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  1. Article ; Online: Dilution of maropitant (Cerenia) in lactated Ringer solution prolongs subcutaneous drug absorption and reduces maximum plasma concentration.

    Yee, Deborah E / Ochigbo, Grace / Menard, Julie / Rosa, Brielle V

    Journal of the American Veterinary Medical Association

    2023  Volume 261, Issue 8, Page(s) 1160–1165

    Abstract: Objective: The aim of this study was to determine whether the pharmacokinetics of maropitant, administered SC as a commercially available maropitant-containing injectable product (Cerenia Injectable), differ when combined with lactated Ringer solution ... ...

    Abstract Objective: The aim of this study was to determine whether the pharmacokinetics of maropitant, administered SC as a commercially available maropitant-containing injectable product (Cerenia Injectable), differ when combined with lactated Ringer solution prior to administration.
    Animals: We used 6 adult spayed female Beagle dogs between 3 and 6 years of age, with a mean weight of 9.58 kg.
    Procedures: In this randomized crossover study, the dogs underwent 2 treatment protocols separated by a 14-day washout period: (1) an SC injection of 1 mg/kg of Cerenia Injectable (maropitant citrate; 10 mg/mL) and (2) 1 mg/kg of Cerenia Injectable diluted in 10 mL/kg of lactated Ringer injectable solution (LRS) given SC. Plasma maropitant concentrations were assessed by mass spectrometry. Pharmacokinetic analysis was performed using pharmacokinetic and pharmacodynamic data-analysis software to determine maximum plasma concentration (Cmax), time to reach maximum concentration, half-life, total exposure to the drug, mean residence time, clearance rate per fraction absorbed, and absorption and elimination kinetic parameters.
    Results: Cmax was reduced by 26% (P = .002), the absorption rate constant decreased 80% (P = .031), and the absorption half-life increased when Cerenia was administered diluted in LRS.
    Clinical relevance: Administration of maropitant (Cerenia) diluted in LRS had a pharmacokinetic impact, resulting in a significantly reduced Cmax and slower absorption. Clinical efficacy was not assessed in this study.
    MeSH term(s) Animals ; Female ; Dogs ; Pharmaceutical Preparations ; Ringer's Lactate ; Cross-Over Studies ; Quinuclidines/therapeutic use
    Chemical Substances Pharmaceutical Preparations ; maropitant (4XE2T9H4DH) ; Ringer's Lactate ; Quinuclidines
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Randomized Controlled Trial, Veterinary ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
    DOI 10.2460/javma.22.09.0409
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    Zs.A 423: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Development of a veterinary trauma score (VetCOT) in canine trauma patients with performance evaluation and comparison to the animal trauma triage score: A VetCOT registry study

    Chik, Colin / Hayes, Galina M. / Menard, Julie

    Journal of veterinary emergency and critical care. 2021 Nov., v. 31, no. 6

    2021  

    Abstract: OBJECTIVE: To develop a population‐derived, parsimonious, and objective risk stratification model for dogs following trauma and compare its predictive performance to the animal trauma triage (ATT) score. DESIGN: Observational cohort study using data from ...

