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Article ; Online: Overview—gold nanoparticles-based sensitive nanosensors in mycotoxins detection

Hou, Silu / Ma, Jingjiao / Cheng, Yuqiang / Wang, Zhaofei / Yan, Yaxian

Critical Reviews in Food Science and Nutrition. 2023 Dec. 20, v. 63, no. 33 p.11734-11749

2023

Abstract: Food-borne mycotoxins is one of the food safety concerns in the world. At present, nanosensors are widely used in the detection and analysis of mycotoxins due to their high specificity and sensitivity. In nanosensor-based mycotoxindetections, the ... ...

Abstract	Food-borne mycotoxins is one of the food safety concerns in the world. At present, nanosensors are widely used in the detection and analysis of mycotoxins due to their high specificity and sensitivity. In nanosensor-based mycotoxindetections, the sensitivity is mainly improved from two aspects. On the one hand, based on the principle of immune response, antigens and antibodies can be modified and developed. Such as single-domain heavy chain antibodies, aptamers, peptides, and antigen mimotopes. On the other hand, improvements and innovations have been made on signal amplification materials, including gold nanoparticles (AuNPs), quantum dots, and graphene, etc. Among them, gold nanoparticles can not only be used as a signal amplification material, but also can be used as carriers for identification elements, which can be used for signal amplification in detection. In this article, we systematically summarized the emerging strategies for enhancing the detection sensitivity of traditional gold nanoparticles-based nanosensors, in terms of recognition elements and signal amplification. Representative examples were selected to illustrate the potential mechanism of each strategy in enhancing the colorimetric signal intensity of AuNP and its potential application in biosensing. Finally, our review suggested the challenges and future prospects of gold particles in detection of mycotoxins.
Keywords	antigens ; colorimetry ; detection limit ; food safety ; gold ; graphene ; immune response ; mycotoxins ; nanogold ; nutrition ; oligonucleotides ; peptides ; sensors (equipment) ; gold nanoparticles ; element recognition ; signal amplification ; immunochromatographic strip ; nanoparticle accumulation
Language	English
Dates of publication	2023-1220
Size	p. 11734-11749.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2022.2095973
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The toxicity mechanisms of DON to humans and animals and potential biological treatment strategies

Hou, Silu / Ma, Jingjiao / Cheng, Yuqiang / Wang, Hengan / Sun, Jianhe / Yan, Yaxian

Critical Reviews in Food Science and Nutrition. 2023 Feb. 28, v. 63, no. 6 p.790-812

2023

Abstract: Deoxynivalenol, also known as vomitotoxin, is produced by Fusarium, belonging to the group B of the trichothecene family. DON is widely polluted, mainly polluting cereal crops such as wheat, barley, oats, corn and related cereal products, which are ... ...

Abstract	Deoxynivalenol, also known as vomitotoxin, is produced by Fusarium, belonging to the group B of the trichothecene family. DON is widely polluted, mainly polluting cereal crops such as wheat, barley, oats, corn and related cereal products, which are closely related to lives of people and animals. At present, there have been articles summarizing DON induced toxicity, biological detoxification and the protective effect of natural products, but there is no systematic summary of this information. In addition to ribosome and endoplasmic reticulum, recent investigations support that mitochondrion is also organelles that DON can damage. DON can’t directly act on mitochondria, but can indirectly cause mitochondrial damage and changes through other means. DON can indirectly inhibit mitochondrial biogenesis and mitochondrial electron transport chain activity, ATP production, and mitochondrial transcription and translation. This review will provide the latest progress on mitochondria as the research object, and systematically summarizes all the toxic mechanisms of DON. Here, we discuss DON induced mitochondrial-mediated apoptosis and various mitochondrial toxicity. For the toxicity of DON, many methods have been derived to prevent or reduce the toxicity. Biological detoxification and the antioxidant effect of natural products are potentially effective treatments for DON toxicity.
Keywords	Fusarium ; antioxidant activity ; apoptosis ; barley ; biogenesis ; biological treatment ; corn ; deoxynivalenol ; electron transport chain ; endoplasmic reticulum ; food science ; mitochondria ; nutrition ; people ; protective effect ; ribosomes ; toxicity ; wheat ; toxicity mechanism ; biological detoxification ; antioxidant
Language	English
Dates of publication	2023-0228
Size	p. 790-812.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2021.1954598
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Article ; Online: Identification of pigeon mitochondrial antiviral signaling protein (MAVS) and its role in antiviral innate immunity.

