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Article ; Online: DCLK1 promotes malignant progression of breast cancer by regulating Wnt/β-Catenin signaling pathway.

Wang, Y-L / Li, Y / Ma, Y-G / Wu, W-Y

European review for medical and pharmacological sciences

2019 Volume 23, Issue 21, Page(s) 9489–9498

Abstract: Objective: The study was aimed to investigate the expression of doublecortin-like kinase-1 (DCLK1) in breast cancer (BCa) tissues and cells and further study its association with clinicopathology and prognosis of BCa patients.: Patients and methods: ... ...

Abstract	Objective: The study was aimed to investigate the expression of doublecortin-like kinase-1 (DCLK1) in breast cancer (BCa) tissues and cells and further study its association with clinicopathology and prognosis of BCa patients. Patients and methods: Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was used to examine the expression of DCLK1 in 44 BCa tumor tissues, as well as adjacent normal tissues. Also, the interplay between DCLK1 level and clinical data or the prognosis of BCa patients was analyzed. QRT-PCR was further used to verify the level of DCLK1 in BCa cell lines. In addition, the DCLK1 knockdown model was constructed using lentivirus in BCa cell lines. Next, cell counting kit-8 (CCK-8) and cell clone formation and tranwell assays were used to analyze the effect of DCLK1 on the biological function of BCa cells. Finally, it was explored whether DCLK1 can act through the Wnt/β-Catenin signaling pathway. Results: In this research, qRT-PCR results revealed that the level of DCLK1 in BCa tumor tissues was remarkably higher than in adjacent tissues. Compared to patients with a low-level of DCLK1, the pathology grading in patients with high-level was higher and the overall survival rate was lower. Similarly, proliferation, as well as the invasion and migration ability of cells in DCLK1 knockdown group was remarkably down-regulated when compared to negative control group. Moreover, the Western Blot results revealed that silencing DCLK1 remarkably decreased the expression of key proteins in Wnt/β-Catenin pathways such as β-Catenin, c-myc, and cyclinD1, thereby promoting the malignant progression of BCa. In addition, the Wnt/β-Catenin pathway inhibitor was found to be able to reverse the impact of DCLK1 overexpression on BCa cell proliferative and metastatic capacity. Conclusions: DCLK1 expression was found remarkably increased in BCa tissues and closely associated with the pathological stage, as well as poor prognosis of BCa patients. Furthermore, DCLK1 may promote the malignant progression of BCa by inhibiting the Wnt/β-Catenin pathway.
MeSH term(s)	Adult ; Aged ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line ; Cell Proliferation ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Middle Aged ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Wnt Signaling Pathway ; beta Catenin/metabolism
Chemical Substances	Intracellular Signaling Peptides and Proteins ; beta Catenin ; DCLK1 protein, human (EC 2.7.1.11) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2019-11-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_201911_19443
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Article: [MiR-451 regulates proliferation and migration of colorectal cells by targeting MIF].

Ma, Y G / Han, Y Z / Zhang, Z S / Yu, Y / Xu, X F / Yuan, L

Zhonghua zhong liu za zhi [Chinese journal of oncology

2020 Volume 42, Issue 4, Page(s) 312–318

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Intramolecular Oxidoreductases/genetics ; Intramolecular Oxidoreductases/metabolism ; Macrophage Migration-Inhibitory Factors/genetics ; Macrophage Migration-Inhibitory Factors/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasm Invasiveness
Chemical Substances	MIRN451 microRNA, human ; Macrophage Migration-Inhibitory Factors ; MicroRNAs ; Intramolecular Oxidoreductases (EC 5.3.-) ; MIF protein, human (EC 5.3.2.1)
Language	Chinese
Publishing date	2020-05-27
Publishing country	China
Document type	Journal Article
ZDB-ID	603424-x
ISSN	0253-3766
ISSN	0253-3766
DOI	10.3760/cma.j.cn112152-20190924-00622
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Article: [Effect of miR-513a-3p targeting MDM2 on proliferation, migration and invasion of gastric cancer cells].

