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  1. Article ; Online: Monoclonal antibody therapies in the management of SARS-CoV-2 infection.

    Miguez-Rey, Enrique / Choi, Dasom / Kim, Seungmin / Yoon, Sangwook / Săndulescu, Oana

    Expert opinion on investigational drugs

    2022  Volume 31, Issue 1, Page(s) 41–58

    Abstract: Introduction: Neutralizing antibodies (NAbs) that target key domains of the spike protein in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have therapeutic value because of their specificity. Depending on the targeted epitope, single ... ...

    Abstract Introduction: Neutralizing antibodies (NAbs) that target key domains of the spike protein in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have therapeutic value because of their specificity. Depending on the targeted epitope, single agents may be effective, but combined treatment involving multiple NAbs may be necessary to prevent the emergence of resistant variants.
    Areas covered: This article highlights the accelerated regulatory processes established to facilitate the review and approval of potential therapies. An overview of treatment approaches for SARS-CoV-2 infection, with detailed examination of the preclinical and clinical evidence supporting the use of NAbs, is provided. Finally, insights are offered into the potential benefits and challenges associated with the use of these agents.
    Expert opinion: NAbs offer an effective, evidence-based therapeutic intervention during the early stages of SARS-CoV-2 infection when viral replication is the primary factor driving disease progression. As the pandemic progresses, appropriate use of NAbs will be important to minimize the risk of escape variants. Ultimately, the availability of effective treatments for COVID-19 will allow the establishment of treatment algorithms for minimizing the substantial rates of hospitalization, morbidity (including long COVID) and mortality currently associated with the disease.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antibodies, Neutralizing/therapeutic use ; COVID-19/complications ; Humans ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Neutralizing
    Language English
    Publishing date 2022-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2022.2030310
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    Zs.A 3739: Show issues Location:
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  2. Article ; Online: Pulmonary nocardiosis treated with tedizolid.

    Giménez-Arufe, Víctor / Gutiérrez-Urbón, José María / Blanco-Aparicio, Marina / Míguez-Rey, Enrique / Martín-Herranz, María Isabel

    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

    2019  Volume 43, Issue 6, Page(s) 208–210

    Title translation Nocardiosis pulmonar tratada con tedizolid.
    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Blood Cell Count ; Female ; Humans ; Middle Aged ; Nocardia ; Nocardia Infections/drug therapy ; Nocardia Infections/microbiology ; Oxazolidinones/adverse effects ; Oxazolidinones/therapeutic use ; Pulmonary Disease, Chronic Obstructive/complications ; Tetrazoles/adverse effects ; Tetrazoles/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Oxazolidinones ; Tetrazoles ; tedizolid (97HLQ82NGL)
    Language English
    Publishing date 2019-11-01
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 1122680-8
    ISSN 2171-8695 ; 1130-6343
    ISSN (online) 2171-8695
    ISSN 1130-6343
    DOI 10.7399/fh.11256
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    Zs.A 3450: Show issues Location:
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  3. Article: Renal profile of patients treated with elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate and dolutegravir/abacavir/lamivudine: 120-week results from a real-world cohort.

    Rotea-Salvo, Sandra / Martínez-Pradeda, Alejandro / Fernández-Oliveira, Carla / Giménez-Arufe, Victor / Balboa-Barreiro, Vanesa / Margusino-Framiñán, Luis / Mena-De-Cea, Álvaro / Vázquez-Rodríguez, Pilar / Castro-Iglesias, Ángeles / López-Calvo, Soledad / Martín-Herranz, Isabel / Míguez-Rey, Enrique / Cid-Silva, Purificación

    European journal of hospital pharmacy : science and practice

    2021  Volume 30, Issue 4, Page(s) 221–226

    Abstract: Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate (EVG/c/FTC/TAF) and dolutegravir/abacavir/lamivudine (DTG/ABC/3TC) are currently available for HIV patients.: Objectives: This study evaluated modifications in the renal safety ... ...

    Abstract Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate (EVG/c/FTC/TAF) and dolutegravir/abacavir/lamivudine (DTG/ABC/3TC) are currently available for HIV patients.
    Objectives: This study evaluated modifications in the renal safety profile in a large real-world cohort of patients who had received EVG/c/FTC/TAF or DTG/ABC/3TC.
    Methods: A retrospective observational study of HIV-infected patients who received EVG/c/FTC/TAF or DTG/ABC/3TC between March 2015 and June 2019 at a reference hospital in north-western Spain was conducted. Epidemiological, clinical, immunovirological data and information regarding antiretroviral therapy were recorded. The statistical differences between treatments were calculated.
    Results: A total of 457 patients were evaluated, 266 using EVG/c/FTC/TAF and 191 using DTG/ABC/3TC. Up to week 120, serum creatinine improved in both study groups among experienced patients (EVG/c/FTC/TAF 1.01±0.24 vs 0.91±0.19, p<0.001; DTG/ABC/3TC 1.08±0.24 vs 1.02±0.31, p<0.001), while in naïve patients serum creatinine remained stable compared with baseline. Statistically significant differences were found in serum creatinine when comparing both treatments at week 48 in experienced (0.94±0.21 vs 1.09±0.28, p<0.001) and naïve patients (0.89±0.16 vs 1.06±0.20, p=0.001), and among experienced patients at week 120 (0.91±0.19 vs 1.02±0.31, p=0.015) for the EVG/c/FTC/TAF and DTG/ABC/3TC groups, respectively. During the follow-up, 39 patients in EVG/c/FTC/TAF and 33 in DTG/ABC/3TC (p=0.449) discontinued treatment. The main reason for stopping treatment was adverse events, which were similar in both groups.
    Conclusions: During the follow-up, patients experienced changes that were not clinically relevant in both treatment groups. Differences in renal events were not found.
    MeSH term(s) Humans ; Lamivudine/adverse effects ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Creatinine ; Anti-HIV Agents/adverse effects ; Emtricitabine/adverse effects ; Cobicistat/therapeutic use ; Fumarates/therapeutic use
    Chemical Substances Lamivudine (2T8Q726O95) ; elvitegravir (4GDQ854U53) ; tenofovir alafenamide (EL9943AG5J) ; abacavir (WR2TIP26VS) ; dolutegravir (DKO1W9H7M1) ; Creatinine (AYI8EX34EU) ; Anti-HIV Agents ; Emtricitabine (G70B4ETF4S) ; Cobicistat (LW2E03M5PG) ; Fumarates
    Language English
    Publishing date 2021-10-14
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2650179-X
    ISSN 2047-9964 ; 2047-9956
    ISSN (online) 2047-9964
    ISSN 2047-9956
    DOI 10.1136/ejhpharm-2021-002896
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  4. Article: Discontinuation due to neuropsychiatric adverse events with efavirenz- and dolutegravir-based antiretroviral therapy: a comparative real-life study.