Shao, Qi / Li, Yawen / Fu, Feiyu / Zhu, Pei / Wang, Hengan / Wang, Zhaofei / Ma, Jingjiao / Yan, Yaxian / Cheng, Yuqiang / Sun, Jianhe

Archives of virology

2024 Volume 169, Issue 2, Page(s) 26

Abstract: Pigeons can be infected with various RNA viruses, and their innate immune system responds to viral infection to establish an antiviral response. Mitochondrial antiviral signaling protein (MAVS), an important adaptor protein in signal transduction, plays ... ...

Abstract	Pigeons can be infected with various RNA viruses, and their innate immune system responds to viral infection to establish an antiviral response. Mitochondrial antiviral signaling protein (MAVS), an important adaptor protein in signal transduction, plays a pivotal role in amplifying the innate immune response. In this study, we successfully cloned pigeon MAVS (piMAVS) and performed a bioinformatics analysis. The results showed that the caspase recruitment domain (CARD) and transmembrane (TM) domain are highly conserved in poultry and mammals but poorly conserved in other species. Furthermore, we observed that MAVS expression is upregulated both in pigeons and pigeon embryonic fibroblasts (PEFs) upon RNA virus infection. Overexpression of MAVS resulted in increased levels of β-interferon (IFN-β), IFN-stimulated genes (ISGs), and interleukin (ILs) mRNA and inhibited Newcastle disease virus (NDV) replication. We also found that piMAVS and human MAVS (huMAVS) induced stronger expression of IFN-β and ISGs when compared to chicken MAVS (chMAVS), and this phenomenon was also reflected in the degree of inhibition of NDV replication. Our findings demonstrate that piMAVS plays an important role in repressing viral replication by regulating the activation of the IFN signal pathway in pigeons. This study not only sheds light on the function of piMAVS in innate immunity but also contributes to a more comprehensive understanding of the innate immunity system in poultry. Our data also provide unique insights into the differences in innate immunity between poultry and mammal.
MeSH term(s)	Animals ; Humans ; Antiviral Agents ; Columbidae ; Immunity, Innate ; Interferon-beta/genetics ; Interferon-beta/metabolism ; Mammals ; Newcastle disease virus ; Signal Transduction
Chemical Substances	Antiviral Agents ; Interferon-beta (77238-31-4)
Language	English
Publishing date	2024-01-12
Publishing country	Austria
Document type	Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-023-05920-5
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Article ; Online: Overview-gold nanoparticles-based sensitive nanosensors in mycotoxins detection.

Hou, Silu / Ma, Jingjiao / Cheng, Yuqiang / Wang, Zhaofei / Yan, Yaxian

Critical reviews in food science and nutrition

2022 Volume 63, Issue 33, Page(s) 11734–11749

Abstract	Food-borne mycotoxins is one of the food safety concerns in the world. At present, nanosensors are widely used in the detection and analysis of mycotoxins due to their high specificity and sensitivity. In nanosensor-based mycotoxindetections, the sensitivity is mainly improved from two aspects. On the one hand, based on the principle of immune response, antigens and antibodies can be modified and developed. Such as single-domain heavy chain antibodies, aptamers, peptides, and antigen mimotopes. On the other hand, improvements and innovations have been made on signal amplification materials, including gold nanoparticles (AuNPs), quantum dots, and graphene, etc. Among them, gold nanoparticles can not only be used as a signal amplification material, but also can be used as carriers for identification elements, which can be used for signal amplification in detection. In this article, we systematically summarized the emerging strategies for enhancing the detection sensitivity of traditional gold nanoparticles-based nanosensors, in terms of recognition elements and signal amplification. Representative examples were selected to illustrate the potential mechanism of each strategy in enhancing the colorimetric signal intensity of AuNP and its potential application in biosensing. Finally, our review suggested the challenges and future prospects of gold particles in detection of mycotoxins.
MeSH term(s)	Gold/chemistry ; Metal Nanoparticles/chemistry ; Mycotoxins/analysis ; Biosensing Techniques ; Limit of Detection
Chemical Substances	Gold (7440-57-5) ; Mycotoxins
Language	English
Publishing date	2022-08-02
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2022.2095973
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Article ; Online: Protective Mechanisms of Various Active Substances on Cell DNA Damage and Apoptosis Induced by Deoxynivalenol.

