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  1. Article ; Online: Pathogenesis and presentation of ALS: examining reasons for delayed diagnosis and identifying opportunities for improvement.

    Lynch, Karen

    The American journal of managed care

    2023  Volume 29, Issue 7 Suppl, Page(s) S104–S111

    Abstract: Amyotrophic lateral sclerosis (ALS), or Lou Gehrig disease, is a progressive, always-fatal neuromuscular disease characterized by motor neuron degeneration in the brain and spinal cord. As upper and lower motor neurons fail, inability to transmit ... ...

    Abstract Amyotrophic lateral sclerosis (ALS), or Lou Gehrig disease, is a progressive, always-fatal neuromuscular disease characterized by motor neuron degeneration in the brain and spinal cord. As upper and lower motor neurons fail, inability to transmit messages to the muscles causes muscle stiffness, atrophy, and wasting. The incidence of this incurable disease is increasing in the United States, and its prognosis is grim. On average, patients survive about 3 to 5 years from symptom onset. Until recently, few risk factors were known, but some are newly emerging. About 10% of cases are related to genetic variants. Patients who develop ALS often experience diagnostic delays (10-16 months on average), and its heterogeneity contributes to that delay. Diagnosis is based primarily on clinical signs and symptoms and exclusion of other causes of motor neuron dysfunction. Reliable, accessible biomarkers are needed to aid early ALS diagnosis, differentiate from ALS-mimicking diseases, predict survival, and monitor disease progression and treatment response. Misdiagnosing ALS can have devastating consequences, including unnecessary emotional burden, delayed and/or inappropriate treatment, and undue financial burden. The grim prognosis and sure progression to death creates considerable burden and reduces quality of life for patients and caregivers.
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/diagnosis ; Delayed Diagnosis ; Quality of Life ; Brain ; Risk Factors
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2035781-3
    ISSN 1936-2692 ; 1088-0224 ; 1096-1860
    ISSN (online) 1936-2692
    ISSN 1088-0224 ; 1096-1860
    DOI 10.37765/ajmc.2023.89390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Optimizing pharmacologic treatment for ALS to improve outcomes and quality of life.

    Lynch, Karen

    The American journal of managed care

    2022  Volume 29, Issue 7 Suppl, Page(s) S112–S119

    Abstract: Just 3 disease-modifying treatments-edaravone, riluzole, and sodium phenylbutyrate and taurursodiol (PB/TURSO)-are currently FDA approved to slow progression of amyotrophic lateral sclerosis (ALS). A fourth therapy has been recently approved under ... ...

    Abstract Just 3 disease-modifying treatments-edaravone, riluzole, and sodium phenylbutyrate and taurursodiol (PB/TURSO)-are currently FDA approved to slow progression of amyotrophic lateral sclerosis (ALS). A fourth therapy has been recently approved under accelerated approval and is contingent upon verification of clinical benefit in confirmatory trials(s). Therapy selection is based largely upon patient characteristics, as guidelines have not been updated since the recent approval of PB/TURSO or accelerated approval of tofersen. Managing ALS symptomatically is important to improve patients' quality of life. Although evidence is lacking for many pharmacologic therapies, providers use symptomatic treatments to address common symptoms including anxiety, depression, emotional lability (pseudobulbar affect), fasciculations, fatigue, insomnia, muscle cramps or spasms, musculoskeletal pain due to immobility, neuropathic type pain, excessive salivation (sialorrhea), spasticity, constipation, and urinary urgency. Emerging agents offer some hope for patients with ALS. Among the drugs, biologics, and interventions under investigation for ALS are an oral tyrosine kinase inhibitor, RIPK1 inhibition, the use of mesenchymal stem cells, antisense oligonucleotides, sequential administration of all experimental treatments in a new study design, and modification of the patient's own mesenchymal stem cells.
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/drug therapy ; Quality of Life ; Riluzole ; Edaravone
    Chemical Substances sodium phenylbutyrate and taurursodiol ; Riluzole (7LJ087RS6F) ; Edaravone (S798V6YJRP)
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2035781-3
    ISSN 1936-2692 ; 1088-0224 ; 1096-1860
    ISSN (online) 1936-2692
    ISSN 1088-0224 ; 1096-1860
    DOI 10.37765/ajmc.2023.89389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Hijacking the 3Ss to ground reflective co-management of beach-dune environments

    Lynch, Kevin

    Ocean & coastal management. 2022 Feb. 15, v. 217

    2022  

    Abstract: The global drive to provide the 3Ss (Sun, Sand and Sea) for the benefit of tourists has been a contributory factor in the parallel deterioration of beach-dune habitats on our coasts. In Europe, this has happened at a time when habitat conservation and ... ...

