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  1. Book: Focus on extrapyramidal dysfunction

    Müller, Th

    (Journal of neural transmission : Suppl. ; 68)

    2004  

    Author's details Th. Müller ... (ed.)
    Series title Journal of neural transmission : Suppl. ; 68
    Journal of neural transmission
    Journal of neural transmission ; Suppl.
    Collection Journal of neural transmission
    Journal of neural transmission ; Suppl.
    Keywords Extrapyramidales Syndrom
    Subject Extrapyramidales System ; Extrapyramidaler Symptomenkomplex ; Extrapyramidal-motorische Bewegungsstörung ; Striopallidärer Symptomenkomplex
    Language English
    Size VIII, 156 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Wien u.a.
    Publishing country Austria
    Document type Book
    HBZ-ID HT014119226
    ISBN 3-211-21112-8 ; 3-211-21114-4 ; 978-3-211-21112-0 ; 978-3-211-21114-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui II Zs 150 -Suppl.68- verfügbar in Königswinter Königswinter

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  2. Article: Seltener Begutachtungsfall - schwere Komplikation einer Fingerphlegmone

    Müller, Th.

    Der medizinische Sachverständige

    2020  Volume 116, Issue 6, Page(s) 277

    Language German
    Document type Article
    ZDB-ID 124110-2
    ISSN 0025-8490
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Un I Zs.156: Show issues Location:
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  3. Book: Schlaf erfolgreich trainieren

    Müller, Tilmann H. / Paterok, Beate

    ein Ratgeber zur Selbsthilfe

    2014  

    Author's details von Tilman Müller und Beate Paterok
    Keywords Schlafstörung ; Schlafrestriktionstherapie
    Subject Agrypnie ; Asomnie ; Insomnie ; Schlaflosigkeit
    Language German
    Size 209 S., 207 mm x 133 mm
    Edition 2., korr. Aufl.
    Publisher Hogrefe
    Publishing place Göttingen u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018365310
    ISBN 978-3-8017-2576-1 ; 3-8017-2576-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 11674 order for loan Magazin

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  4. Article: Synchronising Mobile Electronic Case Report Forms with a Central Database.

    Müller, Thomas H

    Studies in health technology and informatics

    2016  Volume 228, Page(s) 307–311

    Abstract: The increased dissemination of powerful mobile computing devices with access to a variety of wireless communication channels has benefited on-line capture of medical research data many areas. Yet, there is still a need for off-line capture, especially, ... ...

    Abstract The increased dissemination of powerful mobile computing devices with access to a variety of wireless communication channels has benefited on-line capture of medical research data many areas. Yet, there is still a need for off-line capture, especially, when the availability of on-line connectivity cannot be established in advance. The clinical study "BreathEase" presents such a case, because it calls for extensive interviews conducted at the patient's home by visiting study staff. On the other, patient data also needed to be collected in an outpatient clinic. Furthermore, these activities needed to be co-ordinated according to protocol guidelines via a stationary system. Hence, the interview questionnaire data captured off-line needed to be merged with a stationary central database. For this purpose, an existing electronic data capture system (DBFORM) was conFred to include some clinical trial management features and complemented with a module to synchronize data in the mobile and stationary databases. This paper describes the requirements, the procedure, and its implementation. While it is shown that off-line capture followed by on-line synchronization is feasible, certain ambiguities may arise that should be addressed by technical and/or other means.
    MeSH term(s) Clinical Trials as Topic ; Databases, Factual ; Documentation ; Internet ; Mobile Applications ; Wireless Technology
    Language English
    Publishing date 2016
    Publishing country Netherlands
    Document type Journal Article
    ISSN 0926-9630
    ISSN 0926-9630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Schlaf erfolgreich trainieren

    Müller, Tilmann H. / Paterok, Beate

    ein Ratgeber zur Selbsthilfe

    2010  

    Author's details Tilmann Müller ; Beate Paterok
    Keywords Schlafstörung ; Schlafrestriktionstherapie
    Subject Agrypnie ; Asomnie ; Insomnie ; Schlaflosigkeit
    Language German
    Size 191 S. : graph. Darst., 207 mm x 132 mm
    Publisher Hogrefe
    Publishing place Göttingen u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT016320241
    ISBN 978-3-8017-2292-0 ; 3-8017-2292-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 4238 available for loan (reading room) Lesesaal EG

