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Article ; Online ; Conference proceedings: VdGM: Vasco da Gama Movement.

Lygidakis, Charilaos

The European journal of general practice

2011 Volume 17, Issue 4, Page(s) 249–250

MeSH term(s)	Europe ; General Practice/organization & administration ; General Practitioners/organization & administration ; Humans ; Primary Health Care/organization & administration ; Social Media
Language	English
Publishing date	2011-12
Publishing country	England
Document type	Congresses ; News
ZDB-ID	1281338-2
ISSN	1751-1402 ; 1381-4788
ISSN (online)	1751-1402
ISSN	1381-4788
DOI	10.3109/13814788.2011.627432
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Article ; Online: Quality of life among adult patients living with diabetes in Rwanda: a cross-sectional study in outpatient clinics.

Lygidakis, Charilaos / Uwizihiwe, Jean Paul / Bia, Michela / Uwinkindi, Francois / Kallestrup, Per / Vögele, Claus

BMJ open

2021 Volume 11, Issue 2, Page(s) e043997

Abstract: Objectives: To report on the disease-related quality of life of patients living with diabetes mellitus in Rwanda and identify its predictors.: Design: Cross-sectional study, part of the baseline assessment of a cluster-randomised controlled trial.: ...

Abstract	Objectives: To report on the disease-related quality of life of patients living with diabetes mellitus in Rwanda and identify its predictors. Design: Cross-sectional study, part of the baseline assessment of a cluster-randomised controlled trial. Setting: Outpatient clinics for non-communicable diseases of nine hospitals across Rwanda. Participants: Between January and August 2019, 206 patients were recruited as part of the clinical trial. Eligible participants were those aged 21-80 years and with a diagnosis of diabetes mellitus for at least 6 months. Illiterate patients, those with severe hearing or visual impairments, those with severe mental health conditions, terminally ill, and those pregnant or in the postpartum period were excluded PRIMARY AND SECONDARY OUTCOME MEASURES: Disease-specific quality of life was measured with the Kinyarwanda version of the Diabetes-39 (D-39) questionnaire. A glycated haemoglobin (HbA1c) test was performed on all patients. Sociodemographic and clinical data were collected, including medical history, disease-related complications and comorbidities. Results: The worst affected dimensions of the D-39 were 'anxiety and worry' (mean=51.63, SD=25.51), 'sexual functioning' (mean=44.58, SD=37.02), and 'energy and mobility' (mean=42.71, SD=20.69). Duration of the disease and HbA1c values were not correlated with any of the D-39 dimensions. A moderating effect was identified between use of insulin and achieving a target HbA1c of 7% in the 'diabetes control' scale. The most frequent comorbidity was hypertension (49.0% of participants), which had a greater negative effect on the 'diabetes control' and 'social burden' scales in women. Higher education was a predictor of less impact on the 'social burden' and 'energy and mobility' scales. Conclusions: Several variables were identified as predictors for the five dimensions of quality of life that were studied, providing opportunities for tailored preventive programmes. Further prospective studies are needed to determine causal relationships. Trial registration number: NCT03376607.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Ambulatory Care Facilities ; Cross-Sectional Studies ; Diabetes Mellitus ; Female ; Glycated Hemoglobin A ; Humans ; Middle Aged ; Prospective Studies ; Quality of Life ; Rwanda/epidemiology ; Young Adult
Chemical Substances	Glycated Hemoglobin A
Language	English
Publishing date	2021-02-19
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2020-043997
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Article ; Online: Cultural adaptation and psychometric evaluation of the Kinyarwanda version of the diabetes-39 (D-39) questionnaire.

Uwizihiwe, Jean Paul / Lygidakis, Charilaos / Bia, Michela / Dukundane, Damas / Asiimwe-Kateera, Brenda / Nsanzimana, Sabin / Vögele, Claus / Kallestrup, Per

Health and quality of life outcomes

2022 Volume 20, Issue 1, Page(s) 122

Abstract: Background: In recent years, more importance is being given to the assessment of quality of life (QoL) among diabetic patients as a measure of their health and the goal of all health interventions. Other studies have reported a high prevalence of ... ...

