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Article ; Online: Flavonoids and their therapeutic applications in skin diseases.

Ma, Emily Z / Khachemoune, Amor

2022 Volume 315, Issue 3, Page(s) 321–331

Abstract: Flavonoids are a class of plant polyphenols found in a variety of fruits, vegetables, teas, and flowers. These compounds are present in many common dietary sources, such as green tea, wine, pomegranates, and turmeric, and possess a broad spectrum of ... ...

Abstract	Flavonoids are a class of plant polyphenols found in a variety of fruits, vegetables, teas, and flowers. These compounds are present in many common dietary sources, such as green tea, wine, pomegranates, and turmeric, and possess a broad spectrum of biological activity due to their unique chemical structure. Flavonoids exhibit antioxidant, anti-inflammatory, antiviral, and anticarcinogenic properties that have been widely studied as potential therapeutics for diseases ranging from Alzheimer's disease to liver disease. There is currently significant research into therapeutic benefits of flavonoids in various skin conditions as these compounds have been shown to absorb ultraviolet radiation and modulate cancer and inflammation signaling pathways. This review discusses the current research in the application of flavonoids in skin diseases (e.g., prevention of premature photoaging, prevention and treatment of skin cancer, and promotion of skin wound healing) and their proposed mechanisms to provide a basis for future basic and translational research of flavonoids as potential drugs in the prevention and treatment of skin disorders.
MeSH term(s)	Humans ; Flavonoids/pharmacology ; Flavonoids/therapeutic use ; Phenols ; Ultraviolet Rays ; Skin Diseases/drug therapy ; Skin Neoplasms/prevention & control ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Tea
Chemical Substances	Flavonoids ; Phenols ; Antioxidants ; Tea
Language	English
Publishing date	2022-09-21
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-022-02395-3
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Article ; Online: Prurigo Nodularis: New insights into pathogenesis and novel therapeutics.

Liao, Viviane / Cornman, Hannah L / Ma, Emily / Kwatra, Shawn G

The British journal of dermatology

2024

Abstract: Prurigo nodularis (PN) is an inflammatory skin condition characterized by intensely pruritic nodules on the skin. PN patients suffer from an intractable itch-scratch cycle leading to impaired sleep, psychosocial distress, and a significant disruption in ... ...

Abstract	Prurigo nodularis (PN) is an inflammatory skin condition characterized by intensely pruritic nodules on the skin. PN patients suffer from an intractable itch-scratch cycle leading to impaired sleep, psychosocial distress, and a significant disruption in quality of life. The pathogenesis of PN is associated with immune and neural dysregulation, mediated by inflammatory cytokines (such as IL-4, -13, -17, -22, and -31) and neuropeptides (such as substance P and calcitonin gene-related peptide). There is a role for type 2 inflammation in PN in addition to Th17 and Th22-mediated inflammation. The neuroimmune feedback loop in PN involves neuropeptides released from nerve fibers that cause vasodilation and further recruitment of inflammatory cells. Inflammatory cells, particularly mast cells and eosinophils, degranulate and release neurotoxins, as well as nerve growth factor, which may contribute to the neuronal hyperplasia seen in the dermis of PN patients and neural sensitization. Recent studies have also indicated underlying genetic susceptibility to PN in addition to environmental factors, the existence of various disease endotypes centered around degrees of Type 2 inflammation or underlying myelopathy or spinal disc disease, and significant race and ethnicity-based differences with African-Americans having densely fibrotic skin lesions. Dupilumab became the first FDA approved therapeutic for PN, and there are several other agents currently in development. The anti-IL-31RA inhibitor nemolizumab is in late stage development with positive phase 3 data reported. In addition, the oral JAK1 inhibitors, abrocitinib and povorcitinib, are in phase 2 trials while a topical JAK1/2 inhibitor, ruxolitinib, is in phase 3 studies.
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1093/bjd/ljae052
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Article ; Online: Symptoms of Cognitive Impairment Among Children With Atopic Dermatitis.

