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  1. Article ; Online: Global, regional, and national burden of inguinal, femoral, and abdominal hernias: a systematic analysis of prevalence, incidence, deaths, and DALYs with projections to 2030.

    Wang, Fan / Ma, Bangzhen / Ma, Qiuyue / Liu, Xiaoli

    International journal of surgery (London, England)

    2024  Volume 110, Issue 4, Page(s) 1951–1967

    Abstract: Background: Hernias, particularly inguinal, femoral, and abdominal, present a global health challenge. While the global burden of disease (GBD) study offers insights, systematic analyses of hernias remain limited. This research utilizes the GBD dataset ... ...

    Abstract Background: Hernias, particularly inguinal, femoral, and abdominal, present a global health challenge. While the global burden of disease (GBD) study offers insights, systematic analyses of hernias remain limited. This research utilizes the GBD dataset to explore hernia implications, combining current statistics with 2030 projections and frontier analysis.
    Methods: We analyzed data from the 2019 GBD Study, focusing on hernia-related metrics: prevalence, incidence, deaths, and disability-adjusted life years (DALYs) across 204 countries and territories, grouped into 21 GBD regions by the socio-demographic index (SDI). Data analysis encompassed relative change calculations, as well as annual percentage change (APC) and average annual percentage change (AAPC), both of which are based on joinpoint regression analysis. The study additionally employed frontier analysis and utilized the Bayesian age-period-cohort model for predicting trends up to 2030. Analyses utilized R version 4.2.3.
    Results: From 1990 to 2019, the global prevalence of hernia cases surged by 36%, reaching over 32.5 million, even as age-standardized rates declined. A similar pattern was seen in mortality and DALYs, with absolute figures rising but age-standardized rates decreasing. Gender data between 1990 and 2019 showed consistent male dominance in hernia prevalence, even as rates for both genders fell. Regionally, Andean Latin America had the highest prevalence, with Central Sub-Saharan Africa and South Asia noting significant increases and decreases, respectively. Frontier analyses across 204 countries and territories linked higher SDIs with reduced hernia prevalence. Yet, some high SDI countries, like Japan and Lithuania, deviated unexpectedly. Predictions up to 2030 anticipate increasing hernia prevalence, predominantly in males, while age-standardized death rates and age-standardized DALY rates are expected to decline.
    Conclusions: Our analysis reveals a complex interplay between socio-demographic factors and hernia trends, emphasizing the need for targeted healthcare interventions. Despite advancements, vigilance and continuous research are essential for optimal hernia management globally.
    MeSH term(s) Humans ; Prevalence ; Hernia, Inguinal/epidemiology ; Hernia, Inguinal/mortality ; Global Burden of Disease/trends ; Male ; Global Health/statistics & numerical data ; Female ; Hernia, Abdominal/epidemiology ; Hernia, Abdominal/mortality ; Incidence ; Disability-Adjusted Life Years/trends ; Hernia, Femoral/epidemiology ; Hernia, Femoral/mortality ; Middle Aged ; Adult
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000001071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: GFRA4 improves the neurogenic potential of enteric neural crest stem cells via hedgehog pathway.

    Zhang, Fangfang / Cui, Mingyu / Zhang, Lijuan / Ma, Bangzhen / Guo, Feng / Wang, Gang

    Pediatric research

    2024  

    Abstract: Background: Hirschsprung disease (HSCR) is a congenital intestinal disease characterised by functional obstruction of the colon. Herein, we investigated the role and mechanism of the gene GFRA4 in HSCR.: Methods: GFRA4 expression in the ganglionic ... ...

    Abstract Background: Hirschsprung disease (HSCR) is a congenital intestinal disease characterised by functional obstruction of the colon. Herein, we investigated the role and mechanism of the gene GFRA4 in HSCR.
    Methods: GFRA4 expression in the ganglionic and aganglionic segment tissues in patients with HSCR and healthy colon tissues were detected using qRT-PCR, western blot, and immunohistochemistry. Cell proliferation, cycle distribution, apoptosis, changes in mitochondrial membrane potential, and differentiation were assessed in mouse enteric neural crest stem cells (ENCSCs) using the CCK-8 assay, EdU staining, flow cytometry, JC-1 probe, and immunofluorescence, respectively. GSEA analysis was performed to screen the signaling pathways regulated by GFRA4.
    Results: GFRA4 was downregulated in aganglionic segment tissues compared to control and ganglionic segment tissues. GFRA4 overexpression promoted proliferation and differentiation, and inhibited apoptosis in ENCSCs, while GFRA4 down-regulation had the opposite result. GFRA4 activated the hedgehog pathway. GFRA4 overexpression enhanced the expression of key factors of the hedgehog pathway, including SMO, SHH, and GLI1. However, GFRA4 down-regulation reduced their expression. An antagonist of hedgehog pathway, cyclopamine, attenuated the effect of GFRA4 overexpression on proliferation, differentiation, and apoptosis of ENCSCs.
    Conclusion: GFRA4 promotes proliferation and differentiation but inhibits apoptosis of ENCSCs via the hedgehog pathway in HSCR.
    Impact: This study confirms that GFRA4 improves the proliferation and differentiation of ENCSCs via modulation of the hedgehog pathway. This study for the first time revealed the role and the mechanism of the action of GFRA4 in HSCR, which indicates that GFRA4 may play a role in the pathological development of HSCR. Our findings may lay the foundation for further investigation of the mechanisms underlying HSCR development and into targets of HSCR treatment.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-024-03158-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Spatially resolved visualization of reprogrammed metabolism in hepatocellular carcinoma by mass spectrometry imaging.

