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  1. Article: [Advances in research on the clinical phenotype and genetic etiology of jaundice associated with Hereditary bilirubin metabolic disorders].

    Ma, Beibei / Wu, Qinghua

    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

    2023  Volume 40, Issue 11, Page(s) 1436–1440

    Abstract: Hereditary bilirubin metabolic disorder is an important cause for jaundice. For its diverse types and similar clinical manifestations, it has been difficult to make a clear etiological diagnosis. The application of next generation sequencing in recent ... ...

    Abstract Hereditary bilirubin metabolic disorder is an important cause for jaundice. For its diverse types and similar clinical manifestations, it has been difficult to make a clear etiological diagnosis. The application of next generation sequencing in recent years has delineated the more and more genetic etiologies for jaundice. This article has reviewed the clinical manifestations and genetic etiology of bilirubin metabolic disorder jaundice, with an aim to enhance the understanding of such diseases and facilitate their clinical diagnosis and treatment, which will provide a reference for genetic counseling and/or prenatal diagnosis for the affected individuals and families.
    MeSH term(s) Female ; Pregnancy ; Humans ; Metabolic Diseases/genetics ; Jaundice/genetics ; Bilirubin ; Genetic Counseling ; Phenotype
    Chemical Substances Bilirubin (RFM9X3LJ49)
    Language Chinese
    Publishing date 2023-10-31
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1003-9406
    ISSN 1003-9406
    DOI 10.3760/cma.j.cn511374-20210223-00150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Renewables' impacts on ecosystems in China.

    Song, Yongyong / Xue, Dongqian / Wen, Qi / Ye, Hao / Ma, Beibei

    Science (New York, N.Y.)

    2024  Volume 383, Issue 6689, Page(s) 1302–1303

    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Letter
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.ado6369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Design of a new Li-rich Mn-based ternary cathode material based on the Ni, Co, and Mn action mechanism.

    Yin, Chengbin / Wu, Keyang / Liu, Chengzhou / Ma, Beibei / Rong, Ju / Wang, Yuan

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 5, Page(s) 4091–4098

    Abstract: Rechargeable lithium-ion batteries, as the most advanced energy storage devices currently available, urgently require the development of cathode materials with high capacity, large specific energy, and fast charge/discharge performance to satisfy the ... ...

    Abstract Rechargeable lithium-ion batteries, as the most advanced energy storage devices currently available, urgently require the development of cathode materials with high capacity, large specific energy, and fast charge/discharge performance to satisfy the continuous technological innovation. Here, a Li-rich Mn-based ternary cathode material Li
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp04792j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Proteome-metabolome profiling of wax gland complex reveals functional changes in honeybee,

    Xu, Rumeng / Ma, Beibei / Yang, Yiying / Dong, Xuancheng / Li, Jianke / Xu, Xiang / Fang, Yu

    iScience

    2024  Volume 27, Issue 3, Page(s) 109279

    Abstract: Wax gland complex (WGC) serves as the primary generator of beeswax; however, the dynamic biological function in wax secretion remains unclear. To elucidate the developmental mechanism of WGC, we conducted a comprehensive analysis to reveal the variations ...

    Abstract Wax gland complex (WGC) serves as the primary generator of beeswax; however, the dynamic biological function in wax secretion remains unclear. To elucidate the developmental mechanism of WGC, we conducted a comprehensive analysis to reveal the variations in proteins and metabolites among the newly emerged bee (NEB), wax-secreting bee (WSB), and overaged bee (OAB). We identified 3,295 proteins and 159 metabolites in WGC. Specifically, NEB elevated the expression of ribosomal proteins for preparing the glandular organ. While WSB promoted the size of epidermal cells and oenocytes, the enrichment of fatty acids and energy metabolism in WSB suggested a strong ability in wax synthesis. In OAB, disorganized wax tubules, and up-regulated cysteine proteases reflected the gland degeneration. These findings highlight the dynamic changes in the level of molecule and morphological structure in WGC, offering valuable insights into the development and mechanism of wax secretion in honeybees and other wax insects.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Changes in chemical composition and antioxidant activity of royal jelly produced at different floral periods during migratory beekeeping

    Ma, Chuan / Ma, Beibei / Li, Jianke / Fang, Yu

    Food research international. 2022 May, v. 155

    2022  

    Abstract: Over 90% of global royal jelly (RJ), a functional food with various health benefits, is produced in China mainly by migratory beekeeping of a high RJ-producing honeybee (RJB) strain. To explore quality changes of RJ produced by migratory RJBs at ... ...

