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  1. Article ; Online: Biodegradable bioelectronics for biomedical applications.

    Lee, Seunghyeon / M Silva, Saimon / Caballero Aguilar, Lilith M / Eom, Taesik / Moulton, Simon E / Shim, Bong Sup

    Journal of materials chemistry. B

    2022  Volume 10, Issue 42, Page(s) 8575–8595

    Abstract: Biodegradable polymers have been widely used in tissue engineering with the potential to be replaced by regenerative tissue. While conventional bionic interfaces are designed to be implanted in living tissue and organs permanently, biocompatible and ... ...

    Abstract Biodegradable polymers have been widely used in tissue engineering with the potential to be replaced by regenerative tissue. While conventional bionic interfaces are designed to be implanted in living tissue and organs permanently, biocompatible and biodegradable electronic materials are now progressing a paradigm shift towards transient and regenerative bionic engineering. For example, biodegradable bioelectronics can monitor physiologies in a body, transiently rehabilitate disease symptoms, and seamlessly form regenerative interfaces from synthetic electronic devices to tissues by reducing inflammatory foreign-body responses. Conventional electronic materials have not readily been considered biodegradable. However, several strategies have been adopted for designing electroactive and biodegradable materials systems: (1) conductive materials blended with biodegradable components, (2) molecularly engineered conjugated polymers with biodegradable moieties, (3) naturally derived conjugated biopolymers, and (4) aqueously dissolvable metals with encapsulating layers. In this review, we endeavor to present the technical bridges from electrically active and biodegradable material systems to edible and biodegradable electronics as well as transient bioelectronics with pre-clinical bio-instrumental applications, including biodegradable sensors, neural and tissue engineering, and intelligent drug delivery systems.
    MeSH term(s) Biocompatible Materials ; Tissue Engineering ; Polymers ; Electronics ; Electric Conductivity
    Chemical Substances Biocompatible Materials ; Polymers
    Language English
    Publishing date 2022-11-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d2tb01475k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Potential Pulse-Facilitated Active Adsorption of Lubricin Polymer Brushes Can Both Accelerate Self-Assembly and Control Grafting Density.

    Khwannimit, Duangruedee / M Silva, Saimon / Desroches, Pauline E / Quigley, Anita F / Kapsa, Robert M I / Greene, George W / Moulton, Simon E

    Langmuir : the ACS journal of surfaces and colloids

    2021  Volume 37, Issue 37, Page(s) 11188–11193

    Abstract: Self-assembled lubricin (LUB) monolayers are an effective antiadhesive coating for biomedical applications. Long deposition times and limited control over the monolayer grafting density remain impediments to commercialization and applications in advanced ...

    Abstract Self-assembled lubricin (LUB) monolayers are an effective antiadhesive coating for biomedical applications. Long deposition times and limited control over the monolayer grafting density remain impediments to commercialization and applications in advanced sensor technologies. This work describes a novel potential pulse-facilitated coating method that reduces coating times to mere seconds while also providing high-level control over the achieved grafting density. This is the first time that the potential pulse-facilitated method is applied for direct assembling of a large and complex polyelectrolyte.
    MeSH term(s) Adsorption ; Glycoproteins ; Polyelectrolytes ; Polymers
    Chemical Substances Glycoproteins ; Polyelectrolytes ; Polymers ; lubricin
    Language English
    Publishing date 2021-09-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.1c02263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Potential Pulse-Facilitated Active Adsorption of Lubricin Polymer Brushes Can Both Accelerate Self-Assembly and Control Grafting Density

    Khwannimit, Duangruedee / M. Silva, Saimon / Desroches, Pauline E. / Quigley, Anita F. / Kapsa, Robert M. I. / Greene, George W. / Moulton, Simon E.

    Langmuir. 2021 Sept. 10, v. 37, no. 37

    2021  

    Abstract: Self-assembled lubricin (LUB) monolayers are an effective antiadhesive coating for biomedical applications. Long deposition times and limited control over the monolayer grafting density remain impediments to commercialization and applications in advanced ...

    Abstract Self-assembled lubricin (LUB) monolayers are an effective antiadhesive coating for biomedical applications. Long deposition times and limited control over the monolayer grafting density remain impediments to commercialization and applications in advanced sensor technologies. This work describes a novel potential pulse-facilitated coating method that reduces coating times to mere seconds while also providing high-level control over the achieved grafting density. This is the first time that the potential pulse-facilitated method is applied for direct assembling of a large and complex polyelectrolyte.
    Keywords adsorption ; commercialization ; electrolytes ; polymers
    Language English
    Dates of publication 2021-0910
    Size p. 11188-11193.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.1c02263
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Novel Boundary Lubrication Mechanisms from Molecular Pillows of Lubricin Brush-Coated Graphene Oxide Nanosheets

    Russo, Matthew J. / Han, Mingyu / Menon, Nikhil G. / Quigley, Anita F. / Kapsa, Robert M. I. / Moulton, Simon E. / Guijt, Rosanne M. / M Silva, Saimon / Schmidt, Tannin A. / Greene, George W.

    Langmuir. 2022 Apr. 24, v. 38, no. 18

    2022  

    Abstract: There are numerous biomedical applications where the interfacial shearing of surfaces can cause wear and friction, which can lead to a variety of medical complications such as inflammation, irritation, and even bacterial infection. We introduce a novel ... ...

