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  1. Article ; Online: Noncovalent Conjugates of Ionic Liquid with Antibacterial Peptide Melittin

    Juhi Saraswat / Farooq Ahmed Wani / Khalid Imtiyaz Dar / M. Moshahid Alam Rizvi / Rajan Patel

    ACS Omega, Vol 5, Iss 12, Pp 6376-

    An Efficient Combination against Bacterial Cells

    2020  Volume 6388

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  2. Article ; Online: Periodate-Modified Gum Arabic Cross-linked PVA Hydrogels

    Ashiq Hussain Pandit / Nasreen Mazumdar / Khalid Imtiyaz / M. Moshahid Alam Rizvi / Sharif Ahmad

    ACS Omega, Vol 4, Iss 14, Pp 16026-

    A Promising Approach toward Photoprotection and Sustained Delivery of Folic Acid

    2019  Volume 16036

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Antioxidative and anti-proliferative potential of Curculigo orchioides Gaertn in oxidative stress induced cytotoxicity: In vitro, ex vivo and in silico studies

    Hejazi, Iram Iqbal / Abdul Roouf Bhat / Fareeda Athar / M.Moshahid Alam Rizvi / Rashmin Khanam / Sonu Chand Thakur / Syed Hassan Mehdi

    Food and chemical toxicology. 2018 May, v. 115

    2018  

    Abstract: Plant phytoconstituents have been a valuable source of clinically important anticancer agents. Antioxidant and anticancerous activity of plant Curculigo orchioides Gaertn were explored In vitro antioxidant activity, antioxidant enzyme activity of ... ...

    Abstract Plant phytoconstituents have been a valuable source of clinically important anticancer agents. Antioxidant and anticancerous activity of plant Curculigo orchioides Gaertn were explored In vitro antioxidant activity, antioxidant enzyme activity of oxidatively stressed tissue, and cell culture studies on human cancer cell lines HepG2, HeLa and MCF-7 were carried out. Active plant fractions were subjected to GC-MS analysis and compounds selected on the basis of their abundance were screened in silico with the help of Auto Dock 4.2 tools with pre-selected antioxidant enzymes. Curculigo orchioides Gaertn plant fractions exhibited significant antioxidant activities by virtue of scavenging of free radicals having IC50 value of ethylacetate fraction (EA) for DPPH radical scavenging assay to be 52.93 ± 0.66 μg/ml. Further, antioxidant enzyme defense of mammalian tissue when treated with plant fractions revealed that enzyme concentrations were refurbished which were increased during oxidative stress. MTT assay on cell lines HepG2, HeLa and MCF-7 presented IC50 values of ethylacetate (EA) fraction as 171.23 ± 2.1 μg/ml, 144.80 ± 1.08 μg/ml and 153.51 μg/ml and aqueous ethylacetate (AEA) fraction as 133.44 ± 1.1 μg/ml, 136.50 ± 0.8 μg/ml and 145.09 μg/ml respectively. Further EA and AEA plant fractions down regulated the levels of antiapoptotic Bcl-2 expression and upregulated the expression of apoptotic proteins caspase-3 and caspase-8 through an intrinsic ROS-mediated mitochondrial dysfunction pathway.Key findings explained that fractions of Curculigo orchioides Gaertn inhibited oxidative stress by increasing the antioxidant enzyme content and have anticancerous potential on cancer cell lines HepG2, HeLa and MCF-7.
    Keywords 2,2-diphenyl-1-picrylhydrazyl ; antineoplastic activity ; antineoplastic agents ; antioxidant activity ; antioxidants ; apoptosis ; caspase-3 ; caspase-8 ; cell culture ; chemical constituents of plants ; Curculigo orchioides ; cytotoxicity ; ethyl acetate ; free radicals ; gas chromatography-mass spectrometry ; human cell lines ; humans ; inhibitory concentration 50 ; mitochondria ; neoplasm cells ; neoplasms ; oxidative stress ; proteins
    Language English
    Dates of publication 2018-05
    Size p. 244-259.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/j.fct.2018.03.013
    Database NAL-Catalogue (AGRICOLA)

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