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  1. AU="M. Pilar Gómez-Serranillos"
  2. AU=Zhu Jin-Zhou
  3. AU="Rorrer, Nicholas A"
  4. AU="Shengli, Chen"
  5. AU="Valdés-Hernández, Jesús"
  6. AU="Wong, Wei Yin"
  7. AU="Konstantinos Koutroumpas"
  8. AU="Kumar Thulasi"
  9. AU="Elbe, Peter"
  10. AU=Ryffel Gerhart U
  11. AU="López Panadés, Maria"
  12. AU="Tormo, Hélène"
  13. AU="Gardham, Alice"
  14. AU="Chisa Inoue"
  15. AU=Savcenko Michal AU=Savcenko Michal
  16. AU=Dinda Biswanath AU=Dinda Biswanath
  17. AU="Heikinheimo Annamari"
  18. AU="Currie, Geoffrey"
  19. AU="Konno, Adriana Y C"
  20. AU="Nashmi, Raad"
  21. AU="Doligkeit, Daniel"
  22. AU="Caparello, Basilio"
  23. AU="Fricke, T T"
  24. AU="Mummery, C J"
  25. AU="Krantz, Emily"
  26. AU="Bedoya-Arias, Juan E"
  27. AU="Zhou, Heyang"
  28. AU=Latson Larry A
  29. AU=Alhuzimi Eman
  30. AU="Wuerzberger-Davis, Shelly M"
  31. AU="Clippinger, Amy J"
  32. AU="M. S. Islam"
  33. AU="Borrego-Jiménez, Jaime"
  34. AU="Kaoru Dohi"
  35. AU="Tornai, Gábor J"
  36. AU="D'Avella, Christopher"
  37. AU="Lim, Boon L."
  38. AU="Heselden, Marie"
  39. AU=Dias?Polak David
  40. AU="Shahid Umar"
  41. AU="Abu-Shmais, Alexandria A"
  42. AU="Takenaka, Haruka"
  43. AU="Bramley, Andrea"
  44. AU="Sang Hong Lee"

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  1. Artikel ; Online: Phytochemical Characterization and Pharmacological Properties of Lichen Extracts from Cetrarioid Clade by Multivariate Analysis and Molecular Docking

    Isabel Ureña-Vacas / Elena González-Burgos / Simona De Vita / Padreep K. Divakar / Giuseppe Bifulco / M. Pilar Gómez-Serranillos

    Evidence-Based Complementary and Alternative Medicine, Vol

    2022  Band 2022

    Abstract: Introduction. Lichens, due to the presence of own secondary metabolites such as depsidones and depsides, became a promising source of health-promoting organisms with pharmacological activities. However, lichens and their active compounds have been much ... ...

    Abstract Introduction. Lichens, due to the presence of own secondary metabolites such as depsidones and depsides, became a promising source of health-promoting organisms with pharmacological activities. However, lichens and their active compounds have been much less studied. Therefore, the present study aims to evaluate for the first time the antioxidant capacity and enzyme inhibitory activities of 14 lichen extracts belonging to cetrarioid clade in order to identify new natural products with potential pharmacological activity. Materials and Methods. In this study, an integrated strategy was applied combining multivariate statistical analysis (principal component analysis and hierarchical cluster analysis), phytochemical identification, activity evaluation (in vitro battery of antioxidant assays FRAP, DPPH, and ORAC), and enzyme inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) and molecular profiling with in silico docking studies of the most promising secondary metabolites. Results. Among fourteen lichen samples, Dactylina arctica stands out for its higher antioxidant capacities, followed by Nephromopsis stracheyi, Tuckermannopsis americana, Vulpicida pinastri, and Asahinea scholanderi. Moreover, Asahinea scholanderi and Cetraria cucullata extracts were the best inhibitors of AChE and BuChE. The major secondary metabolites identified by HPLC were alectoronic acid and α-collatolic acid for Asahinea scholanderi and usnic acid and protolichesterinic acid for Cetraria cucullata. Molecular docking studies revealed that alectoronic acid exhibited the strongest binding affinity with both AChE and BuChE with and without water molecules. Conclusions. Our results concluded that these species could be effective in the treatment of neurodegenerative diseases, being mandatory further investigation in cell culture and in vivo models.
    Schlagwörter Other systems of medicine ; RZ201-999
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Pharmacological Update Properties of Aloe Vera and its Major Active Constituents

