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  1. Article ; Online: Assessment of the trueness of additively manufactured mol3% zirconia crowns at different printing orientations with an industrial and desktop 3D printer compared to subtractive manufacturing.

    Cameron, Andrew B / Choi, Joanne Jung Eun / Ip, Andrew / Lyons, Nathan / Yaparathna, Navodika / Dehaghani, Ali Ebrahimzadeh / Feih, Stefanie

    Journal of dentistry

    2024  Volume 144, Page(s) 104942

    Abstract: Objectives: This study endeavours to investigate the effect of printing orientation on the trueness of additively manufactured molar zirconia crowns. The areal surface roughness and the characteristics of the marginal regions of the crowns were also ... ...

    Abstract Objectives: This study endeavours to investigate the effect of printing orientation on the trueness of additively manufactured molar zirconia crowns. The areal surface roughness and the characteristics of the marginal regions of the crowns were also considered.
    Methods: Twelve molar crowns were manufactured at 0°, 45°, and, 90° printing orientations in a Lithoz and AON zirconia printer, respectively. Twelve milled crowns were used as a comparison. Samples were scanned and analysed in metrology software to determine the trueness of the groups. Regions of interest were defined as the margins, intaglio surface and contact points. Areal surface roughness and print layer thickness were further analysed using a confocal laser scanning microscope.
    Results: The results indicate that there are clear differences between the investigated desktop (AON) and industrial (Lithoz) 3D printer. The 45° Lithoz group is the only sample group showing no significantly different results in trueness for all regions analysed compared to the milled group. Areal surface roughness analysis indicates that the print layers in the marginal regions are within clinically tolerable limits and surface characteristics.
    Conclusions: The printing orientation for zirconia crowns is critical to trueness, and differences are evident between different AM apparatuses. Considerations for design and orientation between different apparatuses should therefore be considered when utilising direct additive manufacturing processes. The areal surface roughness of the marginal regions is within acceptable clinical limits for all manufacturing processes and print orientations considered.
    Clinical significance: The materials and apparatuses for additive manufacturing of zirconia crowns are now clinically acceptable from the perspective of the trueness of a final crown for critical functional surfaces and areal surface roughness of the marginal regions.
    MeSH term(s) Zirconium/chemistry ; Crowns ; Printing, Three-Dimensional ; Surface Properties ; Computer-Aided Design ; Dental Prosthesis Design ; Humans ; Dental Materials/chemistry ; Microscopy, Confocal ; Molar ; Materials Testing ; Dental Marginal Adaptation
    Chemical Substances Zirconium (C6V6S92N3C) ; zirconium oxide (S38N85C5G0) ; Dental Materials
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article ; Comparative Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 186068-9
    ISSN 1879-176X ; 0300-5712
    ISSN (online) 1879-176X
    ISSN 0300-5712
    DOI 10.1016/j.jdent.2024.104942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Flexible Iron-On Sensor Embedded in Smart Sock for Gait Event Detection.

    Fastier-Wooller, Jarred W / Lyons, Nathan / Vu, Trung-Hieu / Pizzolato, Claudio / Rybachuk, Maksym / Itoh, Toshihiro / Dao, Dzung Viet / Maharaj, Jayishni / Dau, Van Thanh

    ACS applied materials & interfaces

    2023  Volume 16, Issue 1, Page(s) 1638–1649

    Abstract: Portable and wearable electronics for biomechanical data collection have become a growing part of everyday life. As smart technology improves and integrates into our lives, some devices remain ineffective, expensive, or difficult to access. We propose a ... ...

    Abstract Portable and wearable electronics for biomechanical data collection have become a growing part of everyday life. As smart technology improves and integrates into our lives, some devices remain ineffective, expensive, or difficult to access. We propose a washable iron-on textile pressure sensor for biometric data acquisition. Biometric data, such as human gait, are a powerful tool for the monitoring and diagnosis of ambulance and physical activity. To demonstrate this, our washable iron-on device is embedded into a sock and compared to gold standard force plate data. Biomechanical testing showed that our embedded sensor displayed a high aptitude for gait event detection, successfully identifying over 96% of heel strike and toe-off gait events. Our device demonstrates excellent attributes for further investigations into low-cost, washable, and highly versatile iron-on textiles for specialized biometric analysis.
    MeSH term(s) Humans ; Wearable Electronic Devices ; Gait ; Textiles ; Mechanical Phenomena ; Exercise
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c11805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Novel influenza inhibitors designed to target PB1 interactions with host importin RanBP5.

    Mohl, Gregory / Liddle, Nathan / Nygaard, Joseph / Dorius, Alexander / Lyons, Nathan / Hodek, Jan / Weber, Jan / Michaelis, David J / Busath, David D

    Antiviral research

    2019  Volume 164, Page(s) 81–90

    Abstract: In search of novel targets for influenza inhibitors, a site on PB1 was selected for its high conservation and probable interaction with a host protein, RanBP5, that is key to nuclear import of PB1, where it complexes with PB2, PA, and NP to transcribe ... ...

