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  1. Article ; Online: [Årlig kontrol som kvalitetsmål].

    Lykkegaard, Jesper

    Ugeskrift for laeger

    2021  Volume 183, Issue 12

    Language Danish
    Publishing date 2021-04-08
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: National Development in the Use of Inhaled Corticosteroid Treatment in Chronic Obstructive Pulmonary Disease: Repeated Cross-Sectional Studies from 1998 to 2018.

    Klitgaard, Allan / Ibsen, Rikke / Lykkegaard, Jesper / Hilberg, Ole / Løkke, Anders

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: Recommendations for the treatment of chronic obstructive pulmonary disease (COPD) have shifted towards a more restrictive use of inhaled corticosteroids (ICS). We aimed to identify the nationwide development over time in the use of ICS treatment in COPD. ...

    Abstract Recommendations for the treatment of chronic obstructive pulmonary disease (COPD) have shifted towards a more restrictive use of inhaled corticosteroids (ICS). We aimed to identify the nationwide development over time in the use of ICS treatment in COPD. We conducted a register-based repeated cross-sectional study using Danish nationwide registers. On a yearly basis from 1998 to 2018, we included all patients in Denmark ≥ 40 years of age with an ICD-10 diagnosis of COPD (J44). Accumulated ICS use was calculated for each year based on redeemed prescriptions. Patients were divided into the following groups: No ICS, low-dose ICS, medium-dose ICS, or high-dose ICS. From 1998 to 2018, the yearly proportion of patients without ICS treatment increased (from 50.6% to 57.6%), the proportion of patients on low-dose ICS treatment increased (from 11.3% to 14.9%), and the proportion of patients on high-dose ICS treatment decreased (from 17.0% to 9.4%). We demonstrated a national reduction in the use of ICS treatment in COPD from 1998 to 2018, with an increase in the proportion of patients without ICS and on low-dose ICS treatment and a decrease in the proportion of patients on high-dose ICS treatment.
    Language English
    Publishing date 2024-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The durability of previous examinations for cancer: Danish nationwide cohort study.

    Lykkegaard, Jesper / Olsen, Jonas Kanstrup / Wehberg, Sonja / Jarbøl, Dorte Ejg

    Scandinavian journal of primary health care

    2024  Volume 42, Issue 2, Page(s) 246–253

    Abstract: Objective: Patients previously examined for cancer with a negative result may present in general practice with ongoing or new symptoms or signs suggestive of cancer. This paper explores the potential existence of a relatively safe period for cancer ... ...

    Abstract Objective: Patients previously examined for cancer with a negative result may present in general practice with ongoing or new symptoms or signs suggestive of cancer. This paper explores the potential existence of a relatively safe period for cancer occurrence after receiving negative examination results for specific types of cancer, including lung (CT thorax), upper gastrointestinal (gastroscopy), colorectal (colonoscopy), bladder (cystoscopy), and breast (clinical mammography).
    Design: Register-based time-to-event analyses.
    Setting: Denmark.
    Subjects: All 3.3 million citizens aged 30-85 years who on January first, 2017, had not previously been diagnosed with the specific type of cancer were categorized based on the time since their most recent examination.
    Main outcome measures: Using 1-year follow-up, we calculated the age- and sex-adjusted hazard ratios of being diagnosed with the related cancer, with non-examined individuals as reference. Negative examination results were defined as the absence of a cancer diagnosis within 6 months following the examination.
    Results: Previous negative examination results were common, also among those diagnosed with cancer during follow-up. For 10 years after a negative colonoscopy the risk of diagnosing a colorectal cancer was nearly halved. However, already 1 year after a clinical mammography and 2 years after a CT thorax the risk of diagnosing the related cancers was significantly higher among those with a previous negative result compared to non-examined individuals.
    Conclusion: This study did not identify a post-examination period in which the cancer risk, compared to non-examined individuals, was sufficiently low to confidently rule out any of the investigated cancers.
    MeSH term(s) Humans ; Cohort Studies ; Neoplasms/diagnosis ; General Practice ; Physical Examination ; Denmark/epidemiology
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605763-9
    ISSN 1502-7724 ; 0281-3432 ; 0284-6020
    ISSN (online) 1502-7724
    ISSN 0281-3432 ; 0284-6020
    DOI 10.1080/02813432.2024.2305942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Barriers for continuous medical education: cross-sectional questionnaire study among danish general practitioners.

