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Article ; Online: Correlation between the expressions of CXCL8 and miR-150 in the skin lesions and the severity of psoriasis vulgaris

MA Hui, BI Xiaodong

Jichu yixue yu linchuang, Vol 43, Iss 2, Pp 293-

2023 Volume 297

Abstract: Objective To investigate the relationship between the expression of CXC chemokine ligand 8 (CXCL8) and miR-150 in the skin lesions of patients with psoriasis vulgaris and the severity of the disease. Methods The skin lesions of 80 patients with psoriasis ...

Abstract	Objective To investigate the relationship between the expression of CXC chemokine ligand 8 (CXCL8) and miR-150 in the skin lesions of patients with psoriasis vulgaris and the severity of the disease. Methods The skin lesions of 80 patients with psoriasis vulgaris who were treated in Nanyang first people's Hospital from January 2020 to May 2021 were selected as the research objects. The normal tissues around the skin lesion were chosen as a control. The Psoriasis Area and Severity Index (PASI) was used to classify patients with psoriasis, the immunohistochemical method was used to detect the expression of CXCL8 protein, the real time fluorescence quantitative PCR method was used to detect the expression of miR-150, Western blot was used to detect the expression of CXCL8 protein, and the correlation between the expression levels of CXCL8 protein, miR-150 and the severity of the disease was further analyzed. Results The level of CXCL8 mRNA in the skin lesion of patients with psoriasis vulgaris was higher than that in normal tissues (P＜0.05) and the level of miR-150 was lower than that in normal tissues(P＜0.05). The expression of CXCL8 protein in the skin lesions of patients was 68.75%, which was significantly higher than 37.50% in normal tissues (P＜0.05); the expression of CXCL8 protein in the skin lesions of patients was significantly higher than that in normal tissues (P＜0.05); the level of miR-150 gradually decreased with the aggravation of the disease (P＜0.05), and the level of CXCL8 protein gradually increased with the aggravation of the disease (P＜0.05); Pearson results showed that there was a negative correlation between miR-150 level in patients with psoriasis vulgaris and CXCL8 protein level and PASI score (r=-0.467, -0.475, P＜0.05), and there was a positive correlation between CXCL8 protein level and PASI score (r=0.424, P＜0.05). Conclusions The expression of miR-150 decreased and CXCL8 increased in patients with psoriasis vulgaris, both of them were related to the severity of the disease.
Keywords	psoriasis vulgaris\|cxc chemokine ligand 8\|mir-150\|severity of illness ; Medicine ; R
Subject code	616
Language	Chinese
Publishing date	2023-02-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CRA-Net: Transformer guided category-relation attention network for diabetic retinopathy grading.

Zang, Feng / Ma, Hui

Computers in biology and medicine

2024 Volume 170, Page(s) 107993

Abstract: Automated grading of diabetic retinopathy (DR) is an important means for assisting clinical diagnosis and preventing further retinal damage. However, imbalances and similarities between categories in the DR dataset make it highly challenging to ... ...

Abstract	Automated grading of diabetic retinopathy (DR) is an important means for assisting clinical diagnosis and preventing further retinal damage. However, imbalances and similarities between categories in the DR dataset make it highly challenging to accurately grade the severity of the condition. Furthermore, DR images encompass various lesions, and the pathological relationship information among these lesions can be easily overlooked. For instance, under different severity levels, the varying contributions of different lesions to accurate model grading differ significantly. To address the aforementioned issues, we design a transformer guided category-relation attention network (CRA-Net). Specifically, we propose a novel category attention block that enhances feature information within the class from the perspective of DR image categories, thereby alleviating class imbalance problems. Additionally, we design a lesion relation attention block that captures relationships between lesions by incorporating attention mechanisms in two primary aspects: capsule attention models the relative importance of different lesions, allowing the model to focus on more "informative" ones. Spatial attention captures the global position relationship between lesion features under transformer guidance, facilitating more accurate localization of lesions. Experimental and ablation studies on two datasets DDR and APTOS 2019 demonstrate the effectiveness of CRA-Net and obtain competitive performance.
MeSH term(s)	Humans ; Diabetic Retinopathy ; Retinal Diseases ; Diabetes Mellitus
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2024.107993
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Article ; Online: Two-phase Porous Media Flow Model Based on the Incompressible Navier-Stokes Equation.

Ma, Hui / Kinzer-Ursem, Tamara L / Linnes, Jacqueline C

Analytical chemistry

2024 Volume 96, Issue 13, Page(s) 5265–5273

Abstract: Two-phase porous media flow is important in many applications from drug delivery to groundwater diffusion and oil recovery and is of particular interest to biomedical diagnostic test developers using cellulose and nitrocellulose membranes with limited ... ...

