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  1. Article ; Online: Dietary Fiber and Its Potential Role in Obesity: A Focus on Modulating the Gut Microbiota.

    Tian, Shuhua / Chu, Qiang / Ma, Shaotong / Ma, Huan / Song, Haizhao

    Journal of agricultural and food chemistry

    2023  Volume 71, Issue 41, Page(s) 14853–14869

    Abstract: Dietary fiber is a carbohydrate polymer with ten or more monomeric units that are resistant to digestion by human digestive enzymes, and it has gained widespread attention due to its significant role in health improvement through regulating gut ... ...

    Abstract Dietary fiber is a carbohydrate polymer with ten or more monomeric units that are resistant to digestion by human digestive enzymes, and it has gained widespread attention due to its significant role in health improvement through regulating gut microbiota. In this review, we summarized the interaction between dietary fiber, gut microbiota, and obesity, and the beneficial effects of dietary fiber on obesity through the modulation of microbiota, such as modifying selective microbial composition, producing starch-degrading enzymes, improving gut barrier function, reducing the inflammatory response, reducing trimethylamine N-oxide, and promoting the production of gut microbial metabolites (e.g., short chain fatty acids, bile acids, ferulic acid, and succinate). In addition, factors affecting the gut microbiota composition and metabolites by dietary fiber (length of the chain, monosaccharide composition, glycosidic bonds) were also concluded. Moreover, strategies for enhancing the biological activity of dietary fiber (fermentation technology, ultrasonic modification, nanotechnology, and microfluidization) were subsequently discussed. This review may provide clues for deeply exploring the structure-activity relationship between dietary fiber and antiobesity properties by targeting specific gut microbiota.
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Obesity/metabolism ; Microbiota ; Fatty Acids, Volatile/metabolism ; Dietary Fiber/metabolism
    Chemical Substances Fatty Acids, Volatile ; Dietary Fiber
    Language English
    Publishing date 2023-10-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c03923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Effect of

    Shen, Dan / Ma, Shaotong / Li, Xiangfei / Lu, Yingjian

    Journal of agricultural and food chemistry

    2022  Volume 70, Issue 47, Page(s) 14817–14830

    Abstract: Ulcerative colitis (UC) is becoming an increasingly serious health problem. This study aimed to investigate the effect of a newly ... ...

    Abstract Ulcerative colitis (UC) is becoming an increasingly serious health problem. This study aimed to investigate the effect of a newly isolated
    MeSH term(s) Mice ; Animals ; Lactobacillus ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Dextrans
    Chemical Substances feruloyl esterase (EC 3.1.1.73) ; Dextrans ; sodium sulfate (0YPR65R21J)
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.2c02066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Broccoli microgreens have hypoglycemic effect by improving blood lipid and inflammatory factors while modulating gut microbiota in mice with type 2 diabetes

    Ma, Shaotong / Tian, Shuhua / Sun, Jing / Pang, Xinyi / Hu, Qiaobin / Li, Xiangfei / Lu, Yingjian

    Journal of food biochemistry. 2022 July, v. 46, no. 7

    2022  

    Abstract: This study aims to explore the hypoglycemic effect of lyophilized broccoli microgreens on type 2 diabetes (T2D) in mice. The experiment lasted 18 weeks, including 1 week of adaptation (normal diet) and 17‐week experimental period (high‐fat diet). After ... ...

    Abstract This study aims to explore the hypoglycemic effect of lyophilized broccoli microgreens on type 2 diabetes (T2D) in mice. The experiment lasted 18 weeks, including 1 week of adaptation (normal diet) and 17‐week experimental period (high‐fat diet). After ingestion of broccoli microgreens, the body weight and glucose homeostasis were improved. Meanwhile, the blood lipid status, antioxidant indexes, and inflammatory factors level were improved. Moreover, the insulin resistance and the pathological changes in mice organs were reversed. In addition, the composition of gut microbiota and the production of propionic acid in intestinal content were improved. Our experiment proved that broccoli microgreens have the ability to regulate T2D and improve symptoms of mice T2D induced by high‐fat diet and streptozotocin (STZ). PRACTICAL APPLICATIONS: For years, the functionality of broccoli microgreens has attracted much attention. This article will prove the therapeutic effect of broccoli microgreens on T2D and explain its principle of action in the management of T2D.
    Keywords antioxidants ; blood lipids ; body weight ; broccoli ; freeze drying ; glucose ; glycemic effect ; high fat diet ; homeostasis ; ingestion ; insulin resistance ; intestinal microorganisms ; intestines ; microgreens ; noninsulin-dependent diabetes mellitus ; propionic acid ; streptozotocin ; therapeutics
    Language English
    Dates of publication 2022-07
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.14145
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3310: Show issues

