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  1. AU="Ma, Yan-Ming"
  2. AU=Wu Huijuan AU=Wu Huijuan
  3. AU=Li Siwen
  4. AU="Prendergast, Deirdre M"
  5. AU="Saeid Eslami"
  6. AU="Amini, Masoud"
  7. AU="Almeida-de-Oliveira, Natália Ketrin"
  8. AU="Binyamin, Sultana"
  9. AU="Bénédicte Goussault"
  10. AU="Desmettre, Thibault"
  11. AU="Bloom-Ackerman, Zohar"
  12. AU="Allemandou, Delphine"
  13. AU="Negrón Marty, Arnaldo"
  14. AU="Adrian V. Hill"
  15. AU="Du, Jialing"
  16. AU="Marion Migueres"
  17. AU="Sauka-Spengler, Tatjana"
  18. AU="Košir, Mitja"
  19. AU="Narro, Carla"
  20. AU="Antunes-Meireles, Pedro"

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  1. Artikel: Highly bioactive iridium metal-complex alleviates spinal cord injury via ROS scavenging and inflammation reduction

    Ji, Zhi-Sheng / Gao, Gui-Bin / Ma, Yan-Ming / Luo, Jian-Xian / Zhang, Guo-Wei / Yang, Hua / Li, Nan / He, Qing-Yu / Lin, Hong-Sheng

    Biomaterials. 2022 May, v. 284

    2022  

    Abstract: Generation of a promising antioxidative reagent with superior biocompatibility is urgently needed to remedy spinal cord injuries (SCI), repair the damaged neurons and restrain the secondary injuries caused by inflammation-induced oxidative stress. ... ...

    Abstract Generation of a promising antioxidative reagent with superior biocompatibility is urgently needed to remedy spinal cord injuries (SCI), repair the damaged neurons and restrain the secondary injuries caused by inflammation-induced oxidative stress. Inhibitory elements in the injury sites and necessitous inherent neural regeneration ability were major challenges for functional recovery after spinal cord injuries. We here developed a highly bioactive iridium complex (IrFPHtz) with enhanced antioxidative activities and improved SCI therapeutic efficacy. Both in vivo and in vitro, IrFPHtz has exhibited neuroprotective and anti-inflammatory properties. Mechanically, IrFPHtz directly targets SOD1 and upregulates the expression of SOD1 to eliminate the excess Reactive Oxygen Species (ROS) production induced by SCI, and thus protecting neuron cells from further damage. As a result, IrFPHtz safeguarded the neurons and myelin sheaths against trauma, lessened glial scar conformations and facilitated the repair of neurons and long axon expansion in the glial scar. Furthermore, IrFPHtz significantly ameliorated the behavioral functions of SCI mice and promoted a satisfactory curative effect. Therefore, this study sheds light on a novel method for SCI treatment using IrFPHtz as a potential drug and implicates the clinical significance of metal complexes in diseases featuring with upregulated ROS species.
    Schlagwörter animal injuries ; axons ; biocompatibility ; biocompatible materials ; drugs ; inflammation ; iridium ; myelin sheath ; oxidative stress ; spinal cord ; therapeutics
    Sprache Englisch
    Erscheinungsverlauf 2022-05
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 603079-8
    ISSN 0142-9612
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2022.121481
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel ; Online: The effect of posterior lumbar dynamic fixation and intervertebral fusion on paraspinal muscles.

    Lin, Geng-Xiong / Ma, Yan-Ming / Xiao, Yong-Chun / Xiang, Dian / Luo, Jian-Xian / Zhang, Guo-Wei / Ji, Zhi-Sheng / Lin, Hong-Sheng

    BMC musculoskeletal disorders

    2021  Band 22, Heft 1, Seite(n) 1049

    Abstract: Background: The aim of this study was to analyze the effect of unilateral K-rod dynamic internal fixation on paraspinal muscles for lumbar degenerative diseases.: Methods: This study retrospectively collected 52 patients who underwent lumbar surgery ... ...