    Abstract OBJECTIVE: To develop a population‐derived, parsimonious, and objective risk stratification model for dogs following trauma and compare its predictive performance to the animal trauma triage (ATT) score. DESIGN: Observational cohort study using data from the American College of Veterinary Emergency and Critical Care Veterinary Committee on Trauma (VetCOT) trauma registry acquired between September 2013 and October 2017. SETTING: Nine Level I and Level II veterinary trauma centers. ANIMALS: Nine hundred eighty‐four dogs assessed within 24 h of traumatic injury. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Patient mortality was 10.8%. The VetCOT model was constructed based on 4 variables: plasma lactate and ionized calcium obtained within 6 h of admission, and presence or absence of clinical signs consistent with either head or spinal trauma. The VetCOT score had good discriminatory performance (AUROC = 0.87, 95% CI = 0.83‐0.91) comparable to that of the 6 variable ATT score for the same population (area under the receiver operator characteristic [AUROC] = 0.87; 95% CI, 0.84–0.90). No statistical difference in discriminatory performance between the 2 scores was identified (P = 0.98). The VetCOT score showed good calibration on this population (Hosmer–Lemeshow test P = 0.93), whereas the ATT score failed to calibrate (P = 0.02) due to overprediction of mortality at low scores. Sensitivity and specificity for outcome of the VetCOT score at a risk probability cutoff of 0.5 for this population were 28.97% and 97.95%, respectively. CONCLUSIONS: The VetCOT score is a more parsimonious model with comparable discriminatory performance and superior calibration to the ATT score for risk stratification in dogs following trauma. Further prospective validation studies are required to confirm the discriminatory performance of the VetCOT score.
    Keywords calcium ; cohort studies ; dogs ; head ; ionization ; lactic acid ; models ; mortality ; patients ; risk ; risk assessment
    Language English
    Dates of publication 2021-11
    Size p. 708-717.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2077212-9
    ISSN 1476-4431 ; 1479-3261
    ISSN (online) 1476-4431
    ISSN 1479-3261
    DOI 10.1111/vec.13135
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  3. Article ; Online: Noninvasive sampling of the small intestinal chyme for microbiome, metabolome and antimicrobial resistance genes in dogs, a proof of concept.

    Menard, Julie / Bagheri, Sahar / Menon, Sharanya / Yu, Y Tina / Goodman, Laura B

    Animal microbiome

    2023  Volume 5, Issue 1, Page(s) 64

    Abstract: Background: The gastrointestinal microbiome and metabolome vary greatly throughout the different segments of the gastrointestinal tract, however current knowledge of gastrointestinal microbiome and metabolome in health and disease is limited to fecal ... ...

    Abstract Background: The gastrointestinal microbiome and metabolome vary greatly throughout the different segments of the gastrointestinal tract, however current knowledge of gastrointestinal microbiome and metabolome in health and disease is limited to fecal samples due to ease of sampling. The engineered Small Intestinal MicroBiome Aspiration (SIMBA™) capsule allows specific sampling of the small intestine in humans. We aimed to determine whether administration of SIMBA™ capsules to healthy beagle dogs could reliably and safely sample the small intestinal microbiome and metabolome when compared to their fecal microbiome and metabolome.
    Results: Eleven beagle dogs were used for the study. Median transit time of capsules was 29.93 h (range: 23.83-77.88). Alpha diversity, as measured by the Simpson diversity, was significantly different (P = 0.048). Shannon diversity was not different (P = 0.114). Beta diversity results showed a significant difference between capsule and fecal samples regarding Bray-Curtis, weighted and unweighted unifrac (P = 0.002) and ANOSIM distance metric s (R = 0.59, P = 0.002). In addition to observing a statistically significant difference in the microbial composition of capsules and feces, distinct variation in the metabolite profiles was seen between the sample types. Heat map analysis showed 16 compounds that were significantly different between the 2 sampling modes (adj-P value ranged between 0.004 and 0.036) with 10 metabolites more abundant in the capsule than in the feces and 6 metabolites more abundant in the feces compared to the capsules.
    Conclusions: The engineered Small Intestinal MicroBiome Aspiration (SIMBA™) capsule was easy and safe to administer to dogs. Microbiome and metabolome analysis from the capsule samples were significantly different than that of the fecal samples and were like previously published small intestinal microbiome and metabolome composition.
    Language English
    Publishing date 2023-12-16
    Publishing country England
    Document type Journal Article
    ISSN 2524-4671
    ISSN (online) 2524-4671
    DOI 10.1186/s42523-023-00286-0
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  4. Article ; Online: When does exposure to daily negative acts frustrate employees' psychological needs? A within-person approach.

