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  1. Article ; Online: Supercharging cancer-fighting T cells with lithium carbonate.

    Xu, Yue / Ma, Kaili / Zhang, Lianjun / Li, Guideng

    Cell metabolism

    2024  Volume 36, Issue 3, Page(s) 463–465

    Abstract: Lactate influences the behavior of various immune cell types. In a recent Nature Immunology study, Ma et al. revealed that lithium carbonate induces monocarboxylate transporter 1 translocation to mitochondria, enhancing cytoplasmic lactate transport into ...

    Abstract Lactate influences the behavior of various immune cell types. In a recent Nature Immunology study, Ma et al. revealed that lithium carbonate induces monocarboxylate transporter 1 translocation to mitochondria, enhancing cytoplasmic lactate transport into the mitochondria and increasing lactate mitochondrial metabolism, thereby promoting T cell effector function.
    MeSH term(s) Humans ; Lithium Carbonate/pharmacology ; T-Lymphocytes ; Mitochondria ; Lactic Acid ; Neoplasms
    Chemical Substances Lithium Carbonate (2BMD2GNA4V) ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2024.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Overview: Lipid Metabolism in the Tumor Microenvironment.

    Ma, Kaili / Zhang, Lianjun

    Advances in experimental medicine and biology

    2021  Volume 1316, Page(s) 41–47

    Abstract: The tumor microenvironment represents the dynamic network consisting of tumor cells, stromal cells, and multiple lineages of immune subsets. It is well recognized that metabolic crosstalk within the tumor microenvironment (TME) greatly shapes both the ... ...

    Abstract The tumor microenvironment represents the dynamic network consisting of tumor cells, stromal cells, and multiple lineages of immune subsets. It is well recognized that metabolic crosstalk within the tumor microenvironment (TME) greatly shapes both the composition and functionality of the infiltrated immune cells and therefore critically regulate the antitumor immunity. In general, most solid tumors are considered as lipid-enriched environment, which is beneficial for tumor cell growth and immune escape. Here we briefly summarize the effects of accumulated lipids on tumor cells and immune cells. We also discuss the possibility of targeting lipid metabolism within the TME and potential strategies for optimizing cancer treatment.
    MeSH term(s) Humans ; Lipid Metabolism ; Neoplasms ; Tumor Microenvironment
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-33-6785-2_3
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  3. Article ; Online: Zeolite-encapsulated copper(II) complexes with NNO-tridentate Schiff base ligands: catalytic activity for methylene blue (MB) degradation under near neutral conditions.

    Li, Shuyu / Wu, Die / Wang, Xiting / Xiong, Jiaxing / Zhang, Li / Ma, Kaili

    Dalton transactions (Cambridge, England : 2003)

    2024  Volume 53, Issue 4, Page(s) 1517–1527

    Abstract: Three novel copper Schiff base complexes, ... ...

    Abstract Three novel copper Schiff base complexes, L
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt03694d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: SNCA correlates with immune infiltration and serves as a prognostic biomarker in lung adenocarcinoma.

    Zhang, Xiuao / Wu, Zhengcun / Ma, Kaili

    BMC cancer

    2022  Volume 22, Issue 1, Page(s) 406

    Abstract: Background: The SNCA gene is a critical gene in Parkinson's disease (PD) pathology. Accumulating evidence indicates that SNCA is involved in tumorigenesis; however, the role of SNCA in lung adenocarcinoma (LUAD) remains unclear. This study aimed to ... ...

