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  1. Article ; Online: Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice.

    Li, Ang / Yi, Jianxun / Li, Xuejun / Dong, Li / Ostrow, Lyle W / Ma, Jianjie / Zhou, Jingsong

    eLife

    2024  Volume 12

    Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder characterized by progressive weakness of almost all skeletal muscles, whereas extraocular muscles (EOMs) are comparatively spared. While hindlimb and diaphragm muscles of end-stage ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder characterized by progressive weakness of almost all skeletal muscles, whereas extraocular muscles (EOMs) are comparatively spared. While hindlimb and diaphragm muscles of end-stage SOD1G93A (G93A) mice (a familial ALS mouse model) exhibit severe denervation and depletion of Pax7
    MeSH term(s) Animals ; Neuromuscular Junction/metabolism ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Mice ; Satellite Cells, Skeletal Muscle/metabolism ; Disease Models, Animal ; Transcriptome ; Mice, Transgenic ; Oculomotor Muscles/innervation ; Oculomotor Muscles/metabolism
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.92644
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  2. Article: Distinct transcriptomic profile of satellite cells contributes to preservation of neuromuscular junctions in extraocular muscles of ALS mice.

    Li, Ang / Yi, Jianxun / Li, Xuejun / Dong, Li / Ostrow, Lyle W / Ma, Jianjie / Zhou, Jingsong

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder characterized by progressive weakness of almost all skeletal muscles, whereas extraocular muscles (EOMs) are comparatively spared. While hindlimb and diaphragm muscles of end-stage ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder characterized by progressive weakness of almost all skeletal muscles, whereas extraocular muscles (EOMs) are comparatively spared. While hindlimb and diaphragm muscles of end-stage SOD1G93A (G93A) mice (a familial ALS mouse model) exhibit severe denervation and depletion of Pax7
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.12.528218
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  3. Article ; Online: Butyrate Feeding Reverses CypD-Related Mitoflash Phenotypes in Mouse Myofibers.

    Li, Ang / Li, Xuejun / Yi, Jianxun / Ma, Jianjie / Zhou, Jingsong

    International journal of molecular sciences

    2021  Volume 22, Issue 14

    Abstract: Mitoflashes are spontaneous transients of the biosensor mt-cpYFP. In cardiomyocytes, mitoflashes are associated with the cyclophilin D (CypD) mediated opening of mitochondrial permeability transition pore (mPTP), while in skeletal muscle they are ... ...

    Abstract Mitoflashes are spontaneous transients of the biosensor mt-cpYFP. In cardiomyocytes, mitoflashes are associated with the cyclophilin D (CypD) mediated opening of mitochondrial permeability transition pore (mPTP), while in skeletal muscle they are considered hallmarks of mitochondrial respiration burst under physiological conditions. Here, we evaluated the potential association between mitoflashes and the mPTP opening at different CypD levels and phosphorylation status by generating three CypD derived fusion constructs with a red shifted, pH stable Ca
    MeSH term(s) Animals ; Butyrates/pharmacology ; Peptidyl-Prolyl Isomerase F/genetics ; Peptidyl-Prolyl Isomerase F/metabolism ; Female ; Humans ; Male ; Mice ; Mice, Transgenic ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Permeability Transition Pore/metabolism ; Muscle Fibers, Skeletal/drug effects ; Muscle Fibers, Skeletal/metabolism ; Muscle Fibers, Skeletal/pathology ; Mutation ; Superoxide Dismutase-1/physiology
    Chemical Substances Butyrates ; Peptidyl-Prolyl Isomerase F ; Mitochondrial Permeability Transition Pore ; SOD1 protein, human ; Superoxide Dismutase-1 (EC 1.15.1.1)
    Language English
    Publishing date 2021-07-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22147412
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  4. Article ; Online: Reply to: "Protection against acetaminophen-induced liver injury with MG53: Muscle-liver axis and necroptosis".