    Trépanier, Sarah-Geneviève / Peterson, Clayton / Ménard, Julie / Notelaers, Guy

    Journal of occupational health psychology

    2022  Volume 28, Issue 2, Page(s) 65–81

    Abstract: Based on self-determination theory, this two-sample study investigates the effects of negative acts on psychological need frustration in greater depth using a within-person perspective. More specifically, through two distinct diary studies, we aim to ... ...

    Abstract Based on self-determination theory, this two-sample study investigates the effects of negative acts on psychological need frustration in greater depth using a within-person perspective. More specifically, through two distinct diary studies, we aim to contribute to the dearth of research on the daily effects of bullying by investigating the daily relationship between exposure to negative acts and need frustration as well as the moderating role of perceived emotional support at work in this relationship. Overall, results from both studies show that employees experience greater need frustration (perceptions of rejection, oppression, and incompetence) on days they are confronted with negative acts and that daily emotional support buffers the impact of direct negative acts (humiliation, physical intimidation) on frustration of the needs for competence and relatedness at the daily level. As such, the results of the present two-sample study provide a better understanding of the boundary conditions under which exposure to negative acts may result in psychological costs by identifying emotional support as a key resource in the workplace that can offset the immediate harmful effects of certain negative behaviors. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
    MeSH term(s) Humans ; Workplace/psychology ; Personal Autonomy ; Bullying/psychology ; Surveys and Questionnaires ; Databases, Factual
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1364901-2
    ISSN 1939-1307 ; 1076-8998
    ISSN (online) 1939-1307
    ISSN 1076-8998
    DOI 10.1037/ocp0000338
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5092: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Development of a veterinary trauma score (VetCOT) in canine trauma patients with performance evaluation and comparison to the animal trauma triage score: A VetCOT registry study.

    Chik, Colin / Hayes, Galina M / Menard, Julie

    Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

    2021  Volume 31, Issue 6, Page(s) 708–717

    Abstract: Objective: To develop a population-derived, parsimonious, and objective risk stratification model for dogs following trauma and compare its predictive performance to the animal trauma triage (ATT) score.: Design: Observational cohort study using data ...

    Abstract Objective: To develop a population-derived, parsimonious, and objective risk stratification model for dogs following trauma and compare its predictive performance to the animal trauma triage (ATT) score.
    Design: Observational cohort study using data from the American College of Veterinary Emergency and Critical Care Veterinary Committee on Trauma (VetCOT) trauma registry acquired between September 2013 and October 2017.
    Setting: Nine Level I and Level II veterinary trauma centers.
    Animals: Nine hundred eighty-four dogs assessed within 24 h of traumatic injury.
    Interventions: None.
    Measurements and main results: Patient mortality was 10.8%. The VetCOT model was constructed based on 4 variables: plasma lactate and ionized calcium obtained within 6 h of admission, and presence or absence of clinical signs consistent with either head or spinal trauma. The VetCOT score had good discriminatory performance (AUROC = 0.87, 95% CI = 0.83-0.91) comparable to that of the 6 variable ATT score for the same population (area under the receiver operator characteristic [AUROC] = 0.87; 95% CI, 0.84-0.90). No statistical difference in discriminatory performance between the 2 scores was identified (P = 0.98). The VetCOT score showed good calibration on this population (Hosmer-Lemeshow test P = 0.93), whereas the ATT score failed to calibrate (P = 0.02) due to overprediction of mortality at low scores. Sensitivity and specificity for outcome of the VetCOT score at a risk probability cutoff of 0.5 for this population were 28.97% and 97.95%, respectively.
    Conclusions: The VetCOT score is a more parsimonious model with comparable discriminatory performance and superior calibration to the ATT score for risk stratification in dogs following trauma. Further prospective validation studies are required to confirm the discriminatory performance of the VetCOT score.
    MeSH term(s) Animals ; Cohort Studies ; Dog Diseases/diagnosis ; Dogs ; Prospective Studies ; Registries ; Retrospective Studies ; Trauma Centers ; Triage ; Wounds and Injuries/veterinary
    Language English
    Publishing date 2021-09-09
    Publishing country United States
    Document type Journal Article ; Observational Study, Veterinary
    ZDB-ID 2077212-9
    ISSN 1476-4431 ; 1479-3261
    ISSN (online) 1476-4431
    ISSN 1479-3261
    DOI 10.1111/vec.13135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Serial analysis of blood biomarker concentrations in dogs with pneumonia, septic peritonitis, and pyometra

    Goggs, Robert / Robbins, Sarah N. / LaLonde‐Paul, Denise M. / Menard, Julie M.

