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  1. Article ; Online: Patient‐level indirect treatment comparison of lanadelumab versus pdC1‐INH i.v. in hereditary angioedema patients: PATCH study

    Magerl, Markus / Schiffhorst, Guido / Fanter, Lena / Muller, Gerrit / Hirche, Christoph / Berkemeier, Fabian / Aygören, Emel

    Allergy. 2024 Jan., v. 79, no. 1, p. 215-224

    2024  , Page(s) 215–224

    Abstract: BACKGROUND: Hereditary angioedema (HAE) is an autosomal dominant inherited disease in which patients suffer from local attacks primarily affecting skin and gastrointestinal tract, and sometimes even the upper respiratory tract leading to asphyxiation. ... ...

    Abstract BACKGROUND: Hereditary angioedema (HAE) is an autosomal dominant inherited disease in which patients suffer from local attacks primarily affecting skin and gastrointestinal tract, and sometimes even the upper respiratory tract leading to asphyxiation. Since head‐to‐head trials between authorized treatments are lacking, this study compares efficacy and safety of lanadelumab and intravenous plasma‐derived C1‐esterase inhibitor (pdC1‐INH i.v.) in HAE patients on long‐term prophylaxis by means of an indirect treatment comparison. METHODS: Efficacy and safety of lanadelumab against pdC1‐INH i.v. were analyzed in a fully prespecified indirect comparison based on individual patient data (n = 231) from the HELP and CHANGE clinical trials. Primary and secondary efficacy endpoints were compared using a generalized linear model for count data. Confounding variables were identified a priori via systematic literature research and validated by clinical experts. Adjustment of confounders was implemented using a conditional regression model. RESULTS: Lanadelumab showed a statistically significant improvement in reduction of HAE attack rates compared to pdC1‐INH i.v. across multiple endpoints: Monthly attack rate of patients treated with lanadelumab was less than half compared to pdC1‐INH i.v. (Rate ratio: 0.486; 95% CI: 0.253, 0.932). Monthly rate of laryngeal attacks was found to be five times lower for lanadelumab (Rate ratio: 0.2; 95% CI: 0.044, 0.915) and monthly rate of acute treated HAE attacks among lanadelumab patients was about one third of the attack rate of pdC1‐INH i.v. patients (Rate ratio: 0.366; 95% CI: 0.185, 0.727). CONCLUSION: This study contributes to current knowledge in the treatment of HAE by indicating a statistically significant reduction of HAE attacks under lanadelumab compared to pdC1‐INH i.v.
    Keywords asphyxia ; digestive tract ; disease prevention ; genetic disorders ; hypersensitivity ; intravenous injection ; larynx ; linear models ; patients ; regression analysis
    Language English
    Dates of publication 2024-01
    Size p. 215-224
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15861
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 125: Show issues

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  2. Book ; Online ; Thesis: The Impact of Inflammatory Conditions on the Immunological Responses of Cutaneous Dendritic Cells

    Müller, Gerrit [Verfasser]

    2019  

    Author's details Gerrit Müller
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Freie Universität Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article: Detrital Carbonate Minerals in Earth's Element Cycles.

    Müller, Gerrit / Börker, Janine / Sluijs, Appy / Middelburg, Jack J

    Global biogeochemical cycles

    2022  Volume 36, Issue 5, Page(s) e2021GB007231

    Abstract: We investigate if the commonly neglected riverine detrital carbonate fluxes might reconciliate several chemical mass balances of the global ocean. Particulate inorganic carbon (PIC) concentrations in riverine suspended sediments, that is, carbon ... ...

    Abstract We investigate if the commonly neglected riverine detrital carbonate fluxes might reconciliate several chemical mass balances of the global ocean. Particulate inorganic carbon (PIC) concentrations in riverine suspended sediments, that is, carbon contained by these detrital carbonate minerals, were quantified at the basin and global scale. Our approach is based on globally representative data sets of riverine suspended sediment composition, catchment properties, and a two-step regression procedure. The present-day global riverine PIC flux is estimated at 3.1 ± 0.3 Tmol C/y (13% of total inorganic carbon export and 4% of total carbon export) with a flux-weighted mean concentration of 0.26 ± 0.03 wt%. The flux prior to damming was 4.1 ± 0.5 Tmol C/y. PIC fluxes are concentrated in limestone-rich, rather dry and mountainous catchments of large rivers near Arabia, South East Asia, and Europe with 2.2 Tmol C/y (67.6%) discharged between 15°N and 45°N. Greenlandic and Antarctic meltwater discharge and ice-rafting additionally contribute 0.8 ± 0.3 Tmol C/y. This amount of detrital carbonate minerals annually discharged into the ocean implies a significant contribution of calcium (∼4.75 Tmol Ca/y) and alkalinity fluxes (∼10 Tmol (eq)/y) to marine mass balances and moderate inputs of strontium (∼5 Gmol Sr/y) based on undisturbed riverine and cryospheric inputs and a dolomite/calcite ratio of 0.1. Magnesium fluxes (∼0.25 Tmol Mg/y), mostly hosted by less-soluble dolomite, are rather negligible. These unaccounted fluxes help in elucidating respective marine mass balances and potentially alter conclusions based on these budgets.
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2021601-4
    ISSN 1944-9224 ; 0886-6236
    ISSN (online) 1944-9224
    ISSN 0886-6236
    DOI 10.1029/2021GB007231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Patient-level indirect treatment comparison of lanadelumab versus pdC1-INH i.v. in hereditary angioedema patients: PATCH study.