    Marta Sánchez / Elena González-Burgos / Irene Iglesias / M. Pilar Gómez-Serranillos

    Molecules, Vol 25, Iss 6, p

    2020  Band 1324

    Abstract: Aloe vera has been traditionally used to treat skin injuries (burns, cuts, insect bites, and eczemas) and digestive problems because its anti-inflammatory, antimicrobial, and wound healing properties. Research on this medicinal plant has been aimed at ... ...

    Abstract Aloe vera has been traditionally used to treat skin injuries (burns, cuts, insect bites, and eczemas) and digestive problems because its anti-inflammatory, antimicrobial, and wound healing properties. Research on this medicinal plant has been aimed at validating traditional uses and deepening the mechanism of action, identifying the compounds responsible for these activities. The most investigated active compounds are aloe-emodin, aloin, aloesin, emodin, and acemannan. Likewise, new actions have been investigated for Aloe vera and its active compounds. This review provides an overview of current pharmacological studies (in vitro, in vivo, and clinical trials), written in English during the last six years (2014−2019). In particular, new pharmacological data research has shown that most studies refer to anti-cancer action, skin and digestive protective activity, and antimicrobial properties. Most recent works are in vitro and in vivo. Clinical trials have been conducted just with Aloe vera , but not with isolated compounds; therefore, it would be interesting to study the clinical effect of relevant metabolites in different human conditions and pathologies. The promising results of these studies in basic research encourage a greater number of clinical trials to test the clinical application of Aloe vera and its main compounds, particularly on bone protection, cancer, and diabetes.
    Schlagwörter aloe vera ; pharmacology ; extracts ; isolated compounds ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2020-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
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  3. Artikel ; Online: The cytotoxicity effect of 7-hydroxy-3,4-dihydrocadalene from Heterotheca inuloides and semisynthetic cadalenes derivates towards breast cancer cells

    Alan Mendoza-Fuentes / Elena González-Burgos / Omar Emiliano Aparicio Trejo / Guillermo Delgado-Lamas / José Luis Rodríguez-Chávez / José Pedraza-Chaverri / M. Pilar Gómez-Serranillos / Daniela Araiza-Olivera

    PeerJ, Vol 11, p e

    involvement of oxidative stress-mediated apoptosis

    2023  Band 15586

    Abstract: Background Heterotheca inuloides, traditionally employed in Mexico, has demonstrated anticancer activities. Although it has been proven that the cytotoxic effect is attributed to cadinane-type sesquiterpenes such as 7-hydroxy-3,4-dihydrocadalene, the ... ...