Abstract	Two-phase porous media flow is important in many applications from drug delivery to groundwater diffusion and oil recovery and is of particular interest to biomedical diagnostic test developers using cellulose and nitrocellulose membranes with limited fluid sample volumes. This work presents a new two-phase porous media flow model based on the incompressible Navier-Stokes equation. The model aims to address the limitations of existing methods by incorporating a partial saturation distribution in porous media to account for limited fluid volumes. The basic parameters of the model are the pore size distribution and the contact angle. To validate the model, we solved five analytical solutions and compared them to corresponding experimental data. The experimentally measured penetration length data agreed with the model predictions, demonstrating model accuracy. Our findings suggest that this new two-phase porous media flow model can provide a valuable tool for researchers developing fluidic assays in paper and other porous media.
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c05982
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Article ; Online: Characterization of soundscape assessment in outdoor public spaces of urban high-rise residential communitiesa).

Zhu, Guofeng / Kang, Jian / Ma, Hui / Wang, Chao

The Journal of the Acoustical Society of America

2024 Volume 154, Issue 6, Page(s) 3660–3671

Abstract: Soundscape perceptual models were developed in various contexts. However, as the outdoor public space in high-rise residential communities differs in terms of space planning and management, the soundscape perceptual characteristics are still unclear. In ... ...

Abstract	Soundscape perceptual models were developed in various contexts. However, as the outdoor public space in high-rise residential communities differs in terms of space planning and management, the soundscape perceptual characteristics are still unclear. In this study, an on-site survey was conducted to obtain the perceptual dimensions of soundscape in outdoor public spaces in urban high-rise residential communities based on evaluations of residents. Meantime, the soundscape of the space in different community layouts were compared. It was found that: (1) Four dimensions of outdoor soundscape in high-rise communities were extracted, namely Relaxation, Communication, Quietness, and Spatiality. The first three dimensions were positively correlated with overall soundscape satisfaction significantly. (2) Relaxation was mostly correlated with dominance of noise; Communication and Quietness were primarily related to sounds from human beings. (3) Lower traffic noise and higher levels of human sounds were perceived in enclosed communities, resulting in higher Relaxation and lower Quietness scores in outdoor public spaces in enclosed communities than non-enclosed ones. These findings evoke insights into the understanding of soundscape assessment in different contexts, and provide implications for sound environment design in urban high-rise communities.
MeSH term(s)	Humans ; Environment Design ; Sound ; Communication
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/10.0022531
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Article: Correction: Gao et al. Research on Compressive Strength of Manufactured Sand Concrete Based on Response Surface Methodology.

Gao, Kang / Sun, Zhenjiao / Ma, Hui / Ma, Guanguo

Materials (Basel, Switzerland)

2024 Volume 17, Issue 7

Abstract: In the original publication [ ... ]. ...

Abstract	In the original publication [...].
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17071640
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Article ; Online: Activating argumentation schema to write argumentatively and tactfully.

Liu, Donghong / Gan, Qiong / Ma, Hui

Acta psychologica

2024 Volume 246, Page(s) 104256

Abstract: To argue tactfully is a goal in argumentative writing, which entails balanced argumentation schema. Although computer-supported collaborative learning (CSCL) has been widely acknowledged as language learning mediation, especially in writing, few studies ... ...

Abstract	To argue tactfully is a goal in argumentative writing, which entails balanced argumentation schema. Although computer-supported collaborative learning (CSCL) has been widely acknowledged as language learning mediation, especially in writing, few studies investigate its effectiveness in activating the balanced argumentation schema. This study explores the effectiveness of QQ group discussion, a kind of CSCL mediation most popular in China, in argumentative writing by means of quasi-experiment and interview. Fifty-six second-year college students in an English Department participated in this study. The experimental group were asked to have a pre-writing QQ group discussion on a disputable topic while the control group had an in-class face-to-face discussion (a regular teaching method for English majors). Content analysis of the essays was made to investigate the use of Counterargument elements, Qualifier and Concession. The results show that the two groups had no difference in the use of Counterargument-claim and Rebuttal. However, the experimental group surpassed the control group in Counterargument-data, Concession and Qualifier, which signifies more argumentativeness and tactfulness. In the delayed post-test this group still performed better. The interview transcriptions were coded and analyzed by inductive content analysis with the functions of QQ discussion as the themes. The result not only supported that of the experiment, but also revealed why and how QQ mediation could help activate the balanced argumentation schema. It is suggested that CSCL mediation should be promoted in argumentative writing instruction so that the students could write argumentatively and tactfully.
Language	English
Publishing date	2024-04-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1480049-4
ISSN	1873-6297 ; 0001-6918
ISSN (online)	1873-6297
ISSN	0001-6918
DOI	10.1016/j.actpsy.2024.104256
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Article ; Online: Reply.

Ma, Hui / Xia, Bing

Hepatology (Baltimore, Md.)

2022 Volume 77, Issue 1, Page(s) E12

Language	English
Publishing date	2022-08-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.32691
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Article ; Online: Reinforcement learning-based consensus control for MASs with intermittent constraints.

Luo, Ao / Zhou, Qi / Ren, Hongru / Ma, Hui / Lu, Renquan

Neural networks : the official journal of the International Neural Network Society

2024 Volume 172, Page(s) 106105

Abstract: In this article, an adaptive optimal consensus control problem is studied for multiagent systems in the strict-feedback structure with intermittent constraints (the constraints appear intermittently). More specifically, by designing a novel switch-like ... ...