Ma, Emily Z / Chang, Hannah R / Radtke, Sarah / Wan, Joy

JAMA dermatology

2024 Volume 160, Issue 4, Page(s) 447–452

Abstract: Importance: Previous studies suggest that atopic dermatitis (AD) is associated with cognitive impairment in children, but these studies have relied primarily on neurodevelopmental diagnoses (rather than symptoms) as proxy measures of cognitive function. ...

Abstract	Importance: Previous studies suggest that atopic dermatitis (AD) is associated with cognitive impairment in children, but these studies have relied primarily on neurodevelopmental diagnoses (rather than symptoms) as proxy measures of cognitive function. It remains unknown if certain subpopulations of children with AD are at greater risk of cognitive impairment. Objective: To examine the association of AD with symptoms of cognitive impairment (difficulty in learning or memory) among US children and whether this association varies according to the presence or absence of neurodevelopmental comorbidities (attention-deficit/hyperactivity disorder [ADHD], developmental delay, or learning disability). Design, setting, and participants: This cross-sectional study used 2021 data from the US National Health Interview Survey collected on children aged 17 years or younger without intellectual disability or autism. The presence of AD was based on a parent or adult caregiver's report indicating either a current diagnosis of AD or a previous medical confirmation of AD by a health care professional. Main outcomes and measures: Difficulty with learning or memory as reported by the child's caregiver. Results: Among the weighted total of 69 732 807 participants, 9 223 013 (13.2%) had AD. Compared with children without AD, children with AD were more likely to experience difficulties with learning (10.8% [95% CI, 7.8%-15.8%] vs 5.9% [95% CI, 5.1%-6.9%]; P < .001) and difficulties with memory (11.1% [95% CI, 8.0%-15.9%] vs 5.8% [95% CI, 4.9%-6.9%]; P < .001). In multivariable logistic regression models adjusted for sociodemographic factors, asthma, food allergies, and seasonal allergies or hay fever, AD was associated with increased odds of difficulties in learning (adjusted odds ratio [AOR], 1.77; 95% CI, 1.28-2.45) and memory (AOR, 1.69; 95% CI, 1.19-2.41). In analyses stratified by neurodevelopmental comorbidities, AD was associated with 2- to 3-fold greater odds of memory difficulties among children with any neurodevelopmental disorder (AOR, 2.26; 95% CI, 1.43-3.57), including ADHD (AOR, 2.90; 95% CI, 1.60-5.24) or learning disabilities (AOR, 2.04; 95% CI, 1.04-4.00). However, AD was not associated with learning or memory difficulties among children without neurodevelopmental conditions. Conclusions and relevance: Results of this cross-sectional study suggest that pediatric AD was generally associated with greater odds of reported difficulties in learning and memory. However, this association was primarily limited to children with neurodevelopmental comorbidities, such as ADHD or learning disabilities. These findings may improve the risk stratification of children with AD for cognitive impairments and suggest that evaluation for cognitive difficulties should be prioritized among children with AD and neurodevelopmental disorders.
MeSH term(s)	Adult ; Child ; Humans ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/epidemiology ; Cross-Sectional Studies ; Asthma/complications ; Learning Disabilities/diagnosis ; Learning Disabilities/epidemiology ; Learning Disabilities/complications ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/etiology
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2701761-8
ISSN	2168-6084 ; 2168-6068
ISSN (online)	2168-6084
ISSN	2168-6068
DOI	10.1001/jamadermatol.2024.0015
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Article ; Online: Malignant melanoma arising in a burn scar.

Ma, Emily / Ge, Shealinna / Rush, Walter L / Allbritton, Jill

Archives of dermatological research

2024 Volume 316, Issue 5, Page(s) 146

Abstract: Secondary malignancies are rare but devastating complications of longstanding burn scars. Squamous cell carcinoma is the most common, followed by basal cell carcinoma and melanomas. There are fewer than 50 total reported cases of malignant melanomas ... ...

