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Article: Editorial: Circulating biomarkers in prostate cancer.

Nagata, Masayoshi / Horie, Shigeo / Ma, Yafeng

2024 Volume 14, Page(s) 1365353

Language	English
Publishing date	2024-02-07
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1365353
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Article: The impact of diagnosis related group payment on the performance of public hospitals.

Ma, Yafeng / Wang, Wei

American journal of translational research

2021 Volume 13, Issue 6, Page(s) 6796–6801

Abstract: Objective: To investigate the practical value of diagnosis related groups (DRGs) according to payment for assessing the performance of public hospitals.: Methods: According to a random number table, 2400 patients were chosen from 3928 inpatients ... ...

Abstract	Objective: To investigate the practical value of diagnosis related groups (DRGs) according to payment for assessing the performance of public hospitals. Methods: According to a random number table, 2400 patients were chosen from 3928 inpatients admitted for treatment in our hospital. Based on nodes implemented in the DRGs, these patients were assigned to the control group and the experimental group (1200 patients in each group). In the control group, patients didn't receive assistance with DRG payment (a clinical performance management approach was carried out based on the type of disease and cost), while patients in the experimental group received DRG. Bed turnover rate, hospitalization time, average cost, mortality, and subjective satisfaction were obtained and compared between the two groups. Results: Compared with the control group, bed turnover rate, hospitalization time, average cost, and mortality in the experimental group were all significantly decreased (P<0.05), while subjective satisfaction was increased (P<0.05). Conclusion: DRG payment is beneficial for reduced clinical hospitalization time, cost, and mortality, and improved bed utilization rate and subjective satisfaction, which is worthy of clinical promotion.
Language	English
Publishing date	2021-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article ; Online: Melatonin Increases Proliferation and Decreases Apoptosis of GC-1 spg Cells by Upregulating the Expression of circTec.

Xu, Changlong / Yang, Hua / Li, Chunyuan / Wu, Zhuo / Ma, Yafeng

Reproductive sciences (Thousand Oaks, Calif.)

2022 Volume 30, Issue 1, Page(s) 135–144

Abstract: Melatonin has been shown to be beneficial for the motility of human sperm, although its mechanism remains to be uncovered. Circular RNAs (circRNAs) have been shown to regulate cellular function in many diseases. However, there has been no relevant ... ...

Abstract	Melatonin has been shown to be beneficial for the motility of human sperm, although its mechanism remains to be uncovered. Circular RNAs (circRNAs) have been shown to regulate cellular function in many diseases. However, there has been no relevant research on the effect of melatonin on sperm circRNAs. In this study, we aimed to explore the changes in circRNAs after melatonin treatment of GC-1 spg cells and identify key functional circRNAs. The results showed that melatonin enhanced the proliferation and reduced the apoptosis of GC-1 spg cells. A total of 1423 circRNAs were found to be significantly differentially expressed between groups with and without melatonin treatment. Of these circRNAs, 702 were upregulated and 721 were downregulated. circTec was one of the upregulated circRNAs. Suppressing the expression of circTec significantly reduced cell proliferation and mammalian target of rapamycin (mTOR) signaling pathway activation but promoted melatonin-treated GC-1 spg cell apoptosis. In conclusion, melatonin increased the expression of circTec to exert its physiological effects on GC-1 spg cells, possibly by activating the mTOR signaling pathway. These results enhance our understanding of the biological function of circTec and its regulation by melatonin in spermatogenesis and infertility.
MeSH term(s)	Male ; Apoptosis ; Cell Proliferation ; Melatonin/pharmacology ; MicroRNAs/metabolism ; RNA, Circular ; Semen/metabolism ; TOR Serine-Threonine Kinases ; Animals ; Mice ; Cell Line
Chemical Substances	Melatonin (JL5DK93RCL) ; MicroRNAs ; RNA, Circular ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2022-04-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1007/s43032-022-00937-8
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Article ; Online: Molecular Biomarkers in Glioblastoma: A Systematic Review and Meta-Analysis.

