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  1. Book: Extrudierbare, kompostierbare aliphatische Cellulosederivate

    Kuhne / Müller, H.-P. / Fink, H.-P.

    fachlicher Abschlußbericht 01.01.1997 - 30.06.1998 ; Verbund: "Neue polymere Materialien aus Cellulose und Cellulosederivaten"

    1998  

    Title variant Neue polymere Materialien aus Cellulose und Cellulosederivaten
    Institution Wolff-Walsrode-Aktiengesellschaft
    Author's details Wolff Walsrode AG (Projektleiter: Kuhne) in Zusammenarbeit mit: Bayer AG (Projektleiter: H.-P. Müller), Fraunhofer-Gesellschaft Institut für angewandte Polymerforschung (Projektleiter: H.-P. Fink)
    Language German
    Size II, 67 S., Ill., graph. Darst.
    Publishing place Walsrode u.a.
    Publishing country Germany
    Document type Book
    Note Förderkennzeichen BML 96-NR-175-F
    HBZ-ID HT018354034
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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  2. Article: Quantitative and qualitative investigations on the seed proteins of mutants and recombinants of Pisum sativum.

    Gottschalk, W / Müller, H P

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

    2014  Volume 45, Issue 1, Page(s) 7–20

    Abstract: The proteins of the seed flour of 26 X-ray induced mutants and 5 recombinants of the species Pisum sativum were analysed quantitatively and qualitatively. The values obtained were related to the seed yield of the genotypes In this way, the protein yield ... ...

    Abstract The proteins of the seed flour of 26 X-ray induced mutants and 5 recombinants of the species Pisum sativum were analysed quantitatively and qualitatively. The values obtained were related to the seed yield of the genotypes In this way, the protein yield as well as the production of specific amino acids per genotype were determined. The following results were obtained. 1. The mean values for the character "total protein content of the seed flour" of the genotypes studied varied between 14 and 23%. The fasciated mutant 489C produced 18-23% more seed proteins than the initial line in three subsequent generations. The mean values of some other mutants and recombinants were 10-17% higher, the lowest value being 27% lower than that of the control values. In the material investigated there is no correlation between seed size and seed protein content. 2. The buffer-soluble seed proteins of 55 mutants were electrophoretically subdivided in different subfractions and the protein patterns were determined. They are extraordinarily variable. Distinct groups of mutants do not only differ from the initial line but also from one another with regard to the number, position and breadth of their bands. A correlation between the degree of morphological deviations of specific genotypes and the composition of their seed proteins was not observed. Moreover, differences in the concentration of specific protein fractions between the genotypes were densitometrically ascertained. 3. The globulins and albumins of some genotypes were quantitatively determined and electrophoretically subdivided into subfractions which differ between different mutants with regard to their number as well as their concentration. This is especially valid for the albumins which could be essentially stronger subdivided than the globulins. 4. The amino acid spectra of all the mutants investigated agree qualitatively with the spectrum of the initial line, however, clear quantitative differences in distinct amino acids were observed. The proportion of the essential amino acids is increased in two mutants by 5 and 20% in relation to the control line. 5. The protein production of the fasciated mutant 489C was 20-70% higher than the corresponding values of the initial line in three subsequent generations regarding its high seed production. The protein yield of the early flowering mutant 46C was about 20% lower and that of the bifurcated mutant 1201A 12-31% higher as related to the initial line. Mutant 1201A shows an equally favourable situation with regard to the total content of the essential amino acids. Its lysine production exceeded the control values by 20-40%. 6. The different components of the protein synthesis can negatively be influenced by the co-operation of the mutant genes. The protein production per plant, the total production of essential amino acids as well as the lysine production are lower in the recombinants 68C/176A and 68C/1201A as compared to the parental mutants. The combination of genes 68C and 46C does not show any negative interactions.
    Language English
    Publishing date 2014-01-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2170-2
    ISSN 1432-2242 ; 0040-5752
    ISSN (online) 1432-2242
    ISSN 0040-5752
    DOI 10.1007/BF00281168
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  3. Article: Spielt die marginale Parodontitis eine Rolle in der Pathogenese kardio- und zerebrovaskulärer Erkrankungen?

