LIVIVO - Search results -

Search results

Result 1 - 8 of total 8

Search options

Article ; Online: Disease-associated immune cell endotypes in anti-MDA5-positive dermatomyositis using unbiased hierarchical clustering.

Guo, Ruru / Yang, Yang / Gu, Liyang / Li, Xinyu / Ma, Yiyangzi / Liu, Xuesong / Lu, Liangjing

2024 Volume 15, Page(s) 1349611

Abstract: Objective: Clinical and prognostic features of Anti-MDA5-Positive Dermatomyositis (MDA5+ DM) are diverse. This study aimed to examine the peripheral immune cell profiles of patients with MDA5+ DM, identify disease endotypes related to the heterogeneous ... ...

Abstract	Objective: Clinical and prognostic features of Anti-MDA5-Positive Dermatomyositis (MDA5+ DM) are diverse. This study aimed to examine the peripheral immune cell profiles of patients with MDA5+ DM, identify disease endotypes related to the heterogeneous manifestations and prognosis, and guide individualized therapy regimen. Methods: This inpatient cohort included 123 patients with MDA5+ DM. Unsupervised hierarchical clustering analysis was used to derive disease endotypes from the circulating immune cell profiles on admission. Clinical symptoms, laboratory test results, inpatient treatments, and disease outcomes were then analyzed among the identified endotypes. Results: Three disease endotypes in MDA5+ DM were identified from peripheral immune cell profiles. Endotype1 had the highest percentages of CD4 Conclusion: Clustering analysis of peripheral immune cell profiles identified three different endotypes in MDA5+ dermatomyositis. Endotpye2 and 3 showed higher RPILD, 3-month mortality, pneumocystis jiroveci and CMV viremia.
MeSH term(s)	Humans ; Interferon-Induced Helicase, IFIH1 ; Dermatomyositis ; CD8-Positive T-Lymphocytes ; Viremia/complications ; Lung Diseases, Interstitial ; Cytomegalovirus Infections/complications
Chemical Substances	Interferon-Induced Helicase, IFIH1 (EC 3.6.4.13)
Language	English
Publishing date	2024-03-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1349611
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Causality of Opportunistic Pathogen

Li, Jing / Gao, Qiannan / Ma, Yiyangzi / Deng, Yue / Li, Shuangyue / Shi, Na / Niu, Haitao / Liu, Xin-Yu / Cai, Jun

Hypertension (Dallas, Tex. : 1979)

2022 Volume 79, Issue 12, Page(s) 2743–2754

Abstract: Background: Previous studies have reported a strong association between gut microbiome and hypertension; yet, the exact bacterial species associated with the disease development and progression have not yet been detected. This study aimed to investigate ...

Abstract	Background: Previous studies have reported a strong association between gut microbiome and hypertension; yet, the exact bacterial species associated with the disease development and progression have not yet been detected. This study aimed to investigate whether opportunistic pathogen Methods: The enrichment of Results: Klebsiella pneumoniae Conclusions: These results provide evidence that the enrichment of
MeSH term(s)	Mice ; Animals ; Klebsiella pneumoniae/genetics ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Gastrointestinal Microbiome ; Hypertension/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-10-19
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.122.18878
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1488: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Anti-synthetase syndrome is associated with a higher risk of hospitalization among patients with idiopathic inflammatory myopathy and COVID-19.

Wu, Wanlong / Wang, Runci / Xie, Cuiying / Chen, Yi / Teng, Xiangyu / Sun, Shuhui / Xu, Wenwen / Fu, Yakai / Ma, Yiyangzi / Xu, Antao / Lyu, Xia / Ye, Yan / Li, Jia / Zhang, Chunyan / Shen, Nan / Wang, Xiaodong / Ye, Shuang / Fu, Qiong

Frontiers in immunology

2024 Volume 15, Page(s) 1295472

Abstract: Background: Data with fine granularity about COVID-19-related outcomes and risk factors were still limited in the idiopathic inflammatory myopathies (IIMs) population. This study aimed to investigate clinical factors associated with hospitalized and ... ...