Sareen, Heena / Ma, Yafeng / Becker, Therese M / Roberts, Tara L / de Souza, Paul / Powter, Branka

International journal of molecular sciences

2022 Volume 23, Issue 16

Abstract: Background: Glioblastoma (GBM) is a highly aggressive cancer with poor prognosis that needs better treatment modalities. Moreover, there is a lack of reliable biomarkers to predict the response and outcome of current or newly designed therapies. While ... ...

Abstract	Background: Glioblastoma (GBM) is a highly aggressive cancer with poor prognosis that needs better treatment modalities. Moreover, there is a lack of reliable biomarkers to predict the response and outcome of current or newly designed therapies. While several molecular markers have been proposed as potential biomarkers for GBM, their uptake into clinical settings is slow and impeded by marker heterogeneity. Detailed assessment of prognostic and predictive value for biomarkers in well-defined clinical trial settings, if available, is scattered throughout the literature. Here we conducted a systematic review and meta-analysis to evaluate the prognostic and predictive significance of clinically relevant molecular biomarkers in GBM patients. Material and methods: A comprehensive literature search was conducted to retrieve publications from 3 databases (Pubmed, Cochrane and Embase) from January 2010 to December 2021, using specific terms. The combined hazard ratios (HR) and confidence intervals (95% CI) were used to evaluate the association of biomarkers with overall survival (OS) in GBM patients. Results: Twenty-six out of 1831 screened articles were included in this review. Nineteen articles were included in the meta-analyses, and 7 articles were quantitatively summarised. Fourteen studies with 1231 GBM patients showed a significant association of MGMT methylation with better OS with the pooled HR of 1.66 (95% CI 1.32−2.09, p < 0.0001, random effect). Five studies including 541 GBM patients analysed for the prognostic significance of IDH1 mutation showed significantly better OS in patients with IDH1 mutation with a pooled HR of 2.37 (95% CI 1.81−3.12; p < 0.00001]. Meta-analysis performed on 5 studies including 575 GBM patients presenting with either amplification or high expression of EGFR gene did not reveal any prognostic significance with a pooled HR of 1.31 (95% CI 0.96−1.79; p = 0.08). Conclusions: MGMT promoter methylation and IDH1 mutation are significantly associated with better OS in GBM patients. No significant associations were found between EGFR amplification or overexpression with OS.
MeSH term(s)	Biomarkers/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Brain Neoplasms/metabolism ; DNA Methylation ; DNA Modification Methylases/genetics ; DNA Modification Methylases/metabolism ; DNA Repair Enzymes/genetics ; DNA Repair Enzymes/metabolism ; Glioblastoma/drug therapy ; Humans ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
Chemical Substances	Biomarkers ; Biomarkers, Tumor ; Tumor Suppressor Proteins ; DNA Modification Methylases (EC 2.1.1.-) ; DNA Repair Enzymes (EC 6.5.1.-)
Language	English
Publishing date	2022-08-09
Publishing country	Switzerland
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23168835
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Article ; Online: Melatonin enhances spermatogonia activity through promoting KIAA1429-mediated m

Xu, Chang-Long / Tan, Qing-Ying / Yang, Hua / Li, Chun-Yuan / Wu, Zhuo / Ma, Ya-Feng

Reproductive biology

2022 Volume 22, Issue 4, Page(s) 100681

Abstract: Melatonin is a key neuroendocrine hormone that promotes spermatogenesis and sperm motility, but the underlying mechanisms remains poorly understood. In this study, we aimed to investigate the possible roles of ... ...