Ma, Y G / Zhang, Z S / Yu, Y / Xu, X F / Yuan, L

Zhonghua zhong liu za zhi [Chinese journal of oncology

2020 Volume 42, Issue 1, Page(s) 30–36

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Animals ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Mice ; MicroRNAs ; Neoplasm Invasiveness ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology
Chemical Substances	MicroRNAs
Language	Chinese
Publishing date	2020-02-05
Publishing country	China
Document type	Journal Article
ZDB-ID	603424-x
ISSN	0253-3766
ISSN	0253-3766
DOI	10.3760/cma.j.issn.0253-3766.2020.01.004
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Book ; Online: Finite-size scaling phenomenon of nuclear liquid--gas phase transition probes

Liu, H. L. / Ma, Y. G. / Fang, D. Q.

2019

Abstract: Based on the isospin-dependent quantum molecular dynamics model, finite-size scaling effects on nuclear liquid--gas phase transition probes are investigated by studying the de-excitation processes of six thermal sources of different sizes with the same ... ...

Abstract	Based on the isospin-dependent quantum molecular dynamics model, finite-size scaling effects on nuclear liquid--gas phase transition probes are investigated by studying the de-excitation processes of six thermal sources of different sizes with the same initial density and similar $N/Z$. Using several probes including the total multiplicity derivative ($dM_{tot}/dT$), second moment parameter ($M_2$), intermediate mass fragment (IMF) multiplicity ($N_{IMF}$), Fisher's power-law exponent ($\tau$), and Ma's nuclear Zipf's law exponent ($\xi$), the relationship between the phase transition temperature and the source size has been established. It is observed that the phase transition temperatures obtained from the IMF multiplicity, Fisher's exponent, and Ma's nuclear Zipf's law exponent have a strong correlation with the source size. Moreover, by employing the finite-size scaling law, the critical temperature $T_c$ and the critical exponent $\nu$ have been obtained for infinite nuclear matter. Comment: 5 pages, 7 figures
Keywords	Nuclear Theory ; Nuclear Experiment
Subject code	612
Publishing date	2019-09-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis.

Xiao, P-L / Cui, A-Y / Hsu, C-J / Peng, R / Jiang, N / Xu, X-H / Ma, Y-G / Liu, D / Lu, H-D

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

2022 Volume 33, Issue 10, Page(s) 2137–2153

Abstract: This systematic review and meta-analysis estimated the global, regional prevalence, and risk factors of osteoporosis. Prevalence varied greatly according to countries (from 4.1% in Netherlands to 52.0% in Turkey) and continents (from 8.0% in Oceania to ... ...

Abstract	This systematic review and meta-analysis estimated the global, regional prevalence, and risk factors of osteoporosis. Prevalence varied greatly according to countries (from 4.1% in Netherlands to 52.0% in Turkey) and continents (from 8.0% in Oceania to 26.9% in Africa). Osteoporosis is a common metabolic bone disorder in the elderly, usually resulting in bone pain and an increased risk of fragility fracture, but few summarized studies have guided global strategies for the disease. Therefore, we pooled the epidemiologic data to estimate the global, regional prevalence, and potential risk factors of osteoporosis. We conducted a comprehensive literature search through PubMed, EMBASE, Web of Science, and Scopus, to identify population-based studies that reported the prevalence of osteoporosis based on the World Health Organization (WHO) criteria. Meta-regression and subgroup analyses were used to explore the sources of heterogeneity. The study was registered in the PROSPERO database (CRD42021285555). Of the 57,933 citations evaluated, 108 individual studies containing 343,704 subjects were included. The global prevalence of osteoporosis and osteopenia was 19.7% (95%CI, 18.0%-21.4%) and 40.4% (95%CI, 36.9%-43.8%). Prevalence varied greatly according to countries (from 4.1% in Netherlands to 52.0% in Turkey) and continents (from Oceania 8.0% to 26.9% in Africa). The prevalence was higher in developing countries (22.1%, 95%CI, 20.1%-24.1%) than in developed countries (14.5%, 95%CI, 11.5%-17.7%). Our study indicates a considerable prevalence of osteoporosis among the general population based on WHO criteria, and the prevalence varies substantially between countries and regions. Future studies with robust evidence are required to explore risk factors to provide effective preventive strategies for the disease.
MeSH term(s)	Aged ; Bone Diseases, Metabolic/etiology ; Global Health ; Humans ; Osteoporosis/diagnosis ; Osteoporosis/epidemiology ; Osteoporosis/etiology ; Prevalence ; Risk Factors ; World Health Organization
Language	English
Publishing date	2022-06-10
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	1064892-6
ISSN	1433-2965 ; 0937-941X
ISSN (online)	1433-2965
ISSN	0937-941X
DOI	10.1007/s00198-022-06454-3
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Book ; Conference proceedings: Special issue: Quark matter 2006 - The 19th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions

Ma, Y.-G

[the Quark Matter 2006 Conference was held on 14 - 20 November 2006 at the Shanghai Science Hall ...]

(Journal of physics : G, Nuclear and particle physics ; 34.2007,8)

2007

Title variant	Quark matter 2006 - The 19th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions
Institution	International Conference on Ultra-Relativistic Nucleus Nucleus Collisions
Event/congress	International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions (19, 2006.11.14-20, Shanghai) ; Quark Matter Conference (19, 2006.11.14-20, Shanghai)
Author's details	ed. by Y.-G. Ma
Series title	Journal of physics : G, Nuclear and particle physics ; 34.2007,8
Language	English
Size	S. S173 - S1161, Ill., graph. Darst.
Publisher	IOP
Publishing place	Bristol
Document type	Book ; Conference proceedings
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Computational investigation on the large energy gap between the triplet excited-states in acenes

Pan, Y. Y / Huang, J / Wang, Z. M / Yu, D. W / Yang, B / Ma, Y. G

RSC advances. 2017 May 18, v. 7, no. 43

2017

Abstract: The large energy gap between the two triplet excited-states in acenes has a huge impact on their optical and electronic properties. Accurate calculation and full use of this gap have always been a major challenge in the field of organic semiconductor ... ...

Abstract	The large energy gap between the two triplet excited-states in acenes has a huge impact on their optical and electronic properties. Accurate calculation and full use of this gap have always been a major challenge in the field of organic semiconductor materials. In the present study, we focus on the precise description of the large gap between the T1 and T2 states, and taking a series of acenes (benzene, naphthalene, anthracene, tetracene, and pentacene) as examples, investigate their excited state behavior to verify the energy gap structure. The results show that the symmetry of the transition molecular orbital and the excited state properties have a great influence on the transition energy, and may be the main cause of the large energy gap.
Keywords	anthracenes ; benzene ; energy ; naphthalene ; semiconductors
Language	English
Dates of publication	2017-0518
Size	p. 26697-26703.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c7ra02559a
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Application of inverse, strict conformal transformation to design waveguide devices.

Ma, Y G / Wang, N / Ong, C K

Journal of the Optical Society of America. A, Optics, image science, and vision

2010 Volume 27, Issue 5, Page(s) 968–972

Abstract: Integration of transformation optics with development of metamaterials offers great opportunities to create exotic material with electromagnetic functionality absent from nature. It has already led to several significant advancements in physical ... ...

