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  1. Article ; Online: The Veterans Affairs' Dashboard Confessional: Vindication of the VA HF Dashboard.

    Lyle, Melissa A / Belkin, Mark N

    Journal of cardiac failure

    2024  Volume 30, Issue 3, Page(s) 460–461

    MeSH term(s) Humans ; United States ; Veterans ; Heart Failure ; United States Department of Veterans Affairs
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2023.12.011
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    Zs.A 4340: Show issues Location:
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  2. Article ; Online: Failure of intravenous immunoglobulin to improve cardiac function in parvovirus B19-associated chronic dilated cardiomyopathy.

    Lyle, Melissa A / Cooper, Leslie T

    European journal of heart failure

    2021  Volume 23, Issue 2, Page(s) 310–311

    MeSH term(s) Cardiomyopathy, Dilated ; Heart Failure ; Humans ; Immunoglobulins, Intravenous ; Parvoviridae Infections ; Parvovirus B19, Human
    Chemical Substances Immunoglobulins, Intravenous
    Language English
    Publishing date 2021-02-18
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2110
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    Zs.A 5299: Show issues Location:
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  3. Article ; Online: Cardiovascular Outcomes in Sarcoidosis.

    Lyle, Melissa A / Cooper, Leslie T

    Journal of the American College of Cardiology

    2020  Volume 76, Issue 7, Page(s) 778–780

    MeSH term(s) Cardiomyopathies ; Cardiovascular System ; Heart ; Humans ; Sarcoidosis/diagnosis
    Language English
    Publishing date 2020-08-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.06.046
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    Zs.A 1846: Show issues Location:
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  4. Article ; Online: HFpEF, a Disease of the Vasculature: A Closer Look at the Other Half.

    Lyle, Melissa A / Brozovich, Frank V

    Mayo Clinic proceedings

    2018  Volume 93, Issue 9, Page(s) 1305–1314

    Abstract: Patients with heart failure are commonly divided into those with reduced ejection fraction (EF ... 50%). For heart failure with reduced EF, a number of therapies have been found to improve patient ... ...

    Abstract Patients with heart failure are commonly divided into those with reduced ejection fraction (EF<40%) and those with preserved ejection fraction (HFpEF; EF>50%). For heart failure with reduced EF, a number of therapies have been found to improve patient morbidity and mortality, and treatment is guideline based. However for patients with HFpEF, no treatment has been found to have clinical benefit. To objectively assess treatments for HFpEF, a comprehensive PubMed literature search was performed using the terms HFpEF, heart failure, smooth muscle, myosin, myosin phosphatase, and PKG (up to December 31, 2017), with an unbiased focus on pathophysiology, cell signaling, and therapy. This review provides evidence that could explain the lack of clinical benefit in treating patients with HFpEF with sildenafil and long-acting nitrates. Furthermore, the review highlights the vascular abnormalities present in patients with HFpEF, and these abnormalities of the vasculature could potentially contribute to the pathophysiology of HFpEF. Thus, focusing on HFpEF as a vascular disease could result in the development of novel and effective treatment paradigms.
    MeSH term(s) Heart Failure/physiopathology ; Humans ; Stroke Volume ; Vascular Diseases/physiopathology
    Language English
    Publishing date 2018-07-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2018.05.001
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  5. Article ; Online: A 61-Year-Old Woman With New Pericardial Effusion.

    Lyle, Melissa A / Wan, Siu-Hin / Miller, Fletcher A

    JAMA cardiology

    2020  Volume 5, Issue 3, Page(s) 357–358

    MeSH term(s) Blood Flow Velocity ; Cardiac Tamponade/complications ; Cardiac Tamponade/diagnosis ; Cardiac Tamponade/surgery ; Cardiomegaly/diagnostic imaging ; Echocardiography ; Female ; Humans ; Middle Aged ; Pericardial Effusion/diagnostic imaging ; Pericardial Effusion/etiology ; Pericardial Effusion/surgery ; Pericardiocentesis ; Radiography ; Stents/adverse effects ; Vena Cava, Inferior/diagnostic imaging ; Ventricular Dysfunction, Right/diagnostic imaging
    Language English
    Publishing date 2020-01-22
    Publishing country United States
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2019.5276
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  6. Article: Sex and gender differences in myocarditis and dilated cardiomyopathy: An update.

    Fairweather, DeLisa / Beetler, Danielle J / Musigk, Nicolas / Heidecker, Bettina / Lyle, Melissa A / Cooper, Leslie T / Bruno, Katelyn A

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1129348

    Abstract: In the past decade there has been a growing interest in understanding sex and gender differences in myocarditis and dilated cardiomyopathy (DCM), and the purpose of this review is to provide an update on this topic including epidemiology, pathogenesis ... ...

