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  1. Article ; Online: Abschluss statt Ausschluss – die klinische Diagnosesicherung funktioneller Bewegungsstörungen.

    Weissbach, Anne / Bolte, Christina / Münchau, Alexander

    Der Nervenarzt

    2024  

    Abstract: Functional neurological movement disorders are common in neurological practice and lead to a high degree of impairment and chronification. Affected patients usually receive a diagnosis with considerable delay and often do not get disease-specific ... ...

    Title translation Conclusion instead of exclusion-The clinical diagnosis of functional movement disorders.
    Abstract Functional neurological movement disorders are common in neurological practice and lead to a high degree of impairment and chronification. Affected patients usually receive a diagnosis with considerable delay and often do not get disease-specific treatment. The reasons for this delay are related to extensive diagnostic measures to exclude other nonfunctional neurological diseases. As a consequence, functional movement disorders are typically communicated as diagnoses of exclusion, which makes it difficult for patients to understand and accept the diagnosis. This is particularly unfortunate, because in the majority of patients the diagnosis can be made with confidence based on clinical features, i.e., inconsistency and incongruence. The clarification of the symptoms and the resulting treatment options should be supplemented by patient-friendly explanations of the pathophysiological basis of the disease. In this way, patients are enabled to understand and accept the diagnosis. Moreover, it can put an end to the search for a diagnosis, which can sometimes take decades, and paves the way for treatment. Thus, the diagnosis by exclusion itself becomes the starting point for treatment and can itself have a therapeutic effect.
    Language German
    Publishing date 2024-02-14
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 123291-5
    ISSN 1433-0407 ; 0028-2804
    ISSN (online) 1433-0407
    ISSN 0028-2804
    DOI 10.1007/s00115-024-01613-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rethinking Movement Disorders.

    Münchau, Alexander / Klein, Christine / Beste, Christian

    Movement disorders : official journal of the Movement Disorder Society

    2024  Volume 39, Issue 3, Page(s) 472–484

    Abstract: At present, clinical practice and research in movement disorders (MDs) focus on the "normalization" of altered movements. In this review, rather than concentrating on problems and burdens people with MDs undoubtedly have, we highlight their hidden ... ...

    Abstract At present, clinical practice and research in movement disorders (MDs) focus on the "normalization" of altered movements. In this review, rather than concentrating on problems and burdens people with MDs undoubtedly have, we highlight their hidden potentials. Starting with current definitions of Parkinson's disease (PD), dystonia, chorea, and tics, we outline that solely conceiving these phenomena as signs of dysfunction falls short of their complex nature comprising both problems and potentials. Such potentials can be traced and understood in light of well-established cognitive neuroscience frameworks, particularly ideomotor principles, and their influential modern derivatives. Using these frameworks, the wealth of data on altered perception-action integration in the different MDs can be explained and systematized using the mechanism-oriented concept of perception-action binding. According to this concept, MDs can be understood as phenomena requiring and fostering flexible modifications of perception-action associations. Consequently, although conceived as being caught in a (trough) state of deficits, given their high flexibility, people with MDs also have high potential to switch to (adaptive) peak activity that can be conceptualized as hidden potentials. Currently, clinical practice and research in MDs are concerned with deficits and thus the "deep and wide troughs," whereas "scattered narrow peaks" reflecting hidden potentials are neglected. To better delineate and utilize the latter to alleviate the burden of affected people, and destigmatize their conditions, we suggest some measures, including computational modeling combined with neurophysiological methods and tailored treatment. © 2024 International Parkinson and Movement Disorder Society.
    MeSH term(s) Humans ; Movement Disorders ; Parkinson Disease ; Tics ; Dystonia ; Chorea
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Tourette-Syndrom und andere Tic-Störungen

    Müller-Vahl, Kirsten / Brandt, Valerie / Jakubovski, Ewgeni / Münchau, Alexander

    mit einem Manual zum Habit Reversal Training

    (Störungsspezifische Psychotherapie)

    2019  

    Abstract: Große Verhaltenstherapie-Studien haben in den letzten Jahren eine Trendwende in der Therapie des Gilles de la Tourette-Syndroms eingeleitet. Dabei hat sich insbesondere das Habit Reversal Training (HRT) als effektiv durchgesetzt. Ausgehend von der ... ...

    Author's details Kirsten Müller-Vahl, Valerie Brandt, Ewgeni Jakubovski, Alexander Münchau
    Series title Störungsspezifische Psychotherapie
    Abstract Große Verhaltenstherapie-Studien haben in den letzten Jahren eine Trendwende in der Therapie des Gilles de la Tourette-Syndroms eingeleitet. Dabei hat sich insbesondere das Habit Reversal Training (HRT) als effektiv durchgesetzt. Ausgehend von der klinischen Phänomenologie und den neurobiologischen Grundlagen der psychotherapeutischen Behandlung des Tourette-Syndroms, mit einem Hauptaugenmerk auf das HRT, bietet dieses Buch ein praxisrelevantes Manual für Erwachsene.
    Keywords Tourette-Syndrom ; Verhaltenstherapie ; Tic
    Subject Gilles-de-la-Tourette-Syndrom
    Language German
    Size 168 Seiten, Illustrationen
    Edition 1. Auflage
    Publisher Verlag W. Kohlhammer
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT019354877
    ISBN 978-3-17-032653-8 ; 3-17-032653-8 ; 9783170326545 ; 9783170326552 ; 9783170326569 ; 3170326546 ; 3170326554 ; 3170326562
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Towards a systematization of brain oscillatory activity in actions.