    Ibsen, Helle / Ahrenfeldt, Linda Juel / Lykkegaard, Jesper / Søndergaard, Jens / Švab, Igor / Kjaer, Niels Kristian

    BJGP open

    2024  

    Abstract: Background: General practitioners' (GPs') participation in continuous medical education (CME) is essential for patientcare, wellbeing of the GPs, and healthcare expenditures. A quarter of the Danish GPs did not use their reimbursement for CME in 2022. ... ...

    Abstract Background: General practitioners' (GPs') participation in continuous medical education (CME) is essential for patientcare, wellbeing of the GPs, and healthcare expenditures. A quarter of the Danish GPs did not use their reimbursement for CME in 2022. Knowledge of barriers for participating in CME is limited.
    Aim: To analyse GPs' barriers for participation in CME and patterns in perceived barriers.
    Design & setting: The study population comprised all 3257 GPs in Denmark, who in May 2023 were registered as entitled to reimbursement for CME.
    Method: The response rate was 1303/3257 (40%). Based on a question about use of CME, the respondents were divided into frequent, partial, and seldom users. Partial and seldom users answered questions about barriers related to CME (n=726). The presence of barriers was quantified, and a Latent class analysis (LCA) was used to stratify GPs according to their barrier patterns.
    Results: Most frequent barriers were: Too busy (68%), fully booked courses (47%), and no substitute (41%). Based on the LCA, we found three distinctive patterns, clustering around: GPs from clinics with no tradition for CME (17%), GPs who used time on professional work outside clinic (teaching, organisational work) (43%), and GPs who were personally or professionally affected (40%). Singled-handed and male GPs were slightly overrepresented among seldom-users.
    Conclusions: We have identified barriers for CME. We found three different profiles of GPs who perceived different patterns of barriers. Identified patters in barriers should be considered in future CME initiatives.
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ISSN 2398-3795
    ISSN (online) 2398-3795
    DOI 10.3399/BJGPO.2023.0228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sensory impairments and depressive symptoms in Europe: a cross-national cohort study.

    Ahrenfeldt, Linda Juel / Möller, Sören / Nielsen, Dorthe Linding / Kjær, Niels Kristian / Søndergaard, Jens / Lykkegaard, Jesper

    Aging & mental health

    2024  , Page(s) 1–9

    Abstract: Objectives: To investigate the associations between sensory impairments and the development of depressive symptoms across sex, age, and European regions, and to examine the mediating role of cognitive function, activities of daily living (ADL), and ... ...

    Abstract Objectives: To investigate the associations between sensory impairments and the development of depressive symptoms across sex, age, and European regions, and to examine the mediating role of cognitive function, activities of daily living (ADL), and physical activity.
    Method: A cohort study including 56,847 Europeans aged 50+ participating in at least two waves of the Survey of Health, Ageing and Retirement in Europe (SHARE). Associations were analyzed using mixed effects logistic regression models considering several confounders.
    Results: Overall, 17.8% developed depressive symptoms. Compared to participants with good vision and hearing, those with vision impairment (VI) (odds ratio (OR) = 1.35, 95% confidence interval (CI) 1.27-1.44), hearing impairment (HI) OR = 1.32, 95% CI 1.21-1.43, and dual sensory impairment (DSI, i.e. VI and HI) (OR = 1.93, 95% CI 1.75-2.13) had increased odds of depressive symptoms. The associations were consistent across sex and European regions but became stronger with advancing age among men. Dose-response relationships were found for all associations. Mediation analyses revealed that preventing cognitive decline, ADL limitations, and physical inactivity would eliminate 15.0%, 11.5%, and 21.4% of the total effect for VI, HI, and DSI, respectively.
    Conclusion: Our findings emphasize the importance of preventing sensory impairments to avoid depressive symptoms.
    Language English
    Publishing date 2024-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1474804-6
    ISSN 1364-6915 ; 1360-7863
    ISSN (online) 1364-6915
    ISSN 1360-7863
    DOI 10.1080/13607863.2024.2345790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exploring GPs' assessments of their patients' cancer diagnostic processes: a questionnaire study.