    Abstract The global drive to provide the 3Ss (Sun, Sand and Sea) for the benefit of tourists has been a contributory factor in the parallel deterioration of beach-dune habitats on our coasts. In Europe, this has happened at a time when habitat conservation and integrated coastal zone management have been strongly backed to redress declining habitat condition. This paper proposes that we hijack the 3Ss slogan and use it as one tool in the continuing struggle to effect a transition to genuine sustainable coastal management. In this reappropriation of the slogan, the 3Ss stand for Sand, Space and Species. The new 3Ss would facilitate a shared focus on what are the essential components required for long-term, healthy beach-dune systems, using straight-forward language to initiate conversations between very diverse stakeholder groups.
    Keywords coastal zone management ; collaborative management ; habitat conservation ; habitats ; sand ; stakeholders ; Europe
    Language English
    Dates of publication 2022-0215
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0964-5691
    DOI 10.1016/j.ocecoaman.2021.106006
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Accomplices Wanted: Combining Lived Experience and Learned Expertise to Provide Affirming Medical Care to Transgender Patients.

    Lynch, Kyan

    Obstetrics and gynecology

    2020  Volume 135, Issue 2, Page(s) 472–474

    MeSH term(s) Attitude of Health Personnel ; Female ; Humans ; Male ; Primary Health Care ; Transgender Persons
    Language English
    Publishing date 2020-01-10
    Publishing country United States
    Document type Journal Article ; Personal Narrative
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/AOG.0000000000003652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: On Leaving Clinical Medicine.

    Lynch, Kyan

    Annals of internal medicine

    2020  Volume 172, Issue 7, Page(s) 497–498

    Language English
    Publishing date 2020-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M19-2666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Trans Man and the Warrior Women.

    Lynch, Kyan

    Transgender health

    2019  Volume 4, Issue 1, Page(s) 277–279

    Language English
    Publishing date 2019-10-25
    Publishing country United States
    Document type Journal Article
    ISSN 2380-193X
    ISSN 2380-193X
    DOI 10.1089/trgh.2019.0047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Rural-Urban Interaction in the Developing World

    Lynch, Kenny

    2005  

    Abstract: Sustaining the rural and urban populations of the developing world has been identified as a key global challenge for the twenty-first century. Rural-Urban Interaction in the Developing World is an introduction to the relationships between rural and urban ...

    Abstract Sustaining the rural and urban populations of the developing world has been identified as a key global challenge for the twenty-first century. Rural-Urban Interaction in the Developing World is an introduction to the relationships between rural and urban places in the developing world and shows that not all their aspects are as obvious as migration from country to city. There is now a growing realization that rural-urban relations are far more complex. Using a wealth of student-friendly features including boxed case studies, discussion questions and annotated guides to further reading, this innovative book places rural-urban interactions within a broader context, thus promoting a clearer understanding of the opportunities, as well as the challenges, that rural-urban interactions represent
    Keywords Geography (General)
    Size 1 electronic resource ( pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020310147
    ISBN 9780203646274 ; 9780415258708 ; 9780415258715 ; 9781134513987 ; 9781134513970 ; 9781134513932 ; 0203646274 ; 0415258707 ; 0415258715 ; 1134513984 ; 1134513976 ; 1134513933
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: The C-terminal transactivation domain of MITF interacts promiscuously with co-activator CBP/p300.

    Brown, Alexandra D / Lynch, Kyle / Langelaan, David N

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 16094

    Abstract: The microphthalmia-associated transcription factor (MITF) is one of four closely related members of the MiT/TFE family (TFEB, TFE3, TFEC) that regulate a wide range of cellular processes. MITF is a key regulator of melanocyte-associated genes, and ... ...