Abstract	Melatonin is a key neuroendocrine hormone that promotes spermatogenesis and sperm motility, but the underlying mechanisms remains poorly understood. In this study, we aimed to investigate the possible roles of m
MeSH term(s)	Animals ; Male ; Mice ; Apoptosis ; Cell Line, Tumor ; Cell Proliferation ; Melatonin/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol 3-Kinases/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Messenger/metabolism ; Signal Transduction ; Sperm Motility ; Spermatogonia/metabolism ; RNA-Binding Proteins/metabolism ; Adenosine/analogs & derivatives ; Adenosine/metabolism
Chemical Substances	GC 1 compound ; Melatonin (JL5DK93RCL) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; RNA, Messenger ; Virma protein, mouse ; RNA-Binding Proteins ; N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2022-08-17
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2189316-0
ISSN	2300-732X ; 1642-431X
ISSN (online)	2300-732X
ISSN	1642-431X
DOI	10.1016/j.repbio.2022.100681
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Article ; Online: Single-Circulating Tumor Cell Whole Genome Amplification to Unravel Cancer Heterogeneity and Actionable Biomarkers.

Khan, Tanzila / Becker, Therese M / Po, Joseph W / Chua, Wei / Ma, Yafeng

International journal of molecular sciences

2022 Volume 23, Issue 15

Abstract: The field of single-cell analysis has advanced rapidly in the last decade and is providing new insights into the characterization of intercellular genetic heterogeneity and complexity, especially in human cancer. In this regard, analyzing single ... ...

Abstract	The field of single-cell analysis has advanced rapidly in the last decade and is providing new insights into the characterization of intercellular genetic heterogeneity and complexity, especially in human cancer. In this regard, analyzing single circulating tumor cells (CTCs) is becoming particularly attractive due to the easy access to CTCs from simple blood samples called "liquid biopsies". Analysis of multiple single CTCs has the potential to allow the identification and characterization of cancer heterogeneity to guide best therapy and predict therapeutic response. However, single-CTC analysis is restricted by the low amounts of DNA in a single cell genome. Whole genome amplification (WGA) techniques have emerged as a key step, enabling single-cell downstream molecular analysis. Here, we provide an overview of recent advances in WGA and their applications in the genetic analysis of single CTCs, along with prospective views towards clinical applications. First, we focus on the technical challenges of isolating and recovering single CTCs and then explore different WGA methodologies and recent developments which have been utilized to amplify single cell genomes for further downstream analysis. Lastly, we list a portfolio of CTC studies which employ WGA and single-cell analysis for genetic heterogeneity and biomarker detection.
MeSH term(s)	Biomarkers, Tumor/genetics ; Humans ; Liquid Biopsy ; Neoplastic Cells, Circulating/pathology ; Prospective Studies ; Single-Cell Analysis/methods
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2022-07-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23158386
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Article: The use of cell free DNA (cfDNA) for mutational screening of multiple myeloma.

Marivel, A-M Joëlle / Ma, Yafeng / Becker, Therese M / Verma, Anvita / Trieu, Steven / Roberts, Tara L / Ling, Silvia C W

Leukemia research reports

2023 Volume 20, Page(s) 100393

Abstract: Multiple myeloma (MM) is an incurable haematological malignancy which relies heavily on bone marrow biopsies for disease monitoring and prediction of treatment response. In recent years, liquid biopsy derived cell-free DNA (cfDNA) has emerged as ... ...

Abstract	Multiple myeloma (MM) is an incurable haematological malignancy which relies heavily on bone marrow biopsies for disease monitoring and prediction of treatment response. In recent years, liquid biopsy derived cell-free DNA (cfDNA) has emerged as alternative for invasive biopsies. This pilot study aimed to evaluate the feasibility of using cfDNA for the detection of oncogenic mutations in the mitogen-activated protein kinase (MAPK) pathway genes NRAS, KRAS, and BRAF in MM patients. Matched peripheral blood and bone marrow aspirates were collected from thirteen MM patients at various disease stages. cfDNA was isolated using the Qiagen Circulating Nucleic Acid Kit while bone marrow DNA was extracted using the Maxwell Promega platform. The presence of NRAS, KRAS, and BRAF mutations was analysed by ddPCR and compared between the cfDNA and gDNA samples. Although our data come from a small patient cohort, mutations were detected, which supports cfDNA utility for mutational screening and prognostication in MM.
Language	English
Publishing date	2023-10-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2706248-X
ISSN	2213-0489
ISSN	2213-0489
DOI	10.1016/j.lrr.2023.100393
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Article: Melatonin enhances spermatogonia activity through promoting KIAA1429-mediated m6A deposition to activate the PI3K/AKT signaling

