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Article ; Online: Ent-atisane diterpenoids from Euphorbia wallichii and their anti-influenza A virus activity.

Zhang, Jie / Guo, Xiao-Jia / Chen, Xiao-Juan / Zhang, Rong-Rong / Ma, Bai-Ping / Liu, Zhong-Qiu

2024 Volume 220, Page(s) 113996

Abstract: The study entailed the investigation of the roots of Euphorbia wallichii, which resulted in the isolation of 29 ent-atisane diterpenoids (1-29), 14 of which were previously unknown. These previously undescribed ones were named euphorwanoids A-N (3-5, 7, ... ...

Abstract	The study entailed the investigation of the roots of Euphorbia wallichii, which resulted in the isolation of 29 ent-atisane diterpenoids (1-29), 14 of which were previously unknown. These previously undescribed ones were named euphorwanoids A-N (3-5, 7, 9, and 10-18). Various techniques, including comprehensive spectroscopic methods and calculated electronic circular dichroism, were employed to determine their molecular structures. Additionally, the absolute configurations of ten ent-atisane diterpenoids (1, 2, 5, 6, 8, 9, 11, 12, 14 and 16) were established through X-ray crystallographic analyses. All isolated compounds' potential to inhibit the influenza A virus in vitro were evaluated. Compounds 18, 20, and 24 exhibited notable antiviral activity against the A/Puerto Rico/8/1934 strain. Their effective concentrations for reducing viral activity (EC
MeSH term(s)	Euphorbia/chemistry ; Molecular Structure ; Diterpenes/chemistry ; Circular Dichroism ; Magnetic Resonance Spectroscopy
Chemical Substances	Diterpenes
Language	English
Publishing date	2024-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2024.113996
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Article ; Online: [Qualitative and semiquantitative analyses of the chemical components of the seed coat and kernel of Ziziphi Spinosae Semen].

Shi, Yu-Hao / Nan, Yi / Zheng, Wei / Yao, Lan / Liang, Hai-Zhen / Chen, Xiao-Juan / Song, Juan / Zhang, Jie / Jia, De-Xian / Wang, Qian / Ma, Bai-Ping

Se pu = Chinese journal of chromatography

2024 Volume 42, Issue 3, Page(s) 234–244

Abstract: Ziziphi Spinosae Semen refers to the dried seed ... ...

Abstract	Ziziphi Spinosae Semen refers to the dried seed of
MeSH term(s)	Drugs, Chinese Herbal/chemistry ; Betulinic Acid ; Flavones ; Triterpenes ; Alkaloids ; Saponins/chemistry ; Oleic Acids ; Chromatography, High Pressure Liquid ; Ziziphus/chemistry ; Seeds
Chemical Substances	Drugs, Chinese Herbal ; Betulinic Acid (4G6A18707N) ; Flavones ; Triterpenes ; Alkaloids ; Saponins ; Oleic Acids
Language	Chinese
Publishing date	2024-03-18
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1872-2059
ISSN (online)	1872-2059
DOI	10.3724/SP.J.1123.2023.09015
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Article: N-containing compounds from Hymenocallis littoralis and their cytotoxicity against Hep3B cells

Pang, Xu / Duan, Zhi-Wen / Liu, Cai-Yan / Yu, Hai-Yang / Han, Li-Feng / Ma, Bai-Ping

Phytochemical Society of Europe Phytochemistry letters. 2022 Apr., v. 48

2022

Abstract: A chemical study focusing on the N-containing constituents of Hymenocallis littoralis was carried out, leading to the isolation of two new alkaloidal flavonoids (1–2) and five known alkaloids (3-7). Structures of the isolated compounds were established ... ...

Abstract	A chemical study focusing on the N-containing constituents of Hymenocallis littoralis was carried out, leading to the isolation of two new alkaloidal flavonoids (1–2) and five known alkaloids (3-7). Structures of the isolated compounds were established mainly by spectroscopic techniques, including NMR spectroscopy and mass spectrometry as well as the CD experiment. These compounds were subjected to the in vitro cytotoxicity assays using Hep3B cells, and among them only the known pancratistatine (3) and lycorine (5) could significantly inhibit the Hep3B cell proliferation.
Keywords	Hymenocallis littoralis ; cell proliferation ; cytotoxicity ; flavonoids ; lycorine ; mass spectrometry ; nuclear magnetic resonance spectroscopy
Language	English
Dates of publication	2022-04
Size	p. 54-56.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	1874-3900
DOI	10.1016/j.phytol.2022.01.013
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Article: [Non-alkaloid constituents of Hymenocallis littoralis].