    Abstract In the past decade there has been a growing interest in understanding sex and gender differences in myocarditis and dilated cardiomyopathy (DCM), and the purpose of this review is to provide an update on this topic including epidemiology, pathogenesis and clinical presentation, diagnosis and management. Recently, many clinical studies have been conducted examining sex differences in myocarditis. Studies consistently report that myocarditis occurs more often in men than women with a sex ratio ranging from 1:2-4 female to male. Studies reveal that DCM also has a sex ratio of around 1:3 women to men and this is also true for familial/genetic forms of DCM. Animal models have demonstrated that DCM develops after myocarditis in susceptible mouse strains and evidence exists for this progress clinically as well. A consistent finding is that myocarditis occurs primarily in men under 50 years of age, but in women after age 50 or post-menopause. In contrast, DCM typically occurs after age 50, although the age that post-myocarditis DCM occurs has not been investigated. In a small study, more men with myocarditis presented with symptoms of chest pain while women presented with dyspnea. Men with myocarditis have been found to have higher levels of heart failure biomarkers soluble ST2, creatine kinase, myoglobin and T helper 17-associated cytokines while women develop a better regulatory immune response. Studies of the pathogenesis of disease have found that Toll-like receptor (TLR)2 and TLR4 signaling pathways play a central role in increasing inflammation during myocarditis and in promoting remodeling and fibrosis that leads to DCM, and all of these pathways are elevated in males. Management of myocarditis follows heart failure guidelines and there are currently no disease-specific therapies. Research on standard heart failure medications reveal important sex differences. Overall, many advances in our understanding of the effect of biologic sex on myocarditis and DCM have occurred over the past decade, but many gaps in our understanding remain. A better understanding of sex and gender effects are needed to develop disease-targeted and individualized medicine approaches in the future.
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1129348
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  7. Article ; Online: Donation after circulatory death: A transplant cardiologist's take on neuroprognostication.

    Lyle, Melissa A / English, Stephen W / Goswami, Rohan M / Leoni Moreno, Juan C / Nativi-Nicolau, Jose / Yip, Daniel S / Patel, Parag C

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2023  Volume 42, Issue 10, Page(s) 1481–1483

    Abstract: Donation after circulatory death (DCD) is becoming increasingly utilized in heart transplantation and has the potential to further expand the donor pool. As transplant cardiologists gain more familiarity with DCD donor selection, there are many issues ... ...

    Abstract Donation after circulatory death (DCD) is becoming increasingly utilized in heart transplantation and has the potential to further expand the donor pool. As transplant cardiologists gain more familiarity with DCD donor selection, there are many issues that lack consensus including how we incorporate the neurologic examination, how we measure functional warm ischemic time (fWIT), and what fWIT thresholds are acceptable. DCD donor selection calls for prognostication tools to help determine how quickly a donor may expire, and in current practice there is no standardization in how we make these predictions. Current scoring systems help to determine which donor may expire within a specified time window either require the temporary disconnection of ventilatory support or do not incorporate any neurologic examination or imaging. Moreover, the specified time windows differ from other DCD solid organ transplantation without standardization or strong scientific justification for these thresholds. In this perspective, we highlight the challenges faced by transplant cardiologists as they navigate the muddy waters of neuroprognostication in DCD cardiac donation. Given these difficulties, this is also a call to action for the creation of a more standardized approach to improve the DCD donor selection process for appropriate resource allocation and organ utilization.
    MeSH term(s) Humans ; Tissue and Organ Procurement ; Death ; Cardiologists ; Tissue Donors ; Donor Selection ; Graft Survival
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2023.05.015
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    Zs.A 2056: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article: Association of Pulmonary Hypertension and Monoclonal Gammopathy of Undetermined Significance.

    Lyle, Melissa A / Bhatia, Subir / Fenstad, Eric / Schroeder, Darrell / McCully, Robert B / Lacy, Martha Q / Feyereisn, Wayne

    Advances in hematology

    2022  Volume 2022, Page(s) 8918959

    Abstract: Objective: To determine the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in patients with PH as well as precapillary PH.: Methods: Olmsted County residents with PH, diagnosed between 1/1/1995 and 9/30/2017, were identified, ...

    Abstract Objective: To determine the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in patients with PH as well as precapillary PH.
    Methods: Olmsted County residents with PH, diagnosed between 1/1/1995 and 9/30/2017, were identified, and age and sex were matched to a normal control group. The PH group and normal control group were then cross-referenced with the Mayo Clinic MGUS database. Charts were reviewed to verify MGUS and PH. Heart catheterization data were then analyzed in these patients for reference to the gold standard for diagnosis.
    Results: There were 3419 patients diagnosed with PH by echocardiography between 1995 and 2017 in Olmsted County that met the criteria of our study. When the PH group (
    Conclusions: There is a higher prevalence of MGUS in patients with PH and precapillary PH compared with normal controls. This association cannot be explained fully by other underlying diagnoses associated with PH. Assessing for this in patients with PH of unclear etiology may be reasonable in the workup of patients found to have PH.
    Language English
    Publishing date 2022-11-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2494501-8
    ISSN 1687-9112 ; 1687-9104
    ISSN (online) 1687-9112
    ISSN 1687-9104
    DOI 10.1155/2022/8918959
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  9. Article ; Online: Heart transplantation in Val142Ile mutation in the modern era: A single center experience.