    Journal of veterinary internal medicine. 2022 Mar., v. 36, no. 2

    2022  

    Abstract: BACKGROUND: Prolonged antimicrobial drug (AMD) treatment is associated with antimicrobial resistance development. Biomarker measurement may aid treatment decision‐making. OBJECTIVES: Investigate temporal changes in blood biomarker concentrations in dogs ... ...

    Abstract BACKGROUND: Prolonged antimicrobial drug (AMD) treatment is associated with antimicrobial resistance development. Biomarker measurement may aid treatment decision‐making. OBJECTIVES: Investigate temporal changes in blood biomarker concentrations in dogs undergoing treatment for pulmonary and intra‐abdominal infections; compare time to biomarker concentration normalization with duration of clinician‐directed AMD treatment. ANIMALS: Forty‐two client‐owned dogs with pneumonia (n = 22), septic peritonitis (n = 10), or pyometra (n = 10). METHODS: Plasma concentrations of C‐reactive protein (CRP), serum amyloid A (SAA), haptoglobin, procalcitonin, nucleosomes, cell‐free DNA (cfDNA), high‐mobility group box‐1 (HMGB1), CC‐motif chemokine ligand‐2 (CCL2), CXC‐motif chemokine ligand‐8 (CXCL8), and keratinocyte chemoattractant‐like (KC‐Like) were quantitated in samples collected on days 1, 3, 7, 14, 28, and 60. Treatment was directed by clinicians blinded to biomarker concentrations. RESULTS: Concentrations of CCL2, CRP, and KC‐Like were maximal on D1, concentrations of SAA, cfDNA, HMGB1, and nucleosomes were maximal on D3 and haptoglobin concentrations were maximal on D7. These maximal concentrations were significantly different from those on D60. Concentrations of CRP and SAA decreased by 80% from peak and into respective reference intervals before AMDs were discontinued. For CRP, the median (interquartile range [IQR]) times to 20% peak and normal were 7 (6‐9) and 7 (6‐12) days, respectively, and for SAA they were 4 (4, 5) and 6 (5‐8) days, respectively, compared to a median (IQR) duration of AMD prescribing of 16 (12‐23) days (all P < .0001). CONCLUSIONS AND CLINICAL IMPORTANCE: Biomarker concentrations normalized within 7 to 14 days. Serial measurements of CRP and SAA might aid identification of disease resolution and could help guide AMD prescription decision‐making.
    Keywords C-reactive protein ; DNA ; amyloid ; antibiotic resistance ; biomarkers ; blood serum ; decision making ; drugs ; haptoglobins ; keratinocytes ; nucleosomes ; peritonitis ; pneumonia ; pyometra ; veterinary medicine
    Language English
    Dates of publication 2022-03
    Size p. 549-564.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.16374
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4095: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Serial evaluation of thoracic radiographs and acute phase proteins in dogs with pneumonia

    Menard, Julie / Porter, Ian / Lerer, Assaf / Robbins, Sarah / Johnson, Philippa J. / Goggs, Robert

    Journal of veterinary internal medicine. 2022 July, v. 36, no. 4

    2022  

    Abstract: BACKGROUND: Acute phase proteins (APP) may guide treatment of pneumonia in dogs but correlations with radiographic abnormalities are poorly characterized. OBJECTIVES: Develop a thoracic radiographic severity scoring system (TRSS), assess correlation of ... ...