    Abstract Background: The aim of this study was to analyze the effect of unilateral K-rod dynamic internal fixation on paraspinal muscles for lumbar degenerative diseases.
    Methods: This study retrospectively collected 52 patients who underwent lumbar surgery with the K-rod group or PLIF. The operation time, intraoperative blood loss, postoperative drainage volume, postoperative exercise time were compared in the two groups. The visual analog scale (VAS) score and the oswestry dysfunction index (ODI) were employed to evaluate the clinical outcomes. The functional cross-sectional area (FCSA) of the paraspinal muscles and paraspinal muscles fat infiltration were measured to assess on the paraspinal muscles.
    Results: As compared with the PLIF group, the operation time, the postoperative time in the field, and the average postoperative hospital stay in the K-rod internal fixation group were significantly shortened. At the last follow-up, both the groups showed significant improvement in the VAS score and ODI. The FCSA atrophy of the upper and lower adjacent segments (UAS and LAS) of the K-rod internal group was significantly less than that of the PLIF group. The extent of increase in the fatty infiltration of the paraspinal muscles in the K-rod group was significantly lesser than that in the PLIF group. The postoperative low back pain of the two groups of patients was significantly positively correlated with the FCSA atrophy.
    Conclusions: As compared to PLIF, the posterior lumbar unilateral K-rod dynamic internal fixation showed significantly lesser paraspinal muscle atrophy and fatty infiltration, which were significantly positively correlated with postoperative low back pain.
    Mesh-Begriff(e) Fracture Fixation, Internal ; Humans ; Lumbosacral Region/diagnostic imaging ; Lumbosacral Region/surgery ; Paraspinal Muscles/diagnostic imaging ; Postoperative Period ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2021-12-20
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 1471-2474
    ISSN (online) 1471-2474
    DOI 10.1186/s12891-021-04943-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Highly bioactive iridium metal-complex alleviates spinal cord injury via ROS scavenging and inflammation reduction.

    Ji, Zhi-Sheng / Gao, Gui-Bin / Ma, Yan-Ming / Luo, Jian-Xian / Zhang, Guo-Wei / Yang, Hua / Li, Nan / He, Qing-Yu / Lin, Hong-Sheng

    Biomaterials

    2022  Band 284, Seite(n) 121481

    Abstract: Generation of a promising antioxidative reagent with superior biocompatibility is urgently needed to remedy spinal cord injuries (SCI), repair the damaged neurons and restrain the secondary injuries caused by inflammation-induced oxidative stress. ... ...

    Abstract Generation of a promising antioxidative reagent with superior biocompatibility is urgently needed to remedy spinal cord injuries (SCI), repair the damaged neurons and restrain the secondary injuries caused by inflammation-induced oxidative stress. Inhibitory elements in the injury sites and necessitous inherent neural regeneration ability were major challenges for functional recovery after spinal cord injuries. We here developed a highly bioactive iridium complex (IrFPHtz) with enhanced antioxidative activities and improved SCI therapeutic efficacy. Both in vivo and in vitro, IrFPHtz has exhibited neuroprotective and anti-inflammatory properties. Mechanically, IrFPHtz directly targets SOD1 and upregulates the expression of SOD1 to eliminate the excess Reactive Oxygen Species (ROS) production induced by SCI, and thus protecting neuron cells from further damage. As a result, IrFPHtz safeguarded the neurons and myelin sheaths against trauma, lessened glial scar conformations and facilitated the repair of neurons and long axon expansion in the glial scar. Furthermore, IrFPHtz significantly ameliorated the behavioral functions of SCI mice and promoted a satisfactory curative effect. Therefore, this study sheds light on a novel method for SCI treatment using IrFPHtz as a potential drug and implicates the clinical significance of metal complexes in diseases featuring with upregulated ROS species.
    Mesh-Begriff(e) Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Coordination Complexes/pharmacology ; Gliosis ; Inflammation/drug therapy ; Iridium ; Mice ; Reactive Oxygen Species/metabolism ; Spinal Cord ; Spinal Cord Injuries/therapy ; Superoxide Dismutase-1/pharmacology ; Superoxide Dismutase-1/therapeutic use
    Chemische Substanzen Antioxidants ; Coordination Complexes ; Reactive Oxygen Species ; Iridium (44448S9773) ; Superoxide Dismutase-1 (EC 1.15.1.1)
    Sprache Englisch
    Erscheinungsdatum 2022-04-01
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2022.121481
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Bipedicle Advancement Flap for Skin Coverage after Digital Mucous Cyst Excision: A Retrospective Study of 18 Cases.