    Müller, H P

    Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))

    2002  Volume 64, Issue 2, Page(s) 89–98

    Abstract: The role of chronic infections in the initiation of atherosclerotic lesions has been vividly discussed in recent years. A possible causal relationship between cardiovascular diseases and infections with, e. g., Chlamydia pneumoniae, Helicobacter pylori, ... ...

    Title translation Does chronic periodontitis play a role in the pathogenesis of cardiovascular and cerebrovascular diseases?.
    Abstract The role of chronic infections in the initiation of atherosclerotic lesions has been vividly discussed in recent years. A possible causal relationship between cardiovascular diseases and infections with, e. g., Chlamydia pneumoniae, Helicobacter pylori, or herpes viruses had also been established for chronic periodontitis, in particular after discovery of DNA of typical periodontal pathogens in atheromatous plaques. Especially in longitudinal epidemiologic studies, a low or moderate association between existing periodontitis and the development of, e. g., coronary heart disease or non-haemorrhagic stroke had been observed. In this article the respective literature is critically reviewed. In particular, the influence of incomplete or inappropriate adjustment for common risk factors for both diseases, i. e., cardiovascular disease and periodontitis should be analysed. In metaanalyses of prospective studies, in which the respective endpoint occurred after the investigation had commenced, relative risks of periodontitis of 1.12 (95 % confidence interval 0.95-1.33) for coronary heart disease and 1.73 (0.89-3.34) for ischaemic stroke were calculated. Whether chronic periodontitis actually represents an important risk for the development of cardiovascular diseases remains questionable. Already planned intervention studies appear to be premature and ethically highly problematic.
    MeSH term(s) Cerebral Infarction/etiology ; Chronic Disease ; Humans ; Myocardial Infarction/etiology ; Periodontitis/complications ; Risk Factors
    Language German
    Publishing date 2002-02
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 1101426-x
    ISSN 1439-4421 ; 0941-3790 ; 0949-7013
    ISSN (online) 1439-4421
    ISSN 0941-3790 ; 0949-7013
    DOI 10.1055/s-2002-20272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Periodontitis and cardiovascular disease: an ecological fallacy?

    Müller, H P

    European journal of oral sciences

    2001  Volume 109, Issue 4, Page(s) 286–287

    MeSH term(s) Adult ; Arteriosclerosis/epidemiology ; Bias ; Confounding Factors (Epidemiology) ; Ecology ; Europe/epidemiology ; Humans ; Myocardial Infarction/mortality ; Myocardial Ischemia/mortality ; Periodontal Index ; Periodontitis/epidemiology ; Prevalence ; Smoking/epidemiology
    Language English
    Publishing date 2001-07-20
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1224820-4
    ISSN 1600-0722 ; 0909-8836
    ISSN (online) 1600-0722
    ISSN 0909-8836
    DOI 10.1034/j.1600-0722.2001.00109.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Rauchen oder parodontale Gesundheit.

    Müller, H P

    Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))

    2000  Volume 62, Issue 7, Page(s) 400–408

    Abstract: The causal agents of destructive periodontal disease are several gram-negative bacteria. The mere presence, however, in the dental biofilm does not guarantee onset of the disease. The immunological and inflammatory host response as well as connective ... ...

    Title translation Smoking and periodontal health.
    Abstract The causal agents of destructive periodontal disease are several gram-negative bacteria. The mere presence, however, in the dental biofilm does not guarantee onset of the disease. The immunological and inflammatory host response as well as connective tissue and bone metabolism are strongly influenced by genetic, acquired and behavioural risk factors. Among the last, tobacco consumption holds a primary position. Prevalence, extent and severity of periodontitis as well as tooth loss and edentulism are influenced by tobacco consumption in a dose-dependent manner. About 50% of periodontal disease in young adults is attributable to cigarette smoking. Postoperative results in periodontally diseased smokers are considerably poorer than those achieved in non-smokers. As a consequence smoking cessation has to be in corporated in traditional treatment concepts for inflammatory periodontal disease.
    MeSH term(s) Adult ; Female ; Germany ; Humans ; Male ; Periodontal Diseases/epidemiology ; Periodontal Diseases/etiology ; Periodontal Index ; Risk Factors ; Smoking/adverse effects ; Smoking/epidemiology
    Language German
    Publishing date 2000-07
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 1101426-x
    ISSN 1439-4421 ; 0941-3790 ; 0949-7013
    ISSN (online) 1439-4421
    ISSN 0941-3790 ; 0949-7013
    DOI 10.1055/s-2000-12585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Cemental tear treated with guided tissue regeneration: a case report 3 years after initial treatment.

