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  1. Book: Principles of molecular diagnostics and personalized cancer medicine

    Tan, Dongfeng / Lynch, Henry T.

    2013  

    Author's details ed. Dongfeng Tan ; Henry T. Lynch
    Keywords Neoplasms / diagnosis ; Neoplasms / therapy ; Individualized Medicine / methods ; Medical Oncology / methods ; Molecular Diagnostic Techniques ; Molecular Targeted Therapy
    Language English
    Size XXIII, 968 S. : Ill., graph. Darst.
    Publisher Wolters Kluwer Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT017541337
    ISBN 978-1-4511-3197-0 ; 1-4511-3197-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 5180 order for loan Magazin
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Book ; Conference proceedings: American Cancer Society Second National Conference on Cancer Genetics

    Lynch, Henry T.

    San Francisco, California, June 26 - 28, 1998

    (Cancer ; 86,8, Suppl.)

    1999  

    Institution American Cancer Society
    Event/congress National Conference on Cancer Genetics (2, 1998, SanFranciscoCalif.)
    Author's details Co-Chairpersons Henry T. Lynch ... American Cancer Society
    Series title Cancer ; 86,8, Suppl.
    Collection
    Language English
    Size S. 1629 - 1768 : Ill., graph. Darst.
    Publisher Wiley
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT011127804
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh III Zs 146 -86- verfügbar in Königswinter Königswinter

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  3. Book: Hereditary aspects of common cancers

    Lynch, Henry T.

    (Surgical oncology clinics of North America ; 3,3)

    1994  

    Author's details Henry T. Lynch ..., guest. ed
    Series title Surgical oncology clinics of North America ; 3,3
    Collection
    Keywords Neoplasms / genetics ; Krebs ; Erbkrankheit
    Subject Genetische Krankheit ; Heredopathie ; Genetisch bedingte Krankheit ; Genetisches Syndrom ; Erbkrankheiten ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Language English
    Size XVI S., S. 419 - 635 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT006361499
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1339 -3,3- verfügbar in Königswinter Königswinter

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  4. Article ; Online: Gene and pathway based burden analyses in familial lymphoid cancer cases: Rare variants in immune pathway genes.

    Ralli, Sneha / Jones, Samantha J / Leach, Stephen / Lynch, Henry T / Brooks-Wilson, Angela R

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0287602

    Abstract: Genome-wide association studies have revealed common genetic variants with small effect sizes associated with diverse lymphoid cancers. Family studies have uncovered rare variants with high effect sizes. However, these variants explain only a portion of ... ...

    Abstract Genome-wide association studies have revealed common genetic variants with small effect sizes associated with diverse lymphoid cancers. Family studies have uncovered rare variants with high effect sizes. However, these variants explain only a portion of the heritability of these cancers. Some of the missing heritability may be attributable to rare variants with small effect sizes. We aim to identify rare germline variants associated with familial lymphoid cancers using exome sequencing. One case per family was selected from 39 lymphoid cancer families based on early onset of disease or rarity of subtype. Control data was from Non-Finnish Europeans in gnomAD exomes (N = 56,885) or ExAC (N = 33,370). Gene and pathway-based burden tests for rare variants were performed using TRAPD. Five putatively pathogenic germline variants were found in four genes: INTU, PEX7, EHHADH, and ASXL1. Pathway-based association tests identified the innate and adaptive immune systems, peroxisomal pathway and olfactory receptor pathway as associated with lymphoid cancers in familial cases. Our results suggest that rare inherited defects in the genes involved in immune system and peroxisomal pathway may predispose individuals to lymphoid cancers.
    MeSH term(s) Humans ; Genome-Wide Association Study ; Genetic Predisposition to Disease ; Neoplasms ; Germ-Line Mutation ; Exome Sequencing
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0287602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Recent progress in the genetic epidemiology of cancer

    Lynch, Henry T.

    1991  

    Title variant Genetic epidemiology of cancer
    Author's details Henry T. Lynch ... (eds.)
    Keywords Neoplasms / epidemiology ; Neoplasms / genetics ; Krebs ; Erbkrankheit ; Epidemiologie
    Subject Krankheitsverbreitung ; Genetische Krankheit ; Heredopathie ; Genetisch bedingte Krankheit ; Genetisches Syndrom ; Erbkrankheiten ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Language English
    Size X, 162 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    HBZ-ID HT003785372
    ISBN 3-540-53022-3 ; 0-387-53022-3 ; 978-3-540-53022-0 ; 978-0-387-53022-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 2465 order for loan Magazin

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  6. Book: Hereditary malignant melanoma

    Lynch, Henry T.

