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  1. Article: An Early Indicator in Evaluating Cardiac Dysfunction Related to Premature Ventricular Complexes: Cardiorespiratory Capacity.

    Ma, Xiaozhu / Yan, Jiangtao / Liu, Wanjun

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 22

    Abstract: Cardiac dysfunction induced by premature ventricular complexes (PVCs) is relatively controversial and challenging to detect in the early stage. In this observational study, we retrospectively analyzed the cardiopulmonary exercise test (CPET) data of 94 ... ...

    Abstract Cardiac dysfunction induced by premature ventricular complexes (PVCs) is relatively controversial and challenging to detect in the early stage. In this observational study, we retrospectively analyzed the cardiopulmonary exercise test (CPET) data of 94 patients with frequent premature ventricular beats (47 males, 49.83 ± 13.63 years) and 98 participants (55 males, 50.84 ± 9.41 years) whose age and gender were matched with the patient with PVCs. The baseline information and routine echocardiography detection were recorded on admission. PVCs were diagnosed by 24 h Holter monitoring, and cardiorespiratory capacity was assessed using peak oxygen uptake (V'O
    Language English
    Publishing date 2023-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11222940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Epigenetics in diabetic cardiomyopathy.

    Ma, Xiaozhu / Mei, Shuai / Wuyun, Qidamugai / Zhou, Li / Sun, Dating / Yan, Jiangtao

    Clinical epigenetics

    2024  Volume 16, Issue 1, Page(s) 52

    Abstract: Diabetic cardiomyopathy (DCM) is a critical complication that poses a significant threat to the health of patients with diabetes. The intricate pathological mechanisms of DCM cause diastolic dysfunction, followed by impaired systolic function in the late ...

    Abstract Diabetic cardiomyopathy (DCM) is a critical complication that poses a significant threat to the health of patients with diabetes. The intricate pathological mechanisms of DCM cause diastolic dysfunction, followed by impaired systolic function in the late stages. Accumulating researches have revealed the association between DCM and various epigenetic regulatory mechanisms, including DNA methylation, histone modifications, non-coding RNAs, and other epigenetic molecules. Recently, a profound understanding of epigenetics in the pathophysiology of DCM has been broadened owing to advanced high-throughput technologies, which assist in developing potential therapeutic strategies. In this review, we briefly introduce the epigenetics regulation and update the relevant progress in DCM. We propose the role of epigenetic factors and non-coding RNAs (ncRNAs) as potential biomarkers and drugs in DCM diagnosis and treatment, providing a new perspective and understanding of epigenomics in DCM.
    MeSH term(s) Humans ; Diabetic Cardiomyopathies/genetics ; DNA Methylation ; Epigenomics ; Epigenesis, Genetic ; Histone Code ; Diabetes Mellitus/genetics
    Language English
    Publishing date 2024-04-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2553921-8
    ISSN 1868-7083 ; 1868-7075
    ISSN (online) 1868-7083
    ISSN 1868-7075
    DOI 10.1186/s13148-024-01667-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Liquid-Liquid Phase Separation Sheds New Light upon Cardiovascular Diseases.

    Cai, Ziyang / Mei, Shuai / Zhou, Li / Ma, Xiaozhu / Wuyun, Qidamugai / Yan, Jiangtao / Ding, Hu

    International journal of molecular sciences

    2023  Volume 24, Issue 20

    Abstract: Liquid-liquid phase separation (LLPS) is a biophysical process that mediates the precise and complex spatiotemporal coordination of cellular processes. Proteins and nucleic acids are compartmentalized into micron-scale membrane-less droplets via LLPS. ... ...

    Abstract Liquid-liquid phase separation (LLPS) is a biophysical process that mediates the precise and complex spatiotemporal coordination of cellular processes. Proteins and nucleic acids are compartmentalized into micron-scale membrane-less droplets via LLPS. These droplets, termed biomolecular condensates, are highly dynamic, have concentrated components, and perform specific functions. Biomolecular condensates have been observed to organize diverse key biological processes, including gene transcription, signal transduction, DNA damage repair, chromatin organization, and autophagy. The dysregulation of these biological activities owing to aberrant LLPS is important in cardiovascular diseases. This review provides a detailed overview of the regulation and functions of biomolecular condensates, provides a comprehensive depiction of LLPS in several common cardiovascular diseases, and discusses the revolutionary therapeutic perspective of modulating LLPS in cardiovascular diseases and new treatment strategies relevant to LLPS.
    MeSH term(s) Humans ; Cardiovascular Diseases ; Proteins ; Cell Physiological Phenomena ; Autophagy
    Chemical Substances Proteins
    Language English
    Publishing date 2023-10-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242015418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II.

    Li, Yuanyuan / Ma, Xiaozhu / Mei, Shuai / Ji, Yueping / Wang, Dong / He, Liqun / Sun, Dating / Yan, Jiangtao

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 984087

    Abstract: Background and aims: Aortic dissection (AD) is a cardiovascular emergency with degeneration of the aortic media. Mounting evidence indicates obstructive sleep apnea (OSA) as an independent risk factor for AD development with unknown mechanisms. This ... ...

    Abstract Background and aims: Aortic dissection (AD) is a cardiovascular emergency with degeneration of the aortic media. Mounting evidence indicates obstructive sleep apnea (OSA) as an independent risk factor for AD development with unknown mechanisms. This study aims to establish a stable murine model of OSA-related AD (OSA-AD) and uncover the potential changes in gene transcripts in OSA-AD.
    Materials and methods: ApoE
    Results: ApoE
    Conclusion: Our findings help establish a
    Language English
    Publishing date 2022-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.984087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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