Abstract	Background: Data with fine granularity about COVID-19-related outcomes and risk factors were still limited in the idiopathic inflammatory myopathies (IIMs) population. This study aimed to investigate clinical factors associated with hospitalized and severe COVID-19 in patients with IIMs, particularly those gauged by myositis-specific antibodies. Methods: This retrospective cohort study was conducted in the Renji IIM cohort in Shanghai, China, under an upsurge of SARS-CoV-2 omicron variant infections from December 2022 to January 2023. Clinical data were collected and analyzed by multivariable logistic regression to determine risk factors. High-dimensional flow cytometry analysis was performed to outline the immunological features. Results: Among 463 infected patients in the eligible cohort (n=613), 65 (14.0%) were hospitalized, 19 (4.1%) suffered severe COVID-19, and 10 (2.2%) died. Older age (OR=1.59/decade, 95% CI 1.18 to 2.16, p=0.003), requiring family oxygen supplement (2.62, 1.11 to 6.19, 0.028), patients with anti-synthetase syndrome (ASyS) (2.88, 1.12 to 7.34, 0.027, vs. other dermatomyositis), higher IIM disease activity, and prednisone intake >10mg/day (5.59, 2.70 to 11.57, <0.001) were associated with a higher risk of hospitalization. Conversely, 3-dose inactivated vaccination reduced the risk of hospitalization (0.10, 0.02 to 0.40, 0.001, vs. incomplete vaccination). Janus kinase inhibitor (JAKi) pre-exposure significantly reduced the risk of severe COVID-19 in hospitalized patients (0.16, 0.04 to 0.74, 0.019, vs. csDMARDs). ASyS patients with severe COVID-19 had significantly reduced peripheral CD4+ T cells, lower CD4/CD8 ratio, and fewer naive B cells but more class-switched memory B cells compared with controls. Conclusion: ASyS and family oxygen supplement were first identified as risk factors for COVID-19-related hospitalization in patients with IIMs. JAKi pre-exposure might protect IIM patients against severe COVID-19 complications.
MeSH term(s)	Humans ; Retrospective Studies ; Ligases ; COVID-19/therapy ; COVID-19/complications ; SARS-CoV-2 ; China/epidemiology ; Myositis/complications ; Myositis/epidemiology ; Oxygen
Chemical Substances	Ligases (EC 6.-) ; Oxygen (S88TT14065)
Language	English
Publishing date	2024-03-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1295472
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus.

Ma, Yiyangzi / Xu, Xiaoxue / Li, Mengtao / Cai, Jun / Wei, Qiang / Niu, Haitao

Molecular medicine (Cambridge, Mass.)

2019 Volume 25, Issue 1, Page(s) 35

Abstract: Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease whose onset and progression are affected by genetic and environmental factors. The purpose of this study is to identify the influence of gut microbiota in the pathogenesis of ...

Abstract	Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease whose onset and progression are affected by genetic and environmental factors. The purpose of this study is to identify the influence of gut microbiota in the pathogenesis of SLE, and to investigate the mechanism involved. Methods: Fecal microbiota from C57/BL6 mice and SLE prone mice were examined using next-generation sequencing (NGS). Germ free mice were given fecal microbiota transplantation (FMT), and their gut microbiome and gene expression in recipients' colons were examined by NGS. The anti-double stranded DNA (anti-dsDNA) antibodies in recipients were determined using an enzyme-linked immunosorbent assay (ELISA). The immune cell profiles of mice were analyzed by flow cytometry at the 3rd week after FMT, and the expression of genes associated with SLE after FMT was determined using quantitative real-time PCR (qRT-PCR). Results: The fecal microbiota of SLE mice had lower community richness and diversity than healthy mice. Fecal microbiota of recipient mice were similar to their donors. Fecal microbiome from SLE mice could lead to a significant increase of anti-dsDNA antibodies and promote the immune response in recipient mice. Our results also indicated that fecal microbiome from SLE mice resulted in significant changes in the distribution of immune cells and upregulated expression of certain lupus susceptibility genes. Conclusions: SLE is associated with alterations of gut microbiota. Fecal microbiome from SLE mice can induce the production of anti-dsDNA antibodies in germ free mice and stimulate the inflammatory response, and alter the expression of SLE susceptibility genes in these mice.
MeSH term(s)	Animals ; Enzyme-Linked Immunosorbent Assay ; Fecal Microbiota Transplantation ; Feces/microbiology ; Female ; Gastrointestinal Microbiome/physiology ; High-Throughput Nucleotide Sequencing ; Inflammation/microbiology ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/microbiology ; Mice ; Mice, Inbred C57BL ; Microbiota/physiology ; Reverse Transcriptase Polymerase Chain Reaction
Language	English
Publishing date	2019-08-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.1186/s10020-019-0102-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4456: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Applications of Next-generation Sequencing in Systemic Autoimmune Diseases.