    Abstract Over 90% of global royal jelly (RJ), a functional food with various health benefits, is produced in China mainly by migratory beekeeping of a high RJ-producing honeybee (RJB) strain. To explore quality changes of RJ produced by migratory RJBs at different floral periods, we performed metabolomics and proteomics analysis and assessed RJ antioxidant activity. Overall, the RJ metabolic and proteomic profiles were observed to vary with floral periods. Minor sugars (raffinose, erlose, and sucrose) and major RJ protein 5 (MRJP5) were identified among the discriminating components mainly contributing to the altered profiles. Water, crude protein, and the trans-10-hydroxy-2-decenoic acid (10-HDA) content fulfill the requirements of the International Organization for Standardization regardless of floral periods. Notably, the 10-HDA content increased 11.05%–19.65% during tea blooming. Moreover, changes in antioxidants resulted in significant difference in RJ antioxidant activity. The integrated omics data provide a detailed view of chemical composition for RJ quality evaluation.
    Keywords International Organization for Standardization ; antioxidant activity ; apiculture ; crude protein ; food research ; functional foods ; honey bees ; metabolomics ; migratory behavior ; proteomics ; raffinose ; royal jelly ; sucrose ; tea ; China
    Language English
    Dates of publication 2022-05
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2022.111091
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  6. Article ; Online: Farming in arid areas depletes China's water.

    Song, Yongyong / Xue, Dongqian / Ma, Beibei / Xia, Siyou / Ye, Hao

    Science (New York, N.Y.)

    2023  Volume 379, Issue 6633, Page(s) 651

    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Letter
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adg4780
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  7. Article: Revealing phosphorylation regulatory networks during embryogenesis of honey bee worker and drone (

    Ma, Beibei / Ma, Chuan / Li, Jianke / Fang, Yu

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 1006964

    Abstract: Protein phosphorylation is known to regulate a comprehensive scenario of critical cellular processes. However, phosphorylation-mediated regulatory networks in honey bee embryogenesis are mainly unknown. We identified 6342 phosphosites from 2438 ... ...

    Abstract Protein phosphorylation is known to regulate a comprehensive scenario of critical cellular processes. However, phosphorylation-mediated regulatory networks in honey bee embryogenesis are mainly unknown. We identified 6342 phosphosites from 2438 phosphoproteins and predicted 168 kinases in the honey bee embryo. Generally, the worker and drone develop similar phosphoproteome architectures and major phosphorylation events during embryogenesis. In 24 h embryos, protein kinases A play vital roles in regulating cell proliferation and blastoderm formation. At 48-72 h, kinase subfamily dual-specificity tyrosine-regulated kinase, cyclin-dependent kinase (CDK), and induced pathways related to protein synthesis and morphogenesis suggest the centrality to enhance the germ layer development, organogenesis, and dorsal closure. Notably, workers and drones formulated distinct phosphoproteome signatures. For 24 h embryos, the highly phosphorylated serine/threonine-protein kinase minibrain, microtubule-associated serine/threonine-protein kinase 2 (MAST2), and phosphorylation of mitogen-activated protein kinase 3 (MAPK3) at Thr
    Language English
    Publishing date 2022-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.1006964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Spatio-Temporal Patterns of County Population Shrinkage and Influencing Factors in the North-South Transitional Zone of China.

    Wu, Tong / Ma, Beibei / Song, Yongyong

    International journal of environmental research and public health

    2022  Volume 19, Issue 23

    Abstract: Population is the foundation of socio-economic development. However, continued population shrinkage has made the problem of unbalanced and insufficient regional development more prominent, threatening human well-being. How to solve the contradiction ... ...