    Ma, Bangzhen / Zhang, Yang / Ma, Jiwei / Chen, Xinguo / Sun, Chenglong / Qin, Chengkun

    Cancer cell international

    2023  Volume 23, Issue 1, Page(s) 177

    Abstract: Background: Metabolic reprogramming refers to tumor-associated metabolic alterations during tumorigenesis and has been regarded as one of the most important features of cancer. Profiling the altered metabolites and lipids in hepatocellular carcinoma ... ...

    Abstract Background: Metabolic reprogramming refers to tumor-associated metabolic alterations during tumorigenesis and has been regarded as one of the most important features of cancer. Profiling the altered metabolites and lipids in hepatocellular carcinoma with spatial signature will not only enhance our understanding of tumor metabolic reprogramming, but also offer potential metabolic liabilities that might be exploited for hepatocellular carcinoma therapy.
    Methods: We perform matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) analysis on both hepatocellular carcinoma xenograft mouse model and hepatocellular carcinoma patients. Discriminatory metabolites that altered during the development of hepatocellular carcinoma are screened and imaged in xenograft mouse model and are further validated in 21 hepatocellular carcinoma patients.
    Results: We discover stepwise metabolic alterations and progressively increasing metabolic heterogeneity during the growth of hepatocellular carcinoma. Arginine and its metabolites spermine and spermidine, choline and phosphatidylcholine metabolism, and fatty acids were found to be significantly reprogrammed in hepatocellular carcinoma tissues.
    Conclusions: The spatially resolved profiling of the metabolites and lipids in highly heterogeneous hepatocellular carcinoma tissue will contribute to obtaining precise metabolic information for the understanding of tumor metabolic reprogramming.
    Language English
    Publishing date 2023-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091573-1
    ISSN 1475-2867
    ISSN 1475-2867
    DOI 10.1186/s12935-023-03027-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Key Modulation of ROS and HSP for Effective Therapy Against Hypoxic Tumor with Multifunctional Nanosystem.

    Ma, Bangzhen / Zhao, Yisheng / Liu, Xiaoli / Huo, Mengping / Wang, Jinghong / Ma, Jiwei / Zhang, Yang / Qin, Chengkun

    International journal of nanomedicine

    2023  Volume 18, Page(s) 6829–6846

    Abstract: Background: Though nanomedicine-based photothermal therapy (PTT) has demonstrated promising prospect in tumor treatment due to its high therapeutic efficiency and controllable range, the overexpression of heat shock proteins (HSPs) during PTT can lead ... ...

    Abstract Background: Though nanomedicine-based photothermal therapy (PTT) has demonstrated promising prospect in tumor treatment due to its high therapeutic efficiency and controllable range, the overexpression of heat shock proteins (HSPs) during PTT can lead to intracellular thermal resistance and reduce its effectiveness. Reactive oxygen species (ROS), followed by the application of chemodynamic therapy (CDT) and photodynamic therapy (PDT), can eliminate HSPs and overcome thermal resistance. However, the tumor microenvironment, including hypoxia and glutathione (GSH) overexpression, impedes the production of ROS and therapeutic efficacy of CDT and PDT. Therefore, we proposed a multifunctional nanoplatform (HMPB@TCPP-Cu) driving PTT/ PDT/ CDT synergistic therapy for tumor treatment via modulating ROS and HSPs.
    Methods and results: In this work, a novel nanoplatform (HMPB@TCPP-Cu) composed of O
    Conclusion: This study presents a multifunctional nanoplatform that combines photothermal/ chemodynamic/ photodynamic therapy for efficient hepatoblastoma treatment via modulating ROS and HSPs. Collectively, this study provides an appealing strategy in the cleavage of thermal resistance and a novel assistance and enhancement on thermal-related therapies.
    MeSH term(s) Humans ; Hepatoblastoma ; Reactive Oxygen Species ; Neoplasms/drug therapy ; Hypoxia ; Oxygen ; Glutathione ; Heat-Shock Proteins ; Hydrogen Peroxide ; Liver Neoplasms ; Cell Line, Tumor ; Tumor Microenvironment ; Photochemotherapy
    Chemical Substances Reactive Oxygen Species ; Oxygen (S88TT14065) ; Glutathione (GAN16C9B8O) ; Heat-Shock Proteins ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2023-11-18
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2364941-0
    ISSN 1178-2013 ; 1176-9114
    ISSN (online) 1178-2013
    ISSN 1176-9114
    DOI 10.2147/IJN.S432928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of sphincter of Oddi motility on the formation of cholesterol gallstones.