Abstract	Integration of transformation optics with development of metamaterials offers great opportunities to create exotic material with electromagnetic functionality absent from nature. It has already led to several significant advancements in physical conceptions and technological applications such as invisible cloaking. Unfortunately practical application is often restricted by the complex requirements on material properties imposed by the general optical transformation theory. It is therefore necessary to relax the stringent requirements of materials properties in order to practicably use the power of transformation optics to design exotic optical devices. Development of new coordinate transformation mathematics to compromise between the stringent materials properties and the ultimate performance required by a useful novel device is required. In this work the authors employed strict conformal transformation to design physical materials that could guide light in a predetermined way. A simple and efficient numerical approach based on unusual inverse transformation is proposed here to quickly solve partial differential equations and construct the mapping relationship. The results showed that a transformed optical device could be made by purely using isotropic dielectric materials. Two application examples were numerically proposed to verify the versatility of conformal transformation and the robustness of the inverse approach. One was a 90 degrees waveguide beam bend, and the other was a waveguide-type beam splitter or coupler.
Language	English
Publishing date	2010-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	283633-6
ISSN	1520-8532 ; 1084-7529 ; 0740-3232
ISSN (online)	1520-8532
ISSN	1084-7529 ; 0740-3232
DOI	10.1364/JOSAA.27.000968
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Article ; Online: Giant dipole resonance as a fingerprint of α clustering configurations in 12C and 16O.

He, W B / Ma, Y G / Cao, X G / Cai, X Z / Zhang, G Q

Physical review letters

2014 Volume 113, Issue 3, Page(s) 32506

Abstract: It is studied how the α cluster degrees of freedom, such as α clustering configurations close to the α decay threshold in (12)C and (16)O, including the linear chain, triangle, square, kite, and tetrahedron, affect nuclear collective vibrations with a ... ...

Abstract	It is studied how the α cluster degrees of freedom, such as α clustering configurations close to the α decay threshold in (12)C and (16)O, including the linear chain, triangle, square, kite, and tetrahedron, affect nuclear collective vibrations with a microscopic dynamical approach, which can describe properties of nuclear ground states well across the nuclide chart and reproduce the standard giant dipole resonance (GDR) of (16)O quite nicely. It is found that the GDR spectrum is highly fragmented into several apparent peaks due to the α structure. The different α cluster configurations in (12)C and (16)O have corresponding characteristic spectra of GDR. The number and centroid energies of peaks in the GDR spectra can be reasonably explained by the geometrical and dynamical symmetries of α clustering configurations. Therefore, the GDR can be regarded as a very effective probe to diagnose the different α cluster configurations in light nuclei.
Language	English
Publishing date	2014-07-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.113.032506
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Article: A multistage simulation-based optimization model for water resources management in Tarim River Basin, China

Huang, Y / Li, Y. P / Chen, X / Bao, A. M / Ma, Y. G

Stochastic environmental research and risk assessment. 2013 Jan., v. 27, no. 1

2013

Abstract: In this study, a multistage simulation-based optimization model is developed for supporting water resources management under uncertainty. The system couples a lumped rainfall-runoff model with an inexact multistage stochastic program, where its random ... ...

Abstract	In this study, a multistage simulation-based optimization model is developed for supporting water resources management under uncertainty. The system couples a lumped rainfall-runoff model with an inexact multistage stochastic program, where its random parameter is provided by the statistical analysis of simulation outcomes. Moreover, penalties are exercised with recourse against any infeasibility, which permits in-depth analyses of various policy scenarios that are associated with different levels of economic consequences when the promised water-allocation targets are violated. The developed model can also reflect dynamic features of the system conditions through transactions at discrete points in time over a multistage context. The developed model is applied to a real case of planning water resources management in Tarim River Basin, which is one of the most serious water-shortage regions of China. A variety of policies associated with different water-allocation targets are analyzed. The results are helpful for decision makers identifying optimal water-allocation plans for mitigating the conflict among ecological protection, economic development, and regional sustainability.
Keywords	economic development ; hydrologic models ; issues and policy ; planning ; statistical analysis ; uncertainty ; water allocation ; watersheds ; China
Language	English
Dates of publication	2013-01
Size	p. 147-158.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	1481263-0
ISSN	1436-3259 ; 1436-3240 ; 0931-1955
ISSN (online)	1436-3259
ISSN	1436-3240 ; 0931-1955
DOI	10.1007/s00477-012-0585-x
Database	NAL-Catalogue (AGRICOLA)

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