    Müller, H P

    Quintessence international (Berlin, Germany : 1985)

    1999  Volume 30, Issue 2, Page(s) 111–115

    Abstract: Cemental tear is a rare but probably underdiagnosed condition that may be a factor in rapid periodontal breakdown. The present case report describes the regenerative treatment of a periodontal lesion around a mandibular canine in a 50-year-old woman. The ...

    Abstract Cemental tear is a rare but probably underdiagnosed condition that may be a factor in rapid periodontal breakdown. The present case report describes the regenerative treatment of a periodontal lesion around a mandibular canine in a 50-year-old woman. The preoperative radiograph revealed a small cemental tear within an intrabony lesion. The three-wall bony lesion was treated with a barrier membrane and followed for 3 years. Periodontal pocket reduction was 5.5 mm, and attachment gain amounted to 3.5 to 4.5 mm Standardized radiographs showed remarkable, 1.6-mm bone fill of the intrabony lesion. Also, a band of keratinized tissue had formed.
    MeSH term(s) Alveolar Bone Loss/etiology ; Alveolar Bone Loss/surgery ; Cuspid ; Dental Cementum/injuries ; Female ; Guided Tissue Regeneration, Periodontal ; Humans ; Mandible ; Middle Aged ; Periodontitis/etiology ; Periodontitis/surgery ; Tooth Injuries/complications
    Language English
    Publishing date 1999-02
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 7436-6
    ISSN 1936-7163 ; 0033-6572
    ISSN (online) 1936-7163
    ISSN 0033-6572
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  7. Article: The influence of several factors on the validity of measurements made on radiographs as compared to intrasurgical measurements made with a periodontal probe.

    Müller, H P

    Journal of clinical periodontology

    1999  Volume 26, Issue 11, Page(s) 769–770

    MeSH term(s) Alveolar Process/diagnostic imaging ; Alveolar Process/pathology ; Humans ; Image Processing, Computer-Assisted ; Linear Models ; Multivariate Analysis ; Periodontal Diseases/diagnostic imaging ; Periodontal Diseases/pathology ; Periodontal Diseases/surgery ; Periodontics/instrumentation ; Radiography ; Reproducibility of Results ; Tooth Cervix/diagnostic imaging ; Tooth Cervix/pathology
    Language English
    Publishing date 1999-12-01
    Publishing country United States
    Document type Comparative Study ; Letter ; Comment
    ZDB-ID 188647-2
    ISSN 1600-051X ; 0303-6979
    ISSN (online) 1600-051X
    ISSN 0303-6979
    DOI 10.1034/j.1600-051x.1999.t01-12-261101.x
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  8. Article ; Conference proceedings: Evaluation of Enzymatic Liver Function Using Liver Maximum Capacity Test (LiMAx) in Adult Fontan Patients

    Schleiger, A. / Kramer, P. / Jentsch, N. / Pileckaite, M. / Schafstedde, M. / Danne, F. / Müller, H.-P. / Müller, T. / Tacke, F. / Jara, M. / Stockmann, M. / Berger, F. / Ovroutski, S.

    The Thoracic and Cardiovascular Surgeon

    2022  Volume 70, Issue S 02

    Event/congress The 54th Annual Meeting of the German Society for Pediatric Cardiology (DGPK), Online, 2022-02-19
    Language English
    Publishing date 2022-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 800050-5
    ISSN 1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
    ISSN (online) 1439-1902
    ISSN 0171-6425 ; 0946-4778 ; 0172-6137
    DOI 10.1055/s-0042-1742948
    Database Thieme publisher's database

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  9. Article ; Online: Optical coherence tomography-based assessment of retinal vascular pathology in cerebral small vessel disease.

    Abdelhak, A / Huss, A / Brück, A / Sebert, U / Mayer, B / Müller, H P / Tumani, H / Otto, M / Yilmazer-Hanke, D / Ludolph, A C / Kassubek, J / Pinkhardt, E / Neugebauer, H

    Neurological research and practice

    2020  Volume 2, Page(s) 13

    Abstract: Background: Cerebral small vessel disease (CSVD) is a disorder of brain vasculature that causes various structural changes in the brain parenchyma, and is associated with various clinical symptoms such as cognitive impairment and gait disorders. ... ...