    Fernández-Bargiela, Noelia / Rotea-Salvo, Sandra / Margusino-Framiñán, Luis / Balboa-Barreiro, Vanesa / Martín-Herranz, Isabel / Castro-Iglesias, Ángeles / Mena-De-Cea, Álvaro / López-Calvo, Soledad / Vázquez-Rodríguez, Pilar / Míguez-Rey, Enrique / Cid-Silva, Purificación

    European journal of hospital pharmacy : science and practice

    2020  Volume 29, Issue 4, Page(s) 207–211

    Abstract: Objectives: Despite the high efficacy of antiretroviral treatment, no drug is free from adverse events (AEs). Efavirenz (EFV) and dolutegravir (DTG) are antiretroviral drugs for which neuropsychiatric adverse events (NPAEs) have been described. This ... ...

    Abstract Objectives: Despite the high efficacy of antiretroviral treatment, no drug is free from adverse events (AEs). Efavirenz (EFV) and dolutegravir (DTG) are antiretroviral drugs for which neuropsychiatric adverse events (NPAEs) have been described. This study evaluated the safety and tolerability of DTG-based and EFV-based antiretroviral regimens in HIV-infected patients.
    Methods: A retrospective observational study was carried out in HIV-infected patients who started DTG- or EFV-based antiretroviral treatment from January 2008 to December 2018 at a reference hospital in north-western Spain. Epidemiological, clinical and immunovirological data were recorded. A statistical analysis was performed with SPSS software.
    Results: A total of 282 DTG- and 148 EFV-based therapies were initiated. During follow-up, statistically significant differences have been found between the rate of patients who discontinued DTG and EFV due to AEs (12.1% vs 35.8%, p<0.001) and the main AEs in both groups, NPAEs (8.2% vs 25.0%, p<0.001). Female gender (OR 2.610 (95% CI 1.327 to 5.133), p=0.005) was associated with discontinuations due to AEs. Patients with documented psychiatric disorders were at higher risk of discontinuation due to NPAEs (OR 4.782 (95% CI 1.190 to 19.220), p=0.027). The multivariate analysis showed a 61.2% risk reduction in benzodiazepine prescriptions in patients treated with DTG. In both groups, patients needed consultation and follow-up in the psychiatry unit (16.9% in the EFV group and 8.9% in the DTG group, p=0.021).
    Conclusions: We found a high rate of discontinuations due to AEs and NPAEs, prescription of benzodiazepines and a requirement for consultation in a psychiatric unit in both treatment groups, especially with EFV.
    MeSH term(s) Alkynes ; Benzoxazines/adverse effects ; Cyclopropanes ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Heterocyclic Compounds, 3-Ring/adverse effects ; Humans ; Oxazines ; Piperazines ; Pyridones
    Chemical Substances Alkynes ; Benzoxazines ; Cyclopropanes ; Heterocyclic Compounds, 3-Ring ; Oxazines ; Piperazines ; Pyridones ; dolutegravir (DKO1W9H7M1) ; efavirenz (JE6H2O27P8)
    Language English
    Publishing date 2020-10-13
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2650179-X
    ISSN 2047-9964 ; 2047-9956
    ISSN (online) 2047-9964
    ISSN 2047-9956
    DOI 10.1136/ejhpharm-2020-002374
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  5. Article ; Online: Treatment with tenofovir alafenamide fumarate worsens the lipid profile of HIV-infected patients versus treatment with tenofovir disoproxil fumarate, each coformulated with elvitegravir, cobicistat, and emtricitabine.

    Cid-Silva, Purificación / Fernández-Bargiela, Noelia / Margusino-Framiñán, Luis / Balboa-Barreiro, Vanesa / Mena-De-Cea, Álvaro / López-Calvo, Soledad / Vázquez-Rodríguez, Pilar / Martín-Herranz, Isabel / Míguez-Rey, Enrique / Poveda, Eva / Castro-Iglesias, Ángeles

    Basic & clinical pharmacology & toxicology

    2018  Volume 124, Issue 4, Page(s) 479–490

    Abstract: Two elvitegravir/cobicistat-based therapies combined with emtricitabine/tenofovir disoproxil fumarate (EVG/c/FTC/TDF) or emtricitabine/tenofovir alafenamide fumarate (EVG/c/FTC/TAF) are currently available for HIV patients. This study evaluated the ... ...

    Abstract Two elvitegravir/cobicistat-based therapies combined with emtricitabine/tenofovir disoproxil fumarate (EVG/c/FTC/TDF) or emtricitabine/tenofovir alafenamide fumarate (EVG/c/FTC/TAF) are currently available for HIV patients. This study evaluated the modifications in the lipid profile of patients who received these treatments in the last three years at our institution. A retrospective observational study in HIV-infected patients who received EVG/c/FTC/TDF or EVG/c/FTC/TAF from January 2015 to January 2018 at a reference hospital in northwestern Spain was carried out. Epidemiological, clinical and immunovirological data were recorded. A statistical analysis was performed using SPSS software. A total of 384 EVG/c-based therapies were initiated during the study period, 151 EVG/c/FTC/TDF and 233 EVG/c/FTC/TAF. A significantly negative influence in all the lipid profile parameters in experienced patients and total cholesterol (TC), and LDL-C in naïve patients were observed after 48 weeks of treatment with EVG/c/FTC/TAF, while these parameters remained stable in the EVG/c/FTC/TDF group. During follow-up, a greater proportion of patients had lipid levels above the normal range (63.1% TC, 56.2% LDL-C) and new lipid-modifying drugs were prescribed (11.9%) in the EVG/c/FTC/TAF group. The number of cardiovascular risk factors (OR 1.66 [95% CI 1.01-2.72]; P = 0.043) was recognised as an independent predictor of lipid-lowering prescription for patients treated with both EVG/c/FTC/TDF and EVG/c/FTC/TAF. For patients treated with EVG/c/FTC/TAF, the mean total cholesterol to HDL ratio in the first 48 weeks of the study treatment was associated with a higher likelihood of lipid-lowering prescription in multivariate analysis (OR 1.6 [95% CI 1.12-2.52]; P = 0.011). Significant changes in lipid profile have been observed in patients who have received EVG/c/FTC/TAF. It was necessary to prescribe almost twice the number of lipid-lowering drugs to patients who received EVG/c/FTC/TAF (11.9%) vs EVG/c/FTC/TDF (4.7%).
    MeSH term(s) Adenine/administration & dosage ; Adenine/adverse effects ; Adenine/analogs & derivatives ; Adult ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/adverse effects ; Cholesterol/blood ; Cholesterol, LDL/blood ; Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination/administration & dosage ; Female ; Follow-Up Studies ; HIV Infections/drug therapy ; Humans ; Hypolipidemic Agents/administration & dosage ; Lipids/blood ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Spain ; Young Adult
    Chemical Substances Anti-HIV Agents ; Cholesterol, LDL ; Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination ; Hypolipidemic Agents ; Lipids ; Cholesterol (97C5T2UQ7J) ; tenofovir alafenamide (EL9943AG5J) ; Adenine (JAC85A2161)
    Language English
    Publishing date 2018-12-07
    Publishing country England
    Document type Comparative Study ; Journal Article ; Observational Study
    ZDB-ID 2134679-3
    ISSN 1742-7843 ; 1742-7835
    ISSN (online) 1742-7843
    ISSN 1742-7835
    DOI 10.1111/bcpt.13161
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  6. Article ; Online: Role of age and comorbidities in mortality of patients with infective endocarditis.

