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Article ; Online: Hb Andrew-Minneapolis Variant in a Turkish Family

Sümter, Hamza / Mızrak, Soycan / Ceylaner, Serdar / Canatan, Duran

Turkish journal of haematology : official journal of Turkish Society of Haematology

2023 Volume 40, Issue 3, Page(s) 234–235

MeSH term(s)	Humans ; Hemoglobins, Abnormal/genetics ; Hemoglobins, Abnormal/analysis ; Chromatography, High Pressure Liquid
Chemical Substances	hemoglobin Andrew-Minneapolis (53986-72-4) ; Hemoglobins, Abnormal
Language	English
Publishing date	2023-07-31
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2185903-6
ISSN	1308-5263 ; 1300-7777
ISSN (online)	1308-5263
ISSN	1300-7777
DOI	10.4274/tjh.galenos.2023.2023-0239
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Zs.A 6534: Show issues

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Article ; Online: Diagnostic Value of Inflammatory Factors in Patients with Gallbladder Cancer, Dysplasia, and Cholecystitis.

Kucuk, Sirin / Mızrak, Soycan

Cancer control : journal of the Moffitt Cancer Center

2021 Volume 28, Page(s) 10732748211033746

Abstract: Background: Involving pre-sampled patients with cholecystitis, dysplasia, and adenocarcinoma, the present study aimed to compare the neutrophil/lymphocyte (NLR), monocyte/lymphocyte (MLR), platelet/lymphocyte (PLR) ratios, and plateletcrit (PCT), mean ... ...

Abstract	Background: Involving pre-sampled patients with cholecystitis, dysplasia, and adenocarcinoma, the present study aimed to compare the neutrophil/lymphocyte (NLR), monocyte/lymphocyte (MLR), platelet/lymphocyte (PLR) ratios, and plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW) values and to determine their prognostic importance. Methods: The present study involved 187 cholecystectomy specimens that were diagnosed as cholecystitis, dysplasia, and adenocarcinoma. Preoperative neutrophil, monocyte, lymphocyte, and platelet counts, NLR, MLR, and PLR ratios, and PCT, MPV, and PDW levels of the same patient groups were retrospectively recorded. Results: In the present study, the cut-off values for dysplasia of NLR, PLR, and MLR were found as 1.61, 81.45, and .19, whereas those for cancer of NLR, PLR, and MLR were 2.65, 182.69, and .35, respectively. The NLR, PLR, and MLR values of the chronic cholecystitis and chronic calculous cholecystitis groups were statistically significantly lower than those of the chronic active calculous cholecystitis group ( Conclusion: According to the results of the present study, using additional imaging methods, acute-phase cholecystitis can be distinguished using preoperative neutrophil and monocyte counts, and NLR, PLR, and MLR cut-off values can be used to distinguish dysplasia, which is the antecedent of gallbladder cancer. It is thought that this might provide patients with an advantage in terms of early treatment and survival.
MeSH term(s)	Blood Platelets/metabolism ; Cholecystitis/blood ; Cholecystitis/pathology ; Gallbladder Neoplasms/blood ; Gallbladder Neoplasms/pathology ; Humans ; Leukocytes/metabolism ; Lymphocytes/metabolism ; Monocytes/metabolism ; Neutrophils/metabolism ; Prognosis ; Retrospective Studies
Language	English
Publishing date	2021-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1328503-8
ISSN	1526-2359 ; 1073-2748
ISSN (online)	1526-2359
ISSN	1073-2748
DOI	10.1177/10732748211033746
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Zs.A 4467: Show issues

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Article ; Online: Serum Cingulin levels are increased in children with autism spectrum disorder.

Artık, Abdülbaki / Işık, Ümit / Gündüz, Bahar Öztelcan / Mızrak, Soycan

International journal of developmental disabilities

2023 Volume 69, Issue 5, Page(s) 762–766

Abstract: Background: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders in which the underlying pathogenesis and etiologic factors are not fully understood. The blood brain barrier (BBB) plays a critical role in central nervous system ... ...