    Abstract The microphthalmia-associated transcription factor (MITF) is one of four closely related members of the MiT/TFE family (TFEB, TFE3, TFEC) that regulate a wide range of cellular processes. MITF is a key regulator of melanocyte-associated genes, and essential to proper development of the melanocyte cell lineage. Abnormal MITF activity can contribute to the onset of several diseases including melanoma, where MITF is an amplified oncogene. To enhance transcription, MITF recruits the co-activator CREB-binding protein (CBP) and its homolog p300 to gene promoters, however the molecular determinants of their interaction are not yet fully understood. Here, we characterize the interactions between the C-terminal MITF transactivation domain and CBP/p300. Using NMR spectroscopy, protein pulldown assays, and isothermal titration calorimetry we determine the C-terminal region of MITF is intrinsically disordered and binds with high-affinity to both TAZ1 and TAZ2 of CBP/p300. Mutagenesis studies revealed two conserved motifs within MITF that are necessary for TAZ2 binding and critical for MITF-dependent transcription of a reporter gene. Finally, we observe the transactivation potential of the MITF C-terminal region is reliant on the N-terminal transactivation domain for function. Taken together, our study helps elucidate the molecular details of how MITF interacts with CBP/p300 through multiple redundant interactions that lend insight into MITF function in melanocytes and melanoma.
    MeSH term(s) Humans ; CREB-Binding Protein/genetics ; Microphthalmia-Associated Transcription Factor/genetics ; Transcriptional Activation ; Oncogenes ; Melanoma/genetics
    Chemical Substances CREB-Binding Protein (EC 2.3.1.48) ; Microphthalmia-Associated Transcription Factor ; MITF protein, human
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-43207-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: An investigation of Head Start preschool children's executive function, early literacy, and numeracy learning in the midst of the COVID-19 pandemic.

    Lynch, Kathleen / Lee, Monica / Loeb, Susanna

    Early childhood research quarterly

    2023  Volume 64, Page(s) 255–265

    Abstract: The COVID-19 pandemic's impact on preschool children's school readiness skills remains understudied. This research investigates Head Start preschool children's early numeracy, literacy, and executive function outcomes during a pandemic-affected school ... ...

    Abstract The COVID-19 pandemic's impact on preschool children's school readiness skills remains understudied. This research investigates Head Start preschool children's early numeracy, literacy, and executive function outcomes during a pandemic-affected school year. Study children (
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article
    ISSN 0885-2006
    ISSN 0885-2006
    DOI 10.1016/j.ecresq.2023.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: "A Light at the End of the Tunnel": Experiences With Peer Specialists in the Open Dialogue Model.

    Friesen, Phoebe / Wusinich, Christina / Lynch, Katherine / Russell, David

    Psychiatric services (Washington, D.C.)

    2023  Volume 75, Issue 3, Page(s) 283–286

    Abstract: Objective: The authors examined participants' experiences with peer specialists in Parachute NYC, a community mental health program of support teams trained in Open Dialogue and intentional peer support.: Methods: Qualitative interviews were ... ...

    Abstract Objective: The authors examined participants' experiences with peer specialists in Parachute NYC, a community mental health program of support teams trained in Open Dialogue and intentional peer support.
    Methods: Qualitative interviews were conducted with eight enrollees and 10 network members (enrollees' family members). All excerpts coded as pertaining to peers were thematically analyzed.
    Results: Experiences with peer specialists were mostly positive. Participants especially valued peers' relatability and tendency to instill hope and engender empathy among enrollees and network members; peers' ability to foster community connections was also highly regarded. Generally, enrollees benefited from having peers and other health care professionals on a Parachute team because of their different forms of expertise. Concerns about peer specialists in dialogic care were reported by some network members, who questioned peers' degree of shared experiences, professionalism, and contributions to team unity.
    Conclusions: Despite generally positive findings, the optimal role for peers within the Open Dialogue model needs further exploration.
    MeSH term(s) Humans ; Family ; Peer Group
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.20230126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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