    Abstract Background Heterotheca inuloides, traditionally employed in Mexico, has demonstrated anticancer activities. Although it has been proven that the cytotoxic effect is attributed to cadinane-type sesquiterpenes such as 7-hydroxy-3,4-dihydrocadalene, the mechanism of action by which these agents act in tumor lines and their regulation remain unknown. This study was undertaken to investigate for first time the cytotoxic activity and mechanism of action of 7-hydroxy-3,4-dihydrocadalene and two semi-synthetic cadinanes derivatives towards breast cancer cells. Methods Cell viability and proliferation were assayed by thiazolyl blue tetrazolium bromide (MTT) assay and Trypan blue dye exclusion assay. Cell migration measure was tested by wound-healing assay. Moreover, the reactive oxygen species (ROS) and lipid peroxidation generation were measured by 2′,7′-dichlorofluorescein diacetate (DCFH-DA) assay and thiobarbituric acid reactive substance (TBARS) assay, respectively. Furthermore, expression of caspase-3, Bcl-2 and GAPDH were analyzed by western blot. Results The results showed that 7-hydroxy-3,4-dihydrocadalene inhibited MCF7 cell viability in a concentration and time dependent manner. The cytotoxic potency of semisynthetic derivatives 7-(phenylcarbamate)-3,4-dihydrocadalene and 7-(phenylcarbamate)-cadalene was remarkably lower. Moreover, in silico studies showed that 7-hydroxy-3,4-dihydrocadalene, and not so the semi-synthetic derivatives, has optimal physical-chemical properties to lead a promising cytotoxic agent. Further examination on the action mechanism of 7-hydroxy-3,4-dihydrocadalene suggested that this natural product exerted cytotoxicity via oxidative stress as evidenced in a significantly increase of intracellular ROS levels and in an induction of lipid peroxidation. Furthermore, the compound increased caspase-3 and caspase-9 activities and slightly inhibited Bcl-2 levels. Interestingly, it also reduced mitochondrial ATP synthesis and induced mitochondrial uncoupling. Conclusion Taken together, ...
    Schlagwörter Cytotoxicity ; Cadalenes ; Breast cancer ; Oxidative stress ; Apoptosis ; Medicine ; R ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag PeerJ Inc.
    Dokumenttyp Artikel ; Online
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  4. Artikel ; Online: Evaluation of the adaptogenic potential exerted by ginsenosides Rb1 and Rg1 against oxidative stress-mediated neurotoxicity in an in vitro neuronal model.

    Carlos Fernández-Moriano / Elena González-Burgos / Irene Iglesias / Rafael Lozano / M Pilar Gómez-Serranillos

    PLoS ONE, Vol 12, Iss 8, p e

    2017  Band 0182933

    Abstract: Ginseng (Panax sp.) is a drug with multiple pharmacological actions that has been largely used in traditional medicines for the treatment of many health problems. In the therapy of neurodegenerative disorders, it has been employed due to its capacity to ... ...

    Abstract Ginseng (Panax sp.) is a drug with multiple pharmacological actions that has been largely used in traditional medicines for the treatment of many health problems. In the therapy of neurodegenerative disorders, it has been employed due to its capacity to strengthen mental processes by enhancing cognitive performance and psychological function. Current work aimed at evaluating the adaptogenic potential of Rb1 and Rg1 against oxidative-stress mediated degeneration in a model of nervous cells.Oxidative stress and mitochondrial dysfunction were achieved by exposing SH-SY5Y cells to the mitochondrial complex I inhibitor rotenone. The cytoprotective activity of pre-treatments with ginsenosides Rb1 and Rg1 against rotenone was assessed by determining biochemical markers regarding oxidative stress (ROS scavenging, glutathione and lipid peroxidation levels, SOD activity and Nrf2 activation) and apoptosis-related alterations (mitochondrial membrane potential, calcium levels, aconitase activity and pro/antiapoptotic proteins). Their capacity to cross the blood brain barrier was also estimated.At their optimal doses, ginsenosides Rb1 and Rg1 significantly ameliorated redox status within the cells; they reduced ROS and TBARS levels and improved the glutathione system, as well as they enhanced SOD activity and Nrf2 pathway activation. They protected neuronal cells against MMP loss, calcium homeostasis disruption and aconitase inhibition. Consequently, apoptotic cell death was attenuated by the pre-treatment with ginsenosides, as evidenced by the reduction in caspase-3 and Bax, and the increase in Bcl-2 expressions; also, lower levels of cytochrome C were found in the cytosol. Poor BBB permeation was demonstrated for both ginsenosides.In conclusion, ginsenosides Rb1 and Rg1 exhibit neuroprotective potential which is achieved, at least in part, via mitochondrial protection and the plausible involvement of Nrf2 pathway activation. Our results contribute to validate the traditional use of ginseng for cognitive-enhancing purposes and provide basis to encourage further research on the potential of ginsenosides in the treatment of neurodegenerative diseases.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Evaluation of the adaptogenic potential exerted by ginsenosides Rb1 and Rg1 against oxidative stress-mediated neurotoxicity in an in vitro neuronal model.