    Magerl, Markus / Schiffhorst, Guido / Fanter, Lena / Müller, Gerrit / Hirche, Christoph / Berkemeier, Fabian / Aygören, Emel

    Allergy

    2023  Volume 79, Issue 1, Page(s) 215–224

    Abstract: Background: Hereditary angioedema (HAE) is an autosomal dominant inherited disease in which patients suffer from local attacks primarily affecting skin and gastrointestinal tract, and sometimes even the upper respiratory tract leading to asphyxiation. ... ...

    Abstract Background: Hereditary angioedema (HAE) is an autosomal dominant inherited disease in which patients suffer from local attacks primarily affecting skin and gastrointestinal tract, and sometimes even the upper respiratory tract leading to asphyxiation. Since head-to-head trials between authorized treatments are lacking, this study compares efficacy and safety of lanadelumab and intravenous plasma-derived C1-esterase inhibitor (pdC1-INH i.v.) in HAE patients on long-term prophylaxis by means of an indirect treatment comparison.
    Methods: Efficacy and safety of lanadelumab against pdC1-INH i.v. were analyzed in a fully prespecified indirect comparison based on individual patient data (n = 231) from the HELP and CHANGE clinical trials. Primary and secondary efficacy endpoints were compared using a generalized linear model for count data. Confounding variables were identified a priori via systematic literature research and validated by clinical experts. Adjustment of confounders was implemented using a conditional regression model.
    Results: Lanadelumab showed a statistically significant improvement in reduction of HAE attack rates compared to pdC1-INH i.v. across multiple endpoints: Monthly attack rate of patients treated with lanadelumab was less than half compared to pdC1-INH i.v. (Rate ratio: 0.486; 95% CI: 0.253, 0.932). Monthly rate of laryngeal attacks was found to be five times lower for lanadelumab (Rate ratio: 0.2; 95% CI: 0.044, 0.915) and monthly rate of acute treated HAE attacks among lanadelumab patients was about one third of the attack rate of pdC1-INH i.v. patients (Rate ratio: 0.366; 95% CI: 0.185, 0.727).
    Conclusion: This study contributes to current knowledge in the treatment of HAE by indicating a statistically significant reduction of HAE attacks under lanadelumab compared to pdC1-INH i.v.
    MeSH term(s) Humans ; Angioedemas, Hereditary/drug therapy ; Treatment Outcome ; Complement C1 Inhibitor Protein/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use
    Chemical Substances lanadelumab (2372V1TKXK) ; Complement C1 Inhibitor Protein ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-08-29
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.150: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 125: Show issues

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  5. Book ; Thesis: Beiträge zur Erfassung und Ursachenanalyse von Rotwildschälung im Nordschwarzwald

    Müller, Gerrit

    1985  

    Author's details von Gerrit Müller
    Keywords Nordschwarzwald ; Rothirsch ; Schälschaden
    Subject Cervus elaphus ; Edelhirsch ; Rotwild ; Edelwild
    Language German
    Size S. A - E, VI, 140 S., S. A-E : graph. Darst., Kt.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg i. Br., Univ., Diss., 1985
    HBZ-ID HT002572234
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    AY 8817 order for loan Geschlossenes Magazin (U2)

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  6. Book ; Online ; Thesis: Die Rückgewinnungshilfe und der staatliche Auffangrechtserwerb

    Müller, Gerrit [Verfasser]

    2016  

    Author's details Gerrit Müller
    Keywords Recht ; Law
    Subject code sg340
    Language German
    Publisher Peter Lang GmbH, Internationaler Verlag der Wissenschaften
    Publishing place Frankfurt
    Document type Book ; Online ; Thesis
    ISBN 978-3-653-06166-6 ; 3-653-06166-0
    Database Digital theses on the web

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  7. Article: Epidemiology and treatment of children with hereditary angioedema in Germany: A retrospective database study.

    Prenzel, Freerk / Abraham, Susanne / Hirche, Christoph / Müller, Gerrit / Kaiser, Stephan / Serdani-Neuhaus, Leonarda / Zingel, Rebecca / Martinez-Saguer, Inmaculada

    Clinical and translational allergy

    2023  Volume 13, Issue 11, Page(s) e12313

    Abstract: Background: Hereditary angioedema (HAE) is a potentially life-threatening inherited disease that causes recurrent, serious, and debilitating episodes of swelling. While evidence has improved in adult patients, data on the epidemiology and treatment of ... ...