    Abstract In search of novel targets for influenza inhibitors, a site on PB1 was selected for its high conservation and probable interaction with a host protein, RanBP5, that is key to nuclear import of PB1, where it complexes with PB2, PA, and NP to transcribe viral RNA. Docking with libraries of drug-like compounds led to a selection of five candidates that bound tightly and with a pose likely to inhibit protein binding. These were purchased and tested in vitro, found to be active, and then one was synthetically expanded to explore the structure-activity relationship. The top candidates had a carboxylic acid converted to an ester and electron-withdrawing substituents added to a phenyl group in the original structure. Resistance was slow to develop, but cytotoxicity was moderately high. Nuclear localization of PB1 and in vitro polymerase activity were both strongly inhibited.
    MeSH term(s) Computer Simulation ; Drug Discovery ; High-Throughput Screening Assays ; Humans ; Influenza A virus/drug effects ; Influenza A virus/enzymology ; Influenza, Human/drug therapy ; Molecular Docking Simulation ; Structure-Activity Relationship ; Viral Proteins/antagonists & inhibitors ; Virus Replication/drug effects ; beta Karyopherins/metabolism
    Chemical Substances IPO5 protein, human ; Viral Proteins ; beta Karyopherins ; influenza virus polymerase basic protein 1
    Language English
    Publishing date 2019-02-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2019.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Boron-Templated Dimerization of Allylic Alcohols To Form Protected 1,3-Diols via Acid Catalysis.

    Nazari, S Hadi / Forson, Kelton G / Martinez, Erin E / Hansen, Nicholas J / Gassaway, Kyle J / Lyons, Nathan M / Kenney, Karissa C / Valdivia-Berroeta, Gabriel A / Smith, Stacey J / Michaelis, David J

    Organic letters

    2019  Volume 21, Issue 23, Page(s) 9589–9593

    Abstract: We report an unprecedented boron-templated dimerization of allylic alcohols that generates a 1,3-diol product with two stereogenic centers in high yield and diastereoselectivity. This acid-catalyzed reaction is achieved via in situ formation of a boronic ...

    Abstract We report an unprecedented boron-templated dimerization of allylic alcohols that generates a 1,3-diol product with two stereogenic centers in high yield and diastereoselectivity. This acid-catalyzed reaction is achieved via in situ formation of a boronic ester intermediate that facilitates selective cyclization and formation of a cyclic boronic ester product. High yields are observed with a variety of allylic alcohols, and mechanistic studies confirm the role of boron as a template for the reaction.
    Language English
    Publishing date 2019-11-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.9b03760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Boron-Templated Dimerization of Allylic Alcohols To Form Protected 1,3-Diols via Acid Catalysis

    Nazari, S. Hadi / Forson, Kelton G / Gassaway, Kyle J / Hansen, Nicholas J / Kenney, Karissa C / Lyons, Nathan M / Martinez, Erin E / Michaelis, David J / Smith, Stacey J / Valdivia-Berroeta, Gabriel A

    Organic letters. 2019 Nov. 25, v. 21, no. 23

    2019  

    Abstract: We report an unprecedented boron-templated dimerization of allylic alcohols that generates a 1,3-diol product with two stereogenic centers in high yield and diastereoselectivity. This acid-catalyzed reaction is achieved via in situ formation of a boronic ...

    Abstract We report an unprecedented boron-templated dimerization of allylic alcohols that generates a 1,3-diol product with two stereogenic centers in high yield and diastereoselectivity. This acid-catalyzed reaction is achieved via in situ formation of a boronic ester intermediate that facilitates selective cyclization and formation of a cyclic boronic ester product. High yields are observed with a variety of allylic alcohols, and mechanistic studies confirm the role of boron as a template for the reaction.
    Keywords alcohols ; boron ; catalytic activity ; chemical structure ; diastereoselectivity ; dimerization
    Language English
    Dates of publication 2019-1125
    Size p. 9589-9593.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.9b03760
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Scientific visualization of landscapes and landforms

    Mitasova, Helena / Harmon, Russell S. / Weaver, Katherine J. / Lyons, Nathan J. / Overton, Margery F.

    Geomorphology

    Volume v. 137,, Issue no. 1

    Abstract: Scientific visualization of geospatial data provides highly effective tools for analysis and communication of information about the land surface and its features, properties, and temporal evolution. Whereas single-surface visualization of landscapes is ... ...

    Abstract Scientific visualization of geospatial data provides highly effective tools for analysis and communication of information about the land surface and its features, properties, and temporal evolution. Whereas single-surface visualization of landscapes is now routinely used in presentation of Earth surface data, interactive 3D visualization based upon multiple elevation surfaces and cutting planes is gaining recognition as a powerful tool for analyzing landscape structure based on multiple return Light Detection and Ranging (LiDAR) data. This approach also provides valuable insights into land surface changes captured by multi-temporal elevation models. Thus, animations using 2D images and 3D views are becoming essential for communicating results of landscape monitoring and computer simulations of Earth processes. Multiple surfaces and 3D animations are also used to introduce novel concepts for visual analysis of terrain models derived from time-series of LiDAR data using multi-year core and envelope surfaces. Analysis of terrain evolution using voxel models and visualization of contour evolution using isosurfaces has potential for unique insights into geometric properties of rapidly evolving coastal landscapes. In addition to visualization on desktop computers, the coupling of GIS with new types of graphics hardware systems provides opportunities for cutting-edge applications of visualization for geomorphological research. These systems include tangible environments that facilitate intuitive 3D perception, interaction and collaboration. Application of the presented visualization techniques as supporting tools for analyses of landform evolution using airborne LiDAR data and open source geospatial software is illustrated by two case studies from North Carolina, USA.
    Keywords monitoring ; time series analysis ; spatial data ; digital images ; landforms ; cutting ; computer simulation ; case studies ; models ; computers ; computer software ; geographic information systems ; lidar ; landscapes
    Language English
    Document type Article
    ISSN 0169-555X
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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