Xu, Chang-Long / Tan, Qing-Ying / Yang, Hua / Li, Chun-Yuan / Wu, Zhuo / Ma, Ya-Feng

Reproductive Biology. 2022 Dec., v. 22, no. 4

2022

Abstract	Melatonin is a key neuroendocrine hormone that promotes spermatogenesis and sperm motility, but the underlying mechanisms remains poorly understood. In this study, we aimed to investigate the possible roles of m⁶A (N⁶--methyl-adenosine) in mediating melatonin-regulated spermatogonia activity alterations. In this study, mouse-derived GC-1 spermatogonia (spg) cell line was used as the in vitro cellular model. The viability, proliferation rates and apoptosis of spermatogonia were detected via CCK-8, Edu staining and flow cytometry respectively. Total m⁶A level was quantitated by dot blot, while mRNA and proteins contents in spermatogonia were measured by qRT-PCR and western blot respectively. Differentially expressed mRNAs were characterized by deep RNA sequencing method. Results showed that melatonin significantly promoted viability and proliferation rate while inhibited apoptosis in the GC-1 spg cells. The total m⁶A levels in GC-1 spg cells were also greatly increased by melatonin treatment, accompanied by remarkable expressional elevation of the m⁶A writer KIAA1429. Moreover, the regulation of GC-1 spg cell viability, proliferation and apoptosis by melatonin were greatly abrogated by KIAA1429 silencing but effectively strengthened by KIAA1429 overexpression. In addition, KIAA1429 overexpression regulates multiple biological process and signaling pathways in spermatogonia such as the PI3K/AKT signaling. The PI3K inhibitor LY294002 effectively mitigated the regulation of spermatogonia activity by KIAA1429 overexpression under melatonin treatment. Taken together, melatonin promotes spermatogonia activity via enhancing KIAA1429 expression and m⁶A RNA methylation to activate the downstream PI3K/AKT signaling pathway.
Keywords	Western blotting ; apoptosis ; cell lines ; cell viability ; flow cytometry ; melatonin ; methylation ; models ; phosphatidylinositol 3-kinase ; sperm motility ; spermatogenesis ; spermatogonia
Language	English
Dates of publication	2022-12
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2189316-0
ISSN	1642-431X
ISSN	1642-431X
DOI	10.1016/j.repbio.2022.100681
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Distinguishing rosacea from sensitive skin by reflectance confocal microscopy.

Ma, Yafeng / Li, Lulu / Chen, Jia / Chen, Tian / Yuan, Chao

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

2020 Volume 26, Issue 5, Page(s) 671–674

Abstract: Background: The updated standard classification and pathophysiology of rosacea have provided clear and meaningful evaluation parameters; however, differentiating rosacea from sensitive skin (SS) remained an obstacle for dermatologists around the world, ... ...