    Black, Sylvester M / Zhang, Ziyue / Han, Yu / Zeng, Chunyu / Ma, Jianjie

    Journal of hepatology

    2022  Volume 77, Issue 2, Page(s) 562–563

    MeSH term(s) Acetaminophen/adverse effects ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/prevention & control ; Chemical and Drug Induced Liver Injury, Chronic ; Humans ; Liver ; Muscles ; Necroptosis
    Chemical Substances Acetaminophen (362O9ITL9D)
    Language English
    Publishing date 2022-05-05
    Publishing country Netherlands
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2022.04.024
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2027: Show issues Location:
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  5. Article ; Online: Mitochondrial Membrane Potential Identifies a Subpopulation of Mesenchymal Progenitor Cells to Promote Angiogenesis and Myocardial Repair.

    Li, Xiuchun / Wang, Xiaoliang / He, Pan / Bennett, Edward / Haggard, Erin / Ma, Jianjie / Cai, Chuanxi

    Cells

    2022  Volume 11, Issue 10

    Abstract: Identifying effective donor cells is one of obstacles that limits cell therapy for heart disease. In this study, we sorted a subpopulation of human mesenchymal progenitor cells (hMPCs) from the right atrial appendage using the low mitochondrial membrane ... ...

    Abstract Identifying effective donor cells is one of obstacles that limits cell therapy for heart disease. In this study, we sorted a subpopulation of human mesenchymal progenitor cells (hMPCs) from the right atrial appendage using the low mitochondrial membrane potential. Compared to the non-sorted cells, hMPCs hold the capacity for stemness and enrich mesenchymal stem cell markers. The hMPCs display better ability for survival, faster proliferation, less production of reactive oxygen species (ROS), and greater release of cytoprotective cytokines. The hMPCs exhibit decreased expression of senescence genes and increased expression of anti-apoptotic and antioxidant genes. Intramyocardial injection of hMPCs into the infarcted heart resulted in increased left ventricular ejection fraction and reduced cardiac remodeling and infarct size in the group of animals receiving hMPCs. Both in vitro and in vivo studies indicated hMPCs have the potential to differentiate into endothelial cells and smooth muscle cells. Immunohistochemistry staining showed that cell therapy with hMPCs enhances cardiac vascular regeneration and cardiac proliferation, and decreases cardiac cell apoptosis, which is associated with the increased secretion of cytoprotective and pro-angiogenic cytokines. Overall, we discovered a subpopulation of human mesenchymal progenitor cells via their low mitochondrial membrane potential, which might provide an alternative donor cell source for cellular therapy for ischemic heart disease.
    MeSH term(s) Animals ; Cytokines/metabolism ; Endothelial Cells/metabolism ; Membrane Potential, Mitochondrial ; Mesenchymal Stem Cells/metabolism ; Neovascularization, Pathologic/metabolism ; Stroke Volume ; Ventricular Function, Left
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-05-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11101713
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  6. Article ; Online: Remote Ischemic Pre-Conditioning (RIPC).

    Lee, Kyung Eun / Kim, Jongsoo / Park, Ki Ho / Ma, Jianjie / Zhu, Hua

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2597, Page(s) 11–18

    Abstract: Ischemic pre-conditioning has been shown to protect hearts against ischemia/reperfusion (I/R)-induced cardiac injury. However, it is not feasible in clinic. Many researchers have tried to introduce brief I/R in skeletal muscle to mimic cardiac ischemic ... ...