    Armiñanzas, Carlos / Fariñas-Alvarez, Concepción / Zarauza, Jesús / Muñoz, Patricia / González Ramallo, Víctor / Martínez Sellés, Manuel / Miró Meda, José Mª / Pericás, Juan Manuel / Goenaga, Miguel Ángel / Ojeda Burgos, Guillermo / Rodríguez Álvarez, Regino / Castelo Corral, Laura / Gálvez-Acebal, Juan / Martínez Marcos, Francisco Javier / Fariñas, Maria Carmen / Fernández Sánchez, Fernando / Noureddine, Mariam / Rosas, Gabriel / de la Torre Lima, Javier /
    Aramendi, José / Bereciartua, Elena / Blanco, María José / Blanco, Roberto / Boado, María Victoria / Campaña Lázaro, Marta / Crespo, Alejandro / Goikoetxea, Josune / Iruretagoyena, José Ramón / Irurzun Zuazabal, Josu / López-Soria, Leire / Montejo, Miguel / Nieto, Javier / Rodrigo, David / Rodríguez, David / Rodríguez, Regino / Vitoria, Yolanda / Voces, Roberto / García López, Mª Victoria / Georgieva, Radka Ivanova / Ojeda, Guillermo / Rodríguez Bailón, Isabel / Ruiz Morales, Josefa / Cuende, Ana María / Echeverría, Tomás / Fuerte, Ana / Gaminde, Eduardo / Idígoras, Pedro / Iribarren, José Antonio / Izaguirre Yarza, Alberto / Kortajarena Urkola, Xabier / Reviejo, Carlos / Carrasco, Rafael / Climent, Vicente / Llamas, Patricio / Merino, Esperanza / Plazas, Joaquín / Reus, Sergio / Álvarez, Nemesio / Bravo-Ferrer, José María / Castelo, Laura / Cuenca, José / Llinares, Pedro / Miguez Rey, Enrique / Rodríguez Mayo, María / Sánchez, Efrén / Sousa Regueiro, Dolores / Martínez, Francisco Javier / Alonso, Mª Del Mar / Castro, Beatriz / García Rosado, Dácil / Durán, Mª Del Carmen / Miguel Gómez, Mª Antonia / Lacalzada, Juan / Nassar, Ibrahim / Plata Ciezar, Antonio / Reguera Iglesias, José Mª / Asensi Álvarez, Víctor / Costas, Carlos / de la Hera, Jesús / Fernández Suárez, Jonnathan / Iglesias Fraile, Lisardo / León Arguero, Víctor / López Menéndez, José / Mencia Bajo, Pilar / Morales, Carlos / Moreno Torrico, Alfonso / Palomo, Carmen / Paya Martínez, Begoña / Rodríguez Esteban, Ángeles / Rodríguez García, Raquel / Telenti Asensio, Mauricio / Almela, Manuel / Ambrosioni, Juan / Azqueta, Manuel / Brunet, Mercè / Bodro, Marta / Cartañá, Ramón / Falces, Carlos / Fita, Guillermina / Fuster, David / García de la Mària, Cristina / Hernández-Meneses, Marta / Llopis Pérez, Jaume / Marco, Francesc / Miró, José M / Moreno, Asunción / Nicolás, David / Ninot, Salvador / Quintana, Eduardo / Paré, Carlos / Pereda, Daniel / Pericás, Juan M / Pomar, José L / Ramírez, José / Rovira, Irene / Sandoval, Elena / Sitges, Marta / Soy, Dolors / Téllez, Adrián / Tolosana, José M / Vidal, Bárbara / Vila, Jordi / Adán, Iván / Bermejo, Javier / Bouza, Emilio / Celemín, Daniel / Cuerpo Caballero, Gregorio / Delgado Montero, Antonia / Fernández Cruz, Ana / García Mansilla, Ana / García Leoni, Mª Eugenia / Kestler Hernández, Martha / Hualde, Amaia Mari / Marín, Mercedes / Martínez-Sellés, Manuel / Menárguez, Mª Cruz / Rincón, Cristina / Rodríguez-Abella, Hugo / Rodríguez-Créixems, Marta / Pinilla, Blanca / Pinto, Ángel / Valerio, Maricela / Vázquez, Pilar / Verde Moreno, Eduardo / Antorrena, Isabel / Loeches, Belén / Martín Quirós, Alejandro / Moreno, Mar / Ramírez, Ulises / Rial Bastón, Verónica / Romero, María / Saldaña, Araceli / Agüero Balbín, Jesús / Amado, Cristina / Armiñanzas Castillo, Carlos / Arnaiz García, Ana / Cobo Belaustegui, Manuel / Fariñas, María Carmen / Fariñas-Álvarez, Concepción / Gómez Izquierdo, Rubén / García, Iván / González-Rico, Claudia / Gutiérrez-Cuadra, Manuel / Gutiérrez Díez, José / Pajarón, Marcos / Parra, José Antonio / Sarralde, Aurelio / Teira, Ramón / Domínguez, Fernando / García Pavía, Pablo / González, Jesús / Orden, Beatriz / Ramos, Antonio / Centella, Tomasa / Hermida, José Manuel / Moya, José Luis / Martín-Dávila, Pilar / Navas, Enrique / Oliva, Enrique / Del Río, Alejandro / Ruiz, Soledad / Hidalgo Tenorio, Carmen / Almendro Delia, Manuel / Araji, Omar / Barquero, José Miguel / Calvo Jambrina, Román / de Cueto, Marina / Gálvez Acebal, Juan / Méndez, Irene / Morales, Isabel / López-Cortés, Luis Eduardo / de Alarcón, Arístides / García, Emilio / Haro, Juan Luis / Lepe, José Antonio / López, Francisco / Luque, Rafael / Alonso, Luis Javier / Azcárate, Pedro / Azcona Gutiérrez, José Manuel / Blanco, José Ramón / García-Álvarez, Lara / Oteo, José Antonio / Sanz, Mercedes / de Benito, Natividad / Gurguí, Mercé / Pacho, Cristina / Pericas, Roser / Pons, Guillem / Álvarez, M / Fernández, A L / Martínez, Amparo / Prieto, A / Regueiro, Benito / Tijeira, E / Vega, Marino / Canut Blasco, Andrés / Cordo Mollar, José / Gainzarain Arana, Juan Carlos / García Uriarte, Oscar / Martín López, Alejandro / Ortiz de Zárate, Zuriñe / Urturi Matos, José Antonio / García Domínguez, Gloria / Sánchez-Porto, Antonio / Arribas Leal, José Mª / García Vázquez, Elisa / Hernández Torres, Alicia / Blázquez, Ana / de la Morena Valenzuela, Gonzalo / Alonso, Ángel / Aramburu, Javier / Calvo, Felicitas Elena / Moreno Rodríguez, Anai / Tarabini-Castellani, Paola / Heredero Gálvez, Eva / Maicas Bellido, Carolina / Largo Pau, José / Sepúlveda, Mª Antonia / Toledano Sierra, Pilar / Iqbal-Mirza, Sadaf Zafar / Cascales Alcolea, Eva / Egea Serrano, Pilar / Hernández Roca, José Joaquín / Keituqwa Yañez, Ivan / Peláez Ballesta, Ana / Soriano, Víctor / Moreno Escobar, Eduardo / Peña Monje, Alejandro / Sánchez Cabrera, Valme / Vinuesa García, David / Arrizabalaga Asenjo, María / Cifuentes Luna, Carmen / Núñez Morcillo, Juana / Pérez Seco, Mª Cruz / Villoslada Gelabert, Aroa / Aured Guallar, Carmen / Fernández Abad, Nuria / García Mangas, Pilar / Matamala Adell, Marta / Palacián Ruiz, Mª Pilar / Porres, Juan Carlos / Alcaraz Vidal, Begoña / Cobos Trigueros, Nazaret / Del Amor Espín, María Jesús / Giner Caro, José Antonio / Jiménez Sánchez, Roberto / Jimeno Almazán, Amaya / Ortín Freire, Alejandro / Viqueira González, Monserrat / Pericás Ramis, Pere / Ribas Blanco, Mª Ángels / Ruiz de Gopegui Bordes, Enrique / Vidal Bonet, Laura / Bellón Munera, Mª Carmen / Escribano Garaizabal, Elena / Tercero Martínez, Antonia / Segura Luque, Juan Carlos