    Lyle, Melissa A / Brown, Matthew T / Morris, Alanna A / Gupta, Divya / Vega, J David / Cole, Robert T / Bhatt, Kunal N

    Clinical transplantation

    2022  , Page(s) e14780

    Abstract: Little is known about the post heart transplantation management of extra cardiac manifestations in patients with hereditary transthyretin amyloid cardiomyopathy (hATTR-CM) in the new era of disease modifying treatment for ATTR amyloidosis. This is a ... ...

    Abstract Little is known about the post heart transplantation management of extra cardiac manifestations in patients with hereditary transthyretin amyloid cardiomyopathy (hATTR-CM) in the new era of disease modifying treatment for ATTR amyloidosis. This is a retrospective study of all patients with hATTR-CM associated with the Val142Ile variant who underwent heart transplantation (HT) from January 2014 to February 2022. All 10 patients with the Val142Ile mutation were successfully transplanted, with a 1 year survival post heart transplantation (HT) of 90%, comparable to an age, sex, and race matched cohort of patients transplanted for non-amyloid indications. However, 4 (40%) of these patients developed progressive extracardiac manifestations requiring initiation of TTR silencer therapy with the small interfering RNA (siRNA) drug patisiran, which was well tolerated with no significant side effects in this population. We recommend formal neurologic evaluation and assessment of extracardiac manifestations annually as part of routine post-transplant care, and disease modifying therapy, aimed at TTR stabilization or silencing, should be initiated in the context of previously untreated extracardiac manifestations or evidence of subclinical neuropathy to prevent progression.
    Language English
    Publishing date 2022-07-18
    Publishing country Denmark
    Document type Letter
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.14780
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    Zs.A 2204: Show issues Location:
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  10. Article ; Online: Ultrasound-guided fine-needle aspiration biopsy of thyroid nodules in patients taking novel oral anticoagulants.

    Lyle, Melissa A / Dean, Diana S

    Thyroid : official journal of the American Thyroid Association

    2015  Volume 25, Issue 4, Page(s) 373–376

    Abstract: Background: Ultrasound-guided fine-needle aspiration biopsy (USGFNAB) is the most accurate form of evaluation for thyroid nodules. Many patients with thyroid nodules who present for USGFNAB are on anticoagulant agents, including the novel oral ... ...

    Abstract Background: Ultrasound-guided fine-needle aspiration biopsy (USGFNAB) is the most accurate form of evaluation for thyroid nodules. Many patients with thyroid nodules who present for USGFNAB are on anticoagulant agents, including the novel oral anticoagulants (NOACs), for stroke prevention in atrial fibrillation or venous thrombosis prophylaxis.
    Summary: There has been at least one retrospective study describing neck USGFNAB bleeding risks in patients on antithrombotic and/or anticoagulant agents. This study concluded that there was no major bleeding risk or increase in hematoma formation in patients on antithrombotic or anticoagulant agents while undergoing USGFNAB, and there was no need to discontinue these agents prior to the procedure. With the emergence of NOACs, further recommendations should be made for patients on these agents who will be undergoing USGFNAB for thyroid nodules. Currently, there are no published studies regarding patients on NOACs who undergo USGFNAB.
    Conclusions: It has previously been established that patients on historical anticoagulant agents do not need to discontinue therapy prior to minor procedures such as needle aspirations or dental procedures. Therefore, in patients currently taking dabigatran, rivaroxaban, or apixaban, it is concluded that it is reasonable and safe to continue the novel oral anticoagulant agents prior to USGFNAB of thyroid nodules without major risk of bleeding. This conclusion is based not only on the fact that minor procedures are considered safe in patients on NOACs, but also because patients on historical anticoagulant agents do not need to discontinue therapy prior to minor procedures.
    MeSH term(s) Administration, Oral ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Drug Administration Schedule ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/adverse effects ; Hemorrhage/chemically induced ; Hemorrhage/prevention & control ; Humans ; Patient Safety ; Predictive Value of Tests ; Risk Assessment ; Risk Factors ; Thyroid Nodule/pathology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1086044-7
    ISSN 1557-9077 ; 1050-7256
    ISSN (online) 1557-9077
    ISSN 1050-7256
    DOI 10.1089/thy.2014.0307
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    Zs.MO 106: Show issues

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