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  1. Article ; Online: Pharmacogenetics in Psychiatry.

    Müller, Daniel J

    Pharmacopsychiatry

    2020  Volume 53, Issue 4, Page(s) 153–154

    Abstract: This Special Issue on Pharmacogenetics in Psychiatry consists of five selected articles which encompass the first concepts of pharmacogenetics, to implementation strategies applyng pharmacogenetic testing into psychiatric clinical practice. ...

    Abstract This Special Issue on Pharmacogenetics in Psychiatry consists of five selected articles which encompass the first concepts of pharmacogenetics, to implementation strategies applyng pharmacogenetic testing into psychiatric clinical practice.
    MeSH term(s) Humans ; Mental Disorders/genetics ; Pharmacogenetics/trends ; Psychiatry/trends
    Language English
    Publishing date 2020-07-27
    Publishing country Germany
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 605670-2
    ISSN 1439-0795 ; 0720-4280 ; 0176-3679
    ISSN (online) 1439-0795
    ISSN 0720-4280 ; 0176-3679
    DOI 10.1055/a-1212-1101
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  2. Article ; Online: Prevalence of Psychotropic Medication Use and Psychotropic Polypharmacy in Autistic Adults With or Without Intellectual Disability.

    Yoshida, Kazunari / Lunsky, Yona / Müller, Daniel J / Desarkar, Pushpal

    Journal of autism and developmental disorders

    2024  

    Abstract: The aim of this study was to compare the rates of psychotropic medication use and psychotropic polypharmacy between autistic adults with and without intellectual disability (ID) and to examine factors associated with psychotropic medication use and ... ...

    Abstract The aim of this study was to compare the rates of psychotropic medication use and psychotropic polypharmacy between autistic adults with and without intellectual disability (ID) and to examine factors associated with psychotropic medication use and psychotropic polypharmacy in autistic adults, stratified by the presence of ID. We conducted a retrospective medical chart review of outpatients with an autism diagnosis aged 18 years and older. The rates of psychotropic medication use and psychotropic polypharmacy were compared between autistic adults with and without ID. Subsequently, logistic regression analyses were performed to identify factors associated with psychotropic medication use and psychotropic polypharmacy in autistic adults with ID and those without ID, respectively. The rates of prevalence of psychotropic medication use and polypharmacy were significantly higher in participants with ID than those without ID (78.6% vs. 58.8% and 49.3% vs. 31.2%; p-values < 0.05). Age, gender, race, residence, presence of mood disorders, presence of schizophrenia, absence of anxiety disorder, number of psychiatric comorbidities, and presence of behaviors that challenge were significantly associated with these outcomes, depending on the presence/absence of ID. The need to optimize pharmacotherapy in autistic adults, stratifying by the presence of ID, is highlighted.
    Language English
    Publishing date 2024-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-023-06208-y
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  3. Article: Psychiatric manifestations of Kleefstra syndrome: a case report.

    Yoshida, Kazunari / Müller, Daniel J / Desarkar, Pushpal

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1174195

    Abstract: Background: Kleefstra syndrome is a rare genetic condition, which affects at least 1 in 120,000 individuals who have a neurodevelopmental disorder, characterized by the core clinical phenotype of intellectual disability, hypotonia, severe speech delay, ... ...

    Abstract Background: Kleefstra syndrome is a rare genetic condition, which affects at least 1 in 120,000 individuals who have a neurodevelopmental disorder, characterized by the core clinical phenotype of intellectual disability, hypotonia, severe speech delay, and distinct facial characteristics with additional clinical features including sleep disturbance, overweight, psychiatric disorders, and autism spectrum disorder. To date, a limited number of case reports of Kleefstra syndrome with psychiatric manifestations have been reported.
    Case presentation: We reported a case of a 35-year-old male diagnosed with Kleefstra syndrome, who also had diagnoses of autism spectrum disorder and moderate to severe intellectual disability. He exhibited various psychiatric manifestations, including temporarily manic-like symptoms, excessive eating/overweight, addictive/gambling behaviors, inappropriate and unsafe internet use, sleep disturbance, rigid routines, and behaviors that challenged in the form of meltdowns. These symptoms were eventually relatively successfully managed with a combination of non-pharmacological and pharmacological treatments.
    Conclusion: To our knowledge, there is only a limited number of case reports that detail patients with Kleefstra syndrome exhibiting various psychiatric manifestations. Our report adds further knowledge to the paucity of literature and highlights the effectiveness of a combination of non-pharmacological and pharmacological treatments for behavioral/psychiatric difficulties in Kleefstra syndrome.
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1174195
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  4. Article ; Online: Klinische Anwendungsbeispiele einer Next-Generation-Sequencing-basierten Multi-Genpanel-Analyse.