Abstract	Background: Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders in which the underlying pathogenesis and etiologic factors are not fully understood. The blood brain barrier (BBB) plays a critical role in central nervous system defense by limiting access to circulating solutes, macromolecules, and cells that can negatively affect neuronal activity. The loss of BBB integrity is likely to be seen as a common pathologic finding for many psychiatric disorders such as schizophrenia, ASD, and mood disorders. In this study, we aimed to investigate whether serum Cingulin levels are associated with ASD. Subjects and methods: A total of 40 treatment-naive children with ASD and 40 healthy controls were included in the present study. The Schedule for Affective Disorders and Schizophrenia for School-Aged Children, Present and Lifetime Version-DSM-5 (K-SADS-PL-DSM-5) has been used to screen healthy controls for psychiatric disorders by a psychiatrist after a physical examination by a paediatrician. The clinical severity of the ASD symptoms has been assessed by the Childhood Autism Rating Scale (CARS). Venous blood samples were collected and serum Cingulin levels were measured. Results: When the ASD and control groups were compared, CARS and Cingulin values of the patient group were statistically higher than the healthy group. There is a statistically positive correlation between CARS and Cingulin values. Discussion: To the best of our knowledge, this study is a first in the literature conducted about the serum Cingulin levels, which is a component of BBB, among patients with ASD. Our findings demonstrate that serum Cingulin levels are meaningfully higher in ASD group compared to the healthy control group. It has been also indicated that there has been a meaningful relationship between serum Cingulin levels and ASD symptom severity.
Language	English
Publishing date	2023-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2625980-1
ISSN	2047-3877 ; 2047-3869
ISSN (online)	2047-3877
ISSN	2047-3869
DOI	10.1080/20473869.2023.2200314
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Article ; Online: Fecal neopterin level determination: can be a useful screening test for colorectal polyps?

Kilciler, Ayse Guldem / Kutluana, Ufuk / Mizrak, Soycan

European journal of gastroenterology & hepatology

2021 Volume 33, Issue 5, Page(s) 655–661

Abstract: Background: Colorectal cancer (CRC) is a leading cause of cancer death worldwide. The main precursor lesion leading to CRC is the adenomatous colorectal polyp (CP). Nowadays, there is no recognized perfect screening test of CP and CRC. Neopterin is an ... ...

Abstract	Background: Colorectal cancer (CRC) is a leading cause of cancer death worldwide. The main precursor lesion leading to CRC is the adenomatous colorectal polyp (CP). Nowadays, there is no recognized perfect screening test of CP and CRC. Neopterin is an important marker of cellular inflammation. In this study, we aimed to evaluate comparatively immunochromatographic fecal occult blood test (iFOBT) and fecal neopterin levels (FNLs) in patients with CP and controls. Methods: One hundred eleven patients diagnosed with CP and 68 individuals with negative colonoscopy were included in the study. iFOBT and FNLs were assessed in patients and controls. Results: FNLs and iFOBT positivity were significantly higher in patients with CP than in controls (17.15 ± 3.55 µmol/L/g vs. 12.25 ± 2.19 µmol/L/g, P = 0.00 and 46.8% vs. 14.8%, P = 0.00, respectively). FNLs were significantly higher in cases with adenomatous polyps than in hyperplastic polyps (P = 0.002). FNL ≥14.00 µmol/L/g was the best cutoff value to differentiate between patients with CP from controls (P = 0.000). A multiple logistic regression analysis showed that high FNL was positively correlated with presence, number, diameter of CPs, and presence of adenoma (P < 0.005). The sensitivity of high FNL for CP was 81.1%, which was superior to iFOBT positivity (47.7%, P < 0.001). Discussion: FNL level is significantly increased in CPs. The FNL exhibited increased sensitivity for identifying CP and adenomatous lesions compared with iFOBT. FNL determination could have as a new screening and diagnostic test for CP.
MeSH term(s)	Colonic Polyps/diagnosis ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Diagnostic Tests, Routine ; Humans ; Mass Screening ; Neopterin ; Occult Blood
Chemical Substances	Neopterin (670-65-5)
Language	English
Publishing date	2021-02-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1034239-4
ISSN	1473-5687 ; 0954-691X
ISSN (online)	1473-5687
ISSN	0954-691X
DOI	10.1097/MEG.0000000000002036
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Article ; Online: Increased serum levels of tumour necrosis factor-like weak inducer of apoptosis in children with autism spectrum disorder.