    European journal of internal medicine

    2019  Volume 64, Page(s) 63–71

    Abstract: Purpose: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality.: Methods: Prospective cohort study of all ... ...

    Abstract Purpose: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality.
    Methods: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk.
    Results: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32-3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39-1.88),and non-performed surgery (HR:1.64;95% CI:11.16-1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality.
    Conclusion: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group.
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; Area Under Curve ; Comorbidity ; Databases, Factual ; Endocarditis/etiology ; Endocarditis/mortality ; Female ; Heart Failure/mortality ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; Prospective Studies ; ROC Curve ; Risk Factors ; Spain/epidemiology ; Staphylococcal Infections/mortality
    Language English
    Publishing date 2019-03-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
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    ISSN 0953-6205
    DOI 10.1016/j.ejim.2019.03.006
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  7. Article ; Online: Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state

    Rodríguez-Baño, Jesús / Pachón, Jerónimo / Carratalà, Jordi / Ryan, Pablo / Jarrín, Inmaculada / Yllescas, María / Arribas, José Ramón / Berenguer, Juan / Aznar Muñoz, Esther / Gil Divasson, Pedro / González Muñiz, Patricia / Muñoz Aguirre, Clara / Díaz Menéndez, Marta / de la Calle Prieto, Fernando / Arsuaga Vicente, Marta / Trigo Esteban, Elena / Pérez Valero, Ignacio / de Miguel Buckley, Rosa / Cadiñaños Loidi, Julen /
    Diaz Pollan, Beatriz / Martín Carbonero, Luz / Ramos Ramos, Juan Carlos / Loeches Yagüe, Belén / Montejano Sánchez, Rocío / González García, Juan / García Rodríguez, Julio / Ramírez, Margarita / Gutiérrez, Isabel / Tejerina, Francisco / Aldámiz-Echevarría, Teresa / Díez, Cristina / Fanciulli, Chiara / Pérez-Latorre, Leire / Pinilla, Blanca / López, Juan Carlos / Such Diaz, Ana / Álvaro Alonso, Elena / Torres Macho, Juan / Cuevas Tascon, Guillermo / Jiménez González de Buitrago, Eva / Brañas Baztán, Fátima / Valencia de la Rosa, Jorge / Pérez Butragueño, Mario / Fernández Jiménez, Inés / Muñiz Nicolás, Gemma / Sepúlveda Berrocal, Antonia / Gato Díez, Alberto / Toledano Sierra, María Pilar / García Butenegro, María Paz / Peláez Ballesta, Ana Isabel / Morcillo Rodríguez, Elena / Fernández Romero, Isidoro / Peláez Ballesta, Cristina / Guirado Torrecillas, María Isabel / Goikoetxea Agirre, Josune / Bereciartua Bastarrica, Elena / Guio Carrión, Laura / Rodríguez Álvarez, Regino / Ibarrola Hierro, Marta / Pérez Hernández, Isabel A. / Pérez Zapata, Inés / Román Soto, Sergio / Kallouchi, Mohamed / Domínguez Vicent, Juan Ramón / Silvariño Fernández, Rafae / Ugalde Espiñeira, Jon / Sanjuan López, Ainhoa / García Martínez, Silvia / Temprano Gogenola, Mikel / Asensi, Víctor / Suárez, Silvia / Suárez, Lucia / Yllera, Carmen / Rivas-Carmenado, María / Romero-Palacios, Alberto / Ruiz Aragón, Jesús / Jiménez Aguilar, Patricia / Fernández Ávila, Ma Luisa / Castilla Ortiz, Rosario / Alende Castro, Vanesa / Pérez García, Cristina / Fernández Morales, Marta / Valle Feijoo Begoña Rodríguez Ferreira, María Lorena María / Gómez-Junyent, Joan / Villar-García, Judit / López-Montesinos, Inmaculada / Arrieta-Aldea, Itziar / Rial-Villavecchia, Abora / García Vázquez, Elisa / Roura Piloto, Aychel Elena / Moral Escudero, Encarnación / Hernández Torres, Alicia / Albendín Iglesias, Helena / Vinuesa García, David / Martínez Montes, Clara / De la Hera Fernández, Francisco Javier / Anguita Santos, Francisco / Ruiz Sancho, Andrés / Díaz de Brito Fernández, Vicens / Sanmarti Vilamala, Montserrat / España Cueto, Sergio / Molina Morant, Daniel / González-Cuevas, Araceli / Chara Cervantes, Joel Elías / Policarpo Torres, Guillem / Ortega Montoliu, Meritxell / Angerri Nadal, Mònica / De Genover Gil, Ariadna / Patera, Eleni / Godoy Lorenzo, Rita / Zioga, Evangelia Anna María / Isern Fernández, Virginia / Sabbagh Fajardo, Carlos Enrique / Ferrer Ribera, Ana / Bea Serrano, Carlos / Oltra Sempere, Rosa / Vela Bernal, Sara / Albiol Viñals, Paloma / Pedromingo Kus, Miguel / Garcinuño, María Ángeles / Fiorante, Silvana / Pérez Pinto, Sergio / de la Vega, Alexandra / Fariñas Álvarez, María Carmen / González Rico, Claudia / Arnaiz de las Revillas, Francisco / Giménez, Teresa / Calvo, Jorge / Meije Castillo, Yolanda / Duarte Borges, Alejandra / Pareja Coca, Júlia / Clemente Presas, Mercedes / Sanz Salvador, Xavier / Pérez Rodríguez, Ma Teresa / Sousa, Adrián / Pérez González, Alexandre / Longueira, Rebeca / Araujo, Alejandro / Alonso Martínez, Blanca / García Escudero, Laura / Lidia Kamel Rey, Sara / Roa Alonso, David / Avilés Parra, Juan Pablo / Pelegrín Senent, Iván / Rouco Esteves Marques, Rosana / Raich Montiu, Laia / Souto Higueras, Jessica / Gálvez Bobadilla, Manuel Alejandro / Parra Ruiz, Jorge / Ramos Sesma, Violeta / Velasco Fuentes, Sara / García Pereña, Laura / Lluna Carrascosa, Alfonso / Gilaberte Reyzábal, Sergio / Liébana Gómez, Mónica / Salillas Hernando, Juan / Serrano Martínez, Alberto / Torralba González de Suso, Miguel / Martínez Martín, Patricia / Rábago Lorite, Isabel / González-Ruano Pérez, Patricia / Pérez-Monte Mínguez, Beatriz / García Flores, Ángeles / Comas Casanova, Pere / Martín Plata, Andrea / Santana Báez, Sergio Manuel / Sanz Peláez, Oscar / Mohamed Ramírez, Karim / Robaina Bordón, José María / Vílchez Rueda, Helem Haydeé / Riera Jaume, Melchor / Mut Ramon, Gemma / Gavalda Manso, Meritxell / Planas Bibiloni, Lluis / Castelo Corral, Laura / Ramos Merino, Lucía / Sánchez Vidal, Efrén / Rodríguez Mayo, María / Míguez Rey, Enrique / García de Lomas Guerrero, José M. / De la Torre Lima, Javier / Correa Ruiz, Ana / Fernández Sánchez, Fernando / Jiménez-García, Nicolás / Sierra-Monzón, José Luis / Gracia-Tello, Borja / Hernández-Bonaga, María / Pellejero, Galadriel / Asín-Corrochano, Marta / Boix Palop, Lucia / Calbo, Esther / Badía, Cristina / Dietl, Beatriz / Lucía, Gómez / Domínguez-Castellano, Ángel / Ríos-Villegas, María José / del Toro, María D. / Palacios Baena, Zaira R. / Salamanca-Rivera, Elena / Marín, Elena / Almadana, Virginia / Pérez-Galera, Salvador / González-Iglesias, Luisa / Abelenda-Alonso, Gabriela / Álvarez-Pouso, Claudia / Escrihuela, Francesc / Gudiol, Carlota / Lorenzo-Esteller, Laia / Niubó, Jordi / Podzamczer, Daniel / Pujol, Miquel / Rombauts, Alexander / Salvert Lletí, Miguel / Gil Sánchez, Ricardo / Jiménez Escrig, Marta / Parra Gómez, Laura / Tasias Pitarch, Mariona / Navarro Vilasaró, Marta / Machado Sicilia, María Luisa / Gomila Grange, Aina / Calzado Isbert, Sonia / Carrasco Antón, Nerea / Petkova-Saiz, Elizabet / Cabello Úbeda, Alfonso / Górgolas Hernández-Mora, Miguel / Sánchez-Pernaute, Olga / Dueñas Gutiérrez, Carlos / Martin Guerra, Javier / Castrodeza Sanz, José Javier / Fernández Espinilla, Virginia / Rodríguez Fernández, Laura / González-Moreno, Juan / Villoslada Gelabert, Aroa / Ribot Sanso, María Antonia / Fernández-Baca, María Victoria / Hernández Milian, Almudena / Morán Rodríguez, Miguel Ángel / Ortiz de Zárate Ibarra, Zuriñe / Portu Zapirain, José Joaquin / Saez de Adana Arroniz, Ester / Gainzarain Arana, Juan Carlos / Meca Birlanga, Olga / del Amor Espín, Ma Jesús / Viqueira González, Montserrat / García García, Josefina / Martínez Madrid, Onofre / Bernal Morell, Enrique / Alcaraz, Antonia / Muñoz, Ángeles / Pina, Ignacio / de la Rosa, Vicente / Caínzos Romero, Tamara / Sánchez Trigo, Sabela / Mariño Callejo, Ana Isabel / Álvarez Díaz, Hortensia / Valcarce Pardeiro, Nieves / Sánchez Serrano, Adriana / Piñar Cabezos, Diana / García Villalba, Eva Pilar / Aguayo Jiménez, Carmen / Ruíz Campuzano, María / Naranjo Velasco, Virginia / Santos Peña, Marta / Mora Delgado, Juan / Sevilla Moreno, Israel / Lojo Cruz, Cristina / Kortajarena Urkola, Xabier / Iribarren Loyarte, José Antonio / Bustinduy Odriozola, María Jesús / Ibarguren Pinilla, Maialen / Álvarez Rodríguez, Ignacio / Martínez Marcos, Francisco Javier / Rodríguez Gómez, Francisco Javier / Asschert Agüero, Isabel / Muñoz Beamud, Francisco / Ruiz Reina, Antonio José / Llenas-García, Jara / González-Cuello, Inmaculada / Hellín-Valiente, Elena / Martínez Birlanga, Esther / Tafalla Torres, José Manuel / Calderón Parra, Jorge / Escudero López, Gabriela / Gutiérrez Martín, Isabel / Andrés Eisenhofer, Ane / García Prieto, Sonia / Álvarez Franco, Raquel / Roger Zapata, Daniel / Martínez Cifre, Blanca / Aranda Rife, Elena / Martín Rubio, Irene / Barbosa Ventura, André / Garrido, Javier / Gonzalo, Concepción / Piñero, Iván / de la Cruz Felipe, Nieves / Talavera García, Eva / Lamata Subero, Marta / Mendoza Roy, Paula / García de Carlos, María Soledad / Lajusticia Aisa, Justo / Arteche Eguizabal, Lorea / Urrutia Losada, Ainhoa / Domingo Echaburu, Saioa / Cuadros Tito, Pedro Ángel / Orbe Narváez, Gurutz / Liébana Martos, Ma del Carmen / Roldán Fontana, Carolina / Herrero Rodríguez, Carmen / Duro Ruiz, Gaspar / Pérez Parra, Santiago / Mera Fidalgo, Arantzazu / Hortos Alsina, Miquel / Alberich Conesa, Ana / Bladé Vidal, Lourdes / Merchante Gutiérrez, Nicolás / León Jiménez, Eva / Espíndola Gómez, Reinaldo / Erostarbe Gallardo, María / Martínez Pérez-Crespo, Pedro / Cisneros, José Miguel / Aguilar-Guisado, Manuela / Aldabó, Teresa / Bueno, Claudio / Cordero-Matía, Elisa / Escoresca, Ana / Infante, Carmen / Guillermo, Martín / Salto, Sonsoles / Gioia, Francesca / Vizcarra, Pilar / Fortún Abete, Jesús / Martín Dávila, Pilar / Moreno Guillén, Santiago / Oteo Revuelta, José A. / García-García, Concepción / Santibañez Sáenz, Paula / Cervera Acedo, Cristina / Azcona Gutiérrez, José M. / Reguera Iglesias, José María / Plata Ciezar, Antonio / Valiente de Santis, Lucia / Sobrino Diaz, Beatriz / Ruiz Mesa, Juan Diego