    Abstract BACKGROUND: Acute phase proteins (APP) may guide treatment of pneumonia in dogs but correlations with radiographic abnormalities are poorly characterized. OBJECTIVES: Develop a thoracic radiographic severity scoring system (TRSS), assess correlation of radiographic changes with APP concentrations, and compare time to APP and radiograph normalization with duration of antimicrobials treatment. ANIMALS: Sixteen client‐owned dogs, 12 with aspiration pneumonia, and 4 with community‐acquired pneumonia. METHODS: Concentrations of C‐reactive protein (CRP), serum amyloid A (SAA), and haptoglobin were measured on days 1, 3, 7, 14, 28, and 60 and orthogonal 2‐view thoracic radiographs were obtained on days 1, 7, 14, 28, and 60. Treatment was clinician‐guided and blinded to APP concentrations. Radiographic severity scores were assigned by blinded, randomized retrospective review by 2 board‐certified radiologists with arbitration by a third radiologist. RESULTS: Median (interquartile range [IQR]) time to normalization of CRP (7 days [7‐14]) and SAA concentrations (7 days [7‐14]) were shorter than antimicrobial treatment duration (17.5 days [14.5‐33.5]; P = .001 and .002, respectively) and TRSS normalization (14 days [8.8‐52], P = .02 and .02, respectively). The CRP and SAA concentrations were positively correlated with TRSS (CRP rₛ, 0.643; SAA rₛ, 0.634; both P < .0001). Both CRP and SAA identified normal thoracic radiographs area under the curve (AUC) 0.873 and 0.817, respectively, both P < .0001. Interobserver agreement for TRSS assignment was moderate (κ, .499; P < .0001). CONCLUSION AND CLINICAL IMPORTANCE: Concentrations of CRP and SAA normalized before radiographic resolution and before clinicians discontinued antimicrobial treatment. The CRP and SAA concentrations may guide duration of antimicrobial treatment for dogs with pneumonia.
    Keywords C-reactive protein ; amyloid ; anti-infective agents ; blood serum ; haptoglobins ; pneumonia ; radiography ; veterinary medicine
    Language English
    Dates of publication 2022-07
    Size p. 1430-1443.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.16448
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4095: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Hypophosphatemia in Dogs With Presumptive Sepsis: A Retrospective Study (2008-2018).

    Chu, Victoria / Goggs, Robert / Bichoupan, Allison / Radhakrishnan, Shalini / Menard, Julie

    Frontiers in veterinary science

    2021  Volume 8, Page(s) 636732

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2021.636732
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  9. Article ; Online: Serial evaluation of thoracic radiographs and acute phase proteins in dogs with pneumonia.

    Menard, Julie / Porter, Ian / Lerer, Assaf / Robbins, Sarah / Johnson, Philippa J / Goggs, Robert

    Journal of veterinary internal medicine

    2022  Volume 36, Issue 4, Page(s) 1430–1443

    Abstract: Background: Acute phase proteins (APP) may guide treatment of pneumonia in dogs but correlations with radiographic abnormalities are poorly characterized.: Objectives: Develop a thoracic radiographic severity scoring system (TRSS), assess correlation ...