    Abstract Background: The SNCA gene is a critical gene in Parkinson's disease (PD) pathology. Accumulating evidence indicates that SNCA is involved in tumorigenesis; however, the role of SNCA in lung adenocarcinoma (LUAD) remains unclear. This study aimed to explore the potential value of SNCA as a prognostic and diagnostic molecular marker in LUAD.
    Methods: In this study, we explored the expression pattern, prognostic value, and promoter methylation status of SNCA in LUAD based on Oncomine, UALCAN, and Kaplan-Meier Plotter. Then, using TIMER, we investigated the correlation between SNCA expression and immune infiltration. And cBioPortal were used to analysis the correlation between SNCA expression and immune checkpoint. The transcriptome data of A549 cells overexpressing SNCA were used to further study the potential immune role of SNCA in LUAD. The effect of SNCA on proliferation of A549 cells were evaluated by CCK-8, EdU and colony formation. Finally, LUAD cell lines treated with 5-aza-dC were used to explore the correlation between increased promoter methylation and downregulated mRNA expression of SNCA.
    Results: In general, the expression level of SNCA in LUAD tissue was lower than that in normal tissue, and high expression of SNCA was related to better prognosis. There were significant positive correlations between SNCA expression and immune infiltrations, including CD8+ T cells, macrophages, neutrophils, dendritic cells, B cells, and CD4+ T cells, and immune checkpoints, suggesting that immune infiltration was one of the reasons for the influence of SNCA on prognosis in LUAD. The transcriptome data of A549 cells overexpressing SNCA were further used to screen the relevant immune-related genes regulated by SNCA. Enrichment analysis confirmed that SNCA participates in the PI3K-AKT signaling pathway and other key tumor signaling pathways and regulates the expression of MAPK3, SRC, PLCG1, and SHC1. Cellular proliferation assay showed that SNCA could inhabit the growth of A549 cells via inhibiting activity of PI3K/AKT/ mTOR pathway. Finally, analysis of the methylation level of SNCA promoter showed that the promoter methylation negatively correlated with mRNA level. The expression of SNCA in LUAD cell lines was significantly upregulated by treatment with 5-aza-dC.
    Conclusion: High methylation of SNCA promoter in LUAD is one of the reasons for the downregulation of SNCA mRNA level. Given that SNCA could inhibit the proliferation of A549 cells and correlates with immune infiltrates, it may serve as a prognostic biomarker in LUAD.
    MeSH term(s) Adenocarcinoma of Lung/pathology ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Humans ; Lung Neoplasms/pathology ; Phosphatidylinositol 3-Kinases ; Prognosis ; Proto-Oncogene Proteins c-akt ; RNA, Messenger/metabolism ; Tumor Microenvironment ; alpha-Synuclein/genetics
    Chemical Substances Biomarkers, Tumor ; RNA, Messenger ; SNCA protein, human ; alpha-Synuclein ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2022-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-022-09289-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correction to: SNCA correlates with immune infiltration and serves as a prognostic biomarker in lung adenocarcinoma.

    Zhang, Xiuao / Wu, Zhengcun / Ma, Kaili

    BMC cancer

    2022  Volume 22, Issue 1, Page(s) 485

    Language English
    Publishing date 2022-05-02
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-022-09544-x
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  6. Article ; Online: cBAF and MYC: decision makers for T cell memory differentiation.

    Ma, Kaili / Cheng, Hongcheng / Zhang, Lianjun

    Signal transduction and targeted therapy

    2022  Volume 7, Issue 1, Page(s) 389

    Language English
    Publishing date 2022-12-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-022-01238-x
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  7. Article ; Online: SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body-like Pathology In Vitro.

    Wu, Zhengcun / Zhang, Xiuao / Huang, Zhangqiong / Ma, Kaili

    International journal of molecular sciences

    2022  Volume 23, Issue 6

    Abstract: Growing cases of patients reported have shown a potential relationship between (severe acute respiratory syndrome coronavirus 2) SARS-CoV-2 infection and Parkinson's disease (PD). However, it is unclear whether there is a molecular link between these two ...

    Abstract Growing cases of patients reported have shown a potential relationship between (severe acute respiratory syndrome coronavirus 2) SARS-CoV-2 infection and Parkinson's disease (PD). However, it is unclear whether there is a molecular link between these two diseases. Alpha-synuclein (α-Syn), an aggregation-prone protein, is considered a crucial factor in PD pathology. In this study, bioinformatics analysis confirmed favorable binding affinity between α-Syn and SARS-CoV-2 spike (S) protein and nucleocapsid (N) protein, and direct interactions were further verified in HEK293 cells. The expression of α-Syn was upregulated and its aggregation was accelerated by S protein and N protein. It was noticed that SARS-CoV-2 proteins caused Lewy-like pathology in the presence of α-Syn overexpression. By confirming that SARS-CoV-2 proteins directly interact with α-Syn, our study offered new insights into the mechanism underlying the development of PD on the background of COVID-19.
    MeSH term(s) COVID-19 ; HEK293 Cells ; Humans ; Lewy Bodies/metabolism ; Parkinson Disease/metabolism ; SARS-CoV-2 ; alpha-Synuclein/metabolism
    Chemical Substances SNCA protein, human ; alpha-Synuclein
    Language English
    Publishing date 2022-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23063394
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  8. Article: Isolation and identification of pathogens of

    Zhu, Xuetai / Ma, Kaili / Sun, Mingyue / Zhang, Jinming / Liu, Lijuan / Niu, Shiquan

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1231353

    Abstract: Morel mushroom ( ...

