cleft nose deformity after completion of nasal growth in an adult patient cohort. Methods: Adult patients with a residual unilateral cleft nasal deformity were deemed eligible for the proposed "Gujrat Technique". Over a 10-year period (2007-2017), 96 adult patients underwent this composite cleft septorhinoplasty as a single stage operation. Post-operative nasal symmetry evaluation was undertaken using the validated computer program 'SymNose'. Functional outcome and patient satisfaction were assessed using Nasal Obstruction Symptom Evaluation scale and Rhinoplasty Outcome Evaluation (ROE) questionnaires respectively. Various statistical analysis methods were used to validate the obtained results. Results: Due to poor compliance with follow-up, post-operative assessments were undertaken in only 32 patients. The single group study design using the non-parametric matching pairs Wilcoxon Sign test (p < 0.001) showed overall good to excellent functional and aesthetic outcomes and higher scores of the digital SymNose grading system. There was a significant improvement in ROE scores (from 26.4 ± 2.9 to 85.9 ± 4.7, p < 0.001). There were no major complications or revisions needed in our series. Conclusion: The individual components of "The Gujrat Technique" are not novel but their combination in this adult unilateral cleft rhinoplasty cohort has demonstrated a high patient satisfaction with its aesthetic appeal and functional versatility. In the background of limited resources and unpredictable patient follow up, the simplicity, reproducibility and cost effectiveness of this technique make it a practical reconstructive option.
MeSH term(s)	Adult ; Humans ; Rhinoplasty/methods ; Cleft Lip/surgery ; Cleft Lip/complications ; Reproducibility of Results ; Treatment Outcome ; Esthetics, Dental ; Nose/surgery ; Nose Diseases/surgery ; Respiratory System Abnormalities
Language	English
Publishing date	2022-03-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1069409-2
ISSN	1545-1569 ; 0009-8701 ; 1055-6656
ISSN (online)	1545-1569
ISSN	0009-8701 ; 1055-6656
DOI	10.1177/10556656221082765
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Article ; Online: Epidermal burn at a PEG site.

Spolton-Dean, Claire Alyss / Lye, George / Potokar, Tom

BMJ (Clinical research ed.)

2015 Volume 351, Page(s) h5530

MeSH term(s)	Anti-Infective Agents, Local/administration & dosage ; Burns, Chemical/diagnosis ; Burns, Chemical/etiology ; Burns, Chemical/therapy ; Diagnosis, Differential ; Gastric Acid/chemistry ; Gastrostomy/adverse effects ; Gastrostomy/methods ; Humans ; Male ; Postoperative Complications/diagnosis ; Postoperative Complications/therapy ; Silver Sulfadiazine/administration & dosage ; Stroke/therapy ; Therapeutic Irrigation/methods ; Treatment Outcome
Chemical Substances	Anti-Infective Agents, Local ; Silver Sulfadiazine (W46JY43EJR)
Language	English
Publishing date	2015-10-19
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.h5530
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