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  1. Article ; Online: Human salivary Raman fingerprint as biomarker for the diagnosis of Amyotrophic Lateral Sclerosis

    C. Carlomagno / P. I. Banfi / A. Gualerzi / S. Picciolini / E. Volpato / M. Meloni / A. Lax / E. Colombo / N. Ticozzi / F. Verde / V. Silani / M. Bedoni

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 13

    Abstract: Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease leading to progressive and irreversible muscle atrophy. The diagnosis of ALS is time-consuming and complex, with the clinical and neurophysiological evaluation accompanied by ... ...

    Abstract Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease leading to progressive and irreversible muscle atrophy. The diagnosis of ALS is time-consuming and complex, with the clinical and neurophysiological evaluation accompanied by monitoring of progression and a long procedure for the discrimination of similar neurodegenerative diseases. The delayed diagnosis strongly slows the potential development of adequate therapies and the time frame for a prompt intervention. The discovery of new biomarkers could improve the disease diagnosis, as well as the therapeutic and rehabilitative effectiveness and monitoring of the pathological progression. In this work saliva collected from 19 patients with ALS, 10 affected by Parkinson’s disease, 10 affected by Alzheimer’s disease and 10 healthy subjects, was analysed using Raman spectroscopy, optimizing the parameters for detailed and reproducible spectra. The statistical multivariate analysis of the data revealed a significant difference between the groups, allowing the discrimination of the disease onset. Correlation of Raman data revealed a direct relationship with paraclinical scores, identifying multifactorial biochemical modifications related to the pathology. The proposed approach showed a promising accuracy in ALS onset discrimination, using a fast and sensitive procedure that can make more efficient the diagnostic procedure and the monitoring of therapeutic and rehabilitative processes in ALS.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Contrast-Enhanced Ultrasound of Anaplastic Thyroid Cancer

    M. Proiti / A. Andreano / S. Schiaffino / G. Turtulici / P. Laeseke / M. Meloni

    Ultrasound International Open, Vol 01, Iss 01, Pp E27-E

    A Case Report and Review of the Literature

    2015  Volume 29

    Keywords Medicine ; R ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2015-07-01T00:00:00Z
    Publisher Georg Thieme Verlag KG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: CryoSat Ice Baseline-D validation and evolutions

    M. Meloni / J. Bouffard / T. Parrinello / G. Dawson / F. Garnier / V. Helm / A. Di Bella / S. Hendricks / R. Ricker / E. Webb / B. Wright / K. Nielsen / S. Lee / M. Passaro / M. Scagliola / S. B. Simonsen / L. Sandberg Sørensen / D. Brockley / S. Baker /
    S. Fleury / J. Bamber / L. Maestri / H. Skourup / R. Forsberg / L. Mizzi

    The Cryosphere, Vol 14, Pp 1889-

    2020  Volume 1907

    Abstract: The ESA Earth Explorer CryoSat-2 was launched on 8 April 2010 to monitor the precise changes in the thickness of terrestrial ice sheets and marine floating ice. To do that, CryoSat orbits the planet at an altitude of around 720 km with a retrograde orbit ...

    Abstract The ESA Earth Explorer CryoSat-2 was launched on 8 April 2010 to monitor the precise changes in the thickness of terrestrial ice sheets and marine floating ice. To do that, CryoSat orbits the planet at an altitude of around 720 km with a retrograde orbit inclination of 92 ∘ and a quasi repeat cycle of 369 d (30 d subcycle). To reach the mission goals, the CryoSat products have to meet the highest quality standards to date, achieved through continual improvements of the operational processing chains. The new CryoSat Ice Baseline-D, in operation since 27 May 2019, represents a major processor upgrade with respect to the previous Ice Baseline-C. Over land ice the new Baseline-D provides better results with respect to the previous baseline when comparing the data to a reference elevation model over the Austfonna ice cap region, improving the ascending and descending crossover statistics from 1.9 to 0.1 m. The improved processing of the star tracker measurements implemented in Baseline-D has led to a reduction in the standard deviation of the point-to-point comparison with the previous star tracker processing method implemented in Baseline-C from 3.8 to 3.7 m. Over sea ice, Baseline-D improves the quality of the retrieved heights inside and at the boundaries of the synthetic aperture radar interferometric (SARIn or SIN) acquisition mask, removing the negative freeboard pattern which is beneficial not only for freeboard retrieval but also for any application that exploits the phase information from SARIn Level 1B (L1B) products. In addition, scatter comparisons with the Beaufort Gyre Exploration Project (BGEP; https://www.whoi.edu/beaufortgyre , last access: October 2019) and Operation IceBridge (OIB; Kurtz et al., 2013) in situ measurements confirm the improvements in the Baseline-D freeboard product quality. Relative to OIB, the Baseline-D freeboard mean bias is reduced by about 8 cm, which roughly corresponds to a 60 % decrease with respect to Baseline-C. The BGEP data indicate a similar tendency with a mean draft ...
    Keywords Environmental sciences ; GE1-350 ; Geology ; QE1-996.5
    Subject code 290
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Copernicus Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

    Anne L. Robertson / Nikolay V. Ogryzko / Katherine M. Henry / Catherine A. Loynes / Matthew J. Foulkes / Marco M. Meloni / Xingang Wang / Christopher Ford / Malcolm Jackson / Philip W. Ingham / Heather L. Wilson / Stuart N. Farrow / Roberto Solari / Roderick J. Flower / Simon Jones / Moira K. B. Whyte / Stephen A. Renshaw

    Disease Models & Mechanisms, Vol 9, Iss 6, Pp 621-

    2016  Volume 632

    Abstract: Neutrophils are essential for host defence and are recruited to sites of inflammation in response to tissue injury or infection. For inflammation to resolve, these cells must be cleared efficiently and in a controlled manner, either by apoptosis or ... ...