Ma, Yiyangzi / Shi, Na / Li, Mengtao / Chen, Fei / Niu, Haitao

Genomics, proteomics & bioinformatics

2015 Volume 13, Issue 4, Page(s) 242–249

Abstract: Systemic autoimmune diseases are a group of heterogeneous disorders caused by both genetic and environmental factors. Although numerous causal genes have been identified by genome-wide association studies (GWAS), these susceptibility genes are correlated ...

Abstract	Systemic autoimmune diseases are a group of heterogeneous disorders caused by both genetic and environmental factors. Although numerous causal genes have been identified by genome-wide association studies (GWAS), these susceptibility genes are correlated to a relatively low disease risk, indicating that environmental factors also play an important role in the pathogenesis of disease. The intestinal microbiome, as the main symbiotic ecosystem between the host and host-associated microorganisms, has been demonstrated to regulate the development of the body's immune system and is likely related to genetic mutations in systemic autoimmune diseases. Next-generation sequencing (NGS) technology, with high-throughput capacity and accuracy, provides a powerful tool to discover genomic mutations, abnormal transcription and intestinal microbiome identification for autoimmune diseases. In this review, we briefly outlined the applications of NGS in systemic autoimmune diseases. This review may provide a reference for future studies in the pathogenesis of systemic autoimmune diseases.
MeSH term(s)	Animals ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/immunology ; Base Sequence ; Gastrointestinal Microbiome/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/immunology ; Mice ; Multiple Sclerosis/genetics ; Multiple Sclerosis/immunology ; Mutation/genetics ; RNA, Ribosomal, 16S/genetics ; Rats ; Sequence Analysis, DNA ; Spondylitis, Ankylosing/genetics ; Spondylitis, Ankylosing/immunology
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2015-10-15
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2240213-5
ISSN	2210-3244 ; 1672-0229
ISSN (online)	2210-3244
ISSN	1672-0229
DOI	10.1016/j.gpb.2015.09.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6438: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Lupus gut microbiota transplants cause autoimmunity and inflammation.

Ma, Yiyangzi / Guo, Ruru / Sun, Yiduo / Li, Xin / He, Lun / Li, Zhao / Silverman, Gregg J / Chen, Guobing / Gao, Feng / Yuan, Jiali / Wei, Qiang / Li, Mengtao / Lu, Liangjing / Niu, Haitao

Clinical immunology (Orlando, Fla.)

2021 Volume 233, Page(s) 108892

Abstract: Background: The etiology of systemic lupus erythematosus (SLE) is multifactorial. Recently, growing evidence suggests that the microbiota plays a role in SLE, yet whether gut microbiota participates in the development of SLE remains largely unknown. To ... ...