    Ma, Yan-Ming / Meng, Xiang-Jun / Su, Yun / Yan, Zuo-Fa / Shao, Quan-Sheng / Chen, Yi-Qing

    Orthopaedic surgery

    2020  Band 13, Heft 1, Seite(n) 196–201

    Abstract: Objectives: To assess the clinical outcomes of using a bipedicle advancement flap to cover the skin defects after digital mucous cyst (DMC) excision.: Methods: Data for 15 patients (18 fingers) with DMC, admitted to the Department of Orthopaedics and ...

    Abstract Objectives: To assess the clinical outcomes of using a bipedicle advancement flap to cover the skin defects after digital mucous cyst (DMC) excision.
    Methods: Data for 15 patients (18 fingers) with DMC, admitted to the Department of Orthopaedics and Surgery of the Affiliated Zhongshan Hospital of Dalian University from January 2016 to January 2018, were analyzed retrospectively. This study included 4 men and 11 women, with a mean age of 64 ± 7.8 years (range, 47-77 years). A total of 5 cases involved the thumb, 4 involved the index finger, 5 involved ithe middle finger, and 4 involved the ring finger. Among a total of 18 digital mucous cysts, 7 cases were in the left hand and 11 were in the right hand. Approximately 77.8% of cases had osteophytes. The cysts ranged in size from 0.5-1.0 cm to 0.7-1.2 cm. All patients underwent cyst and osteophyte excision and a bipedicle advancement flap to cover the resultant defect. The same surgical procedure was applied to all patients. Postoperative flap survival, healing, and infection were evaluated. The preoperative and postoperative ranges of motion (ROM) of the distal interphalangeal (DIP) and thumb interphalangeal joints (TIPJ) were recorded. Postoperative patient satisfaction was assessed by the visual analog scale (VAS, 0-10) during follow-up visits. The Shapiro-Wilk test was used to determine whether the data for the difference between the preoperative and postoperative ROM of the DIP/TIPJ were normally distributed or not. The homogeneity of variance was expressed as mean ± standard deviation. A paired t-test was used to compare the preoperative and postoperative ROM of the DIP/TIPJ.
    Results: The patients were followed up for 20 ± 6.0 months (range, 12-36 months). All the flaps survived after surgery, and the incisions healed well. The sutures were removed 2 weeks postoperatively. No infections occurred and there was no cyst recurrence at follow up. After systemic physical therapy and functional exercises, the ROM of all the fingers was restored to the preoperative ROM by 1 month after surgery. The scores for patient satisfaction with surgery by means of the VAS were 8.5 ± 1.0 points, 2.8 ± 1.4 points, 2.0 ± 1.6 points, 1.5 ± 1.2 points, and 1.1 ± 1.3 points preoperatively, and 1, 3, 6, and 12 months postoperatively, respectively. The data for the difference between preoperative and postoperative VAS scores were normally distributed. There were significant differences between the preoperative and postoperative VAS scores. The preoperative DIP/TIPJ ROM was 71.7° ± 14.0°, and the postoperative ROM at 1, 3, 6, and 12 months were 69.3° ± 15.3°, 70.4° ± 12.7°, 71.5° ± 15.6°, and 71.8° ± 15.6°, respectively. The data for the difference between preoperative and postoperative ROM of the DIP/TIPJ were normally distributed. No difference was found between the preoperative and postoperative ROM.
    Conclusion: The bipedicle advancement flap provides a simple and effective technique for covering skin defects following DMC excision.
    Mesh-Begriff(e) Aged ; Cysts/surgery ; Female ; Fingers/surgery ; Humans ; Male ; Middle Aged ; Osteophyte/surgery ; Pain Measurement ; Patient Satisfaction ; Reconstructive Surgical Procedures/methods ; Retrospective Studies ; Surgical Flaps
    Sprache Englisch
    Erscheinungsdatum 2020-12-06
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2503162-4
    ISSN 1757-7861 ; 1757-7853 ; 1757-7861
    ISSN (online) 1757-7861 ; 1757-7853
    ISSN 1757-7861
    DOI 10.1111/os.12869
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: [Analysis for development and impacting factors about HIV/AIDS policy in China].