Abstract	Background: The updated standard classification and pathophysiology of rosacea have provided clear and meaningful evaluation parameters; however, differentiating rosacea from sensitive skin (SS) remained an obstacle for dermatologists around the world, especially in China. Herein, we aimed to find a better characteristic to distinguish rosacea from SS by using reflectance confocal microscopy (RCM). Method: Forty rosacea patients and 143 healthy subjects were recruited in this study. Firstly, a SS questionnaire and a lactic acid sting test were conducted among healthy subjects. Next, two major groups were divided out, including a SS group (40 subjects) and a normal skin control group (NS, 60 subjects). The cutaneous structures of face and fossa cubitalia were imaged by RCM. Results: We found that more parakeratosis, honeycomb pattern, spongiform edema, and dermal papillae (P < .05) in rosacea patients than that of the NS group, whereas there were no significant differences, were found in rosacea patients and the SS group. Strikingly, we found that rosacea patients have a larger depth of honeycomb pattern than that of SS subjects (P < .05). But, the epidermal thickness of rosacea did not differ from that of SS groups. There was also no significant difference of epidermal thickness and honeycomb structure depth between rosacea patients and NS group. Conclusion: From the RCM images of parakeratosis, honeycomb pattern, spongiform edema, and dermal papillae, we found that RCM might be a faithful tool to distinguish rosacea from NS group. The depth of honeycomb structure of SS was more superficial than rosacea patients, whereas no significant difference between rosacea patients and NS group. RCM may provide a new method for evaluating the development of rosacea although it failed to distinguish rosacea and SS effectively.
MeSH term(s)	China ; Diagnosis, Differential ; Humans ; Microscopy, Confocal ; Rosacea/diagnostic imaging ; Skin/diagnostic imaging ; Skin Diseases/diagnostic imaging
Language	English
Publishing date	2020-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1229160-2
ISSN	1600-0846 ; 0909-752X ; 1397-1344
ISSN (online)	1600-0846
ISSN	0909-752X ; 1397-1344
DOI	10.1111/srt.12851
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Article ; Online: Differential gene expression for carotenoid biosynthesis in a green alga Ulva prolifera based on transcriptome analysis.

He, Yuan / Ma, Yafeng / Du, Yu / Shen, Songdong

BMC genomics

2018 Volume 19, Issue 1, Page(s) 916

Abstract: Background: Carotenoids are widely distributed in plants and algae, and their biosynthesis has attracted widespread interest. Carotenoid-related research has mostly focused on model species, and there is a lack of data on the carotenoid biosynthetic ... ...

Abstract	Background: Carotenoids are widely distributed in plants and algae, and their biosynthesis has attracted widespread interest. Carotenoid-related research has mostly focused on model species, and there is a lack of data on the carotenoid biosynthetic pathway in U. prolifera that is the main species leading to green tide, a harmful plague of floating green algae. Results: The carotenoid content of U. prolifera samples, that is the main species leading to green tide, a harmful plague of floating green algae at different temperatures revealed that its terpenoid was highest in the samples subjected to high temperature at 28 °C (H), followed by the samples subjected to low temperature at 12 °C (L). Its terpenoid was lowest in the samples subjected to medium temperature at 20 °C (M). We conducted transcriptome sequencing (148.5 million raw reads and 49,676 unigenes in total) of samples that were subjected to different temperatures to study the carotenoid biosynthesis of U. prolifera. There were 1125-3164 significant differentially expressed genes between L, M and H incubation temperatures, of which 11-672 genes were upregulated and 453-3102 genes were downregulated. A total of 3164 genes were significantly differentially expressed between H and M, of which 62 genes were upregulated and 3102 genes were downregulated. A total of 2669 significant differentially expressed genes were observed between L and H, of which 11 genes were upregulated and 2658 genes were downregulated. A total of 13 genes were identified to be involved in carotenoid biosynthesis in U. prolifera, and the expression levels of the majority were highest at H and lowest at M of incubation temperature. Both the carotenoid concentrations and the expression of the analysed genes were lowest in the normal temperature group, while low temperature and high temperature seemed to activate the biosynthesis of carotenoids in U. prolifera. Conclusions: In this study, transcriptome sequencing provided critical information for understanding the accumulation of carotenoids and will serve as an important reference for the study of other metabolic pathways in U. prolifera.
MeSH term(s)	Carotenoids/analysis ; Carotenoids/biosynthesis ; Chlorophyll/analysis ; Chlorophyll A/analysis ; Gene Expression Profiling ; Gene Expression Regulation, Plant ; Genes, Plant ; Phylogeny ; RNA, Plant/chemistry ; RNA, Plant/isolation & purification ; RNA, Plant/metabolism ; Sequence Analysis, RNA ; Temperature ; Ulva/classification ; Ulva/genetics
Chemical Substances	RNA, Plant ; Chlorophyll (1406-65-1) ; Carotenoids (36-88-4) ; chlorophyll b (5712ZB110R) ; Chlorophyll A (YF5Q9EJC8Y)
Language	English
Publishing date	2018-12-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-018-5337-y
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