    Clinical Microbiology and Infection ; ISSN 1198-743X

    a multicentre cohort study (SAM-COVID-19)

    2020  

    Keywords Microbiology (medical) ; Infectious Diseases ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.cmi.2020.08.010
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Characteristics and predictors of death among 4035 consecutively hospitalized patients with COVID-19 in Spain

    Berenguer, Juan / Ryan, Pablo / Rodríguez-Baño, Jesús / Jarrín, Inmaculada / Carratalà, Jordi / Pachón, Jerónimo / Yllescas, María / Arriba, José Ramón / Aznar Muñoz, Esther / Gil Divasson, Pedro / González Muñiz, Patricia / Muñoz Aguirre, Clara / López, Juan Carlos / Ramírez-Schacke, Margarita / Gutiérrez, Isabel / Tejerina, Francisco / Aldámiz-Echevarría, Teresa / Díez, Cristina / Fanciulli, Chiara /
    Pérez-Latorre, Leire / Parras, Francisco / Catalán, Pilar / García-Leoni, María E. / Pérez-Tamayo, Isabel / Puente, Luis / Cedeño, Jamil / Díaz Menéndez, Marta / de la Calle Prieto, Fernando / Arsuaga Vicente, Marta / Trigo Esteban, Elena / Lago Núñez, Mª del Mar / de Miguel Buckley, Rosa / Cadiñaños Loidi, Julen / Busca Arenzana, Carmen / Mican, Alfredo / Mora Rillo, Marta / Ramos Ramos, Juan Carlos / Loeches Yagüe, Belén / Bernardino de la Serna, José Ignacio / García Rodríguez, Julio / Arribas López, José Ramón / Such Diaz, Ana / Álvaro Alonso, Elena / Izquierdo García, Elsa / Torres Macho, Juan / Cuevas Tascon, Guillermo / Troya García, Jesús / Mestre Gómez, Beatriz / Jiménez González de Buitrago, Eva / Fernández Jiménez, Inés / Tebar Martínez, Ana Josefa / Brañas Baztán, Fátima / Valencia de la Rosa, Jorge / Pérez Butragueño, Mario / Alvarado Blasco, Marta / Sepúlveda Berrocal, Mª Antonia / Yera Bergua, Carmen / Toledano Sierra, Pilar / Cano Llorente, Verónica / Zafar Iqubal-Mirza, Sadaf / Muñiz, Gema / Martín Pérez, Inmaculada / Mozas Moriñigo, Helena / Alguacil, Ana / García Butenegro, María Paz / Peláez Ballesta, Ana Isabel / Morcillo Rodríguez, Elena / Goikoetxea Agirre, Josune / Blanco Vidal, María José / Nieto Arana, Javier / del Álamo Martínez de Lagos, Mikel / Pérez Hernández, Isabel A. / Pérez Zapata, Inés / Silvariño Fernández, Rafael / Ugalde Espiñeira, Jon / Asensi Álvarez, Víctor / Suárez Pérez, Lucia / Suárez Diaz, Silvia / Yllera Gutiérrez, Carmen / Boix, Vicente / Díez Martínez, Marcos / Carreres Candela, Melissa / Gómez-Ayerbe, Cristina / Sánchez-Lora, Javier / Velasco Garrido, José Luis / López-Jódar, María / Santos González, Jesús / Ruiz Aragón, Jesús / Virto Peña, Ianire / Alende Castro, Vanessa / Brea Aparicio, Ruth / Vega Molpeceres, Sonia / Pons Viñas, Estel / del Río Pérez, Oscar / Valero Rovira, Silvia / Villar-García, Judit / Gómez-Junyent, Joan / Knobel, Hernando / Cánepa, María Cecilia / Castañeda Espinosa, Silvia / Sorli Redò, Luisa / Güerri-Fernández, Roberto / Milagro Montero, María / Horcajada, Juan Pablo / García Vázquez, Elisa / Moral Escudero, Encarnación / Hernández Torres, Alicia / García Almodóvar, Esther / Sáez Barberá, Carmen / Karroud, Zineb / Hernández Quero, José / Vinuesa García, David / García Fogeda, José Luis / Peregrina, José Antonio / Novella Mena, María / Hernández Gutiérrez, Cristina / Sanz Moreno, José / Pérez Tanoira, Ramón / Sierra Rodríguez, Rodrigo / Alonso Menchén, David / Gutiérrez García, Aida / Arranz Caso, Alberto / Cuadros González, Juan / Álvarez de Mon Soto, Melchor / Díaz de Brito Fernández, Vicente Ferrer / Sanmarti Vilamala, Montserrat / Gabarrell Pascuet, Aina / Molina Morant, Daniel / España Cueto, Sergio / Cámara Fernández, Jonathan / Sabater Gil, Albert / Muñoz López, Laura / Sáez Escolano, Paula / Bejarano Tello, Esperanza / Sempere Alcocer, Marco Antonio / Álvarez Martin, Salvador / De los Santos Gil, Ignacio / García-Fraile, Lucio / Sampedro Núñez, Miguel / Barrios Blandino, Ana / Rodríguez Franco, Carlos / Useros Brañas, Daniel / Villa Martí, Almudena / Oliver Ortega, Javier / Costanza Espiño Álvarez, Alexia / Sanz Sanz, Jesús / Rexach Fumaña, María / Abascal Cambras, Ivette / Pérez Jaén, Ana