    Abstract Morel mushroom (
    Language English
    Publishing date 2023-11-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1231353
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  9. Article ; Online: Prognostic significance of SNCA and its methylation in bladder cancer.

    Wu, Zhengcun / Xia, Chengxing / Zhang, Chao / Yang, Delin / Ma, Kaili

    BMC cancer

    2022  Volume 22, Issue 1, Page(s) 330

    Abstract: Background: The epidemiological investigation of different cancer types in the global population has reported a decreased risk of bladder cancer (BLCA) in Parkinson's diseases (PD). SNCA a critical gene in PD pathology have been reported involved in ... ...

    Abstract Background: The epidemiological investigation of different cancer types in the global population has reported a decreased risk of bladder cancer (BLCA) in Parkinson's diseases (PD). SNCA a critical gene in PD pathology have been reported involved in tumorigenesis recently. However, the role of SNCA in BLCA remains unclear. This study aimed to explore the potential value of SNCA as a prognostic diagnostic molecular biomarker in BLCA.
    Methods: In this study, we explored the expression pattern, prognostic value and promoter methylation level of SNCA in BLCA by GEPIA2, UALCAN, TCGA, GENT2, GEO and c-BioPortal database. Then, we used LinkedOmics database to obtain the co-expression genes of SNCA for further study by WGCNA. We further investigated the correlations between SNCA expression and six main types of immune cell infiltrations and immune signatures by TIMER. Finally, BLCA cell lines treated with 5-Aza-CdR were used to explore the correlation between increased methylation and downregulated mRNA expression.
    Results: SNCA was downregulated in tumor tissues in TCGA-BLCA, GENT2 and GEO, which was validated in our cohort by qRT-PCR and immunohistochemistry. SNCA was confirmed as an independent predictor of poor overall survival (OS). LinkedOmics analysis suggested that SNCA regulates cell adhesion molecules, cytokine-cytokine receptor interaction, and complement and coagulation cascades. Twenty-two co-expression gene modules were constructed by WGCNA, and most of them were significantly associated with OS and disease-free survival (DFS). Six key genes (CNTN1, DACT3, MYLK1, PDE2A, RBM24, and ST6GALNAC3) screened also significantly correlated with prognosis. There were significant correlations between SNCA expression and immune infiltrations, especially T cell, suggesting that immune infiltration was one of the reasons for the influence of SNCA on prognosis in BLCA. Analysis by ULACAN and c-BioPortal showed that the promoter methylation of SNCA negatively correlated with its mRNA level. Furthermore, BLCA cell treatment with 5-Aza-CdR revealed that SNCA expression levels were upregulated with decreased methylation.
    Conclusion: Our research showed that SNCA was downregulated in BLCA and negatively correlation with DNA methylation. High SNCA expression was confirmed as an independent risk for prognosis. SNCA probably plays an important role in the infiltration of immune cells, especially with T cells. Thus, SNCA may be a promising prognostic biomarker in BLCA patients.
    MeSH term(s) DNA Methylation ; Gene Regulatory Networks ; Humans ; Prognosis ; Promoter Regions, Genetic ; RNA-Binding Proteins/genetics ; Urinary Bladder Neoplasms/pathology ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism
    Chemical Substances RBM24 protein, human ; RNA-Binding Proteins ; SNCA protein, human ; alpha-Synuclein
    Language English
    Publishing date 2022-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-022-09411-9
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  10. Article: [Effect of Continuous Cropping on the Physicochemical Properties, Microbial Activity, and Community Characteristics of the Rhizosphere Soil of

    Yang, Yang / Li, Hai-Liang / Ma, Kai-Li / Yu, Fan-Feng / Niu, Shi-Quan

    Huan jing ke xue= Huanjing kexue

    2023  Volume 44, Issue 11, Page(s) 6387–6398

    Abstract: Effects of continuous cropping on rhizosphere soil physical and chemical properties, soil microbial activity, and community characteristics ... ...

    Abstract Effects of continuous cropping on rhizosphere soil physical and chemical properties, soil microbial activity, and community characteristics of
    MeSH term(s) Soil/chemistry ; Codonopsis ; Carbon ; Rhizosphere ; Soil Microbiology ; Fungi ; Bacteria/genetics ; Nitrogen ; Phosphorus ; Potassium
    Chemical Substances Soil ; Carbon (7440-44-0) ; Nitrogen (N762921K75) ; Phosphorus (27YLU75U4W) ; Potassium (RWP5GA015D)
    Language Chinese
    Publishing date 2023-11-16
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 0250-3301
    ISSN 0250-3301
    DOI 10.13227/j.hjkx.202211100
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