    Rong, Zhong-Hou / Chen, Hong-Yuan / Wang, Xin-Xing / Wang, Zhi-Yi / Xian, Guo-Zhe / Ma, Bang-Zhen / Qin, Cheng-Kun / Zhang, Zhen-Hai

    World journal of gastroenterology

    2016  Volume 22, Issue 24, Page(s) 5540–5547

    Abstract: Aim: To investigate the mechanisms and effects of sphincter of Oddi (SO) motility on cholesterol gallbladder stone formation in guinea pigs.: Methods: Thirty-four adult male Hartley guinea pigs were divided randomly into two groups, the control group ...

    Abstract Aim: To investigate the mechanisms and effects of sphincter of Oddi (SO) motility on cholesterol gallbladder stone formation in guinea pigs.
    Methods: Thirty-four adult male Hartley guinea pigs were divided randomly into two groups, the control group (n = 10) and the cholesterol gallstone group (n = 24), which was sequentially divided into four subgroups with six guinea pigs each according to time of sacrifice. The guinea pigs in the cholesterol gallstone group were fed a cholesterol lithogenic diet and sacrificed after 3, 6, 9, and 12 wk. SO manometry and recording of myoelectric activity were obtained by a multifunctional physiograph at each stage. Cholecystokinin-A receptor (CCKAR) expression levels in SO smooth muscle were detected by quantitative real-time PCR (qRT-PCR) and serum vasoactive intestinal peptide (VIP), gastrin, and cholecystokinin octapeptide (CCK-8) were detected by enzyme-linked immunosorbent assay at each stage in the process of cholesterol gallstone formation.
    Results: The gallstone formation rate was 0%, 0%, 16.7%, and 83.3% in the 3, 6, 9, and 12 wk groups, respectively. The frequency of myoelectric activity in the 9 wk group, the amplitude of myoelectric activity in the 9 and 12 wk groups, and the amplitude and the frequency of SO in the 9 wk group were all significantly decreased compared to the control group. The SO basal pressure and common bile duct pressure increased markedly in the 12 wk group, and the CCKAR expression levels increased in the 6 and 12 wk groups compared to the control group. Serum VIP was elevated significantly in the 9 and 12 wk groups and gastrin decreased significantly in the 3 and 9 wk groups. There was no difference in serum CCK-8 between the groups.
    Conclusion: A cholesterol gallstone-causing diet can induce SO dysfunction. The increasing tension of the SO along with its decreasing activity may play an important role in cholesterol gallstone formation. Expression changes of CCKAR in SO smooth muscle and serum VIP and CCK-8 may be important causes of SO dysfunction.
    MeSH term(s) Animals ; Cholesterol ; Disease Models, Animal ; Electromyography ; Enzyme-Linked Immunosorbent Assay ; Gallstones/genetics ; Gallstones/metabolism ; Gallstones/physiopathology ; Gastrins/genetics ; Gastrins/metabolism ; Guinea Pigs ; Manometry ; Muscle, Smooth/metabolism ; Real-Time Polymerase Chain Reaction ; Receptor, Cholecystokinin A/genetics ; Receptor, Cholecystokinin A/metabolism ; Sincalide/genetics ; Sincalide/metabolism ; Sphincter of Oddi/metabolism ; Sphincter of Oddi/physiopathology ; Sphincter of Oddi Dysfunction/genetics ; Sphincter of Oddi Dysfunction/metabolism ; Sphincter of Oddi Dysfunction/physiopathology ; Vasoactive Intestinal Peptide/genetics ; Vasoactive Intestinal Peptide/metabolism
    Chemical Substances Gastrins ; Receptor, Cholecystokinin A ; Vasoactive Intestinal Peptide (37221-79-7) ; Cholesterol (97C5T2UQ7J) ; Sincalide (M03GIQ7Z6P)
    Language English
    Publishing date 2016-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v22.i24.5540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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