Abstract	Background: In recent years, more importance is being given to the assessment of quality of life (QoL) among diabetic patients as a measure of their health and the goal of all health interventions. Other studies have reported a high prevalence of diabetes-related effects on; however, there is a knowledge gap in the region of Sub-Saharan Africa, as is the case for Rwanda, where the prevalence of diabetes is expected to rise over the next decade. The aim of this study is to report on the translation and cultural adaptation of the Diabetes-39 (D-39) questionnaire into the Kinyarwanda and its psychometric properties among diabetic patients in Rwanda. Methods: The D-39 questionnaire-a five-scale, disease-specific QoL questionnaire-was translated from English to Kinyarwanda, then back-translated to English. A consensus meeting discussed discrepancies and agreed on changes. Interviews were conducted with 26 participants before producing a final version. For the psychometric evaluation, the adapted version was administered to 309 patients with diabetes mellitus. Participants either came from a separate cluster-randomised controlled trial or were recruited ad hoc for this study. The evaluation included testing internal consistency, known group validity, and construct validity. Results: Participants' mean age was 51 ± 12.7 years with a predominance of women (64%) in the sample. All five scales of the questionnaire showed a good internal consistency, with composite reliability of above 0.7. The five-factor model of the questionnaire was fitted to the 39 items. Although the fit was not exact, there was a satisfactory approximate fit (CFI = 0.93, TLI = 0.92, RMSEA = 0.05). There was a good discriminant validity except for the "social burden" and "anxiety and worry" scales (inter-factor correlation = 0.80). Conclusions: Diabetes-39 is a questionnaire developed in English that was adapted and translated into Kinyarwanda. The Kinyarwanda version of D-39 is a reliable and valid instrument to measure QoL among diabetic patients in Rwanda. The questionnaire can be helpful in research and clinical practice improving health outcomes for patients with diabetes in Rwanda and other Kinyarwanda-competent areas in the sub-region. However, certain cross-cultural differences should be considered.
MeSH term(s)	Adult ; Diabetes Mellitus ; Female ; Humans ; Male ; Middle Aged ; Psychometrics ; Quality of Life ; Reproducibility of Results ; Surveys and Questionnaires
Language	English
Publishing date	2022-08-16
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2098765-1
ISSN	1477-7525 ; 1477-7525
ISSN (online)	1477-7525
ISSN	1477-7525
DOI	10.1186/s12955-022-02034-5
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Article ; Online: Lower gastric sensitivity in quiescent inflammatory bowel disease than in irritable bowel syndrome

Schulz, André / Welsch, Sina Katharina / Etringer, Sarah / Hansen, Greta / Milbert, Léa / Schneider, Jochen / Taddei, Gennaro / Bravo, Raquel Gomez / Lygidakis, Charilaos / van Dyck, Zoé / Lutz, Annika / Wilmes, Paul / Vögele, Claus

Physiology & Behavior. 2023 July 17, p.114293-

2023 , Page(s) 114293–

Abstract: Visceral hypersensitivity is considered a key symptom in inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), both of which seriously affect health-related quality of life (HrQoL). Previous findings are mostly based on invasive ... ...

Abstract	: Visceral hypersensitivity is considered a key symptom in inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), both of which seriously affect health-related quality of life (HrQoL). Previous findings are mostly based on invasive procedures that may interfere with the assessment of visceral perception. The current study, therefore, investigates whether IBD and IBS are characterized by altered perception of “natural” gastric distensions (“interoception”). : Twenty IBD patients in remission (13 Crohn's disease, 7 ulcerative colitis), 12 IBS patients, and 20/12 matched healthy control (HC) individuals, respectively, underwent the water load test, in which they could drink ad libitum until the subjective thresholds of satiation (stage 1) and fullness (stage 2) were reached. Gastric motility was assessed using electrogastrography. : IBD patients drank significantly more water until satiation than IBS patients, whereas no differences between patients and HC groups were observed. Electrogastrographic patterns were comparable between groups, suggesting no pathologies in gastric motility in IBD or IBS. The amount of water consumed until satiation negatively correlated with HrQoL related to bowel symptoms in IBD patients, but was positively associated with emotional well-being in IBS patients. : Our findings implicate relative gastric hypersensitivity in IBS, and relative hyposensitivity in IBD patients, which are both related to specific HrQoL aspects.
Keywords	Crohn disease ; behavior ; gastrointestinal motility ; hypersensitivity ; irritable bowel syndrome ; quality of life ; remission ; satiety ; ulcerative colitis ; inflammatory bowel disease ; interoception ; visceral hypersensitivity ; health-related quality of life
Language	English
Dates of publication	2023-0717
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2023.114293
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Article ; Online: Lower gastric sensitivity in quiescent inflammatory bowel disease than in irritable bowel syndrome.