    Abstract Neutrophils are essential for host defence and are recruited to sites of inflammation in response to tissue injury or infection. For inflammation to resolve, these cells must be cleared efficiently and in a controlled manner, either by apoptosis or reverse migration. If the inflammatory response is not well-regulated, persistent neutrophils can cause damage to host tissues and contribute to the pathogenesis of chronic inflammatory diseases, which respond poorly to current treatments. It is therefore important to develop drug discovery strategies that can identify new therapeutics specifically targeting neutrophils, either by promoting their clearance or by preventing their recruitment. Our recent in vivo chemical genetic screen for accelerators of inflammation resolution identified a subset of compounds sharing a common chemical signature, the bicyclic benzopyrone rings. Here, we further investigate the mechanisms of action of the most active of this chemical series, isopimpinellin, in our zebrafish model of neutrophilic inflammation. We found that this compound targets both the recruitment and resolution phases of the inflammatory response. Neutrophil migration towards a site of injury is reduced by isopimpinellin and this occurs as a result of PI3K inhibition. We also show that isopimpinellin induces neutrophil apoptosis to drive inflammation resolution in vivo using a new zebrafish reporter line detecting in vivo neutrophil caspase-3 activity and allowing quantification of flux through the apoptotic pathway in real time. Finally, our studies reveal that clinically available ‘cromones’ are structurally related to isopimpinellin and have previously undescribed pro-resolution activity in vivo. These findings could have implications for the therapeutic use of benzopyrones in inflammatory disease.
    Keywords Zebrafish ; Inflammation ; Neutrophil apoptosis ; Chromone ; Benzopyrone ; Medicine ; R ; Pathology ; RB1-214
    Subject code 610
    Language English
    Publishing date 2016-06-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: ULF fluctuations of the geomagnetic field and ionospheric sounding measurements at low latitudes during the first CAWSES campaign

    U. Villante / M. Vellante / P. Francia / M. De Lauretis / M. Meloni / P. Palangio / B. Zolesi / M. Pezzopane / Matthias Förster / T. L. Zhang / W. Magnes / P. Nenovski / I. Cholakov / V. Wesztergom

    Annales Geophysicae

    2006  

    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Analisi dei processi di un ambulatorio per i viaggiatori internazionali

    M.L. Demarchi / D. Sarasino / M. Luparia / M. Renna / M.C. Antoniotti / E. Moia / M. Minola / M. Panella / E. Dessì / G. Motta / A.M. Meloni

    Italian Journal of Public Health, Vol 1, Iss

    2003  

    Abstract: Obiettivi : 1) determinare i costi di gestione dell’ambulatorio del viaggiatore internazionale dell’ASL13 di Novara; 2) predisporre un piano di riorganizzazione dell’ambulatorio. Materiali e metodi: per la determinazione dei costi di gestione dell’ ... ...

    Abstract Obiettivi : 1) determinare i costi di gestione dell’ambulatorio del viaggiatore internazionale dell’ASL13 di Novara; 2) predisporre un piano di riorganizzazione dell’ambulatorio. Materiali e metodi: per la determinazione dei costi di gestione dell’ambulatorio è stata applicata la metodologia dell’Activity Based Costing (ABC) che consiste nello scomporre, secondo un criterio gerarchico, le attività che costituiscono un processo, partendo da quelle poste a livello più elevato (macroattività) e giungendo al singolo compito professionale (microattività). In seguito per ogni attività individuata ciascun operatore del servizio indica, in percentuale, il tempo mediamente dedicato a tale attività, al fine di quantificarne il costo. Le attività individuate sono state rappresentate graficamente con la tecnica del Work design secondo cui per ciascun processo sono identificati input, output, risorse utilizzate, nonché eventuali regole e controlli a cui è soggetto. Risultati : lo studio ha coinvolto tutti gli operatori dell’ambulatorio (4 medici, 2 assistenti sanitari e 1 assistente amministrativo). Sono state identificate 180 attività. Il costo annuale complessivo della gestione dell’ambulatorio, attribuibile alle risorse umane, è pari a ¤ 288.934. Complessivamente il costo di alcune attività è risultato particolarmente elevato, in quanto le attività stesse vengono svolte da figure professionali non pertinenti (es. attività amministrative svolte dall’infermiere, attività di pertinenza infermieristica effettuate dal medico). Attraverso la definizione di input, output, controlli e meccanismi, è stato possibile evidenziare sia le macro criticità del processo organizzativo, quali ad esempio la necessità di integrare l’utilizzo di supporti informatizzati per la gestione delle informazioni relative all’utente, sia le micro criticità, come l’esigenza di predisporre materiale informativo anche in lingua straniera. L’analisi ha inoltre rilevato l’assenza di un sistema informativo di feed-back che consentisse il monitoraggio della morbosità delle patologie contratte all’estero, elemento utile in un’ottica di programmazione. Conclusioni : l’ABC, grazie all’individuazione delle criticità, ha consentito di definire un piano per la riorganizzazione dell’ambulatorio, volto all’ottimizzazione delle risorse disponibili garantendo l’erogazione di prestazioni efficaci ed efficienti.
    Keywords Public aspects of medicine ; RA1-1270 ; Medicine ; R ; DOAJ:Public Health ; DOAJ:Health Sciences
    Language English
    Publishing date 2003-05-01T00:00:00Z
    Publisher Prex spa
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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