    Carlos Fernández-Moriano / Elena González-Burgos / Irene Iglesias / Rafael Lozano / M Pilar Gómez-Serranillos

    PLoS ONE, Vol 12, Iss 8, p e

    2017  Band 0182933

    Abstract: Ginseng (Panax sp.) is a drug with multiple pharmacological actions that has been largely used in traditional medicines for the treatment of many health problems. In the therapy of neurodegenerative disorders, it has been employed due to its capacity to ... ...

    Abstract Ginseng (Panax sp.) is a drug with multiple pharmacological actions that has been largely used in traditional medicines for the treatment of many health problems. In the therapy of neurodegenerative disorders, it has been employed due to its capacity to strengthen mental processes by enhancing cognitive performance and psychological function. Current work aimed at evaluating the adaptogenic potential of Rb1 and Rg1 against oxidative-stress mediated degeneration in a model of nervous cells.Oxidative stress and mitochondrial dysfunction were achieved by exposing SH-SY5Y cells to the mitochondrial complex I inhibitor rotenone. The cytoprotective activity of pre-treatments with ginsenosides Rb1 and Rg1 against rotenone was assessed by determining biochemical markers regarding oxidative stress (ROS scavenging, glutathione and lipid peroxidation levels, SOD activity and Nrf2 activation) and apoptosis-related alterations (mitochondrial membrane potential, calcium levels, aconitase activity and pro/antiapoptotic proteins). Their capacity to cross the blood brain barrier was also estimated.At their optimal doses, ginsenosides Rb1 and Rg1 significantly ameliorated redox status within the cells; they reduced ROS and TBARS levels and improved the glutathione system, as well as they enhanced SOD activity and Nrf2 pathway activation. They protected neuronal cells against MMP loss, calcium homeostasis disruption and aconitase inhibition. Consequently, apoptotic cell death was attenuated by the pre-treatment with ginsenosides, as evidenced by the reduction in caspase-3 and Bax, and the increase in Bcl-2 expressions; also, lower levels of cytochrome C were found in the cytosol. Poor BBB permeation was demonstrated for both ginsenosides.In conclusion, ginsenosides Rb1 and Rg1 exhibit neuroprotective potential which is achieved, at least in part, via mitochondrial protection and the plausible involvement of Nrf2 pathway activation. Our results contribute to validate the traditional use of ginseng for cognitive-enhancing purposes ...
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2017-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel: Antioxidant activity, neuroprotective properties and bioactive constituents analysis of varying polarity extracts from Eucalyptus globulus leaves

    González-Burgos, Elena / Jonas Viškelis / M. Pilar Gómez-Serranillos / Mindaugas Liaudanskas / Vaidotas Žvikas / Valdimaras Janulis

    Yàowù shípǐn fēnxī. 2018 Oct., v. 26, no. 4

    2018  

    Abstract: Eucalyptus globulus is employed as herbal tea and therapeutical purposes. In this work, it is investigated for first time the neuroprotective activities, based on antioxidant properties, of varying polarity extracts (acetone, ethanol and methanol) from E. ...