    Lauridsen, Gitte Bruun / Jarbøl, Dorte Ejg / Thye-Rønn, Peter / Rasmussen, Sanne / Balasubramaniam, Kirubakaran / Lykkegaard, Jesper

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2023  Volume 73, Issue 737, Page(s) e941–e948

    Abstract: Background: Most cancer diagnostic pathways start from primary care and several factors affect the diagnostic processes.: Aim: To analyse the associations between patient characteristics, symptom presentation, and cancer type and the GP's assessment ... ...

    Abstract Background: Most cancer diagnostic pathways start from primary care and several factors affect the diagnostic processes.
    Aim: To analyse the associations between patient characteristics, symptom presentation, and cancer type and the GP's assessment of the diagnostic processes.
    Design and setting: General practices in the North, Central, and Southern regions of Denmark were invited to participate in a questionnaire survey.
    Method: Participating GPs received a list of patients with incident cases of cancer in the period between 1 March 2019 and 28 February 2021 based on administrative hospital data. A questionnaire was completed for each patient, addressing symptom presentation and the GP's assessment of the diagnostic process both overall and in four subcategories (the patient's role, the GP's role, the transition between primary and secondary care, and the secondary sector's role).
    Results: A total of 187 general practices informed on 8240 patients. For 5868 patients, diagnostic pathways started in general practice. Almost half (48.3%, 2837/5868) presented with specific cancer symptoms. GPs assessed 55.6% (3263) and 32.3% (1897) of the diagnostic processes as 'very good' and 'predominantly good', respectively; 11.9% (700) were 'predominantly poor' or 'very poor' for these 5868 patients. Long symptom duration of ≥2 months prior to GP contact and presenting with non-specific or a combination of non-specific and specific symptoms were associated with a poor overall assessment of the diagnostic process. Assessment in the four subcategories showed that the patient's role was assessed less positively than the other three categories.
    Conclusion: A longer symptom duration and presenting without cancer-specific symptoms were associated with GPs assessing the diagnostic process as poor.
    MeSH term(s) Humans ; General Practice ; Family Practice ; Surveys and Questionnaires ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Time Factors ; General Practitioners
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/BJGP.2022.0651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Exacerbations Predict Severe Cardiovascular Events in Patients with COPD and Stable Cardiovascular Disease-A Nationwide, Population-Based Cohort Study.

    Løkke, Anders / Hilberg, Ole / Lange, Peter / Ibsen, Rikke / Telg, Gunilla / Stratelis, Georgios / Lykkegaard, Jesper

    International journal of chronic obstructive pulmonary disease

    2023  Volume 18, Page(s) 419–429

    Abstract: Objective: Patients with chronic obstructive pulmonary disease (COPD) commonly present with cardiovascular disease (CVD). We investigated the association between COPD exacerbations and major cardiovascular (CV) events in a COPD population with a history ...