    Enko, Dietmar / Schaflinger, Erich / Müller, Daniel J

    Deutsche medizinische Wochenschrift (1946)

    2023  Volume 148, Issue 11, Page(s) 695–702

    Abstract: This review provides an overview of clinically useful applications of a next-generation sequencing (NGS)-based multi-gene panel testing strategy in the areas of oncology, hereditary tumor syndromes, and hematology. In the case of solid tumors (e.g. lung ... ...

    Title translation Clinical Application Examples of a Next-Generation Sequencing based Multi-Genepanel Analysis.
    Abstract This review provides an overview of clinically useful applications of a next-generation sequencing (NGS)-based multi-gene panel testing strategy in the areas of oncology, hereditary tumor syndromes, and hematology. In the case of solid tumors (e.g. lung carcinoma, colon-rectal carcinoma), the detection of somatic mutations contributes not only to a better diagnostic but also therapeutic stratification of those affected. The increasing genetic complexity of hereditary tumor syndromes (e.g. breast and ovarian carcinoma, lynch syndrome/polyposis) requires a multi-gene panel analysis of germline mutations in affected families. Another useful indication for a multi-gene panel diagnostics and prognosis assessment are acute and chronic myeloid diseases. The criteria of the WHO-classification and the European LeukemiaNet-prognosis system for acute myeloid leukemia can only be met by a multi-gene panel test strategy.
    MeSH term(s) Humans ; Genetic Predisposition to Disease ; Genetic Testing ; Germ-Line Mutation/genetics ; Carcinoma/genetics ; High-Throughput Nucleotide Sequencing ; Mutation/genetics
    Language German
    Publishing date 2023-05-22
    Publishing country Germany
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-2033-5329
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  5. Article: Pharmacogenetics in Psychiatry

    Müller, Daniel J.

    Pharmacopsychiatry

    (Special Issue: Pharmacogenetics in Psychiatry)

    2020  Volume 53, Issue 04, Page(s) 153–154

    Abstract: This Special Issue on Pharmacogenetics in Psychiatry consists of five selected articles which encompass the first concepts of pharmacogenetics, to implementation strategies applyng pharmacogenetic testing into ... ...

    Series title Special Issue: Pharmacogenetics in Psychiatry
    Abstract This Special Issue on Pharmacogenetics in Psychiatry consists of five selected articles which encompass the first concepts of pharmacogenetics, to implementation strategies applyng pharmacogenetic testing into psychiatric clinical practice.
    Language English
    Publishing date 2020-07-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605670-2
    ISSN 1439-0795 ; 0176-3679 ; 0720-4280
    ISSN (online) 1439-0795
    ISSN 0176-3679 ; 0720-4280
    DOI 10.1055/a-1212-1101
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  6. Article ; Online: Light Color-Controlled pH-Adjustment of Aqueous Solutions Using Engineered Proteoliposomes.

    Harder, Daniel / Ritzmann, Noah / Ucurum, Zöhre / Müller, Daniel J / Fotiadis, Dimitrios

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  Volume 11, Issue 15, Page(s) e2307524

    Abstract: Controlling the pH at the microliter scale can be useful for applications in research, medicine, and industry, and therefore represents a valuable application for synthetic biology and microfluidics. The presented vesicular system translates light of ... ...

    Abstract Controlling the pH at the microliter scale can be useful for applications in research, medicine, and industry, and therefore represents a valuable application for synthetic biology and microfluidics. The presented vesicular system translates light of different colors into specific pH changes in the surrounding solution. It works with the two light-driven proton pumps bacteriorhodopsin and blue light-absorbing proteorhodopsin Med12, that are oriented in opposite directions in the lipid membrane. A computer-controlled measuring device implements a feedback loop for automatic adjustment and maintenance of a selected pH value. A pH range spanning more than two units can be established, providing fine temporal and pH resolution. As an application example, a pH-sensitive enzyme reaction is presented where the light color controls the reaction progress. In summary, light color-controlled pH-adjustment using engineered proteoliposomes opens new possibilities to control processes at the microliter scale in different contexts, such as in synthetic biology applications.
    MeSH term(s) Hydrogen-Ion Concentration ; Bacteriorhodopsins ; Proteolipids
    Chemical Substances proteoliposomes ; Bacteriorhodopsins (53026-44-1) ; Proteolipids
    Language English
    Publishing date 2024-02-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202307524
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  7. Article ; Online: Frequencies of