    Abstract Eucalyptus globulus is employed as herbal tea and therapeutical purposes. In this work, it is investigated for first time the neuroprotective activities, based on antioxidant properties, of varying polarity extracts (acetone, ethanol and methanol) from E. globulus leaves and elucidate their main bioactive constituents. Methanol and acetone extracts contained the highest phenolic compounds amount and chlorogenic acid was the major compound identified by UPLC-ESI-MS/MS. Moreover, the three tested extracts showed significant antioxidant properties, varying their potency depending on the in vitro technique used. Furthermore, E.globulus extracts were effective in ameliorating H2O2-induced oxidative stress by increasing cell viability, GSH levels and antioxidant enzymes activity and, by decreasing ROS production and lipid peroxidation levels in SH-SY5Y cells. Taken together, E.globulus leaves extracts could be used as raw material for food and pharmaceutical supplements for their high content in antioxidant compounds with health benefits properties against oxidative stress.
    Schlagwörter acetone ; antioxidant activity ; antioxidants ; cell viability ; chlorogenic acid ; ethanol ; Eucalyptus globulus ; herbal tea ; leaf extracts ; leaves ; lipid peroxidation ; methanol ; neuroprotective effect ; oxidative stress ; phenolic compounds ; raw materials
    Sprache Englisch
    Erscheinungsverlauf 2018-10
    Umfang p. 1293-1302.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1292535-4
    ISSN 1021-9498
    ISSN 1021-9498
    DOI 10.1016/j.jfda.2018.05.010
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel: Protective properties of Salvia lavandulifolia Vahl. essential oil against oxidative stress-induced neuronal injury

    Porres-Martínez, María / Elena González-Burgos / M. Emilia Carretero / M. Pilar Gómez-Serranillos

    Food and chemical toxicology. 2015 June, v. 80

    2015  

    Abstract: Salvia lavandulifolia Vahl., known as “Spanish sage”, has potential value in dementia for its sedative, antioxidant, anti-inflammatory and anticholinesterase properties. This work aimed to evaluate the in vitro neuroprotective activity of S. ... ...

    Abstract Salvia lavandulifolia Vahl., known as “Spanish sage”, has potential value in dementia for its sedative, antioxidant, anti-inflammatory and anticholinesterase properties. This work aimed to evaluate the in vitro neuroprotective activity of S. lavandulifolia essential oils, obtained from plants at different phenological stages (vegetative and flowering phases) and plants grown at different densities, against H2O2-induced oxidative stress in PC12 cells. The effect on cell viability and morphology, lipid peroxidation, GSH/GSSG ratio, intracellular ROS levels, antioxidant enzymes (CAT, SOD, GR, GPx, HO-1) and apoptotic enzymes was investigated. Comparing with H2O2-treated PC12 cells, pretreatments with essential oil samples attenuated morphological changes and loss of cell viability, decreased MDA levels and intracellular ROS production and increased GSH/GSSG ratio. Moreover, Spanish sage increased antioxidant status as evidenced in an increase of antioxidant enzyme activity and protein expression and inhibited caspase-3 activity. Furthermore, our results suggest that S. lavandulifolia essential oils are able to activate Nrf2 transcription factor. Collectively, the sample of essential oil obtained with the highest densities of planting and at flowering phase exerted the major neuroprotective activity. Our findings demonstrate that S. lavandulifolia essential oils may have therapeutic value for the prevention and treatment of neurodegenerative diseases associated with oxidative stress-induced neuronal injury.
    Schlagwörter Salvia lavandulifolia ; antioxidants ; apoptosis ; caspase-3 ; cell viability ; dementia ; enzyme activity ; essential oils ; flowering ; lipid peroxidation ; neurodegenerative diseases ; neurons ; neuroprotective effect ; oxidative stress ; phenology ; planting ; protein synthesis ; sage ; sedatives ; superoxide dismutase ; toxicology ; transcription factors
    Sprache Englisch
    Erscheinungsverlauf 2015-06
    Umfang p. 154-162.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2015.03.002
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel ; Online: Phenolic Composition and Evaluation of Antioxidant and Cytoprotective Activity of Chiliadenus montanus

    Tarek F. Eissa / Elena González-Burgos / M. Emilia Carretero / M. Pilar Gómez-Serranillos

    Records of Natural Products, Vol 7, Iss 3, Pp 184-

    2013  Band 191

    Abstract: The antioxidant and cytoprotective activities of the hydroalcoholic extract of Chiliadenus montanus, widely used in Egyptian traditional medicine, were investigated. The antioxidant potential, determined using ORAC assay, revealed that Chiliadenus ... ...