    1991  

    Author's details ed. Henry T. Lynch
    Keywords Dysplastic Nevus Syndrome ; Melanoma / genetics ; Melanom ; Erbkrankheit ; Erblichkeit ; Vererblichkeit
    Subject Vererbbarkeit ; Malignes Melanom ; Melanocytoblastom ; Melanozytoblastom ; Melanosarkom ; Melanoma maligna ; Heredität ; Genetische Krankheit ; Heredopathie ; Genetisch bedingte Krankheit ; Genetisches Syndrom ; Erbkrankheiten
    Size 114 S. : Ill., graph. Darst., Kt.
    Publisher CRC Pr
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003861082
    ISBN 0-8493-6051-X ; 978-0-8493-6051-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 3732 order for loan Magazin

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  7. Book: Genetic epidemiology of cancer

    Hirayama, Takeshi / Lynch, Henry T.

    1989  

    Title variant Genetic epidemiology of cancer / Henry T. Lynch ; Takeshi Hirayama
    Author's details ed.: Henry T. Lynch
    Keywords Neoplasms / genetics ; Neoplasms / epidemiology ; Krebs ; Erbkrankheit ; Epidemiologie
    Subject Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung ; Krankheitsverbreitung ; Genetische Krankheit ; Heredopathie ; Genetisch bedingte Krankheit ; Genetisches Syndrom ; Erbkrankheiten
    Size 361 S. : Ill., graph. Darst.
    Publisher CRC Pr
    Publishing place Boca Raton, Fla
    Publishing country United States
    Document type Book
    HBZ-ID HT003579520
    ISBN 0-8493-6756-5 ; 978-0-8493-6756-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 6405 order for loan Magazin

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  8. Book: GENETICS AND BREAST CANCER

    Lynch, Henry T.

    1981  

    Author's details ED. BY HENRY T. LYNCH
    Keywords BREAST NEOPLASMS / GENETICS ; GENETIC COUNSELING
    Size XII, 253 S.
    Publisher VAN NOSTRAND REINHOLD
    Publishing place NEW YORK (U.A.)
    Document type Book
    HBZ-ID HT002632430
    ISBN 0-442-24919-5 ; 978-0-442-24919-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1982 A 3489 order for loan Magazin

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  9. Article ; Online: Variation in cancer risk among families with genetic susceptibility.

    Huang, Theodore / Braun, Danielle / Lynch, Henry T / Parmigiani, Giovanni

    Genetic epidemiology

    2020  Volume 45, Issue 2, Page(s) 209–221

    Abstract: Germline mutations in many genes have been shown to increase the risk of developing cancer. This risk can vary across families who carry mutations in the same gene due to differences in the specific variants, gene-gene interactions, other susceptibility ... ...

    Abstract Germline mutations in many genes have been shown to increase the risk of developing cancer. This risk can vary across families who carry mutations in the same gene due to differences in the specific variants, gene-gene interactions, other susceptibility mutations, environmental factors, and behavioral factors. We develop an analytic tool to explore this heterogeneity using family history data. We propose to evaluate the ratio between the number of observed cancer cases in a family and the number of expected cases under a model where risk is assumed to be the same across families. We perform this analysis for both carriers and noncarriers in each family, using carrier probabilities when carrier statuses are unknown, and visualize the results. We first illustrate the approach in simulated data and then apply it to data on colorectal cancer risk in families carrying mutations in Lynch syndrome genes from Creighton University's Hereditary Cancer Center. We show that colorectal cancer risk in carriers can vary widely across families, and that this variation is not matched by a corresponding variation in the noncarriers from the same families. This suggests that the sources of variation in these families are to be found predominantly in variants harbored in the mutated MMR genes considered, or in variants interacting with them.
    MeSH term(s) Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Genetic Predisposition to Disease ; Humans ; Models, Genetic ; Mutation
    Language English
    Publishing date 2020-10-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 605785-8
    ISSN 1098-2272 ; 0741-0395
    ISSN (online) 1098-2272
    ISSN 0741-0395
    DOI 10.1002/gepi.22366
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1969: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Family Chronicles of Missed Opportunities.

    Flugelman, Anath A / Lynch, Henry T

    JAMA oncology

    2016  Volume 2, Issue 5, Page(s) 573–574

    Language English
    Publishing date 2016-04-08
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2016.0110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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