Abstract	In this article, an adaptive optimal consensus control problem is studied for multiagent systems in the strict-feedback structure with intermittent constraints (the constraints appear intermittently). More specifically, by designing a novel switch-like function and an improved coordinate transformation, the constrained states are converted into unconstrained states, and the problem of intermittent constraints is resolved without requiring "feasibility conditions". In addition, using the composite learning algorithm and neural networks to construct the identifier, a simplified identifier-actor-critic-based reinforcement learning strategy is proposed to obtain the approximate optimal controller under the framework of backstepping. Meanwhile, with the aid of the nonlinear dynamic surface control technique, the issue of "explosion of complexity" in backstepping is removed, and the requirements for filter parameters are loosened. Based on Lyapunov stability theory, it is demonstrated that all signals in the closed-loop system are bounded. Finally, two simulation examples are used to verify the effectiveness of the proposed method.
MeSH term(s)	Consensus ; Algorithms ; Computer Simulation ; Neural Networks, Computer ; Nonlinear Dynamics
Language	English
Publishing date	2024-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	740542-x
ISSN	1879-2782 ; 0893-6080
ISSN (online)	1879-2782
ISSN	0893-6080
DOI	10.1016/j.neunet.2024.106105
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Article ; Online: Study on anisotropy orientation due to well-ordered fibrous biological microstructures.

Liu, Zhidi / Song, Jiawei / Fu, Qiqi / Zeng, Nan / Ma, Hui

Journal of biomedical optics

2024 Volume 29, Issue 5, Page(s) 52919

Abstract: Significance: Most biological fibrous tissues have anisotropic optical characteristics, which originate from scattering by their fibrous microstructures and birefringence of biological macromolecules. The orientation-related anisotropic interpretation ... ...

Abstract	Significance: Most biological fibrous tissues have anisotropic optical characteristics, which originate from scattering by their fibrous microstructures and birefringence of biological macromolecules. The orientation-related anisotropic interpretation is of great value in biological tissue characterization and pathological diagnosis. Aim: We focus on intrinsic birefringence and form birefringence in biological tissue samples. By observing and comparing the forward Mueller matrix of typical samples, we can understand the interpretation ability of orientation-related polarization parameters and further distinguish the sources and trends of anisotropy in tissues. Approach: For glass fiber, silk fiber, skeletal muscle, and tendon, we construct a forward measuring device to obtain the Mueller matrix image and calculate the anisotropic parameters related to orientation. The statistical analysis method based on polar coordinates can effectively analyze the difference in anisotropic parameters. Results: For those birefringent fibers, the statistical distribution of fast-axis values derived from Mueller matrix polar decomposition was found to exhibit bimodal characteristics, which is a key point in distinguishing the single-layer birefringent fiber sample from a layered, multioriented fibrous sample. The application conditions and interference factors of anisotropic orientation parameters are analyzed. Based on the parameters extracted from the orientation bimodal distribution, we can evaluate the relative change trend of intrinsic birefringence and form birefringence in anisotropic samples. Conclusions: The cross-vertical bimodal distribution of the fast axis of anisotropic fibers is beneficial to accurately analyze the anisotropic changes in biological tissues. The results imply the potential of anisotropic orientation analysis for applications in pathological diagnosis.
MeSH term(s)	Anisotropy ; Muscle, Skeletal ; Tendons/diagnostic imaging ; Birefringence
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1309154-2
ISSN	1560-2281 ; 1083-3668
ISSN (online)	1560-2281
ISSN	1083-3668
DOI	10.1117/1.JBO.29.5.052919
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Article ; Online: Observer-Based Neural Control of N-Link Flexible-Joint Robots.

Ma, Hui / Ren, Hongru / Zhou, Qi / Li, Hongyi / Wang, Zhenyou

IEEE transactions on neural networks and learning systems

2024 Volume 35, Issue 4, Page(s) 5295–5305

Abstract: This article concentrates on the adaptive neural control approach of n -link flexible-joint electrically driven robots. The presented control method only needs to know the position and armature current information of the flexible-joint manipulator. An ... ...

Abstract	This article concentrates on the adaptive neural control approach of n -link flexible-joint electrically driven robots. The presented control method only needs to know the position and armature current information of the flexible-joint manipulator. An adaptive observer is designed to estimate the velocities of links and motors, and radial basis function neural networks are applied to approximate the unknown nonlinearities. Based on the backstepping technique and the Lyapunov stability theory, the observer-based neural control issue is addressed by relying on uplink-event-triggered states only. It is demonstrated that all signals are semi-globally ultimately uniformly bounded and the tracking errors can converge to a small neighborhood of zero. Finally, simulation results are shown to validate the designed event-triggered control strategy.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ISSN	2162-2388
ISSN (online)	2162-2388
DOI	10.1109/TNNLS.2022.3203074
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