    Scherf-Clavel, Maike / Weber, Heike / Unterecker, Stefan / Müller, Daniel J / Deckert, Jürgen

    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

    2024  Volume 25, Issue 4, Page(s) 214–221

    Abstract: Objectives: Previous results demonstrated that : Methods: We analysed : Results: Out of the 154 patients included, 44.8% of patients were classified as CYP2D6 normal metabolizer, 38.3% as intermediate metabolizers, 8.4% as poor metabolizers, and 2. ...

    Abstract Objectives: Previous results demonstrated that
    Methods: We analysed
    Results: Out of the 154 patients included, 44.8% of patients were classified as CYP2D6 normal metabolizer, 38.3% as intermediate metabolizers, 8.4% as poor metabolizers, and 2.6% as ultrarapid metabolizers. As for CYP2C19, 40.9% of patients were classified as normal metabolizers, 19.5% as intermediate metabolizers, 2.6% as poor metabolizers, 31.2% as rapid metabolizers, and 5.8% as ultrarapid metabolizers. Approximately, 80% of patients had at least one actionable PGx variant.
    Conclusion: There is a high prevalence of actionable PGx variants in psychiatric inpatients which may affect treatment response. Physicians should refer to PGx-informed dosing guidelines in carriers of these variants. Pre-emptive PGx testing in general may facilitate
    MeSH term(s) Humans ; Cytochrome P-450 CYP2D6/genetics ; Cytochrome P-450 CYP2C19/genetics ; Female ; Male ; Germany ; Adult ; Middle Aged ; Anxiety Disorders/genetics ; Anxiety Disorders/drug therapy ; Antidepressive Agents/therapeutic use ; Mood Disorders/genetics ; Mood Disorders/drug therapy ; Inpatients ; Genotype ; Alleles ; Phenotype ; Gene Frequency ; Pharmacogenomic Variants ; Aged ; Cohort Studies
    Chemical Substances Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1) ; CYP2C19 protein, human (EC 1.14.14.1) ; Antidepressive Agents
    Language English
    Publishing date 2024-05-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2051402-5
    ISSN 1814-1412 ; 1562-2975
    ISSN (online) 1814-1412
    ISSN 1562-2975
    DOI 10.1080/15622975.2024.2321553
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  8. Article ; Online: Pharmacogenetics of Antipsychotic Treatment in Schizophrenia.

    Elsheikh, Samar S M / Müller, Daniel J / Pouget, Jennie G

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2547, Page(s) 389–425

    Abstract: Antipsychotics are the mainstay treatment for schizophrenia. There is large variability between individuals in their response to antipsychotics, both in efficacy and adverse effects of treatment. While the source of interindividual variability in ... ...

    Abstract Antipsychotics are the mainstay treatment for schizophrenia. There is large variability between individuals in their response to antipsychotics, both in efficacy and adverse effects of treatment. While the source of interindividual variability in antipsychotic response is not completely understood, genetics is a major contributing factor. The identification of pharmacogenetic markers that predict antipsychotic efficacy and adverse reactions is a growing area of research and holds the potential to replace the current trial-and-error approach to treatment selection in schizophrenia with a personalized medicine approach.In this chapter, we provide an overview of the current state of pharmacogenetics in schizophrenia treatment. The most promising pharmacogenetic findings are presented for both antipsychotic response and commonly studied adverse reactions. The application of pharmacogenetics to schizophrenia treatment is discussed, with an emphasis on the clinical utility of pharmacogenetic testing and directions for future research.
    MeSH term(s) Antipsychotic Agents/adverse effects ; Humans ; Pharmacogenetics ; Precision Medicine ; Schizophrenia/drug therapy ; Schizophrenia/genetics
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2573-6_14
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  9. Article: Klinische Anwendungsbeispiele einer Next-Generation-Sequencing-basierten Multi-Genpanel-Analyse

    Enko, Dietmar / Schaflinger, Erich / Müller, Daniel J.