Artık, Abdülbaki / Öztelcan Gündüz, Bahar / Mızrak, Soycan / Işık, Ümit

International journal of developmental disabilities

2022 Volume 69, Issue 4, Page(s) 611–616

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2022-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2625980-1
ISSN	2047-3877 ; 2047-3869
ISSN (online)	2047-3877
ISSN	2047-3869
DOI	10.1080/20473869.2022.2143033
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Article ; Online: The effect of long term nicotine exposure on endothelial function in rats.

Mizrak, Soycan / Göksel Ülker, Sibel / Ercan, Gulinnaz / Sönmez, Birol

Drug and chemical toxicology

2020 Volume 45, Issue 4, Page(s) 1522–1527

Abstract: Nicotine is one of the main chemicals in the cigarettes responsible for addiction formation. Many researches investigating the effects of nicotine on coronary heart disease and atherosclerosis have been published. The robustness of endothelial cells is ... ...

Abstract	Nicotine is one of the main chemicals in the cigarettes responsible for addiction formation. Many researches investigating the effects of nicotine on coronary heart disease and atherosclerosis have been published. The robustness of endothelial cells is very important in the development of atherosclerosis. The aim of this study is to evaluate the effect of nicotine exposure on the indicators of endothelial function either by examining the vascular reactivity of aorta taken from rats exposed to nicotine during prenatal (starting by the mating period) and postnatal periods (6 weeks after delivery), or by determining the protein expression of nitric oxide synthase (NOS) enzymes, NADPH oxidase (Nox) and nitrotyrosine. Chronic nicotine exposure at 6 mg/L in drinking water produced a significant decrease in phenylephrine contractility of thoracic aortic rings compared to control and low dose exposure group (0.4 mg/L,
MeSH term(s)	Animals ; Aorta, Thoracic/metabolism ; Atherosclerosis/metabolism ; Endothelial Cells ; Endothelium/metabolism ; Endothelium, Vascular ; NADPH Oxidases/metabolism ; NADPH Oxidases/pharmacology ; Nicotine/toxicity ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/metabolism ; Nitric Oxide Synthase/pharmacology ; Rats ; Vasodilation
Chemical Substances	Nitric Oxide (31C4KY9ESH) ; Nicotine (6M3C89ZY6R) ; Nitric Oxide Synthase (EC 1.14.13.39) ; NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2020-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	548368-2
ISSN	1525-6014 ; 0148-0545
ISSN (online)	1525-6014
ISSN	0148-0545
DOI	10.1080/01480545.2020.1845714
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Article: Can neopterin be a useful immune biomarker for differentiating gastric intestinal metaplasia and gastric atrophy from non-atrophic non-metaplastic chronic gastritis?

Kutluana, Ufuk / Kilciler, Ayse Guldem / Mizrak, Soycan / Dilli, Utku

Gastroenterologia y hepatologia

2019 Volume 42, Issue 5, Page(s) 289–295

Abstract: Introduction: Helicobacter pylori (H. pylori) is closely related to pre-neoplastic lesions such as gastric atrophy (GA), gastric intestinal metaplasia (GIM) and eventually gastric cancer (GC). The diagnosis of GIM and GA is usually based on endoscopic ... ...

Abstract	Introduction: Helicobacter pylori (H. pylori) is closely related to pre-neoplastic lesions such as gastric atrophy (GA), gastric intestinal metaplasia (GIM) and eventually gastric cancer (GC). The diagnosis of GIM and GA is usually based on endoscopic and histopathological features. Nowadays, there are no recognized good serological markers of GIM and GA. Neopterin is an important marker of cellular inflammation. In this study, we aimed to comparatively evaluate C-reactive protein (CRP) and neopterin levels in patients with GIM, GA and chronic gastritis, and to show the increased serum neopterin levels in GIM and GA according to non-atrophic and non-metaplastic chronic gastritis. Patients and methods: 98 patients with GIM and 68 patients with GA and 70 patients with non-atrophic non-metaplastic gastritis were included in the study. CRP and neopterin levels were assessed in patients and controls. Results: CRP and neopterin levels were significantly higher in patients with GIM and GA than in controls (p<0.05 and p<0.001, respectively). A multiple logistic regression analysis showed that high levels of serum neopterin were positively correlated with GIM and GA. According to the ROC curve analysis, the best cut-off value to differentiate between patients with GIM and/or GA from controls was ≥10.15nmol/l (p<0.001) for serum neopterin levels and ≥1.95mg/l (p<0.001) for serum CRP levels. Discussion: CRP and neopterin levels are significantly increased in GIM and GA. Neopterin may be a useful biomarker and diagnostic test for detecting GIM and GA in clinical practice. CRP levels may be helpful for this observation.
MeSH term(s)	Adult ; Aged ; Biomarkers/blood ; C-Reactive Protein/analysis ; Chronic Disease ; Diagnosis, Differential ; Female ; Gastritis/blood ; Gastritis/diagnosis ; Gastritis, Atrophic/blood ; Gastritis, Atrophic/diagnosis ; Humans ; Intestines/pathology ; Male ; Metaplasia/blood ; Metaplasia/diagnosis ; Middle Aged ; Neopterin/blood ; Stomach/pathology
Chemical Substances	Biomarkers ; Neopterin (670-65-5) ; C-Reactive Protein (9007-41-4)
Language	Spanish
Publishing date	2019-02-20
Publishing country	Spain
Document type	Comparative Study ; Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2019.01.005
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Article ; Online: The effect of long-term nicotine exposure on bone mineral density and oxidative stress in female Swiss Albino rats.