    Abstract Background: Hereditary angioedema (HAE) is a potentially life-threatening inherited disease that causes recurrent, serious, and debilitating episodes of swelling. While evidence has improved in adult patients, data on the epidemiology and treatment of pediatric patients with HAE remain very limited. The aim of this study was to determine the incidence and prevalence of pediatric patients with HAE aged <12 years, as well as treatment patterns, co-medication, and specialties involved.
    Methods: In this retrospective study (2016-2021), the German IQVIA
    Results: We found an HAE prevalence in pediatric patients aged <12 years of 2.51:100,000 and a 12-month prevalence of up to 1.02:100,000 between 2016 and 2021. Most HAE treatments were prescribed by outpatient clinics and pediatricians, with an increasing proportion of icatibant as an on-demand treatment and low rates of long-term prophylaxis (LTP). The prescription rate of analgesics as the most common co-medication decreased notably after HAE diagnosis.
    Conclusion: Our findings provide insights into the epidemiology and current pediatric HAE treatment landscape in Germany. The obtained HAE prevalence in pediatric patients aged <12 years was even higher than the previously reported average of overall cohorts, whereas the LTP rate was low, which might indicate an unmet need for newer LTP treatment options in pediatric patients.
    Language English
    Publishing date 2023-11-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630865-4
    ISSN 2045-7022
    ISSN 2045-7022
    DOI 10.1002/clt2.12313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Lysosomotropic beta blockers induce oxidative stress and IL23A production in Langerhans cells.

    Müller, Gerrit / Lübow, Charlotte / Weindl, Günther

    Autophagy

    2019  Volume 16, Issue 8, Page(s) 1380–1395

    Abstract: Oxidative stress and T: Abbreviations: ATF: activating transcription factor; DC: dendritic cell; ChIP: chromatin immunoprecipitation; gDNA: genomic DNA; IL: interleukin; LAMP1: lysosomal associated membrane protein 1; LC: Langerhans cell; LPS: ... ...

    Abstract Oxidative stress and T
    Abbreviations: ATF: activating transcription factor; DC: dendritic cell; ChIP: chromatin immunoprecipitation; gDNA: genomic DNA; IL: interleukin; LAMP1: lysosomal associated membrane protein 1; LC: Langerhans cell; LPS: lipopolysaccharide; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAPK: mitogen-activated protein kinase; MoDC: monocyte-derived DC; MoLC: monocyte-derived Langerhans-like cell; mtDNA: mitochondrial DNA; NAC: N-acetyl-L-cysteine; NLRP3: NLR family pyrin domain containing 3; PBMC: peripheral blood mononuclear cell; PI: propidium iodide; PYCARD/ASC: PYD and CARD domain containing; qRT-PCR: quantitative real-time PCR; ROS: reactive oxygen species; SQSTM1/p62: sequestosome 1; TLR: Toll-like receptor; TRAF6: TNF receptor associated factor 6; TNF: tumor necrosis factor; Ub: ubiquitin.
    Language English
    Publishing date 2019-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2019.1686728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6741: Show issues Location:
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  9. Book: Systems architecting

    Muller, Gerrit

    a business perspective

    2012  

    Abstract: Process and organization -- Role and task of the systems architect -- From customer understanding to requirements -- Systems architect methods and means -- Strategy -- Harvesting synergy, product families -- Supporting processes -- Systems and software -- ...

    Author's details Gerrit Muller
    Abstract Process and organization -- Role and task of the systems architect -- From customer understanding to requirements -- Systems architect methods and means -- Strategy -- Harvesting synergy, product families -- Supporting processes -- Systems and software -- Boardroom presentation -- Human side -- Reflection and wrap-up
    Keywords Entrepreneurship ; Organizational effectiveness ; Product design ; Project management ; Systems engineering ; Systems Engineering ; Produktgestaltung ; Projektmanagement
    Language English
    Size XIX, 243 S., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton, Fla. u.a.
    Document type Book
    Note Includes bibliographical references (p. 217 - 218) and index
    ISBN 9781439847626 ; 1439847622
    Database ECONomics Information System

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  10. Book ; Online: Systems Architecting

    Muller, Gerrit

    A Business Perspective

    2011  

    Abstract: Process and Organization Process Decomposition of a BusinessIntermezzo: What Is a Process?Product Creation ProcessIntermezzo: The Importance of Feedback The Systems Architecting ProcessIntermezzo: Products, Projects, ServicesRole and Task of the Systems ... ...

    Abstract Process and Organization Process Decomposition of a BusinessIntermezzo: What Is a Process?Product Creation ProcessIntermezzo: The Importance of Feedback The Systems Architecting ProcessIntermezzo: Products, Projects, ServicesRole and Task of the Systems ArchitectThe Awakening of a Systems ArchitectIntermezzo: Systems Titles and Roles The Role and Task of the Systems ArchitectIntermezzo: Dynamic Range of Abstraction Levels in Architecting Architecting Interaction Styles From Customer Understanding to RequirementsCAFCR+: A Model to Relate Customer Needs to System Realization Fundamentals of Requ
    Language English
    Size Online-Ressource (265 p)
    Publisher CRC Press
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781439847626 ; 1439847622
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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