Duan, Zhi-Wen / Zhang, Jie / Chen, Xiao-Juan / Pang, Xu / Ma, Bai-Ping

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2021 Volume 46, Issue 20, Page(s) 5304–5309

Abstract: Perennial herb Hymenocallis littoralis(Amaryllidaceae) boasts anti-tumor, anti-virus, and anti-inflammatory activities. As the representative constituents, alkaloids have attracted much attention, whereas the non-alkaloid constituents have been rarely ... ...

Abstract	Perennial herb Hymenocallis littoralis(Amaryllidaceae) boasts anti-tumor, anti-virus, and anti-inflammatory activities. As the representative constituents, alkaloids have attracted much attention, whereas the non-alkaloid constituents have been rarely reported. Therefore, this study investigated the non-alkaloid constituents of H. littoralis and their contribution to the various pharmacological activities of the herb. Thirteen non-alkaloid compounds were isolated from the 95% ethanol extract of dried whole plant of H. littoralis after a series of chromatographic separation steps and spectral analysis, and they were identified as 5,7-dihydroxy-6,8-dimethoxy-2-hydroxymethyl-4H-chromoen-4-one(1), undulatoside A(2),(2S)-7,4'-dihydroxyflavane(3), naringenin(4), 4',7-hydroxy-8-methylflavanone(5), 8-methylnaringenin(6), 8-demethylfarrerol(7), 6-methyl-aromadendrin(8), 4',5,7-trihydroxy-8-methylflavanone(9), syzalterin(10), 6-methylapigenin(11), isoliquiritigenin(12), and undatuside C(13) based on the spectroscopic data analysis. Among them, compound 1 was a new chromone derivative, and compounds 2 and 4-13 were isolated form this plant for the first time.
MeSH term(s)	Alkaloids ; Amaryllidaceae ; Chromones ; Liliaceae
Chemical Substances	Alkaloids ; Chromones
Language	Chinese
Publishing date	2021-11-04
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20210610.320
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Article ; Online: Steroidal saponins from Trillium tschonoskii rhizome repress cancer stemness and proliferation of intrahepatic cholangiocarcinoma.

Pang, Xu / Wan, Ling-Fei / Yang, Jie / Bai, Pei-Ying / Zhang, Jie / Chen, Xiao-Juan / Yan, Xin-Long / Ma, Bai-Ping

Bioorganic chemistry

2022 Volume 121, Page(s) 105679

Abstract: A phytochemical study was carried out on the extract of Trillium tschonoskii rhizomes, resulting in the isolation of thirty-six steroidal glycosides (1-36). Their structures were established mainly by spectroscopic analyses as well as necessary chemical ... ...

Abstract	A phytochemical study was carried out on the extract of Trillium tschonoskii rhizomes, resulting in the isolation of thirty-six steroidal glycosides (1-36). Their structures were established mainly by spectroscopic analyses as well as necessary chemical evidence, of which 1-25 were identified as new analogues. Herein, all the isolated analogues were screened for the cytotoxicity against intrahepatic cholangiocarcinoma (ICC) cell lines of HuCCT1 and RBE through tumor colony formation and CCK-8 survival analysis, and the results demonstrated that three compounds 9, 12, and 26 significantly repressed tumor colony and sphere formation in both cell lines, respectively. Furthermore, the three analogues possessed a remarkable inhibitory role of organoid formation established from hydrodynamic induced mouse primary intrahepatic cholangiocarcinoma. Moreover, the functional assays of flow cytometry analysis, cancer stemness related gene expression, and western blotting assays all indicated that compound 26 could significantly repress cancer stem markers. Taken together, these results demonstrate that steroidal glycosides derived from T. tschonoskii rhizomes could be potentially implicated in human ICC therapy.
MeSH term(s)	Animals ; Cell Proliferation ; Cholangiocarcinoma/drug therapy ; Glycosides/pharmacology ; Mice ; Rhizome/chemistry ; Saponins/chemistry ; Saponins/pharmacology ; Trillium/chemistry
Chemical Substances	Glycosides ; Saponins
Language	English
Publishing date	2022-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2022.105679
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Article: [Change of icariin content in five Epimedium species by heating process].