Schulz, André / Welsch, Sina-Katharina / Etringer, Sarah / Hansen, Greta / Milbert, Léa / Schneider, Jochen / Taddei, Gennaro / Gomez Bravo, Raquel / Lygidakis, Charilaos / van Dyck, Zoé / Lutz, Annika / Wilmes, Paul / Vögele, Claus

Physiology & behavior

2023 Volume 270, Page(s) 114293

Abstract: Objective: Visceral hypersensitivity is considered a key symptom in inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), both of which seriously affect health-related quality of life (HrQoL). Previous findings are mostly based on ... ...

Abstract	Objective: Visceral hypersensitivity is considered a key symptom in inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), both of which seriously affect health-related quality of life (HrQoL). Previous findings are mostly based on invasive procedures that may interfere with the assessment of visceral perception. The current study, therefore, investigates whether IBD and IBS are characterized by altered perception of 'natural' gastric distensions ('interoception'). Methods: Twenty IBD patients in remission (13 Crohn's disease, 7 ulcerative colitis), 12 IBS patients, and 20/12 matched healthy control (HC) individuals, respectively, underwent the water load test, in which they could drink ad libitum until the subjective thresholds of satiation (stage 1) and fullness (stage 2) were reached. Gastric motility was assessed using electrogastrography. Results: IBD patients drank significantly more water until satiation than IBS patients, whereas no differences between patients and HC groups were observed. Electrogastrographic patterns were comparable between groups, suggesting no pathologies in gastric motility in IBD or IBS. The amount of water consumed until satiation negatively correlated with HrQoL related to bowel symptoms in IBD patients, but was positively associated with emotional well-being in IBS patients. Conclusion: Our findings implicate relative gastric hypersensitivity in IBS, and relative hyposensitivity in IBD patients, which are both related to specific HrQoL aspects.
MeSH term(s)	Humans ; Irritable Bowel Syndrome/complications ; Quality of Life ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/psychology ; Stomach ; Emotions
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2023.114293
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Article ; Online: Cultural adaptation and psychometric evaluation of the Kinyarwanda version of the problem areas in diabetes (PAID) questionnaire.

Lygidakis, Charilaos / Uwizihiwe, Jean Paul / Bia, Michela / Kallestrup, Per / Dukundane, Damas / Asiimwe-Kateera, Brenda / Niyonsenga, Simon Pierre / Vögele, Claus

Health and quality of life outcomes

2021 Volume 19, Issue 1, Page(s) 183

Abstract: Background: High prevalence rates in diabetes-related distress have been observed in several studies; however, in the region of Sub-Saharan Africa evidence is lacking as is, for example, the case for Rwanda, where diabetes prevalence is expected to ... ...