    TumorDiagnostik & Therapie

    2023  Volume 44, Issue 06, Page(s) 401–408

    Abstract: Dieser Übersichtsartikel bietet einen Überblick über klinisch sinnvolle Anwendungsgebiete einer Next-Generation-Sequencing-basierten (NGS) Multi-Genpanel-Teststrategie in den Bereichen Onkologie, hereditärer Tumorsyndrome und Hämatologie. Bei soliden ... ...

    Abstract Dieser Übersichtsartikel bietet einen Überblick über klinisch sinnvolle Anwendungsgebiete einer Next-Generation-Sequencing-basierten (NGS) Multi-Genpanel-Teststrategie in den Bereichen Onkologie, hereditärer Tumorsyndrome und Hämatologie. Bei soliden Tumoren (z.B. Lungenkarzinom, Kolonrektalkarzinom) trägt die Detektion somatischer Mutationen nicht nur zu einer besseren diagnostischen, sondern auch therapeutischen Stratifizierung der Betroffenen bei. Die zunehmende genetische Komplexität hereditärer Tumorsyndrome (z.B. Brust- und Ovarialkarzinom, Lynchsyndrom/Polypose) erfordert in betroffenen Familien eine Multi-Genpanel-Analyse von Keimbahnmutationen. Ein weiteres sinnvolles Indikationsgebiet einer Multi-Genpanel-Diagnostik und Prognoseabschätzung sind akute und chronische myeloische Erkrankungen. Die Kriterien der WHO-Klassifikation und des „European LeukemiaNet“-Prognosesystems der akuten myeloischen Leukämie können nur durch eine Multi-Genpanel-Teststrategie erfüllt werden.
    Keywords Next-Generation-Sequencing ; Multi-Genpanel ; Onkologie ; hereditäre Tumorsyndrome ; Hämatologie ; Next-generation sequencing ; targeted sequencing ; oncology ; hereditary tumor syndromes ; hematology
    Language German
    Publishing date 2023-07-31
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2072365-9
    ISSN 1439-1279 ; 0722-219X
    ISSN (online) 1439-1279
    ISSN 0722-219X
    DOI 10.1055/a-2114-2698
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  10. Article: Klinische Anwendungsbeispiele einer Next-Generation-Sequencing-basierten Multi-Genpanel-Analyse

    Enko, Dietmar / Schaflinger, Erich / Müller, Daniel J.

    DMW - Deutsche Medizinische Wochenschrift

    2023  Volume 148, Issue 11, Page(s) 695–702

    Abstract: Dieser Übersichtsartikel bietet einen Überblick über klinisch sinnvolle Anwendungsgebiete einer Next-Generation-Sequencing-basierten (NGS) Multi-Genpanel-Teststrategie in den Bereichen Onkologie, hereditärer Tumorsyndrome und Hämatologie. Bei soliden ... ...

    Abstract Dieser Übersichtsartikel bietet einen Überblick über klinisch sinnvolle Anwendungsgebiete einer Next-Generation-Sequencing-basierten (NGS) Multi-Genpanel-Teststrategie in den Bereichen Onkologie, hereditärer Tumorsyndrome und Hämatologie. Bei soliden Tumoren (z.B. Lungenkarzinom, Kolonrektalkarzinom) trägt die Detektion somatischer Mutationen nicht nur zu einer besseren diagnostischen, sondern auch therapeutischen Stratifizierung der Betroffenen bei. Die zunehmende genetische Komplexität hereditärer Tumorsyndrome (z.B. Brust- und Ovarialkarzinom, Lynchsyndrom/Polypose) erfordert in betroffenen Familien eine Multi-Genpanel-Analyse von Keimbahnmutationen. Ein weiteres sinnvolles Indikationsgebiet einer Multi-Genpanel-Diagnostik und Prognoseabschätzung sind akute und chronische myeloische Erkrankungen. Die Kriterien der WHO-Klassifikation und des „European LeukemiaNet“-Prognosesystems der akuten myeloischen Leukämie können nur durch eine Multi-Genpanel-Teststrategie erfüllt werden.
    Keywords Next-Generation-Sequencing ; Multi-Genpanel ; Onkologie ; hereditäre Tumorsyndrome ; Hämatologie ; Next-generation sequencing ; targeted sequencing ; oncology ; hereditary tumor syndromes ; hematology
    Language German
    Publishing date 2023-05-22
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-2033-5329
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