Abstract	Secondary malignancies are rare but devastating complications of longstanding burn scars. Squamous cell carcinoma is the most common, followed by basal cell carcinoma and melanomas. There are fewer than 50 total reported cases of malignant melanomas arising in burn scars. We report a case of malignant melanoma arising within a longstanding burn scar confirmed by histology, FISH, and PRAME staining to further characterize melanomas arising in burn scars and to illustrate the diagnostic challenges they present.
MeSH term(s)	Humans ; Melanoma/diagnosis ; Melanoma/pathology ; Melanoma/complications ; Burns/complications ; Burns/diagnosis ; Burns/pathology ; Cicatrix/etiology ; Cicatrix/pathology ; Cicatrix/diagnosis ; Skin Neoplasms/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/etiology ; Male ; Middle Aged ; gp100 Melanoma Antigen ; Melanoma, Cutaneous Malignant ; Female ; In Situ Hybridization, Fluorescence
Chemical Substances	gp100 Melanoma Antigen
Language	English
Publishing date	2024-05-02
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-024-02861-0
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Article ; Online: Association of atopic dermatitis with emotional and behavioral problems in childhood.

Ma, Emily Z / Hooper, Stephen R / Seegan, Paige L / Wan, Joy

Journal of the American Academy of Dermatology

2024 Volume 90, Issue 6, Page(s) 1249–1252

MeSH term(s)	Humans ; Dermatitis, Atopic/psychology ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/epidemiology ; Child ; Female ; Male ; Child, Preschool ; Child Behavior Disorders/etiology ; Child Behavior Disorders/epidemiology ; Child Behavior Disorders/psychology ; Adolescent ; Affective Symptoms/psychology ; Affective Symptoms/etiology ; Affective Symptoms/epidemiology
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Letter ; Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2024.01.068
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Article ; Online: Divalent Ion Specific Outcomes on Stern Layer Structure and Total Surface Potential at the Silica:Water Interface.

Ma, Emily / Geiger, Franz M

The journal of physical chemistry. A

2021 Volume 125, Issue 46, Page(s) 10079–10088

Abstract: The second-order nonlinear susceptibility, ... ...

Abstract	The second-order nonlinear susceptibility, χ
Language	English
Publishing date	2021-11-11
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.1c08143
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Article ; Online: Quantification of Stern Layer Water Molecules, Total Potentials, and Energy Densities at Fused Silica:Water Interfaces for Adsorbed Alkali Chlorides, CTAB, PFOA, and PFAS.

Chang, HanByul / Lozier, Emilie H / Ma, Emily / Geiger, Franz M

The journal of physical chemistry. A

2023 Volume 127, Issue 40, Page(s) 8404–8414

Abstract: We have employed amplitude- and phase-resolved second-harmonic generation spectroscopy to investigate ion-specific effects of monovalent cations at the fused silica:water interface maintained under acidic, neutral, and alkaline conditions. We find a ... ...

Abstract	We have employed amplitude- and phase-resolved second-harmonic generation spectroscopy to investigate ion-specific effects of monovalent cations at the fused silica:water interface maintained under acidic, neutral, and alkaline conditions. We find a negligible dependence of the total potential (as negative as -400 mV at pH 14), the second-order nonlinear susceptibility (as large as 1.5 × 10
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.3c04434
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Article ; Online: Progressive Skull Osteolysis in the Setting of Endotine Implantation: A Case Report.

Ma, Emily / Smith, Sullivan / Simon, Joshua / Prabhu, Vikram / Pittman, Amy

The Annals of otology, rhinology, and laryngology

2023 Volume 133, Issue 2, Page(s) 239–243

Abstract: Objectives: To report a case of a 71-year-old woman who presented 8 years following 2 endoscopic brow lift procedures for evaluation of bony irregularities of her frontoparietal skull. To highlight a novel complication of Endotine fixation following an ... ...