Sun, Xin-Guang / Zhou, Ming / Ma, Bai-Ping / Guo, Bao-Lin

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2019 Volume 44, Issue 9, Page(s) 1857–1861

Abstract: The change of icariin( ICA) content in thirty-three samples of five Epimedium species listed in the Chinese Pharmacopoeia( 2015 edition),including E. brevicornu,E. sagittatum,E. pubescens,E. koreanum,and E. wushanense has been investigated in this study. ...

Abstract	The change of icariin( ICA) content in thirty-three samples of five Epimedium species listed in the Chinese Pharmacopoeia( 2015 edition),including E. brevicornu,E. sagittatum,E. pubescens,E. koreanum,and E. wushanense has been investigated in this study. The results indicated that the optimized process procedure was baking at 150 ℃ for 30 min,and 3'''-carbonyl-2″-β-L-quinovosyl icariin( CQICA) could not be translated into ICA and ICA could be converted under this heating process condition. ICA increased remarkably after the heating process by 1-3 times in E. brevicornu,E. wushanense and E. koreanum,and increased lightly in E. brevicornum and E. pubescens,while ICA slightly increased or decreased in E. sagittatum and E. wushanense.
MeSH term(s)	Drugs, Chinese Herbal/chemistry ; Epimedium/chemistry ; Flavonoids/analysis ; Hot Temperature ; Phytochemicals/analysis ; Specimen Handling
Chemical Substances	Drugs, Chinese Herbal ; Flavonoids ; Phytochemicals ; icariin (VNM47R2QSQ)
Language	Chinese
Publishing date	2019-07-24
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20190222.001
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Article: New steroidal glycosides from the roots of Asparagus cochinchinensis

Pang, Xu / Gao, Lin / Wang, Bei / Chen, Xiao-Juan / Zhang, Jie / Guo, Bao-Lin / Ma, Bai-Ping

Journal of Asian natural products research. 2021 Apr. 1, v. 23, no. 3

2021

Abstract: Steroidal saponins were the main active constituents of the traditional medicinal herb Asparagus cochinchinensis. A phytochemical investigation of A. cochinchinensis roots led to the isolation of nine new steroidal glycosides (1–9) and seven known ... ...

Abstract	Steroidal saponins were the main active constituents of the traditional medicinal herb Asparagus cochinchinensis. A phytochemical investigation of A. cochinchinensis roots led to the isolation of nine new steroidal glycosides (1–9) and seven known analogues (10–16). Their structures were established by spectroscopic analyses as well as necessary chemical evidence.
Keywords	medicinal plants ; phytochemicals ; research ; spectroscopy ; steroid saponins
Language	English
Dates of publication	2021-0401
Size	p. 205-216.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2021.1873956
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Article: Acute toxicity, 28-day repeated-dose toxicity and toxicokinetic study of timosaponin BII in beagle dogs

Zhou, Fei / Liu, Bao-Feng / Wang, Can / Zhang, Jie / Dong, Guo-Ming / Jin, Hong-Tao / Ma, Bai-Ping / Zhong, Xiao-Ming

Journal of Asian natural products research. 2022 Sept. 2, v. 24, no. 9

2022

Abstract: The safety evaluation of timosaponin BII (TBII) in beagle dogs with toxicokinetic study was performed. For the acute oral toxicity study, the minimum lethal dose (MLD) of TBII was more than 2000 mg/kg and suggested the characteristics of absorption ... ...

Abstract	The safety evaluation of timosaponin BII (TBII) in beagle dogs with toxicokinetic study was performed. For the acute oral toxicity study, the minimum lethal dose (MLD) of TBII was more than 2000 mg/kg and suggested the characteristics of absorption saturation. For the 28-day repeated dose oral toxicity and toxicokinetic studies, there was no significant effect on all test parameters except for prolonged APTT in the 60 and 180 mg/kg groups, which recovered after withdrawal. The increase of drug exposure of 180 mg/kg group was not proportional to the increase of administration dose, showing the characteristics of absorption saturation.
Keywords	Beagle ; absorption ; acute oral toxicity ; drugs ; lethal dose ; research
Language	English
Dates of publication	2022-0902
Size	p. 860-876.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2021.1993834
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Article: New prenylated flavonoid glycosides derived from Epimedium wushanense by β-glucosidase hydrolysis and their testosterone production-promoting effects

SUN, Xin-Guang / PANG, Xu / LIANG, Hai-Zhen / ZHANG, Jie / WANG, Bei / LI, Qi / WANG, Jie / CHEN, Xiao-Juan / GUO, Bao-Lin / MA, Bai-Ping

Chinese journal of natural medicines. 2022 Sept., v. 20, no. 9

2022

Abstract: Six new prenylated flavonoid glycosides, including four new furan-flavonoid glycosides wushepimedoside A–D (1–4) and two new prenyl flavonoid derivatives wushepimedoside E–F (5–6), and one know analog epimedkoreside B (7) were isolated from ... ...

