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  1. Article ; Online: Incidental FAPI Localization in Benign Bone Lesions in a Case of Carcinoma Stomach.

    Manda, Divya / M V, Manikandan / Suresh, Arvind / Shukla, Varun

    Clinical nuclear medicine

    2023  Volume 48, Issue 12, Page(s) e572–e573

    Abstract: Abstract: Recently developed radiolabeled FAPI (fibroblast-activation protein inhibitors) have attracted researcher's attention in diagnosing various tumors because of its high specificity and better tumor-to-background ratio. Increasing use of 68 Ga- ... ...

    Abstract Abstract: Recently developed radiolabeled FAPI (fibroblast-activation protein inhibitors) have attracted researcher's attention in diagnosing various tumors because of its high specificity and better tumor-to-background ratio. Increasing use of 68 Ga-FAPI PET/CT has resulted in reporting of incidental benign findings as well. We hereby present a case of suspected carcinoma stomach showing increased uptake in primary tumor in stomach as well as incidental uptake in benign subchondral cysts in bilateral shoulder joints and right hip joint on 68 Ga-FAPI PET CT scan.
    MeSH term(s) Humans ; Positron Emission Tomography Computed Tomography ; Stomach Neoplasms ; Bone Diseases ; Gallium Radioisotopes ; Carcinoma ; Fluorodeoxyglucose F18
    Chemical Substances Gallium-68 (98B30EPP5S) ; Gallium Radioisotopes ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rare Case of Neuroendocrine Tumor of Common Bile Duct Identified With Somatostatin Receptor But Not With Glucose Transporter Imaging.

    Mohite, Ashish / Shukla, Varun / M V, Manikandan / Chowdhury, Zachariah / Chaturvedi, Meenakshi

    Clinical nuclear medicine

    2022  Volume 47, Issue 11, Page(s) e715–e717

    Abstract: Abstract: Neuroendocrine tumors (NETs) are heterogeneous group of tumors arising from enterochromaffin cells. Neuroendocrine tumors are most commonly found in bowel and pancreatic tissue. Because of paucity of enterochromaffin cells in biliary tract, ... ...

    Abstract Abstract: Neuroendocrine tumors (NETs) are heterogeneous group of tumors arising from enterochromaffin cells. Neuroendocrine tumors are most commonly found in bowel and pancreatic tissue. Because of paucity of enterochromaffin cells in biliary tract, NETs of bile duct are very rare. Most of the neoplasms in the extrahepatic bile duct are adenocarcinomas; only 0.2% to 0.3% of NETs arise from the bile duct. Cases reported in the literature of biliary carcinoid are diagnosed postoperatively on histopathologic evaluation. We hereby demonstrate a rare presentation of CBD NET identified preoperatively on somatostatin receptor but not on glucose transporter imaging, confirmed by histopathology and immunohistochemistry to be grade 2 NET (Ki-67, 20%).
    MeSH term(s) Bile Duct Neoplasms/pathology ; Common Bile Duct/pathology ; Glucose Transport Proteins, Facilitative ; Humans ; Ki-67 Antigen ; Neuroendocrine Tumors/pathology ; Receptors, Somatostatin
    Chemical Substances Glucose Transport Proteins, Facilitative ; Ki-67 Antigen ; Receptors, Somatostatin
    Language English
    Publishing date 2022-08-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is FAST FORWARD the Way Forward in Radiotherapy for Locally Advanced Breast Cancer - Learnings From the COVID Pandemic.

    Giridhar, Prashanth / Pradhan, Satyajit / Pujari, Lincoln / Singh, Prarabdh / Shinghal, Abhishek / Khandelwal, Chaturbhaj / Mukherjee, Chandrima / Tripathi, Mayank / Shukla, Varun / M V, Manikandan / Choudary, Zacchariah / Gupta, Anuj

    Clinical breast cancer

    2023  Volume 24, Issue 3, Page(s) e116–e125

    Abstract: Introduction: Low middle-income countries (LMICs), including India, have paucity of external beam radiotherapy (RT) machines leading to prolonged wait times for RT. Delay in delivery of RT has been shown to adversely affect outcomes in locally advanced ... ...

    Abstract Introduction: Low middle-income countries (LMICs), including India, have paucity of external beam radiotherapy (RT) machines leading to prolonged wait times for RT. Delay in delivery of RT has been shown to adversely affect outcomes in locally advanced breast cancer (LABC). With the availability of results of multiple randomized controlled trials, hypofractionated RT delivered over 3 to 4 weeks became the standard of care in breast cancer RT.
    Methods: We conducted a retrospective audit of 172 LABC patients treated with ultrahypofractionated adjuvant RT (radiotherapy completed in 1 week) during the COVID pandemic. Log rank and Cox-regression model used for univariate and multi-variate analyses.
    Results: No patient developed grade 3 esophagitis. Grade 2 esophagitis requiring short term narcotic analgesics was seen in 12 (6.9%) patients. Grade 2 or higher toxicity peaked between 2 and 3 weeks after RT. The estimated 2 and 3- year recurrence free survival (RFS) for the cohort is 87.1 % and 81.4 %, respectively. The estimated 2 and 3-year overall survival for the cohort is 95% and 91.3%. On multivariate analysis, presence of extra-nodal extension was found to be an independent factor associated with worse RFS (P = .028).
    Conclusions: FAST FORWARD protocol RT in LABC appears well tolerated.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/drug therapy ; Retrospective Studies ; Pandemics ; COVID-19/epidemiology ; Radiotherapy, Adjuvant/adverse effects ; Esophagitis
    Language English
    Publishing date 2023-11-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2106734-X
    ISSN 1938-0666 ; 1526-8209
    ISSN (online) 1938-0666
    ISSN 1526-8209
    DOI 10.1016/j.clbc.2023.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Renal granulomas mimicking as malignant renal masses on F18 FDG PET/CT in a case of urothelial carcinoma.

    M V, Manikandan / Agrawal, Archi / Menon, Santosh / Purandare, Nilendu / Shah, Sneha / Puranik, Ameya / Bakshi, Ganesh / Prakash, Gagan / Rangarajan, Venkatesh

    European journal of nuclear medicine and molecular imaging

    2020  Volume 47, Issue 12, Page(s) 2930–2931

    MeSH term(s) Carcinoma ; Carcinoma, Renal Cell/diagnostic imaging ; Fluorodeoxyglucose F18 ; Granuloma ; Humans ; Kidney Neoplasms/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Radiopharmaceuticals
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2020-03-10
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-020-04728-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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