del Cielo / Sala Jofre, Clara / Casas Rodríguez, Susana / Tortajada Alamilla, Cecilia / Oltra, Carmina / Masiá Canuto, Mar / Gutiérrez Rodero, Félix / Ferrer Ribera, Ana / Bea Serrano, Carlos / Pedromingo Kus, Miguel / Garcinuño, María Ángeles / Fiorante, Silvana / Pérez Pinto, Sergio / Hernández Machín, Pilar / Alastrué Violeta, Alba / Fariñas Álvarez, María Carmen / González Rico, Claudia / Arnaiz de las Revillas, Francisco / Calvo, Jorge / Gozalo, Mónica / Mora Gómez, Francisco / Milagro Beamonte, Ana / Latorre-Millán, Miriam / Rezusta López, Antonio / Martínez Sapiña, Ana / Meije, Yolanda / Duarte Borges, Alejandra / Pareja Coca, Julia / Clemente Presas, Mercedes / Losa García, Juan Emilio / Vegas Serrano, Ana / Pérez-Rodríguez, M. Teresa / Pérez González, Alexandre / Belhassen-García, Moncef / Rodríguez-Alonso, Beatriz / López-Bernus, Amparo / Carbonell, Cristina / Torres Perea, Rafael / Cantón de Seoane, Juan / Alonso, Blanca / Kamal, Sara Lidia / Cajuela, Lucia / Roa, David / Cervero, Miguel / Oreja, Alberto / Avilés, Juan Pablo / Martín, Lidia / Pelegrín Senent, Iván / Rouco Esteves Marques, Rosana / Parra Ruiz, Jorge / Ramos Sesma, Violeta / Abadia Otero, Jessica / Salillas Hernando, Juan / Torres Sánchez del Arco, Robert / Torralba González de Suso, Miguel / Serrano Martínez, Alberto / Gilaberte Reyzábal, Sergio / Pacheco Martínez-Atienza, Marina / Liébana Gómez, Mónica / Fernández Rodríguez, Sara / Varela Plaza, Álvaro / Calvo Sánchez, Henar / Martínez Martín, Patricia / González- Ruano, Patricia / Malmierca Corral, Eduardo / Rábago Lorite, Isabel / Pérez-Monte Mínguez, Beatriz / García Flores, Ángeles / Comas Casanova, Pere / Sirisi, Merce / Rojas, Richard / Díaz de Tuesta del Arco, José Luis / Figueroa Cerón, Ruth / González Sarria, Ander / Alemán Valls, Remedios / Alonso Socas, María del Mar / Sanz Peláez, Oscar / Mohamed Ramírez, Karim / Riera Jaume, Melchor / Vilchez, Helem Haydee / Albertí, Francesc / Cañabate, Ana Isabel / Moreno Cuerda, Víctor J. / Álvarez Kaelis, Silvia / Álvarez Zapatero, Beatriz / García García, Alejandro / Isaba Ares, Elena / Morcate Fernández, Covadonga / Pérez Rodríguez, Andrea / Ramos Merino, Lucía / Castelo Corral, Laura / Rodríguez Mahía, María / González Bardanca, Mónica / Sánchez Vidal, Efrén / Míguez Rey, Enrique / De la Torre Lima, Javier / García de Lomas Guerrero, José Mª / Morte, Elena / Loscos, Silvia / Camón, Ana / Gómez García, Lucía / Boix Palop, Lucia / Dietl Gómez-Luengo, Beatriz / Pedrola Gorrea, Iris / Blasco Claramunt, Amparo / López Mestanza, Cristina / Fraile Villarejo, Esther / Tosco Núñez, Tomás / Aroca Ferri, María / Algado Rabasa, José Tomas / Garijo Saiz, Ana María / Amador Prous, Concepción / Baño, Jesús Rodriguez / Retamar, Pilar / Valiente, Adoración / López-Cortés, Luis E. / Sojo, Jesús / Gutiérrez-Gutiérrez, Belén / Bravo-Ferrer, José / Salamanca, Elena / Palacios, Zaira R. / Pérez-Palacios, Patricia / Peral, Enrique / Pérez de León, José Antonio / Sánchez-Gómez, Jesús / Marín-Barrera, Lucía / García-Jiménez, Domingo / Abelenda-Alonso, Gabriela / Ardanuy, Carmen / Bergas, Alba / Cuervo, Guillermo / Domínguez, María Ángeles / Fernández-Huerta, Miguel / Gudiol, Carlota / Lorenzo-Esteller, Laia / Niubó, Jordi / Pérez-Recio, Sandra / Podzamczer, Daniel / Pujol, Miquel / Rombauts, Alexander / Trullen, Núria / Salavert Lletí, Miguel / Castro Hernández, Iván / Hernández Belmonte, Adriana / Martínez Goñi, Raquel / Navarro Vilasaró, Marta / Calzado Isbert, Sonia / Cervantes García, Manuel / Gomila Grange, Aina / Gasch Blasi, Oriol / Machado Sicilia, María Luisa / Van den Eynde Otero, Eva / Falgueras López, Luis / Navarro Sáez, María del Carmen / Martínez, Esteban / Marcos, Mª Ángeles / Mosquera, Mar / Blanco, José Luis / Laguno, Montserrat / Rojas, Jhon / González-Cordón, Ana / Inciarte, Alexy / Torres, Berta / De la Mora, Lorena / Soriano, Alex / Martínez Macias, Olalla / Pérez Doñate, Virginia / Cabello Úbeda, Alfonso / Carrasco Antón, Nerea / Álvarez Álvarez, Beatriz / Petkova Saiz, Elizabet / Górgolas