    Abstract Ischemic pre-conditioning has been shown to protect hearts against ischemia/reperfusion (I/R)-induced cardiac injury. However, it is not feasible in clinic. Many researchers have tried to introduce brief I/R in skeletal muscle to mimic cardiac ischemic pre-conditioning, called remote ischemia pre-conditioning (RIPC). Studies from our group and other groups have shown that RIPC induces the release of cytokines from skeletal muscle (myokines) for tissue protection. Myokines play a central role in repair, inflammatory, and immune responses after injury. Thus, the detailed protocol for RIPC might be useful for researchers to study mechanisms underlying RIPC-mediated tissue protection and crosstalk. Here, we describe a detailed RIPC protocol and show MG53 secretion after RIPC into the blood.
    MeSH term(s) Humans ; Ischemic Preconditioning/methods ; Reperfusion Injury/prevention & control ; Cytokines ; Muscle, Skeletal ; Ischemia
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-11-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2835-5_2
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  7. Article ; Online: Activation of MG53 Enhances Cell Survival and Engraftment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Injured Hearts.

    Park, Ki Ho / He, Xingyu / Jiang, Lin / Zhu, Hua / Liang, Jialiang / Wang, Yigang / Ma, Jianjie

    Stem cell reviews and reports

    2023  Volume 19, Issue 7, Page(s) 2420–2428

    Abstract: Background and objective: Our previous studies demonstrated that MG53 protein can protect the myocardium, but its use as a therapeutic is challenging due to its short half-life in blood circulation. This study aimed to investigate the cardioprotective ... ...

    Abstract Background and objective: Our previous studies demonstrated that MG53 protein can protect the myocardium, but its use as a therapeutic is challenging due to its short half-life in blood circulation. This study aimed to investigate the cardioprotective role of MG53 on human induced pluripotent stem cell-derived cardiomyocytes (HiPSC-CMs) in the context of myocardial ischemia/reperfusion (I/R).
    Methods: In vitro: HiPSC-CMs were transfected with adenoviral MG53 (HiPSC-CMs
    Results: MG53 can be expressed in HiPSC-CM
    Conclusion: Inducible MG53 expression is a promising approach to enhance cell survival and engraftment of HiPSC-CMs for cardiac repair.
    MeSH term(s) Humans ; Mice ; Animals ; Myocytes, Cardiac/metabolism ; Induced Pluripotent Stem Cells ; Cell Survival ; Hydrogen Peroxide/pharmacology ; Hydrogen Peroxide/metabolism ; Ischemia/metabolism ; Membrane Proteins/metabolism
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; MG53 protein, mouse ; Membrane Proteins
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2495577-2
    ISSN 2629-3277 ; 1558-6804 ; 1550-8943
    ISSN (online) 2629-3277 ; 1558-6804
    ISSN 1550-8943
    DOI 10.1007/s12015-023-10596-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6198: Show issues Location:
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  8. Article ; Online: MG53 mitigates warm ischemic lung injury in a murine model of transplantation.

    Gouchoe, Doug A / Yi, Tai / Kim, Jung-Lye / Lee, Yong Gyu / Black, Sylvester M / Breuer, Christopher / Ma, Jianjie / Whitson, Bryan A

    The Journal of thoracic and cardiovascular surgery

    2023  

    Abstract: Objectives: Lung transplant warm ischemia-reperfusion injury (IRI) results in cellular injury, inflammation, and poor graft function. Mitsugumin 53 (MG53) is an endogenous protein with cell membrane repair properties and the ability to modulate the ... ...