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  6. Book: Schlaftraining

    Müller, Tilmann H. / Paterok, Beate

    ein Therapiemanual zur Behandlung von Schlafstörungen

    (Therapeutische Praxis)

    2010  

    Author's details von Tilmann Müller ; Beate Paterok
    Series title Therapeutische Praxis
    Keywords Sleep Disorders / therapy ; Schlafrestriktionstherapie
    Language German
    Size 152 S. : graph. Darst.
    Edition 2. überarb. Aufl.
    Publisher Hogrefe
    Publishing place Göttingen u.a.
    Publishing country Germany
    Document type Book
    Accompanying material 1 CD-ROM (12 cm)
    HBZ-ID HT016296018
    ISBN 978-3-8017-2291-3 ; 9783840922916 ; 3-8017-2291-0 ; 3840922917
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 C 51 order for loan Magazin
    2010 MO 365 <<[Begleitmaterial]>> order for loan Magazin

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  7. Article ; Online: Digital polymerase chain reaction to monitor platelet transfusions in cardiac surgery patients.

    Ali, Khaldoun / Müller, Thomas H / Garritsen, Henk S P / Harringer, Wolfgang / Doescher, Andrea

    Vox sanguinis

    2023  Volume 118, Issue 5, Page(s) 384–391

    Abstract: Background and objectives: Corrected count increment (CCI) measurements monitor the effectiveness of platelet transfusions in haemato-oncology, but they usually fail in patients undergoing cardiac surgery. We investigated whether polymerase chain ... ...

    Abstract Background and objectives: Corrected count increment (CCI) measurements monitor the effectiveness of platelet transfusions in haemato-oncology, but they usually fail in patients undergoing cardiac surgery. We investigated whether polymerase chain reaction (PCR) of mitochondrial single-nucleotide polymorphisms (SNPs) is able to monitor the survival of transfused platelets in these patients.
    Materials and methods: Leukocyte-free, platelet-rich plasma was prepared from patients' blood to measure platelet counts based on patient-/donor-specific SNPs by digital PCR after DNA extraction. Platelet counts in samples from patients with severe thrombocytopenia were analysed by both PCR and flow cytometry. Ten patients undergoing cardiac surgery with the use of heart lung machine and without overt bleeding received a single apheresis platelet concentrate because of either dual platelet inhibition during a non-elective intervention or a complex procedure. Blood samples were collected at nine defined intervals (0-120 h) post transfusion.
    Results: The digital PCR of the seven SNPs reliably quantified levels ≥0.6 G/L platelets, in good agreement with flow cytometry and without interference by other SNPs or by platelet activation. A mean 24-h CCI of 11.8 (range: 5.6-19.8) and a mean 120-h area under the curve (AUC) of 1386 (915-1821) hxG/L were observed for the transfused platelets. The mean AUC of 14,103 (3415-27,305) hxG/L for the patients' endogenous platelets indicates that transfused platelets represented only 11% (5-25) of the total platelet counts during 120 h post transfusion.
    Conclusion: PCR of mitochondrial SNPs offers a tool to assess the survival of platelets from apheresis concentrates in cardiac surgery patients to facilitate the implementation of improved transfusion strategies.
    MeSH term(s) Humans ; Platelet Transfusion/methods ; Blood Platelets/physiology ; Thrombocytopenia ; Polymerase Chain Reaction ; Cardiac Surgical Procedures
    Language English
    Publishing date 2023-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 74: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Begutachtung der sekundär sklerosierenden Cholangitis

    Müller, Th.

    Der medizinische Sachverständige

    2016  Volume 112, Issue 1, Page(s) 22

    Language German
    Document type Article
    ZDB-ID 124110-2
    ISSN 0025-8490
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Un I Zs.156: Show issues Location:
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  9. Article: Calibration of regional hydraulic and transport properties of an arid-region aquifer under modern and paleorecharge conditions using water levels and environmental tracers

    Müller, Th / Ward Sanford

    Hydrogeology journal. 2019 Mar., v. 27, no. 2

    2019  

    Abstract: A two-dimensional numerical groundwater flow model was established and calibrated for the hyperarid Najd region in southern Oman. The results indicate that recent recharge rates are required to sustain the observed groundwater heads in the Najd. The ... ...