    Abstract Objective: Patients with chronic obstructive pulmonary disease (COPD) commonly present with cardiovascular disease (CVD). We investigated the association between COPD exacerbations and major cardiovascular (CV) events in a COPD population with a history of CVD.
    Methods: This population-based and register-based cohort study identified all Danish COPD patients aged ≥40 years who visited a hospital-based, pulmonary outpatient clinic for COPD between 1st January, 2010, and 31st December, 2016, from a nationwide COPD registry. Patients with a history of a major CV event 36‒6 months prior to their COPD measurement date and no CV event 6 months before this date were included. During a 6-month assessment period, the risks of a new CV event (hospitalization with fatal/non-fatal stroke, myocardial infarction, or heart failure) and moderate and severe COPD exacerbations were evaluated. Odds ratios with 95% confidence intervals for CV events and death were estimated using adjusted logistic regression models.
    Results: Of the 1501 COPD patients included, 55% experienced a COPD exacerbation and 13% experienced both an exacerbation and a CV event during follow-up (6 months). The odds of a CV event were 1.5 times higher in patients with a moderate exacerbation and more than 6-times higher in those with a severe exacerbation vs patients with no exacerbation(s). The majority of CV events occurred within 30 days post exacerbation in patients who experienced both an exacerbation and a CV event. In total, 113 patients died during the study period: 28% of deaths were caused by CVD and 72% by reasons other than CVD, mostly COPD.
    Conclusion: In patients with known CVD, severe COPD exacerbations are associated with increased odds of major CV events that occur within 30 days post exacerbation, highlighting the need to prevent exacerbations in COPD patients with concomitant CVD to potentially improve both respiratory and CV health.
    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cohort Studies ; Stroke ; Myocardial Infarction ; Disease Progression
    Language English
    Publishing date 2023-04-01
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2212419-6
    ISSN 1178-2005 ; 1176-9106
    ISSN (online) 1178-2005
    ISSN 1176-9106
    DOI 10.2147/COPD.S396790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Variation in daytime general practice services and association with out-of-hours use for older patients: protocol for a Danish cohort study.

    Olsen, Jonas K / Wehberg, Sonja / Waldorff, Frans Boch / Henriksen, Daniel Pilsgaard / Lykkegaard, Jesper

    BMJ open

    2023  Volume 13, Issue 7, Page(s) e073229

    Abstract: Introduction: Out-of-hours primary care services cannot provide the same continuity and coordination of care as general practice. Thus, patients with high risk of complex care trajectories should, when possible, be treated by the general practitioner ... ...

    Abstract Introduction: Out-of-hours primary care services cannot provide the same continuity and coordination of care as general practice. Thus, patients with high risk of complex care trajectories should, when possible, be treated by the general practitioner during daytime opening hours. This study aims to analyse the variation among general practices in the frequencies of daytime services for persons aged ≥75 years and how it relates to the patients' use of out-of-hours services.
    Methods and analysis: Register-based cohort study of all Danish citizens aged ≥75 years, of whom >98% are listed with a general practice. Using Poisson regression, we will estimate each practice's excess variation in delivered daytime services compared with the expected based on the characteristics of its listed patients. Delivered daytime services will be analysed overall and separately for face-to-face, phone, email, home visit and preventive services. The association with the use of out-of-hours services will be analysed by Poisson regression.
    Ethics and dissemination: Complying with European data protection rules, the legal services at University of Southern Denmark (Research & Innovation Organisation) approved the data processing activities regarding this project (journal number 11.593). According to section 14.2 of the Act on Research Ethics Review of Health Research Projects, because the study is based solely on register data, approval from the ethics committee and informed consent are not required. Results from the study will be disseminated as publications in peer-reviewed scientific journals and at international conferences.
    MeSH term(s) Humans ; Cohort Studies ; General Practice ; General Practitioners ; After-Hours Care ; Denmark
    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-073229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Exploring diagnostic events and first referrals in cancer patient pathways in primary care. A questionnaire survey.

    Lauridsen, Gitte B / Jarbøl, Dorte E / Thye-Rønn, Peter / Rasmussen, Sanne / Balasubramaniam, Kirubakaran / Lykkegaard, Jesper

    Family practice

    2023  Volume 41, Issue 2, Page(s) 67–75

    Abstract: Background: Cancer diagnostic pathways in general practice are often nonlinear, and several events can delay timely diagnosis.: Objectives: To explore cancer diagnostic processes in general practice, examining how patients' symptom presentations, sex, ...