    Abstract There are numerous biomedical applications where the interfacial shearing of surfaces can cause wear and friction, which can lead to a variety of medical complications such as inflammation, irritation, and even bacterial infection. We introduce a novel nanomaterial additive comprised of two-dimensional graphene oxide nanosheets (2D-NSCs) coated with lubricin (LUB) to reduce the amount of tribological stress in biomedical settings, particularly at low shear rates where boundary lubrication dominates. LUB is a glycoprotein found in the articular joints of mammals and has recently been discovered as an ocular surface boundary lubricant. The ability of LUB to self-assemble into a “telechelic” brush layer on a variety of surfaces was exploited here to coat the top and bottom surfaces of the ultrathin 2D-NSCs in solution, effectively creating a biopolymer-coated nanosheet. A reduction in friction of almost an order of magnitude was measured at a bioinspired interface. This reduction was maintained after repeated washing (5×), suggesting that the large aspect ratio of the 2D-NSCs facilitates effective lubrication even at diluted concentrations. Importantly, and unlike LUB-only treatment, the lubrication effect can be eliminated over 15 rinsing cycles, suggesting that the LUB-coated 2D-NSCs do not exhibit any binding interactions with the shearing surfaces. The effective lubricating properties of the 2D-NSCs combined with full reversibility through rinsing make the LUB-coated 2D-NSCs an intriguing candidate as a lubricant for biomedical applications.
    Keywords bacterial infections ; friction ; glycoproteins ; graphene oxide ; inflammation ; lubricants ; lubrication ; nanosheets
    Language English
    Dates of publication 2022-0424
    Size p. 5351-5360.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.1c02970
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Rapid Point-of-Care Electrochemical Sensor for the Detection of Cancer Tn Antigen Carbohydrate in Whole Unprocessed Blood.

    M Silva, Saimon / Langley, Daniel P / Cossins, Luke R / Samudra, Anushka N / Quigley, Anita F / Kapsa, Robert M I / Tothill, Richard W / Greene, George W / Moulton, Simon E

    ACS sensors

    2022  Volume 7, Issue 11, Page(s) 3379–3388

    Abstract: Improving outcomes for cancer patients during treatment and monitoring for cancer recurrence requires personalized care which can only be achieved through regular surveillance for biomarkers. Unfortunately, routine detection for blood-based biomarkers is ...

    Abstract Improving outcomes for cancer patients during treatment and monitoring for cancer recurrence requires personalized care which can only be achieved through regular surveillance for biomarkers. Unfortunately, routine detection for blood-based biomarkers is cost-prohibitive using currently specialized laboratories. Using a rapid self-assembly sensing interface amenable to methods of mass production, we demonstrate the ability to detect and quantify a small carbohydrate-based cancer biomarker, Tn antigen (αGalNAc-Ser/Thr) in a small volume of blood, using a test format strip reminiscent of a blood glucose test. The detection of Tn antigen at picomolar levels is achieved through a new transduction mechanism based on the impact of Tn antigen interactions on the molecular dynamic motion of a lectin cross-linked lubricin antifouling brush. In tests performed on retrospective blood plasma samples from patients presenting three different tumor types, differentiation between healthy and diseased patients was achieved, highlighting the clinical potential for cancer monitoring.
    MeSH term(s) Humans ; Point-of-Care Systems ; Retrospective Studies ; Neoplasms/diagnosis ; Carbohydrates
    Chemical Substances Tn antigen ; Carbohydrates
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-3694
    ISSN (online) 2379-3694
    DOI 10.1021/acssensors.2c01460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Novel Boundary Lubrication Mechanisms from Molecular Pillows of Lubricin Brush-Coated Graphene Oxide Nanosheets.

    Russo, Matthew J / Han, Mingyu / Menon, Nikhil G / Quigley, Anita F / Kapsa, Robert M I / Moulton, Simon E / Guijt, Rosanne M / M Silva, Saimon / Schmidt, Tannin A / Greene, George W

    Langmuir : the ACS journal of surfaces and colloids

    2022  Volume 38, Issue 18, Page(s) 5351–5360

    Abstract: There are numerous biomedical applications where the interfacial shearing of surfaces can cause wear and friction, which can lead to a variety of medical complications such as inflammation, irritation, and even bacterial infection. We introduce a novel ... ...

    Abstract There are numerous biomedical applications where the interfacial shearing of surfaces can cause wear and friction, which can lead to a variety of medical complications such as inflammation, irritation, and even bacterial infection. We introduce a novel nanomaterial additive comprised of two-dimensional graphene oxide nanosheets (2D-NSCs) coated with lubricin (LUB) to reduce the amount of tribological stress in biomedical settings, particularly at low shear rates where boundary lubrication dominates. LUB is a glycoprotein found in the articular joints of mammals and has recently been discovered as an ocular surface boundary lubricant. The ability of LUB to self-assemble into a "telechelic" brush layer on a variety of surfaces was exploited here to coat the top and bottom surfaces of the ultrathin 2D-NSCs in solution, effectively creating a biopolymer-coated nanosheet. A reduction in friction of almost an order of magnitude was measured at a bioinspired interface. This reduction was maintained after repeated washing (5×), suggesting that the large aspect ratio of the 2D-NSCs facilitates effective lubrication even at diluted concentrations. Importantly, and unlike LUB-only treatment, the lubrication effect can be eliminated over 15 rinsing cycles, suggesting that the LUB-coated 2D-NSCs do not exhibit any binding interactions with the shearing surfaces. The effective lubricating properties of the 2D-NSCs combined with full reversibility through rinsing make the LUB-coated 2D-NSCs an intriguing candidate as a lubricant for biomedical applications.
    MeSH term(s) Animals ; Friction ; Glycoproteins/chemistry ; Graphite ; Lubricants ; Lubrication ; Mammals
    Chemical Substances Glycoproteins ; Lubricants ; graphene oxide ; lubricin ; Graphite (7782-42-5)
    Language English
    Publishing date 2022-04-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.1c02970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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