    Abstract Background: Cerebral small vessel disease (CSVD) is a disorder of brain vasculature that causes various structural changes in the brain parenchyma, and is associated with various clinical symptoms such as cognitive impairment and gait disorders. Structural changes of brain arterioles cannot be visualized with routine imaging techniques in vivo. However, optical coherence tomography (OCT) is thought to be a "window to the brain". Thus, retinal vessel parameters may correlate with CSVD characteristic brain lesions and cerebrospinal fluid biomarkers (CSF) of the neuropathological processes in CSVD like endothelial damage, microglial activation and neuroaxonal damage.
    Methods: We applied OCT-based assessment of retinal vessels, magnetic resonance imaging (MRI), and CSF biomarker analysis in a monocentric prospective cohort of 24 patients with sporadic CSVD related stroke and cognitive impairment. MRI lesions were defined according to the STandards for ReportIng Vascular changes on nEuroimaging (STRIVE). Biomarkers were assessed using commercially available ELISA kits. Owing to the unavailability of an age-matched control-group lacking MRI-characteristics of CSVD, we compared the retinal vessel parameters in CSVD patients (73.8 ± 8.5 years) with a younger group of healthy controls (51.0 ± 16.0 years) by using an age- and sex-adjusted multiple linear regression analysis model.
    Results: Among the parameters measured with OCT, the Wall to Lumen Ratio (WLR) but not Mean Wall Thickness (MWT) of the superior branch of the retinal artery correlated significantly with the volume of white matter hyperintensities on MRI (r
    Conclusions: In this exploratory study, WLR correlated with the volume of white matter hyperintensities, and markers of vascular integrity, microglial activation, and neuroaxonal damage in CSVD. Further prospective studies should clarify whether retinal vessel parameters and CSF biomarkers may serve to monitor the natural course and treatment effects in clinical studies on CSVD.
    Language English
    Publishing date 2020-05-15
    Publishing country England
    Document type Journal Article
    ISSN 2524-3489
    ISSN (online) 2524-3489
    DOI 10.1186/s42466-020-00062-4
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  10. Article: Multivariate multilevel models for repeated measures in the study of smoking effects on the association between plaque and gingival bleeding.

    Müller, H P / Stadermann, S

    Clinical oral investigations

    2006  Volume 10, Issue 4, Page(s) 311–316

    Abstract: Multivariate multilevel modeling was applied to analyze repeated measures data on the influence of heavy smoking on the association between the amount of supragingival plaque and gingival bleeding on probing (BOP) in a steady-state plaque environment. ... ...

    Abstract Multivariate multilevel modeling was applied to analyze repeated measures data on the influence of heavy smoking on the association between the amount of supragingival plaque and gingival bleeding on probing (BOP) in a steady-state plaque environment. Data acquired in 65 systemically healthy young adults with mild plaque-induced gingivitis were analyzed. 33 heavy smokers consumed at least 20 cigarettes per day while 32 were non-smokers. Periodontal examinations at the outset consisted of periodontal probing depth, clinical attachment level, BOP, plaque index, and presence of calculus at 6 sites of every tooth present. They were repeated 3 times every 8 weeks. A multivariate 4-level variance component model revealed that the odds of BOP was twice as high in smokers. In addition, females had a lower likelihood for BOP but, with increasing bleeding scores during the course of the study, this effect attenuated. Low biserial correlations for BOP at the site level of between 0.11 and 0.2 were found. At the tooth level, correlations were moderate (0.2-0.5), and highest at the subject level (0.8-0.9). Variations at subject and tooth levels were very large at the outset but notably attenuated in the course of the study. Plaque consistently influenced the tendency for BOP with an odds ratio of about 1.7-1.8 for each increase in score in both smokers and non-smokers. The present study did not reveal evidence for attenuation of the plaque/gingival bleeding relationship in heavy smokers.
    MeSH term(s) Adult ; Dental Plaque/complications ; Epidemiologic Methods ; Female ; Gingivitis/etiology ; Humans ; Male ; Periodontal Index ; Smoking/adverse effects
    Language English
    Publishing date 2006-12
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1364490-7
    ISSN 1436-3771 ; 1432-6981
    ISSN (online) 1436-3771
    ISSN 1432-6981
    DOI 10.1007/s00784-006-0067-y
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