Abstract	Background: High prevalence rates in diabetes-related distress have been observed in several studies; however, in the region of Sub-Saharan Africa evidence is lacking as is, for example, the case for Rwanda, where diabetes prevalence is expected to increase over the next decade. The aim of this study is to report on the translation and cultural adaption of the problem areas in diabetes (PAID) questionnaire into Kinyarwanda and its psychometric properties. Methods: The questionnaire was translated following a standard procedure. Interviews were conducted with 29 participants before producing a final version. For the psychometric evaluation, a sample of 266 patients with diabetes mellitus, aged 21-64 years old were examined. Participants either came from a separate cluster-randomised controlled trial or were recruited ad-hoc for this study. The evaluation included testing internal consistency, known groups validity, and construct validity. A series of confirmatory factor analysis were conducted investigating seven previously established factorial structures. An exploratory factor analysis (EFA) was also carried out to examine the structure further. Results: The full scale showed good internal reliability (Cronbach's α = 0.88). A four-factor solution previously tested in Spain with subdimensions of emotional, treatment, food-related and social-support problems demonstrated adequate approximate fit (RMSEA = 0.056; CFI = 0.951; TLI = 0.943). The EFA revealed a four-factor structure; however, two of these factors were not as homogeneous and easily interpretable as those of the Spanish model. Conclusions: The psychometric properties of the Kinyarwanda version of PAID are acceptable. The questionnaire can be helpful in research and clinical practice in Rwanda, however certain cross-cultural differences should be taken into account.
MeSH term(s)	Adult ; Cross-Cultural Comparison ; Diabetes Mellitus/psychology ; Factor Analysis, Statistical ; Female ; Humans ; Male ; Middle Aged ; Psychometrics ; Reproducibility of Results ; Rwanda ; Surveys and Questionnaires ; Translations ; Young Adult
Language	English
Publishing date	2021-07-22
Publishing country	England
Document type	Journal Article
ISSN	1477-7525
ISSN (online)	1477-7525
DOI	10.1186/s12955-021-01821-w
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Article ; Online: VDGM:Vasco Da Gama Movement Awards, fund and web site.

Lygidakis, Charilaos / Freund, Tobias

The European journal of general practice

2013 Volume 19, Issue 3, Page(s) 203–204

MeSH term(s)	Europe ; Family Practice/organization & administration ; General Practice/organization & administration ; General Practitioners/organization & administration ; Humans ; Physicians, Family/organization & administration
Language	English
Publishing date	2013-09
Publishing country	England
Document type	News
ZDB-ID	1281338-2
ISSN	1751-1402 ; 1381-4788
ISSN (online)	1751-1402
ISSN	1381-4788
DOI	10.3109/13814788.2013.816951
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Article ; Online: Family Violence Curricula in Europe (FAVICUE): a cross-sectional descriptive study protocol.

Gómez Bravo, Raquel / Lygidakis, Charilaos / Feder, Gene / Reuter, Robert A P / Vögele, Claus

BMJ open

2019 Volume 9, Issue 2, Page(s) e024519

Abstract: Introduction: Family violence (FV) is a widespread public health problem of epidemic proportions and serious consequences. Doctors may be the first or only point of contact for victims who may be hesitant or unable to seek other sources of assistance, ... ...

Abstract	Introduction: Family violence (FV) is a widespread public health problem of epidemic proportions and serious consequences. Doctors may be the first or only point of contact for victims who may be hesitant or unable to seek other sources of assistance, and they tend not to disclose abuse to doctors if not specifically asked. A comprehensive healthcare response is key to a coordinated community-wide approach to FV, but most of the practising physicians have received either no or insufficient education or training in any aspect of FV. Training of medical students concerning FV is often delivered in an inconsistent or ad hoc manner.The main aim of this project, Family Violence Curricula in Europe (FAVICUE), is to (1) describe current FV education delivery in European medical universities (undergraduate period) and during the specialist training in general practice (GP)/family medicine (FM) (postgraduate residency programme), and (2) compare it with WHO recommendations for FV curriculum. Methods and analysis: This is the protocol of a cross-sectional descriptive study consisting of two self-report online surveys (for undergraduate and postgraduate training, respectively) with 40 questions each. For both surveys, general practitioners, residents, medical students and professionals involved in their education from countries of the European region will be identified through the European Regional Branch of the World Organization of National Colleges, Academies and Academic Associations of General Practitioners/Family Physicians (WONCA Europe) and will be invited to provide information regarding the training on FV. Descriptive tests will be carried out and a thematic analysis will be conducted on the open-ended questions. Ethics and dissemination: Ethics approval has been obtained by the University of Luxembourg (ERP 17-015 FAVICUE). The results will provide important information concerning current curricula on FV, and can be used for mapping the educational needs and planning the implementation of future training interventions. They will be published and disseminated through WONCA Europe and its networks.
MeSH term(s)	Clinical Protocols ; Cross-Sectional Studies ; Curriculum ; Domestic Violence/prevention & control ; Education, Medical/methods ; Education, Medical/statistics & numerical data ; Europe ; General Practice/education ; General Practice/methods ; Humans ; Students, Medical ; Surveys and Questionnaires
Language	English
Publishing date	2019-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2018-024519
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Article ; Online: Community- and mHealth-based integrated management of diabetes in primary healthcare in Rwanda (D²Rwanda): the protocol of a mixed-methods study including a cluster randomised controlled trial.