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  4. Article ; Online: The protective effects of sulforaphane on high-fat diet-induced metabolic associated fatty liver disease in mice

    Ma, Shaotong / Pang, Xinyi / Tian, Shuhua / Sun, Jing / Hu, Qiaobin / Li, Xiangfei / Lu, Yingjian

    Food & function

    2022  

    Abstract: Metabolic-associated fatty liver disease (MAFLD) is becoming the key factor in causing chronic liver disease all over the world. Sulforaphane (SFN) has been proven to be effective in alleviating many metabolic diseases, such as obesity and type 2 ... ...

    Abstract Metabolic-associated fatty liver disease (MAFLD) is becoming the key factor in causing chronic liver disease all over the world. Sulforaphane (SFN) has been proven to be effective in alleviating many metabolic diseases, such as obesity and type 2 diabetes. In this study, C57BL/6 mice were fed a high-fat diet for 12 weeks to induce MAFLD and given SFN (10 mg per kg bw) daily. Our results showed that SFN not only improved the excessive accumulation of fat in the liver cells but also ameliorated liver and serum inflammatory and antioxidant levels. In addition, SFN can regulate bile-acid metabolism and fatty-acid synthesis by affecting their farnesoid X receptor (FXR)/liver X receptor alpha (LXRα) signaling pathway, ultimately alleviating MAFLD. Our study provides a theoretical basis for the mechanism by which SFN alleviates hepatic steatosis.
    Language English
    Publishing date 2022-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d2fo02341e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Z 7872: Show issues

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  5. Article ; Online: Broccoli microgreens have hypoglycemic effect by improving blood lipid and inflammatory factors while modulating gut microbiota in mice with type 2 diabetes.

    Ma, Shaotong / Tian, Shuhua / Sun, Jing / Pang, Xinyi / Hu, Qiaobin / Li, Xiangfei / Lu, Yingjian

    Journal of food biochemistry

    2022  Volume 46, Issue 7, Page(s) e14145

    Abstract: This study aims to explore the hypoglycemic effect of lyophilized broccoli microgreens on type 2 diabetes (T2D) in mice. The experiment lasted 18 weeks, including 1 week of adaptation (normal diet) and 17-week experimental period (high-fat diet). After ... ...

    Abstract This study aims to explore the hypoglycemic effect of lyophilized broccoli microgreens on type 2 diabetes (T2D) in mice. The experiment lasted 18 weeks, including 1 week of adaptation (normal diet) and 17-week experimental period (high-fat diet). After ingestion of broccoli microgreens, the body weight and glucose homeostasis were improved. Meanwhile, the blood lipid status, antioxidant indexes, and inflammatory factors level were improved. Moreover, the insulin resistance and the pathological changes in mice organs were reversed. In addition, the composition of gut microbiota and the production of propionic acid in intestinal content were improved. Our experiment proved that broccoli microgreens have the ability to regulate T2D and improve symptoms of mice T2D induced by high-fat diet and streptozotocin (STZ). PRACTICAL APPLICATIONS: For years, the functionality of broccoli microgreens has attracted much attention. This article will prove the therapeutic effect of broccoli microgreens on T2D and explain its principle of action in the management of T2D.
    MeSH term(s) Animals ; Brassica ; Diabetes Mellitus, Type 2/drug therapy ; Gastrointestinal Microbiome ; Hypoglycemic Agents/pharmacology ; Lipids ; Mice ; Mice, Inbred C57BL
    Chemical Substances Hypoglycemic Agents ; Lipids
    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.14145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 3310: Show issues

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  6. Article: Effects of L‐arabinose by hypoglycemic and modulating gut microbiome in a high‐fat diet‐ and streptozotocin‐induced mouse model of type 2 diabetes mellitus

    Shen, Dan / Lu, Yingjian / Tian, Shuhua / Ma, Shaotong / Sun, Jing / Hu, Qiaobin / Pang, Xinyi / Li, Xiangfei

    Journal of food biochemistry. 2021 Dec., v. 45, no. 12

    2021  

    Abstract: L‐arabinose is a good and healthy food additive. This study was conducted to investigate the effect of L‐arabinose in a mouse model of type 2 diabetes mellitus (T2DM) induced by exposure to a high‐fat diet (HFD) and streptozotocin (STZ). The model mice ... ...