    Yan, Jiang-ying / Chen, Qiu-lan / Ma, Yan-ming

    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

    2005  Band 26, Heft 11, Seite(n) 855–860

    Mesh-Begriff(e) Acquired Immunodeficiency Syndrome/prevention & control ; China ; Health Plan Implementation ; History, 20th Century ; History, 21st Century ; Humans ; Internationality ; Public Policy/history ; Quality Control
    Sprache Chinesisch
    Erscheinungsdatum 2005-11
    Erscheinungsland China
    Dokumenttyp Historical Article ; Journal Article
    ZDB-ID 645026-x
    ISSN 0254-6450
    ISSN 0254-6450
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: QTL mapping for quality traits of northern-style hand-made Chinese steamed bread

    Fan, Yu-ding / Sun, Hai-yan / Zhao, Jing-Ian / Ma, Yan-ming / Li, Rui-jun / Li, Si-shen

    Journal of cereal science. 2009 Mar., v. 49, issue 2

    2009  

    Abstract: QTLs for quality traits of northern-style hand-made Chinese steamed bread (CSB) were mapped based on recombinant inbred lines (RILs) derived from the cross between two Chinese winter wheat varieties, Chuang 35050 and Shannong 483. We detected eight ... ...

    Abstract QTLs for quality traits of northern-style hand-made Chinese steamed bread (CSB) were mapped based on recombinant inbred lines (RILs) derived from the cross between two Chinese winter wheat varieties, Chuang 35050 and Shannong 483. We detected eight putative QTLs for eight quality traits on seven chromosomes, 2B, 2D, 4A, 5B, 5D, 6B and 7B. The contributions of QTLs ranged from 9.88 to 64.87%. The additive effects of QTLs for color, elasticity, and stickiness were positive, with Chuan 35050 increasing the effects. Additive effects for volume, specific volume, appearance, smell, and total score were negative, with Shannong 483 increasing the effects. Two co-location QTLs were detected in the marker region Xgwm644-Xgwm193-Xgwm608b on chromosome 6B. The contributions of four QTLs for appearance, stickiness, smell and total score were very high (29.80-64.87%), indicating that these traits are controlled by major gene loci. The contribution of the smell QTL in Xissr25b-Xissr23b-Xwmc308-Xsrap7c on chromosome 4A was the highest (64.87%). We speculate that a major gene related to the smell or taste is located on chromosome 4A.
    Schlagwörter breads ; steaming ; cooking ; cooking quality ; Triticum aestivum ; winter wheat ; varieties ; chromosomes ; quantitative trait loci ; inbred lines ; additive gene effects ; breadmaking quality ; food quality ; baking quality ; flavor ; texture ; odors
    Sprache Englisch
    Erscheinungsverlauf 2009-03
    Umfang p. 225-229.
    Dokumenttyp Artikel
    ZDB-ID 408468-8
    ISSN 0733-5210
    ISSN 0733-5210
    DOI 10.1016/j.jcs.2008.10.004
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel ; Online: Two dimensional Dirac carbon allotropes from graphene.

    Xu, Li-Chun / Wang, Ru-Zhi / Miao, Mao-Sheng / Wei, Xiao-Lin / Chen, Yuan-Ping / Yan, Hui / Lau, Woon-Ming / Liu, Li-Min / Ma, Yan-Ming

    Nanoscale

    2014  Band 6, Heft 2, Seite(n) 1113–1118

    Abstract: Using a structural search method in combination with first-principles calculations, we found lots of low energy 2D carbon allotropes and examined all possible Dirac points around their Fermi levels. Three amazing 2D Dirac carbon allotropes have been ... ...

    Abstract Using a structural search method in combination with first-principles calculations, we found lots of low energy 2D carbon allotropes and examined all possible Dirac points around their Fermi levels. Three amazing 2D Dirac carbon allotropes have been discovered, named as S-graphene, D-graphene and E-graphene. By analyzing the topology correlations among S-, T, net W graphene and graphene, we found that a general rule is valuable for constructing 2D carbon allotropes that are keen to possess Dirac cones in their electronic structures. Based on this rule, we have successfully designed many new 2D carbon allotropes possessing Dirac cones. Their energy order can be well described by an Ising-like model, and some allotropes are energetically more stable than those recently reported. The related electronic structures of these Dirac allotropes are anisotropy distinguished from those of graphene. Moreover, the fact that D- and E-graphene present Dirac cones suggests that sp hybridization or sp(3) hybridization could not suppress the emerging of Dirac features. Our results demonstrate that the Dirac cone and carrier linear dispersion is a very common feature in 2D carbon allotropes and can exist beyond the limitations of fundamental structure features of graphene.
    Sprache Englisch
    Erscheinungsdatum 2014-01-21
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/c3nr04463g
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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