    Abstract Objectives: Lung transplant warm ischemia-reperfusion injury (IRI) results in cellular injury, inflammation, and poor graft function. Mitsugumin 53 (MG53) is an endogenous protein with cell membrane repair properties and the ability to modulate the inflammasome. We hypothesize that the absence of circulating MG53 protein in the recipient increases IRI, and higher levels of circulating MG53 protein mitigate IRI associated with lung transplantation.
    Methods: To demonstrate protection, wild-type (wt) lung donor allografts were transplanted into a wt background, a MG53 knockout (mg53-/-), or a constitutively overexpressed MG53 (tissue plasminogen activator-MG53) recipient mouse after 1 hour of warm ischemic injury. Mice survived for 5 days after transplantation. Bronchioalveolar lavage, serum, and tissue were collected at sacrifice. Bronchioalveolar lavage, serum, and tissue markers of apoptosis and a biometric profile of lung health were analyzed.
    Results: mg53-/- mice had significantly greater levels of markers of overall cell lysis and endothelial cell injury. Overexpression of MG53 resulted in a signature similar to that of wt controls. At the time of explant, tissue plasminogen activator-MG53 recipient tissue expressed significantly greater levels of MG53, measured by immunohistochemistry, compared with mg53-/-, demonstrating uptake of endogenous overexpressed MG53 into donor tissue.
    Conclusions: In a warm IRI model of lung transplantation, the absence of MG53 resulted in increased cell injury and inflammation. Endogenous overexpression of MG53 in the recipient results in protection in the wt donor. Together, these data suggest that MG53 is a potential therapeutic agent for use in lung transplantation to mitigate IRI.
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3104-5
    ISSN 1097-685X ; 0022-5223
    ISSN (online) 1097-685X
    ISSN 0022-5223
    DOI 10.1016/j.jtcvs.2023.10.056
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  9. Article: Cardiac effects and clinical applications of MG53.

    Zhong, Weina / Benissan-Messan, Dathe Z / Ma, Jianjie / Cai, Chuanxi / Lee, Peter H U

    Cell & bioscience

    2021  Volume 11, Issue 1, Page(s) 115

    Abstract: Heart disease remains the leading cause of mortality globally, so further investigation is required to identify its underlying mechanisms and potential targets for treatment and prevention. Mitsugumin 53 (MG53), also known as TRIM72, is a TRIM family ... ...

    Abstract Heart disease remains the leading cause of mortality globally, so further investigation is required to identify its underlying mechanisms and potential targets for treatment and prevention. Mitsugumin 53 (MG53), also known as TRIM72, is a TRIM family protein that was found to be involved in cell membrane repair and primarily found in striated muscle. Its role in skeletal muscle regeneration and myogenesis has been well documented. However, accumulating evidence suggests that MG53 has a potentially protective role in heart tissue, including in ischemia/reperfusion injury of the heart, cardiomyocyte membrane injury repair, and atrial fibrosis. This review summarizes the regulatory role of MG53 in cardiac tissues, current debates regarding MG53 in diabetes and diabetic cardiomyopathy, as well as highlights potential clinical applications of MG53 in treating cardiac pathologies.
    Language English
    Publishing date 2021-06-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-021-00629-x
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  10. Article ; Online: Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration.

    Whitson, Bryan A / Tan, Tao / Gong, Nianqiao / Zhu, Hua / Ma, Jianjie

    Current opinion in pharmacology

    2021  Volume 59, Page(s) 26–32

    Abstract: Through stress and injury to tissues, the cell membrane is damaged and can lead to cell death and a cascade of inflammatory events. Soluble factors that mitigate and repair membrane injury are important to normal homeostasis and are a potential ... ...

    Abstract Through stress and injury to tissues, the cell membrane is damaged and can lead to cell death and a cascade of inflammatory events. Soluble factors that mitigate and repair membrane injury are important to normal homeostasis and are a potential therapeutic intervention for regenerative medicine. A myokine is a type of naturally occurring factors that come from muscle and have impact on remote organs. MG53, a tripartite motif-containing family protein, is such a myokine which has protective effects on lungs, kidneys, liver, heart, eye, and brain. Three mechanisms of action for the beneficial regenerative medicine potential of MG53 have been identified and consist of 1) repair of acute injury to the cellular membrane, 2) anti-inflammatory effects associated with chronic injuries, and 3) rejuvenation of stem cells for tissue regeneration. As such, MG53 has the potential to be a novel and effective regeneration medicine therapeutic.
    MeSH term(s) Cell Membrane ; Homeostasis ; Muscle, Skeletal ; Tripartite Motif Proteins ; Wound Healing
    Chemical Substances Tripartite Motif Proteins
    Language English
    Publishing date 2021-05-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2021.04.005
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