Abstract	Six new prenylated flavonoid glycosides, including four new furan-flavonoid glycosides wushepimedoside A–D (1–4) and two new prenyl flavonoid derivatives wushepimedoside E–F (5–6), and one know analog epimedkoreside B (7) were isolated from biotransformation products of the aerial parts of Epimedium wushanense. Their structures were elucidated according to comprehensive analysis of HR-MS and NMR spectroscopic data, and the absolute configurations were assigned using experimental and calculated electronic circular dichroism (ECD) data. The regulatory activity of compounds 1–7 on the production of testosterone in primary rat Leydig cells were investigated, and 4 and 5 exhibited testosterone production-promoting activities. Molecular docking analysis suggested that bioactive compounds 4 and 5 showed the stable binding with 3β-HSD and 4 also had good affinity with Cyp17A1, which suggested that these compounds may regulate testosterone production through stimulating the expression of the above two key proteins.
Keywords	Epimedium wushanense ; biotransformation ; circular dichroism spectroscopy ; flavonoids ; glycosides ; hydrolysis ; rats ; spectral analysis ; testosterone
Language	English
Dates of publication	2022-09
Size	p. 712-720.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(22)60188-2
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: An effective and high-throughput sample preparation method involving demalonylation followed by an ultrahigh-performance liquid chromatography-charged aerosol detector for analyzing gypenoside XLIX and gypenoside A in Gynostemma longipes.

Li, Gang / Lu, Peng-Xin / Liang, Hai-Zhen / Zheng, Wei / Chen, Xiao-Juan / Zhang, Jie / Song, Juan / Yang, Guang / Wang, Ya-Xi / Zhang, Tao / Guo, Bao-Lin / Ma, Bai-Ping

Journal of pharmaceutical and biomedical analysis

2023 Volume 230, Page(s) 115393

Abstract: Gypenosides (Gps) are the major bioactive components in Gynostemma species. They include neutral Gps and acidic malonylgypenosides (MGps). MGps are abundant in Gynostemma species and can be transformed into corresponding Gps via extraction, concentration, ...

Abstract	Gypenosides (Gps) are the major bioactive components in Gynostemma species. They include neutral Gps and acidic malonylgypenosides (MGps). MGps are abundant in Gynostemma species and can be transformed into corresponding Gps via extraction, concentration, and drying. If only the Gps were quantified and MGps were ignored, the quality of Gynostemma species would be underestimated. This study aimed to develop a sample preparation method involving demalonylation and ultrahigh-performance liquid chromatography-charged aerosol detector (UHPLC-CAD) analysis to determine the contents of gypenoside XLIX (Gp XLIX) and gypenoside A (Gp A). First, the optimized ultrasonic extraction method was established to extract G. longipes powder ultrasonically. Then, the extracted solution was put into a closed container (centrifuge tube) and heated in a water bath at 95 °C. Then, MGps were converted into corresponding Gps. The proposed preparation method was compared with the other three methods, including water bath reflux heating, alkali hydrolysis, and extraction of heated powder, and was shown to exhibit higher conversion and better convenience. Subsequently, an UHPLC-CAD method was established and validated. Gp XLIX and Gp A showed excellent linear correlations between 15.55 and 248.8 μg/mL and 24.10-385.5 μg/mL, respectively (R
MeSH term(s)	Gynostemma ; Powders ; Plant Extracts ; Chromatography, Liquid ; Water
Chemical Substances	gypenoside ; 3-((O-6-deoxymannopyranosyl-1-2-O-(xylopyranosyl-1-3)arabinopyranosyl)oxy)-21-glucopyranosyloxy-20-hydroxydammar-24-en-19-al ; Powders ; Plant Extracts ; Water (059QF0KO0R)
Language	English
Publishing date	2023-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2023.115393
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