    Abstract Background: Cancer diagnostic pathways in general practice are often nonlinear, and several events can delay timely diagnosis.
    Objectives: To explore cancer diagnostic processes in general practice, examining how patients' symptom presentations, sex, and age are associated with the occurrence of predefined potentially delaying events and the first referrals.
    Method: General practices in 3 Danish Regions were invited to participate in a questionnaire survey, addressing patient's symptom presentation, diagnostic process events, and first referral. The general practitioners (GPs) received a list of their incident cancer patients from the preceding 2 years.
    Results: In total 187 general practices participated, including 5,908 patients with the cancer diagnostic pathways initiated in general practice. Presenting with nonspecific symptoms was associated with potentially delaying events, even when the patient also had specific symptoms. Almost half of the patients were referred to a cancer patient pathway (CPP) first, men more often than women, and 10% were referred for acute hospitalization. In 23% of the diagnostic processes, GPs initially treated or referred patients on suspicion of another disease rather than cancer and waited due to normal examinations in 1 out of 20 patients. Excluding sex-specific cancers, these 2 events were more prevalent in women. Men less often complied to the follow-up agreement. Younger patients were less often first referred to a CPP and together with older patients more often first acutely hospitalized.
    Conclusion: In cancer diagnostic processes in general practice, first referrals and the occurrence of potentially delaying events are associated with the patient's age, sex, and specificity of symptoms.
    MeSH term(s) Male ; Humans ; Female ; General Practice ; General Practitioners ; Referral and Consultation ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Surveys and Questionnaires ; Primary Health Care
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 605939-9
    ISSN 1460-2229 ; 0263-2136
    ISSN (online) 1460-2229
    ISSN 0263-2136
    DOI 10.1093/fampra/cmad110
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  10. Article ; Online: General practitioners' management of patients with psychological stress: audit results from Denmark.

    Lykkegaard, Jesper / Prior, Anders / Rosendal, Marianne

    BMC family practice

    2020  Volume 21, Issue 1, Page(s) 67

    Abstract: Background: In western countries, psychological stress is among the most common causes of long-lasting sick leave and a frequent reason to consult the general practitioner (GP). This study aimed to investigate how GPs manage patients with psychological ... ...

    Abstract Background: In western countries, psychological stress is among the most common causes of long-lasting sick leave and a frequent reason to consult the general practitioner (GP). This study aimed to investigate how GPs manage patients with psychological stress and how the management is associated with the patient's sex, the GP's assessment of causality, and coexisting mental disorders.
    Methods: We conducted an audit of consecutive cases in Danish general practice. The GPs used electronic medical records to fill in a registration form for each 18-65-year-old patient with whom they had had at least one consultation regarding stress during the past 6 months. Only patients initially in the workforce were included. Age- and sex-adjusted binary regression was applied.
    Results: Fifty-six GPs (61% women) identified 785 cases. The patients' mean age was 44 years and 70% were women. The cause of stress was considered at least partially work-related in 69% of the cases and multifactorial in a third of cases. The management included sick leave (54%), counselling (47%), pharmaceutical treatment (37%), and referral to psychologist (38%). Compared to women, stress in men was less often considered work-related (RR: 0.84, CI95%: 0.77-0.92) and men were less often sick-listed (RR: 0.83 CI95%: 0.73-0.96) but were more often prescribed tranquilizers (RR: 1.72 CI95%: 1.08-2.74).
    Conclusions: GPs' management of patients with stress usually involve elements of counselling, sick leave, referral to psychologist, and medication. Women and men with stress are perceived of and managed differently.
    MeSH term(s) Adult ; Age Factors ; Clinical Audit ; Female ; General Practice/methods ; General Practice/standards ; General Practitioners/statistics & numerical data ; Humans ; Male ; Mental Disorders/epidemiology ; Middle Aged ; Patient Care Management/methods ; Patient Care Management/standards ; Physician-Patient Relations ; Psychotherapy/methods ; Psychotherapy/statistics & numerical data ; Referral and Consultation/statistics & numerical data ; Sex Factors ; Sick Leave/statistics & numerical data ; Stress, Psychological/epidemiology ; Stress, Psychological/psychology ; Stress, Psychological/therapy ; Tranquilizing Agents/therapeutic use
    Chemical Substances Tranquilizing Agents
    Language English
    Publishing date 2020-04-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2296
    ISSN (online) 1471-2296
    DOI 10.1186/s12875-020-01137-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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