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  1. Article ; Online: Structural and immunoendocrine remodeling in gut, pancreas and thymus in weaning rats fed powdered milk diets rich in Maillard reactants

    J. Dereke / E. Ekblad / B. Weström / C. Erlanson-Albertsson / M. Landin-Olsson / I. Sjöholm / M. Hillman

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 14

    Abstract: Abstract Western diet is extending worldwide and suspected to be associated with various metabolic diseases. Many food products have skim milk powder added to it and, during processing, lactose reacts with milk proteins and Maillard reaction products ( ... ...

    Abstract Abstract Western diet is extending worldwide and suspected to be associated with various metabolic diseases. Many food products have skim milk powder added to it and, during processing, lactose reacts with milk proteins and Maillard reaction products (MRPs) are formed. Dietary MRPs are suggested risk factors for metabolic dysregulation, but the mechanisms behind are still enigmatic. Here we describe that weaning rats fed diets rich in MRPs are affected in both their immune and endocrine systems. Marked structural changes in pancreas, intestine and thymus are noted already after 1 week of exposure. The pancreatic islets become sparser, the intestinal mucosa is thinner, and thymus displays increased apoptosis and atrophy. Glucagon- like peptide-1 (GLP-1) seems to play a key role in that the number of GLP-1 expressing cells is up-regulated in endocrine pancreas but down-regulated in the intestinal mucosa. Further, intestinal GLP-1-immunoreactive cells are juxta positioned not only to nerve fibres and tuft cells, as previously described, but also to intraepithelial CD3 positive T cells, rendering them a strategic location in metabolic regulation. Our results suggest dietary MRPs to cause metabolic disorders, dysregulation of intestinal GLP-1- immunoreactive cells, arrest in pancreas development and thymus atrophy.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610 ; 570
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: El trabajo de las mujeres voluntarias en el Laboratorio de Farmacia Militar de Santiago de Compostela (1936-1939) The work of volunteer women at the Military Pharmaceutical Laboratory of Santiago de Compostela (1936-1939)

    B. Brasa Arias / M. Landín Pérez

    Sanidad Militar, Vol 67, Pp 177-

    2011  Volume 192

    Abstract: Este trabajo trata sobre el Laboratorio de Farmacia Militar que, durante la guerra civil española, existió en la Facultad de Farmacia de Santiago de Compostela y que contó con la colaboración de mujeres voluntarias para producir los medicamentos ... ...

    Abstract Este trabajo trata sobre el Laboratorio de Farmacia Militar que, durante la guerra civil española, existió en la Facultad de Farmacia de Santiago de Compostela y que contó con la colaboración de mujeres voluntarias para producir los medicamentos necesarios para el frente. El hecho de que una institución académica se transformase en un centro militar, reintegrando a su platilla docente en el ejército y fabricando análogos de fármacos que escaseaban por la situación de guerra, confiere al tema un particular interés. La participación de las jóvenes compostelanas que sirvieron como mano de obra en este Laboratorio Militar nos permite analizar el papel de las mujeres al servicio del ejército en la retaguardia, en una labor tan importante como silenciada por los historiadores. De este Laboratorio de Farmacia Militar, de su producción, de la plantilla y de los hechos con él relacionados versa este trabajo de investigación. This work is about the Military Pharmaceutical Laboratory placed at the Faculty of Pharmacy of University of Santiago de Compostela during the Spanish civil war and the help of volunteer women to produce the necessary drugs for the Franco's Army. The fact that an academic institution would become a military center, restoring his teaching staff in the Army and manufacturing the necessary drugs for the particular war situation, gives the subject a great interest. Local young women participation as workers in such as labor in the Military Lab allows us to analyze the role of women in the Army service in the rear. An important subject often silenced by historians. The Military Pharmaceutical Laboratory, its production, its staff and the facts related to it is the goal of this research.
    Keywords Facultad ; Farmacia ; Santiago de Compostela ; Guerra Civil española ; Laboratorio Farmacia Militar ; Voluntarias ; Faculty ; Pharmacy ; Spanish Civil War ; Military Pharmaceutical Laboratory ; Volunteer women ; Public aspects of medicine ; RA1-1270 ; Medicine ; R ; DOAJ:Public Health ; DOAJ:Health Sciences
    Language Spanish
    Publishing date 2011-07-01T00:00:00Z
    Publisher Ministerio de Defensa
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Suitability of Biomorphic Silicon Carbide Ceramics as Drug Delivery Systems against Bacterial Biofilms

    J. Serra / M. Landin / P. González / R. Seoane / A. Pérez-Estévez / P. Díaz-Rodríguez

    ISRN Pharmaceutics, Vol

    2013  Volume 2013

    Keywords Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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