    Abstract Background: Acute phase proteins (APP) may guide treatment of pneumonia in dogs but correlations with radiographic abnormalities are poorly characterized.
    Objectives: Develop a thoracic radiographic severity scoring system (TRSS), assess correlation of radiographic changes with APP concentrations, and compare time to APP and radiograph normalization with duration of antimicrobials treatment.
    Animals: Sixteen client-owned dogs, 12 with aspiration pneumonia, and 4 with community-acquired pneumonia.
    Methods: Concentrations of C-reactive protein (CRP), serum amyloid A (SAA), and haptoglobin were measured on days 1, 3, 7, 14, 28, and 60 and orthogonal 2-view thoracic radiographs were obtained on days 1, 7, 14, 28, and 60. Treatment was clinician-guided and blinded to APP concentrations. Radiographic severity scores were assigned by blinded, randomized retrospective review by 2 board-certified radiologists with arbitration by a third radiologist.
    Results: Median (interquartile range [IQR]) time to normalization of CRP (7 days [7-14]) and SAA concentrations (7 days [7-14]) were shorter than antimicrobial treatment duration (17.5 days [14.5-33.5]; P = .001 and .002, respectively) and TRSS normalization (14 days [8.8-52], P = .02 and .02, respectively). The CRP and SAA concentrations were positively correlated with TRSS (CRP r
    Conclusion and clinical importance: Concentrations of CRP and SAA normalized before radiographic resolution and before clinicians discontinued antimicrobial treatment. The CRP and SAA concentrations may guide duration of antimicrobial treatment for dogs with pneumonia.
    MeSH term(s) Acute-Phase Proteins/metabolism ; Animals ; Biomarkers ; C-Reactive Protein/metabolism ; Dog Diseases/diagnostic imaging ; Dog Diseases/drug therapy ; Dogs ; Haptoglobins ; Pneumonia/veterinary ; Serum Amyloid A Protein/metabolism
    Chemical Substances Acute-Phase Proteins ; Biomarkers ; Haptoglobins ; Serum Amyloid A Protein ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.16448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4095: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Serial analysis of blood biomarker concentrations in dogs with pneumonia, septic peritonitis, and pyometra.

    Goggs, Robert / Robbins, Sarah N / LaLonde-Paul, Denise M / Menard, Julie M

    Journal of veterinary internal medicine

    2022  Volume 36, Issue 2, Page(s) 549–564

    Abstract: Background: Prolonged antimicrobial drug (AMD) treatment is associated with antimicrobial resistance development. Biomarker measurement may aid treatment decision-making.: Objectives: Investigate temporal changes in blood biomarker concentrations in ... ...

    Abstract Background: Prolonged antimicrobial drug (AMD) treatment is associated with antimicrobial resistance development. Biomarker measurement may aid treatment decision-making.
    Objectives: Investigate temporal changes in blood biomarker concentrations in dogs undergoing treatment for pulmonary and intra-abdominal infections; compare time to biomarker concentration normalization with duration of clinician-directed AMD treatment.
    Animals: Forty-two client-owned dogs with pneumonia (n = 22), septic peritonitis (n = 10), or pyometra (n = 10).
    Methods: Plasma concentrations of C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin, procalcitonin, nucleosomes, cell-free DNA (cfDNA), high-mobility group box-1 (HMGB1), CC-motif chemokine ligand-2 (CCL2), CXC-motif chemokine ligand-8 (CXCL8), and keratinocyte chemoattractant-like (KC-Like) were quantitated in samples collected on days 1, 3, 7, 14, 28, and 60. Treatment was directed by clinicians blinded to biomarker concentrations.
    Results: Concentrations of CCL2, CRP, and KC-Like were maximal on D1, concentrations of SAA, cfDNA, HMGB1, and nucleosomes were maximal on D3 and haptoglobin concentrations were maximal on D7. These maximal concentrations were significantly different from those on D60. Concentrations of CRP and SAA decreased by 80% from peak and into respective reference intervals before AMDs were discontinued. For CRP, the median (interquartile range [IQR]) times to 20% peak and normal were 7 (6-9) and 7 (6-12) days, respectively, and for SAA they were 4 (4, 5) and 6 (5-8) days, respectively, compared to a median (IQR) duration of AMD prescribing of 16 (12-23) days (all P < .0001).
    Conclusions and clinical importance: Biomarker concentrations normalized within 7 to 14 days. Serial measurements of CRP and SAA might aid identification of disease resolution and could help guide AMD prescription decision-making.
    MeSH term(s) Animals ; Biomarkers ; C-Reactive Protein/analysis ; Dog Diseases/drug therapy ; Dogs ; Peritonitis/drug therapy ; Peritonitis/veterinary ; Pneumonia/veterinary ; Pyometra/veterinary ; Serum Amyloid A Protein/metabolism
    Chemical Substances Biomarkers ; Serum Amyloid A Protein ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.16374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4095: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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