Hou, Silu / Ma, Jingjiao / Cheng, Yuqiang / Wang, Zhaofei / Wang, Hengan / Sun, Jian-He / Wang, Guiping / Jia, Aiqing / Yan, Ya-Xian

Journal of agricultural and food chemistry

2024 Volume 72, Issue 12, Page(s) 6651–6659

Abstract: Deoxynivalenol (DON) is a secondary metabolite of fungi that is harmful to humans and animals. This study examined the protective effects of natural substances, including resveratrol, quercetin, vitamin E, vitamin C, and microbe-derived antioxidants (MA), ...

Abstract	Deoxynivalenol (DON) is a secondary metabolite of fungi that is harmful to humans and animals. This study examined the protective effects of natural substances, including resveratrol, quercetin, vitamin E, vitamin C, and microbe-derived antioxidants (MA), on both human gastric mucosal cells (GES-1) and pig small intestinal epithelial cells (IPEC-1) when induced by DON. Cells were incubated with active substances for 3 h and then exposed to DON for 24 h. The oxidative stress index, cell cycle, and apoptosis were measured. As compared to cells treated only with DON, pretreatment with active substances improved the balance of the redox status in cells caused by DON. Specifically, quercetin, vitamin E, vitamin C, and MA showed the potential to alleviate the G2 phase cell cycle arrest effect that was induced by DON in both kinds of cells. It was observed that vitamin E and vitamin C can alleviate DON-induced apoptosis and the G2 phase cycle arrest effect mediated via the ATM-Chk 2-Cdc 25C and ATM-P53 signaling pathways in GES-1 cells. In IPEC-1 cells, vitamin C and MA can alleviate both DON-induced apoptosis and the G2 phase cycle arrest effect via the ATM-Chk 2-Cdc 25C signaling pathway. Different bioactive substances utilize different protective mechanisms against DON in interacting with different cells. The proper addition of vitamin E and vitamin C to food can neutralize the toxic effect of DON, while the addition of vitamin C and MA to animal feed can reduce the harm DON does to animals.
MeSH term(s)	Humans ; Animals ; Swine ; Quercetin/pharmacology ; Cell Line ; Apoptosis ; Antioxidants/metabolism ; G2 Phase Cell Cycle Checkpoints ; Ascorbic Acid/pharmacology ; Vitamin E ; DNA Damage ; Trichothecenes
Chemical Substances	deoxynivalenol (JT37HYP23V) ; Quercetin (9IKM0I5T1E) ; Antioxidants ; Ascorbic Acid (PQ6CK8PD0R) ; Vitamin E (1406-18-4) ; Trichothecenes
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c09100
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Article ; Online: Bat MAVS involved in antiviral innate immunity via regulating IFN-beta production

Fu, Feiyu / Shao, Qi / Wang, Jie / Zhang, Jianjian / Wang, Zhaofei / Ma, Jingjiao / Yan, Yaxian / Cheng, Yuqiang / Sun, Jianhe

Developmental and Comparative Immunology. 2023 Sept., v. 146 p.104724-

2023

Abstract: Mitochondrial antiviral signaling protein (MAVS) is an essential articulatory protein in immune responses against most RNA viruses. Whether bats, the natural hosts of numerous zoonotic RNA viruses, utilize conserved signaling pathways involving MAVS- ... ...