Turan, Volkan / Mizrak, Soycan / Yurekli, Banu / Yilmaz, Candeger / Ercan, Gulinnaz

Archives of gynecology and obstetrics

2013 Volume 287, Issue 2, Page(s) 281–287

Abstract: Purpose: To evaluate the effect of long-term low or high-dose nicotine exposure on bone mass via measuring bone mineral density (BMD) and oxidant-antioxidant status markers.: Methods: Thirty-five female Swiss Albino rats weighing 70 ± 10 g were ... ...

Abstract	Purpose: To evaluate the effect of long-term low or high-dose nicotine exposure on bone mass via measuring bone mineral density (BMD) and oxidant-antioxidant status markers. Methods: Thirty-five female Swiss Albino rats weighing 70 ± 10 g were divided as the control group (n = 12), low-dose nicotine group (n = 12) and high-dose nicotine group (n = 11). While the control group was given only normal drinking water, the low-dose nicotine group had 0.4 mg/kg per day and the high-dose nicotine group, 6.0 mg/kg per day of nicotine added to their water for the period of 1 year. BMD was determined with X-ray absorptiometry of lumbar vertebra, corpus femoris, proximal and distal femur. To evaluate oxidant-antioxidant status malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activities were determined. Results: When comparing the nicotine groups and controls, neither BMD nor oxidant-antioxidant status markers showed any statistically significant difference. In comparison to the controls, 12 months of high-dose oral nicotine exposure did not have a significant effect on BMD and low-dose nicotine exposure led to a statistically insignificant increase in BMD. Conclusions: Contrary to common belief, the results of this study show that nicotine is not responsible for the decrease in BMD leading to osteoporosis frequently seen in smokers. However, there is a need to explore the other harmful materials in tobacco which may be responsible for the alterations seen in BMD of smokers.
MeSH term(s)	Absorptiometry, Photon ; Animals ; Biomarkers ; Bone Density/drug effects ; Catalase/blood ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Malondialdehyde/blood ; Nicotine/administration & dosage ; Nicotine/pharmacology ; Nicotinic Agonists/administration & dosage ; Nicotinic Agonists/pharmacology ; Oxidative Stress/drug effects ; Random Allocation ; Rats ; Superoxide Dismutase/blood
Chemical Substances	Biomarkers ; Nicotinic Agonists ; Malondialdehyde (4Y8F71G49Q) ; Nicotine (6M3C89ZY6R) ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2013-02
Publishing country	Germany
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-012-2535-8
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Article: The effect of long term nicotine exposure on nicotine addiction and fetal growth.

Mızrak, Soycan / Turan, Volkan / Terek, Mustafa Coşan / Ercan, Gülinnaz

Journal of the Turkish German Gynecological Association

2012 Volume 13, Issue 4, Page(s) 237–241

Abstract: Objective: To investigate the effect of nicotine exposure starting before coitus and continuing during pregnancy and lactation period on delivery rate, fetal growth and nicotine addiction in rats.: Material and methods: Ten female Swiss Albino rats ... ...