Abstract	Objectives: To report a case of a 71-year-old woman who presented 8 years following 2 endoscopic brow lift procedures for evaluation of bony irregularities of her frontoparietal skull. To highlight a novel complication of Endotine fixation following an endoscopic brow lift procedure. Methods: A chart review, bicoronal cranioplasty and a review of literature. Results: The patient was satisfied with her post-surgical outcome and no complications were observed at the 1-month follow-up visit. A review of the literature revealed no previous reports of focal skull osteolysis relating to Endotine implants. Conclusion: We believe that our patient's focal calvarial osteolysis is a direct complication of Endotine fixation. Future research into the long-term effects of endoscopic brow lift procedures using Endotine implants is necessary to help ensure patient safety and guide future practices.
MeSH term(s)	Humans ; Female ; Aged ; Osteolysis/etiology ; Osteolysis/surgery ; Eyebrows ; Rhytidoplasty/methods ; Endoscopy ; Skull/surgery
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/00034894231190969
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Article ; Online: Bioinformatic and Machine Learning Applications in Melanoma Risk Assessment and Prognosis: A Literature Review.

Ma, Emily Z / Hoegler, Karl M / Zhou, Albert E

Genes

2021 Volume 12, Issue 11

Abstract: Over 100,000 people are diagnosed with cutaneous melanoma each year in the United States. Despite recent advancements in metastatic melanoma treatment, such as immunotherapy, there are still over 7000 melanoma-related deaths each year. Melanoma is a ... ...

Abstract	Over 100,000 people are diagnosed with cutaneous melanoma each year in the United States. Despite recent advancements in metastatic melanoma treatment, such as immunotherapy, there are still over 7000 melanoma-related deaths each year. Melanoma is a highly heterogenous disease, and many underlying genetic drivers have been identified since the introduction of next-generation sequencing. Despite clinical staging guidelines, the prognosis of metastatic melanoma is variable and difficult to predict. Bioinformatic and machine learning analyses relying on genetic, clinical, and histopathologic inputs have been increasingly used to risk stratify melanoma patients with high accuracy. This literature review summarizes the key genetic drivers of melanoma and recent applications of bioinformatic and machine learning models in the risk stratification of melanoma patients. A robustly validated risk stratification tool can potentially guide the physician management of melanoma patients and ultimately improve patient outcomes.
MeSH term(s)	Computational Biology/methods ; Deep Learning ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Melanoma/genetics ; Melanoma/pathology ; Prognosis ; Risk Assessment ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Melanoma, Cutaneous Malignant
Language	English
Publishing date	2021-10-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12111751
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Article: COVID-19 impacts, coping strategies, and management reflection: A lodging industry case.

Smart, Kaleb / Ma, Emily / Qu, Hailin / Ding, Li

International journal of hospitality management

2021 Volume 94, Page(s) 102859

Abstract: The COVID-19 pandemic has hit the global tourism and hospitality industry with drastic results. Hotels have been experiencing unprecedented challenges, leaving many to temporarily or permanently closed. Employing a case study approach supported by both ... ...

Abstract	The COVID-19 pandemic has hit the global tourism and hospitality industry with drastic results. Hotels have been experiencing unprecedented challenges, leaving many to temporarily or permanently closed. Employing a case study approach supported by both quantitative and qualitative analysis, this study examined how two hotels in Oklahoma City had coped with challenges presented by the COVID-19 pandemic, from day to day operations, health and safety measures to marketing, human resources and cost-saving strategies. The study contributes to the tourism crisis and disaster literature by providing micro-level coping strategies, a literature gap that needs to be addressed, particularly under the current pandemic.
Language	English
Publishing date	2021-01-11
Publishing country	England
Document type	Journal Article
ISSN	0278-4319
ISSN	0278-4319
DOI	10.1016/j.ijhm.2021.102859
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