Abstract	Mitochondrial antiviral signaling protein (MAVS) is an essential articulatory protein in immune responses against most RNA viruses. Whether bats, the natural hosts of numerous zoonotic RNA viruses, utilize conserved signaling pathways involving MAVS-mediated interferon (IFN) responses remains elusive. In this study, we performed the cloning and functional analysis of bat MAVS (BatMAVS). Amino acid sequence analysis revealed that BatMAVS was poorly conserved among species and evolutionarily closer to other mammals. Overexpression of BatMAVS significantly inhibited the replication of green fluorescent protein (GFP)-tagged VSV (VSV-GFP) and GFP-tagged Newcastle disease virus (NDV) (NDV-GFP) by activating the type I IFN pathway, and its expression at the transcriptional level was upregulated at the late stage of VSV-GFP infection. We further demonstrated that the CARD_2 and TM domains occupy a large proportion in the ability of BatMAVS to activate IFN-β. These results suggest that BatMAVS acts as an important regulatory molecule in IFN-induction and anti-RNA viruses in bats.
Keywords	Avian orthoavulavirus 1 ; Chiroptera ; RNA ; amino acid sequences ; green fluorescent protein ; innate immunity ; interferons ; mitochondria ; sequence analysis ; transcription (genetics) ; Bat ; MAVS ; IFN ; RNA virus
Language	English
Dates of publication	2023-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2023.104724
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Article: Non-Canonical NF-κB Signaling Stratifies LGG into Subtypes with Distinct Molecular and Cellular Characteristic and Survival Expectancy.

Lin, Minhua / Huang, Tianxiang / Wang, Xuan / Li, Xuenan / Ma, Jingjiao / Su, Lan / Wu, Jun

International journal of general medicine

2022 Volume 15, Page(s) 3677–3686

Abstract: Introduction: NF-κB signaling is involved in a wide range of biological processes including cell proliferation, cell survival and immunity. Meanwhile, as one of the major oncogenic pathways, its upregulation has been observed in many cancer types. ... ...

Abstract	Introduction: NF-κB signaling is involved in a wide range of biological processes including cell proliferation, cell survival and immunity. Meanwhile, as one of the major oncogenic pathways, its upregulation has been observed in many cancer types. Compared with canonical NF-κB signaling, its non-canonical branch was much less studied in cancerous context. Methods: In this study, we leveraged multi-omics data across multiple platforms to investigate the activity of non-canonical NF-κB signaling in low-grade glioma (LGG) and explore its connection with molecular characteristics of LGG. Results: We found that non-canonical NF-κB signaling could classify LGG patients into subgroups with significant survival difference. Non-canonical NF-κB-low group enriched with oligodendroglioma featured by CIC mutations and 1p19q co-deletion. On the another hand, LGG in non-canonical NF-κB-high group showed high frequency of EGFR mutations but relatively low frequency of IDH mutations. In addition, LGG in this group reflected immunosuppressive environment characterized by high level of cytotoxic T cell exhaustion and macrophage M2 infiltration. More comprehensive evaluation implied that LGG in non-canonical NF-κB-high group reflected significantly higher immunogenicity. Through a series of feature selection technique, we developed a model that can predict the prognosis of LGG patients in a cost-effective way. Conclusion: Our analysis demonstrated the prognostic value of non-canonical NF-κB signaling in LGG. The survival difference between non-canonical NF-κB stratified groups may be explained by their distinct molecular characteristics as well as cellular context. Our prognostic model may help in offering better therapeutic strategy and clinical management.
Language	English
Publishing date	2022-04-05
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S347654
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Article: Bat STING drives IFN-beta production in anti-RNA virus innate immune response.

Fu, Feiyu / Shao, Qi / Zhang, Jianjian / Wang, Jie / Wang, Zhaofei / Ma, Jingjiao / Yan, Yaxian / Sun, Jianhe / Cheng, Yuqiang

Frontiers in microbiology

2023 Volume 14, Page(s) 1232314

Abstract: The ability of stimulator of interferon genes (STING) to activate interferon (IFN) responses during RNA virus infection has been demonstrated in different mammalian cells. Despite being the host of numerous RNA viruses, the role of STING in bats during ... ...

Abstract	The ability of stimulator of interferon genes (STING) to activate interferon (IFN) responses during RNA virus infection has been demonstrated in different mammalian cells. Despite being the host of numerous RNA viruses, the role of STING in bats during RNA virus infection has not been elucidated. In this study, we identified and cloned the STING gene of the Brazilian free-tailed bat
Language	English
Publishing date	2023-09-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1232314
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Article ; Online: Bat MAVS involved in antiviral innate immunity via regulating IFN-beta production.