    Abstract Population is the foundation of socio-economic development. However, continued population shrinkage has made the problem of unbalanced and insufficient regional development more prominent, threatening human well-being. How to solve the contradiction between population shrinkage and regional development has become an urgent scientific problem. Therefore, taking a typical underdeveloped mountainous region, the North-South Transitional Zone of China, as an example, we analyzed the spatial and temporal evolution of regional population shrinkage from 2000 to 2020, classified the types of regional population shrinkage, and revealed the key influencing factors and driving mechanisms for the formation of population shrinkage patterns in poor mountainous counties. The results showed that: (1) From 2000 to 2020, the number of counties in the North-South Transitional Zone of China with population shrinkage grew, and the degree of shrinkage increased. The shrinking counties were mainly municipal counties, and the shrinkage types were mainly continuous shrinkage and expansion followed by shrinkage. (2) Spatially, the shrinking counties had significant and strengthening spatial autocorrelation, with obvious characteristics of the contiguous shrinkage of county units, and the shrinkage center of gravity and shrinkage agglomeration areas showed an evolutionary trend of shifting from east to west. The shrinking counties had obvious divergence in both the "east-west" and "north-south" directions. (3) Natural factors had an endogenous rooting role, while human factors had a strong driving role, and the impact of different influencing factors varied significantly. (4) The formation and evolution of the spatial pattern of county population shrinkage was subject to the synergistic effect of natural factors and human factors. The interaction between natural and human factors had a non-linear enhancement effect and a two-factor enhancement effect. The results of this study are expected to provide a scientific basis for coordinating regional human-land relations in order to optimize population-flow governance and sustainable regional development in the North-South Transitional Zone and less-developed regions of China.
    MeSH term(s) Humans ; China/epidemiology ; Sustainable Development ; Spatial Analysis
    Language English
    Publishing date 2022-11-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192315801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Changes in chemical composition and antioxidant activity of royal jelly produced at different floral periods during migratory beekeeping.

    Ma, Chuan / Ma, Beibei / Li, Jianke / Fang, Yu

    Food research international (Ottawa, Ont.)

    2022  Volume 155, Page(s) 111091

    Abstract: Over 90% of global royal jelly (RJ), a functional food with various health benefits, is produced in China mainly by migratory beekeeping of a high RJ-producing honeybee (RJB) strain. To explore quality changes of RJ produced by migratory RJBs at ... ...

    Abstract Over 90% of global royal jelly (RJ), a functional food with various health benefits, is produced in China mainly by migratory beekeeping of a high RJ-producing honeybee (RJB) strain. To explore quality changes of RJ produced by migratory RJBs at different floral periods, we performed metabolomics and proteomics analysis and assessed RJ antioxidant activity. Overall, the RJ metabolic and proteomic profiles were observed to vary with floral periods. Minor sugars (raffinose, erlose, and sucrose) and major RJ protein 5 (MRJP5) were identified among the discriminating components mainly contributing to the altered profiles. Water, crude protein, and the trans-10-hydroxy-2-decenoic acid (10-HDA) content fulfill the requirements of the International Organization for Standardization regardless of floral periods. Notably, the 10-HDA content increased 11.05%-19.65% during tea blooming. Moreover, changes in antioxidants resulted in significant difference in RJ antioxidant activity. The integrated omics data provide a detailed view of chemical composition for RJ quality evaluation.
    MeSH term(s) Animals ; Antioxidants ; Beekeeping ; Bees ; Fatty Acids/analysis ; Proteomics/methods
    Chemical Substances Antioxidants ; Fatty Acids ; royal jelly (L497I37F0C)
    Language English
    Publishing date 2022-03-05
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2022.111091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Psychometric Challenges in the Measurement of Constructs Underlying Criminal Responsibility in Children and Young Adults: A Cross-Sectional Study.

    Shang, Yuxi / Fu, Yumiao / Ma, Beibei / Wang, Li / Wang, Dexin

    Frontiers in psychology

    2022  Volume 12, Page(s) 781669

    Abstract: At present, many countries have lowered the minimum age of criminal responsibility to deal with the trend of juvenile crime. In practical terms, whether countries advocate for lowering the age of criminal responsibility along with early puberty, or ... ...

    Abstract At present, many countries have lowered the minimum age of criminal responsibility to deal with the trend of juvenile crime. In practical terms, whether countries advocate for lowering the age of criminal responsibility along with early puberty, or regulating the minimum age of juvenile criminal responsibility through their policies, their deep-rooted hypothesis is that age is tied to adolescents' psychological growth, and, with the rise in age, the capacity for dialectical thinking, self-control, and empathy gradually improves. With this study, we aimed to test whether this hypothesis is valid. The participants were 3,208 students from junior high school, senior high school, and freshman in the S province of the People's Republic of China (PRC). We subjected the gathered materials to independent-samples
    Language English
    Publishing date 2022-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.781669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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