    Abstract The antioxidant and cytoprotective activities of the hydroalcoholic extract of Chiliadenus montanus, widely used in Egyptian traditional medicine, were investigated. The antioxidant potential, determined using ORAC assay, revealed that Chiliadenus montanus extracts are active radical scavengers (ORAC value 1.720 µmol TE/mg sample). Total phenolic content, measured by Folin-Ciocalteau, was 107.4 mg galic acid/g sample. HPLC and HPLC-MS analysis allowed individual polyphenolic compounds to be identified. Furthermore, the cytoprotective effect of Chiliadenus montanus hydroalcoholic extracts was analyzed in an in vitro oxidative stress model employing H 2O 2 as an oxidant inductor and the human astrocytoma U373-MG cell line as cell model. The results obtained showed that Chiliadenus montanus hydroalcoholic extracts exert a protective action by decreasing cell death and by inhibiting intracellular ROS production, suggesting that these polyphenol-enriched extracts may be useful for those oxidative stress-related neurodegenerative diseases.
    Schlagwörter Chiliadenus montanus ; phenolic compounds ; antioxidant ; oxidative stress ; Chemistry ; QD1-999 ; Organic chemistry ; QD241-441 ; Botany ; QK1-989
    Sprache Englisch
    Erscheinungsdatum 2013-05-01T00:00:00Z
    Verlag ACG Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel: Neuroprotective effect of individual ginsenosides on astrocytes primary culture.

    López, M Victoria Naval / Cuadrado, M Pilar Gómez-Serranillos / Ruiz-Poveda, Olga M Palomino / Del Fresno, Angel M Villar / Accame, M Emilia Carretero

    Biochimica et biophysica acta

    2007  Band 1770, Heft 9, Seite(n) 1308–1316

    Abstract: Most of the known pharmacological effects of Panax ginseng on the central nervous system are due to its major components - ginsenosides. Although the antioxidant ability of ginseng root has already been established, this activity has never been evaluated ...

    Abstract Most of the known pharmacological effects of Panax ginseng on the central nervous system are due to its major components - ginsenosides. Although the antioxidant ability of ginseng root has already been established, this activity has never been evaluated for isolated ginsenosides on astrocytes. The activity of protopanaxadiols Rb(1), Rb(2), Rc and Rd, and protopanaxatriols Re and Rg(1) was evaluated in vitro on astrocytes primary culture by means of an oxidative stress model with H(2)O(2). The viability of astrocytes was determined by the MTT reduction assay and by the LDH release into the incubation medium. The effects on the antioxidant enzymes catalase, superoxide dismutase (SOD), glutathione peroxidases (GPx) and glutathione reductase (GR) and on the intracellular reactive oxygen species (ROS) formation were also investigated. Exposure of astrocytes to H(2)O(2) decreased cell viability as well as the antioxidant enzymes activity and increased ROS formation. Oxidative stress produced significant cell death that was reduced by previous treatment with the tested ginsenosides. Ginsenosides Rb(1), Rb(2), Re and Rg(1) were effective in reducing astrocytic death, while Rb(1), Rb(2), Rd, Re and Rg(1) decreased ROS formation, ginsenoside Re being the most active. Ginsenosides from P. ginseng induce neuroprotection mainly through activation of antioxidant enzymes.
    Mesh-Begriff(e) Animals ; Astrocytes/drug effects ; Catalase/metabolism ; Cells, Cultured ; Ginsenosides/pharmacology ; Hydrogen Peroxide/toxicity ; Neuroprotective Agents/pharmacology ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism
    Chemische Substanzen Ginsenosides ; Neuroprotective Agents ; Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V) ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1)
    Sprache Englisch
    Erscheinungsdatum 2007-09
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbagen.2007.06.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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