Hernández-Mora, Miguel / Prieto Pérez, Laura / Carrillo Acosta, Irene / Heili Frades, Sara / Villar Álvarez, Felipe / Fernández Roblas, Ricardo / Milicua Muñoz, José María / Fernández Espinilla, Virginia / Dueñas Gutiérrez, Carlos Jesús / Hernán García, Cristina / González-Romo, Fernando / Merino Amador, Paloma / Rueda López, Alba / Martínez Jordán, Jorge / Medrano Pardo, Sara / Díaz de la Torre, Irene / Posada Franco, Yolanda / Delgado-Iribarren, Alberto / López-Contreras González, Joaquín / Pascual Alonso, Pablo / Pomar Solchaga, Virginia / Rabella García, Nuria / Benito Hernández, Natividad / Domingo Pedrol, Pere / Bonfill Cosp, Xavier / Padrós Selma, Rafael / Puig Campmany, Mireia / Mancebo Cortés, Jordi / Gurguí Ferrer, Mercè / Íñigo Pestaña, Melania / Pérez García, Alejandra / Sorní Moreno, Patricia / Izko Gartzia, Nora / Membrillo de Novales, Francisco Javier / Simón Sacristán, María / Zamora Cintas, Maribel / Martínez Martínez, Yolanda / Fernández-González, Pablo / Alcántara Nicolás, Francisco / Aguirre Vila-Cora, Alejandro / López Tizón, Elena / Ramírez-Olivencia, Germán / Estébanez Muñoz, Miriam / Sáez de Adana Arróniz, Ester / Portu Zapirain, Joseba / Gainzarain Arana, Juan Carlos / Ortiz de Zárate Ibarra, Zuriñe / Moran Rodríguez, Miguel Ángel / Canut Blasco, Andrés / Hernáez Crespo, Silvia / Balerdi Sarasola, Leire / Morales García, Cristina / Corral Saracho, Miguel / Valcarce González, Zeltia / Arenal Andrés, Noelia / Rodríguez Tarazona, Raquel Elisa / Iglesias Llorente, Laura / Loureiro Rodríguez, Beatriz / Sánchez Montalvá, Adrián / Espinosa Pereiro, Juan / Almirante, Benito / Miarons, Marta / Sellarés, Júlia / Larrosa, María / García, Sonia / Marzo, Blanca / Villamarín, Miguel / Fernández, Nuria / Pérez-Jorge Peremarch, Conchita / Resino Foz, Elena / Espigares Correa, Andrea / Álvarez de Espejo Montiel, Teresa / Navas Clemente, Iván / Quijano Contreras, María Isabel / Nieto Fernández del Campo, Luis Alberto / Jiménez Álvarez, Guillermo / Guillamón Sánchez, Mercedes / García García, Josefina / Muñoz Hornero, Constanza / Mariño Callejo, Ana / Valcarce Pardeiro, Nieves / Smithson Amat, Alex / Chico Chumillas, Cristina / Sánchez Serrano, Adriana / García Villalba, Eva Pilar / Jiménez Martínez, Isabel / Estrada Fernández, Guillermo / Lorén Vargas, María / Parra Arribas, Nuria / Martínez Cilleros, Carmen / Villasante de la Puente, Aránzazu / García Delange, Teresa / Ruiz Rodríguez, María José / Robledo del Prado, Marta / Abad Almendro, Juan Carlos / Muñoz del Rey, José Román / Jiménez Álvaro, Montaña / Coy Coy, Javier / Poquet Catala, Inmaculada / Santos Peña, Marta / Naranjo Velasco, Virginia / Manso Gómez, Tamara / Quilez Ágreda, Delia / Barbeito Castiñeiras, Gema / Domínguez Santalla, María Jesús / Mao Martín, Laura / Alonso Navarro, Rodrigo / Ampuero Martinich, Jose David / Barrós González, Raquel / Galindo Martín, María Aránzazu / Herrera Pacheco, Lourdes / Martínez Avilés, Rocío / Rodrigo González, Sara / Rodríguez Leal, Cristóbal Manuel / Romay Lema, Eva María / Suárez Gil, Roi / Ibarguren Pinilla, Maialen / Marimón Ortiz de Zárate, José María / Vidaur Tello, Loreto / Kortajarena Urkola, Xabier / García Gómez, Miriam / Aranguren Arostegui, Asier / Álvarez de Castro, Maria / Martínez Mateu, Cintia María / Rodríguez Gómez, Francisco / Muñoz Beamud, Francisco / Chamarro Martí, Elena / Cardona Rivera, Merce / Zakariya-Yousef Breval, Ismail / Rico Rodríguez, Marta / Llenas García, Jara / Sánchez Arenas, Mª Carmen / Fernández Cruz, Ana / Calderón Parra, Jorge / López Dosil, Marcos / Ramos Martínez, Antonio / Múñez Rubio, Elena / Callejas Díaz, Alejandro / Vázquez Comendador, José Manuel / Diego Yagüe, Itziar / 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    Clinical Microbiology and Infection

    2020  Volume 26, Issue 11, Page(s) 1525–1536

    Keywords Microbiology (medical) ; Infectious Diseases ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2020.07.024
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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