Fu, Feiyu / Shao, Qi / Wang, Jie / Zhang, Jianjian / Wang, Zhaofei / Ma, Jingjiao / Yan, Yaxian / Cheng, Yuqiang / Sun, Jianhe

Developmental and comparative immunology

2023 Volume 146, Page(s) 104724

Abstract	Mitochondrial antiviral signaling protein (MAVS) is an essential articulatory protein in immune responses against most RNA viruses. Whether bats, the natural hosts of numerous zoonotic RNA viruses, utilize conserved signaling pathways involving MAVS-mediated interferon (IFN) responses remains elusive. In this study, we performed the cloning and functional analysis of bat MAVS (BatMAVS). Amino acid sequence analysis revealed that BatMAVS was poorly conserved among species and evolutionarily closer to other mammals. Overexpression of BatMAVS significantly inhibited the replication of green fluorescent protein (GFP)-tagged VSV (VSV-GFP) and GFP-tagged Newcastle disease virus (NDV) (NDV-GFP) by activating the type I IFN pathway, and its expression at the transcriptional level was upregulated at the late stage of VSV-GFP infection. We further demonstrated that the CARD_2 and TM domains occupy a large proportion in the ability of BatMAVS to activate IFN-β. These results suggest that BatMAVS acts as an important regulatory molecule in IFN-induction and anti-RNA viruses in bats.
MeSH term(s)	Animals ; Chiroptera/genetics ; Immunity, Innate/genetics ; Interferon Type I/metabolism ; Newcastle disease virus ; Signal Transduction ; Antiviral Restriction Factors/immunology
Chemical Substances	Interferon Type I ; Antiviral Restriction Factors
Language	English
Publishing date	2023-05-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2023.104724
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Article ; Online: DON induced DNA damage triggers absence of p53-mediated G2 arrest and apoptosis in IPEC-1 cells.

Hou, Silu / Ma, Jingjiao / Cheng, Yuqiang / Wang, Zhaofei / Wang, Guiping / Jia, Aiqing / Wang, Hengan / Sun, Jianhe / Yan, Yaxian

Toxicology

2023 Volume 501, Page(s) 153707

Abstract: Deoxynivalenol (DON) stands among the prevalent mycotoxins, and usually contaminates cereal foods and animal feed, leading to human and animal clinical poisoning symptoms such as abdominal pain, diarrhea, and vomiting. To date, the mechanism of toxicity ... ...

Abstract	Deoxynivalenol (DON) stands among the prevalent mycotoxins, and usually contaminates cereal foods and animal feed, leading to human and animal clinical poisoning symptoms such as abdominal pain, diarrhea, and vomiting. To date, the mechanism of toxicity of DON in different mammalian cells is not fully elucidated. In this study, we explored the detrimental impacts of DON on porcine intestinal epithelial cells (IPEC-1), serving as a representative model for porcine intestinal epithelial cells. After treating cells with DON for 24 h, DON can significantly inhibit the activity of cells, induce the production of reactive oxygen species (ROS), significantly reduce the content of glutathione and the activity of catalase, and increase the activity of superoxide dismutase and malondialdehyde, leading to an imbalance in intracellular redox status. In addition, DON can induce DNA double-strand breaks, and decrease mitochondrial membrane potential. Furthermore, DON can promote the release of Cyt C through changes in mitochondrial permeability through inhibit the expression of B-cell lymphoma 2 (Bcl-2) proteins, leading to apoptosis through the mitochondrial pathway. On the other hand, we found that DON can cause IPEC-1 cells G2 phase cycle arrest. Different with our pervious study, DON induces cell cycle arrest in the G2 phase only by activating the ATM-Chk2-Cdc 25 C pathway, but cannot regulate the cell cycle arrest via the ATM-p53 pathway. These results indicate that DON can induce the same toxic phenotype in different cells, but its toxic mechanism is different. All these provide a rationale for revealing DON induced cytotoxicity and intestinal diseases.
MeSH term(s)	Animals ; Swine ; Humans ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Trichothecenes/toxicity ; Cell Line ; Apoptosis ; Epithelial Cells/metabolism ; DNA Damage ; Mammals
Chemical Substances	Tumor Suppressor Protein p53 ; Trichothecenes
Language	English
Publishing date	2023-12-16
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	184557-3
ISSN	1879-3185 ; 0300-483X
ISSN (online)	1879-3185
ISSN	0300-483X
DOI	10.1016/j.tox.2023.153707
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