Lygidakis, Charilaos / Uwizihiwe, Jean Paul / Kallestrup, Per / Bia, Michela / Condo, Jeanine / Vögele, Claus

BMJ open

2019 Volume 9, Issue 7, Page(s) e028427

Abstract: Introduction: In Rwanda, diabetes mellitus prevalence is estimated between 3.1% and 4.3%. To address non-communicable diseases and the shortage of health workforce, the Rwandan Ministry of Health has introduced the home-based care practitioners (HBCPs) ... ...

Abstract	Introduction: In Rwanda, diabetes mellitus prevalence is estimated between 3.1% and 4.3%. To address non-communicable diseases and the shortage of health workforce, the Rwandan Ministry of Health has introduced the home-based care practitioners (HBCPs) programme: laypeople provide longitudinal care to chronic patients after receiving a six-month training. Leveraging technological mobile solutions may also help improve health and healthcare. The D²Rwanda study aims at: (a) determining the efficacy of an integrated programme for the management of diabetes in Rwanda, which will provide monthly patient assessments by HBCPs, and an educational and self-management mHealth patient tool, and; (b) exploring qualitatively the ways the interventions will have been enacted, their challenges and effects, and changes in the patients' health behaviours and HBCPs' work satisfaction. Methods and analysis: This is a mixed-methods sequential explanatory study. First, there will be a one-year cluster randomised controlled trial including two interventions ((1) HBCPs' programme; (2) HBCPs' programme + mobile health application) and usual care (control). Currently, nine hospitals run the HBCPs' programme. Under each hospital, administrative areas implementing the HBCPs' programme will be randomised to receive intervention 1 or 2. Eligible patients from each area will receive the same intervention. Areas without the HBCPs' programme will be assigned to the control group. The primary outcome will be changes in glycated haemoglobin. Secondary outcomes include medication adherence, mortality, complications, health-related quality of life, diabetes-related distress and health literacy. Second, at the end of the trial, focus group discussions will be conducted with patients and HBCPs. Financial support was received from the Karen Elise Jensens Fond, and the Universities of Aarhus and Luxembourg. Ethics and dissemination: Ethics approval was obtained from the Rwanda National Ethics Committee and the Ethics Review Panel of the University of Luxembourg. Findings will be disseminated via peer-reviewed publications and conference presentations. Trial registration number: NCT03376607; Pre-results.
MeSH term(s)	Caregivers/education ; Caregivers/organization & administration ; Diabetes Mellitus, Type 2/therapy ; Female ; Home Care Services/organization & administration ; Humans ; Male ; Primary Health Care/organization & administration ; Program Evaluation ; Qualitative Research ; Quality of Life ; Randomized Controlled Trials as Topic ; Rwanda ; Telemedicine/methods
Language	English
Publishing date	2019-07-24
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2018-028427
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Article ; Online: The twin-PhD model contributes to knowledge production in Africa.

Cubaka, Vincent Kalumire / Schriver, Michael / Uwizihiwe, Jean Paul / Lygidakis, Charilaos / Kallestrup, Per

Lancet (London, England)

2019 Volume 393, Issue 10191, Page(s) 2590

MeSH term(s)	Africa ; Education, Graduate ; Knowledge
Language	English
Publishing date	2019-06-27
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(19)30301-0
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