Abstract	Objective: To investigate the effect of nicotine exposure starting before coitus and continuing during pregnancy and lactation period on delivery rate, fetal growth and nicotine addiction in rats. Material and methods: Ten female Swiss Albino rats were divided into 2 groups as the nicotine group (NG) (n=5), and the control group (n=5), conceived by adding 2 male rats to each group. While the control group was given only normal drinking water, 0.4 mg/kg body weight (BW)/day nicotine was given to the NG in drinking water. After delivery, the BWs of pups were recorded weekly for 6 weeks and their drinking water preferences were assessed. Meanwhile, pups of the NG continued to receive 0.4 mg/kg/day nicotine for 12 months while the controls continued with normal drinking water. Results: At the end of the 6(th) week, it was determined that 30 (69%) rats out of 43 in the NG and only 7 rats (20%) out of 35 in the control group preferred the nicotine added drinking water (p<0.05). No significant difference was observed between control and NGs in post-natal birth weights and BWs recorded for 6 weeks. On the contrary, a significant decrease (p< 0.05) was observed in the BWs of NG at the end of 12 months nicotine exposure. Conclusion: Use of maternal nicotine in pregnancy and lactation periods, even at a low dose, may be effective in nicotine addiction development although it may not affect delivery rate, and BWs of pups after delivery and during six weeks follow up in the lactation period.
Language	English
Publishing date	2012-12-01
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2425806-4
ISSN	1309-0380 ; 1303-9695 ; 1309-0399
ISSN (online)	1309-0380 ; 1303-9695
ISSN	1309-0399
DOI	10.5152/jtgga.2012.37
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Article ; Online: Effect of nicotine on RANKL and OPG and bone mineral density.

Mizrak, Soycan / Turan, Volkan / Inan, Sevinc / Uysal, Aysegul / Yilmaz, Candeger / Ercan, Gülinnaz

Journal of investigative surgery : the official journal of the Academy of Surgical Research

2014 Volume 27, Issue 6, Page(s) 327–331

Abstract: Aim: The signaling pathway OPG/RANK/RANKL is a key in maintaining the balance between the activity of osteoblasts and osteoclasts in order to prevent bone loss. In this study, our aim was to assess the effects of long-term nicotine exposure on plasma ... ...

Abstract	Aim: The signaling pathway OPG/RANK/RANKL is a key in maintaining the balance between the activity of osteoblasts and osteoclasts in order to prevent bone loss. In this study, our aim was to assess the effects of long-term nicotine exposure on plasma RANKL and OPG levels, tissue RANKL and OPG immunoreactivities, and bone mineral density (BMD) scores in rats. Materials and methods: Thirty-six Swiss Albino rats weighing 70 ± 10 g were divided into three groups. While the controls (n = 12) were only given normal drinking water, for low-dose nicotine (LDN) group (n = 12) 0.4 mg/kg/day; for high-dose nicotine (HDN) group (n = 12), 6.0 mg/kg/day nicotine was added to drinking water for a year. At the end of 12th month, BMD scores were measured using an X-ray absorptiometry and bone turnover was assessed by measuring plasma RANKL and OPG levels and RANKL and OPG immunoreactivities in tail vertebrae of the rats. Results: There was no statistically significant difference in BMD scores of lumbar spine and femoral regions of the nicotine groups in comparison to controls. Plasma OPG levels were found to be significantly higher in HDN group, in comparison to the controls and LDN groups (p = .001) unlike plasma RANKL levels. Tissue RANKL and OPG immunoreactivities decreased significantly in the LDN and HDN groups (p < .001, p < .01, respectively). Conclusions: The results of this study show that nicotine is not primarily responsible for the decrease in BMD frequently seen in smokers. Measuring plasma RANKL and OPG levels did not reflect tissue immunoreactivities.
MeSH term(s)	Absorptiometry, Photon ; Administration, Oral ; Animals ; Bone Density/drug effects ; Dose-Response Relationship, Drug ; Female ; Male ; Models, Animal ; Nicotine/administration & dosage ; Nicotine/pharmacology ; Osteoprotegerin/metabolism ; RANK Ligand/metabolism ; Rats ; Rats, Inbred Strains ; Risk Factors ; Spine/drug effects ; Spine/metabolism
Chemical Substances	Osteoprotegerin ; RANK Ligand ; Tnfrsf11b protein, rat ; Nicotine (6M3C89ZY6R)
Language	English
Publishing date	2014-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639444-9
ISSN	1521-0553 ; 0894-1939
ISSN (online)	1521-0553
ISSN	0894-1939
DOI	10.3109/08941939.2014.916369
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