    Beste, Christian / Münchau, Alexander / Frings, Christian

    Communications biology

    2023  Volume 6, Issue 1, Page(s) 137

    Abstract: Information processing in the brain is governed by oscillatory activity. Activity oscillations in specific frequency bands (theta, alpha, beta and gamma) have been associated with various cognitive functions. A drawback of this is that the plethora of ... ...

    Abstract Information processing in the brain is governed by oscillatory activity. Activity oscillations in specific frequency bands (theta, alpha, beta and gamma) have been associated with various cognitive functions. A drawback of this is that the plethora of findings led to considerable uncertainty as to the functional relevance of activity in different frequency bands and their interrelation. Here, we use a novel cognitive-science theoretical framework to better understand and conceptually harmonize neurophysiological research on human action control. We outline how this validated starting point can systematize and probably reframe the functional relevance of oscillatory activity relevant for action control and beyond.
    MeSH term(s) Humans ; Brain/physiology ; Cognition/physiology ; Brain Waves
    Language English
    Publishing date 2023-02-02
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-04531-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Funktionelle neurologische Bewegungsstörungen - Ein Update zur Diagnosestellung, Forschung und Therapie

    Weißbach, Anne / Münchau, Alexander

    Nervenheilkunde

    2023  Volume 42, Issue 8, Page(s) 507

    Language German
    Document type Article
    ZDB-ID 604504-2
    ISSN 0722-1541
    Database Current Contents Medicine

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  6. Article: Funktionelle neurologische Bewegungsstörungen - Ein Update zur Diagnosestellung, Forschung und Therapie

    Weißbach, Anne / Münchau, Alexander

    Nervenheilkunde

    2023  Volume 42, Issue 8, Page(s) 507

    Language German
    Document type Article
    ZDB-ID 604504-2
    ISSN 0722-1541
    Database Current Contents Medicine

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  7. Article: Funktionelle neurologische Bewegungsstörungen – Ein Update zur Diagnosestellung, Forschung und Therapie

    Weißbach, Anne / Münchau, Alexander

    Nervenheilkunde

    2023  Volume 42, Issue 08, Page(s) 507–509

    Language German
    Publishing date 2023-07-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2223503-6
    ISSN 2567-5788 ; 0722-1541
    ISSN (online) 2567-5788
    ISSN 0722-1541
    DOI 10.1055/a-2083-8039
    Database Thieme publisher's database

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  8. Article ; Online: Neurophysiological processes reflecting the effects of the immediate past during the dynamic management of actions.

    Rawish, Tina / Wendiggensen, Paul / Friedrich, Julia / Frings, Christian / Münchau, Alexander / Beste, Christian

    NeuroImage

    2024  Volume 288, Page(s) 120526

    Abstract: In recent years, there has been many efforts to establish a comprehensive theoretical framework explaining the working mechanisms involved in perception-action integration. This framework stresses the importance of the immediate past on mechanisms ... ...

    Abstract In recent years, there has been many efforts to establish a comprehensive theoretical framework explaining the working mechanisms involved in perception-action integration. This framework stresses the importance of the immediate past on mechanisms supporting perception-action integration. The present study investigates the neurophysiological principles of dynamic perception-action bindings, particularly considering the influence of the immediate history on action control mechanisms. For this purpose, we conducted an established stimulus-response binding paradigm during EEG recording. The SR-task measures stimulus-response binding in terms of accuracy and reaction time differences depending on the degree of feature overlap between conditions. Alpha, beta and theta band activity in distinct time domains as well as associated brain regions were investigated applying time-frequency analyses, a beamforming approach as well as correlation analyses. We demonstrate, for the first time, interdependencies of neuronal processes relying on the immediate past. The reconfiguration of an action seems to overwrite immediately preceding processes. The analyses revealed modulations of theta (TBA), alpha (ABA) and beta band activity (BBA) in connection with fronto-temporal structures supporting the theoretical assumptions of the considered conceptual framework. The close interplay of attentional modulation by gating irrelevant information (ABA) and binding and retrieval processes (TBA) is reflected by the correlation of ABA in all pre-probe-intervals with post-probe TBA. Likewise, the role of BBA in maintaining the event file until retrieval is corroborated by BBA preceding the TBA-associated retrieval of perception-action codes. Following action execution, TBA shifted towards visual association cortices probably reflecting preparation for upcoming information, while ABA and BBA continue to reflect processes of attentional control and information selection for goal-directed behavior. The present work provides the first empirical support for concepts about the neurophysiological mechanisms of dynamic management of perception and action.
    MeSH term(s) Humans ; Brain ; Attention/physiology ; Cerebral Cortex ; Electroencephalography
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2024.120526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Partially Levodopa-Responsive Parkinsonism in a Carrier of a Novel Pathogenic CLTC Variant.

    Usnich, Tatiana / Becker, Leonie F / Nagel, Inga / Bäumer, Tobias / Münchau, Alexander

    Movement disorders clinical practice

    2024  

    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Letter
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.14037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Seltene neurologische Erkrankungen

    Münchau, Alexander

    Nervenheilkunde

    2018  Volume 37, Issue 03, Page(s) 119–121

    Language German
    Publishing date 2018-02-01
    Publisher Schattauer GmbH
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2223503-6
    ISSN 2567-5788 ; 0722-1541
    ISSN (online) 2567-5788
    ISSN 0722-1541
    DOI 10.1055/s-0038-1642085
    Database Thieme publisher's database

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