    Abstract L‐arabinose is a good and healthy food additive. This study was conducted to investigate the effect of L‐arabinose in a mouse model of type 2 diabetes mellitus (T2DM) induced by exposure to a high‐fat diet (HFD) and streptozotocin (STZ). The model mice received L‐arabinose at 20 and 60 mg (kg body weight [bw])⁻¹d⁻¹, metformin at 300 mg (kg bw)⁻¹d⁻¹ (positive control) or sterile water (control) via oral gavage. Compared with the model group, mice treated with L‐arabinose exhibited attenuated symptoms of diabetes mellitus, including a slower rate of body weight loss, increased homeostasis model assessment of β‐cell function index levels, decreased blood glucose, alleviation of steatosis, and repair of pancreatic islet cells. L‐arabinose also exerted an anti‐inflammatory effect and partially mitigated dyslipidemia. A 16S‐rRNA sequence analysis of the gut microbiota revealed that at the phylum level, treatment with L‐arabinose significantly reduced the ratio of Firmicutes to Bacteroidetes due to a decreased relative abundance of Firmicutes; at the genus level, it reversed the increase in the relative abundance of Allobaculum and the decrease abundance of Oscillospira caused by exposure to an HFD and STZ. And the model mice received L‐arabinose at 20 mg (kg bw)⁻¹d⁻¹ had a better effect on improving T2DM than the high‐dose group supplemented L‐arabinose at 60 mg (kg bw)⁻¹d⁻¹. These results strongly suggest L‐arabinose as an excellent candidate supplement to prevent or treat T2DM. PRACTICAL APPLICATIONS: L‐arabinose, xylitol and sucralose are well‐known substitutes for sucrose. L‐arabinose has been reported to have beneficial effects on hyperglycemia, glycemic index, and fat accumulation. In this study, we found that low‐dose (20 mg (kg bw)⁻¹d‐¹) supplementation of L‐arabinose significantly improved glucose intolerance and gut microbiota incoordination in T2DM caused by HFD and STZ.
    Keywords Bacteroidetes ; Oscillospira ; anti-inflammatory activity ; arabinose ; ataxia (disorder) ; blood glucose ; body weight changes ; food additives ; glucose ; glycemic index ; healthy diet ; high fat diet ; homeostasis ; hyperglycemia ; hyperlipidemia ; intestinal microorganisms ; islets of Langerhans ; metformin ; mice ; noninsulin-dependent diabetes mellitus ; sequence analysis ; streptozotocin ; sucralose ; sucrose ; xylitol
    Language English
    Dates of publication 2021-12
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.13991
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    In stock of ZB MED Bonn / Germany

    Z 3310: Show issues

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  7. Article ; Online: Effects of L-arabinose by hypoglycemic and modulating gut microbiome in a high-fat diet- and streptozotocin-induced mouse model of type 2 diabetes mellitus.

    Shen, Dan / Lu, Yingjian / Tian, Shuhua / Ma, Shaotong / Sun, Jing / Hu, Qiaobin / Pang, Xinyi / Li, Xiangfei

    Journal of food biochemistry

    2021  Volume 45, Issue 12, Page(s) e13991

    Abstract: L-arabinose is a good and healthy food additive. This study was conducted to investigate the effect of L-arabinose in a mouse model of type 2 diabetes mellitus (T2DM) induced by exposure to a high-fat diet (HFD) and streptozotocin (STZ). The model mice ... ...

    Abstract L-arabinose is a good and healthy food additive. This study was conducted to investigate the effect of L-arabinose in a mouse model of type 2 diabetes mellitus (T2DM) induced by exposure to a high-fat diet (HFD) and streptozotocin (STZ). The model mice received L-arabinose at 20 and 60 mg (kg body weight [bw])
    MeSH term(s) Animals ; Arabinose ; Diabetes Mellitus, Type 2/drug therapy ; Diet, High-Fat/adverse effects ; Gastrointestinal Microbiome ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Mice ; Mice, Inbred C57BL ; Streptozocin
    Chemical Substances Hypoglycemic Agents ; Streptozocin (5W494URQ81) ; Arabinose (B40ROO395Z)
    Language English
    Publishing date 2021-11-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 433846-7
    ISSN 1745-4514 ; 0145-8884
    ISSN (online) 1745-4514
    ISSN 0145-8884
    DOI 10.1111/jfbc.13991
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Bonn / Germany

    Z 3310: Show issues

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