    Title translation Calage des propriétés régionales hydrauliques et de transport d’un aquifère de région aride sous des conditions actuelles et anciennes de recharge utilisant des niveaux d’eau et des traceurs environnementaux Calibración de las propiedades hidráulicas y del transporte regional de un acuífero de una región árida en condiciones actuales y de paleorecarga utilizando niveles de agua y trazadores ambientales 利用水位和和环境示踪剂校准现代补给和古代补给条件下的干旱地区含水层的区域水力特性和传输特性 Calibração das propriedades hidráulicas e de transporte regionais de um aquífero de região árida sob condições modernas e de paleo recarga usando níveis de água e traçadores ambientais
    Abstract A two-dimensional numerical groundwater flow model was established and calibrated for the hyperarid Najd region in southern Oman. The results indicate that recent recharge rates are required to sustain the observed groundwater heads in the Najd. The model was also used to estimate possible ranges of past recharge rates and the effective porosity of the main aquifer unit. Recharge rates during past humid periods were estimated to be no more than 1–3 times modern rates. The effective porosity was estimated to be between 0.06 and 0.093. Insight into the nature of the long-term transport within the aquifer was gained by using transient model runs over the last 350 ka and (1) varying the recharge intensity (from 0.1 to 2.5 times modern), and (2) the timing and duration of humid and dry periods. Finally, results indicate that although recharge rates and the flow conditions have likely changed over time, a steady-state model is capable of reproducing the observed groundwater residence times in the Najd based on carbon-14, helium and chlorine-36 dating.
    Keywords aquifers ; carbon 14 ; groundwater ; groundwater flow ; helium ; models ; porosity ; tracer techniques ; Oman
    Language English
    Dates of publication 2019-03
    Size p. 685-701.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 1227482-3
    ISSN 0941-2816 ; 1431-2174
    ISSN 0941-2816 ; 1431-2174
    DOI 10.1007/s10040-018-1894-z
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    ((Einzelsign.)): Show issues

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  10. Article ; Online: A nait-associated and previously unreported mutation in the ITGB3 gene with a low frequency in the local population.

    Norrenbrock, Stefan / Müller, Thomas H / Mayer, Christiane / Doescher, Andrea

    Transfusion medicine (Oxford, England)

    2021  Volume 31, Issue 4, Page(s) 286–291

    Abstract: Background: Neonatal alloimmune thrombocytopenia is a rare but potentially severe postnatal complication caused by maternal allo-antibodies against platelet antigens of the newborn. In relatively few cases, immunisation against low-frequency antigens ... ...

    Abstract Background: Neonatal alloimmune thrombocytopenia is a rare but potentially severe postnatal complication caused by maternal allo-antibodies against platelet antigens of the newborn. In relatively few cases, immunisation against low-frequency antigens has been reported.
    Methods: Platelet antigens of a newborn with severe thrombocytopenia and his family members were investigated by serological and molecular biological methods. A real-time PCR assay was developed to reliably detect this mutation in pools of DNA from up to seven individuals.
    Results: Serological testing showed positive reactions of maternal plasma with paternal platelets but not with conventional platelet donor panels. Sequencing of the ITGB3 gene revealed a G > A polymorphism in position c.1915 of exon 12 for the father, the newborn and three of four paternal relatives. Screening of samples from a local population of 1575 Caucasian blood donors identified only a single individual with this mutation.
    Conclusion: This finding of a previously unreported private platelet antigen demonstrates that the identification of the target glycoprotein by MAIPA assay followed by sequencing of the affected gene can be combined with an efficient population screening by real-time PCR with pooling of DNA samples.
    MeSH term(s) Antigens, Human Platelet ; Blood Platelets ; Humans ; Infant, Newborn ; Integrin beta3/genetics ; Isoantibodies ; Mutation ; Polymorphism, Genetic ; Thrombocytopenia, Neonatal Alloimmune/genetics
    Chemical Substances Antigens, Human Platelet ; ITGB3 protein, human ; Integrin beta3 ; Isoantibodies
    Language English
    Publishing date 2021-03-16
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1067989-3
    ISSN 1365-3148 ; 0958-7578
    ISSN (online) 1365-3148
    ISSN 0958-7578
    DOI 10.1111/tme.12769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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