Abstract	Background: The etiology of systemic lupus erythematosus (SLE) is multifactorial. Recently, growing evidence suggests that the microbiota plays a role in SLE, yet whether gut microbiota participates in the development of SLE remains largely unknown. To investigate this issue, we carried out 16 s rDNA sequencing analyses in a cohort of 18 female un-treated active SLE patients and 7 female healthy controls, and performed fecal microbiota transplantation from patients and healthy controls to germ-free (GF) mice. Results: Compared to the healthy controls, we found no significant different microbial diversity but some significantly different species in SLE patients including Turicibacter genus and other 5 species. Fecal transfer from SLE patients to GF mice caused GF mice to develop a series of lupus-like phenotypic features, including increased serum autoimmune antibodies, imbalanced cytokines, altered distribution of immune cells in mucosal and peripheral immune response, and upregulated expression of genes related to SLE in recipient mice that received SLE fecal microbiota transplantation (FMT). Moreover, the metabolism of histidine was significantly altered in GF mice treated with SLE patient feces, as compared to those which received healthy fecal transplants. Conclusions: Overall, our results describe a causal role of aberrant gut microbiota in contributing to the pathogenesis of SLE. The interplay of gut microbial and histidine metabolism may be one of the mechanisms intertwined with autoimmune activation in SLE.
MeSH term(s)	Animals ; Autoimmunity/immunology ; Fecal Microbiota Transplantation ; Female ; Gastrointestinal Microbiome ; Germ-Free Life ; Histidine/metabolism ; Humans ; Inflammation/immunology ; Lupus Erythematosus, Systemic/microbiology ; Mice ; Mice, Inbred C57BL
Chemical Substances	Histidine (4QD397987E)
Language	English
Publishing date	2021-11-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2021.108892
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 880: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Applications of Next-generation Sequencing in Systemic Autoimmune Diseases

Ma, Yiyangzi / Fei Chen / Haitao Niu / Mengtao Li / Na Shi

Genomics, proteomics & bioinformatics. 2015 Aug., v. 13, no. 4

2015

Abstract	Systemic autoimmune diseases are a group of heterogeneous disorders caused by both genetic and environmental factors. Although numerous causal genes have been identified by genome-wide association studies (GWAS), these susceptibility genes are correlated to a relatively low disease risk, indicating that environmental factors also play an important role in the pathogenesis of disease. The intestinal microbiome, as the main symbiotic ecosystem between the host and host-associated microorganisms, has been demonstrated to regulate the development of the body’s immune system and is likely related to genetic mutations in systemic autoimmune diseases. Next-generation sequencing (NGS) technology, with high-throughput capacity and accuracy, provides a powerful tool to discover genomic mutations, abnormal transcription and intestinal microbiome identification for autoimmune diseases. In this review, we briefly outlined the applications of NGS in systemic autoimmune diseases. This review may provide a reference for future studies in the pathogenesis of systemic autoimmune diseases.
Keywords	autoimmune diseases ; ecosystems ; environmental factors ; genes ; genome-wide association study ; high-throughput nucleotide sequencing ; immune system ; intestinal microorganisms ; mutation ; pathogenesis ; risk ; transcription (genetics)
Language	English
Dates of publication	2015-08
Size	p. 242-249.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2240213-5
ISSN	2210-3244 ; 1672-0229
ISSN (online)	2210-3244
ISSN	1672-0229
DOI	10.1016/j.gpb.2015.09.004
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 6438: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Alterations in the gut microbiome and metabolism with coronary artery disease severity.

Liu, Honghong / Chen, Xi / Hu, Xiaomin / Niu, Haitao / Tian, Ran / Wang, Hui / Pang, Haiyu / Jiang, Lingjuan / Qiu, Bintao / Chen, Xiuting / Zhang, Yang / Ma, Yiyangzi / Tang, Si / Li, Hanyu / Feng, Siqin / Zhang, Shuyang / Zhang, Chenhong

Microbiome

2019 Volume 7, Issue 1, Page(s) 68

Abstract: Background: Coronary artery disease (CAD) is associated with gut microbiota alterations in different populations. Gut microbe-derived metabolites have been proposed as markers of major adverse cardiac events. However, the relationship between the gut ... ...

Abstract	Background: Coronary artery disease (CAD) is associated with gut microbiota alterations in different populations. Gut microbe-derived metabolites have been proposed as markers of major adverse cardiac events. However, the relationship between the gut microbiome and the different stages of CAD pathophysiology remains to be established by a systematic study. Results: Based on multi-omic analyses (sequencing of the V3-V4 regions of the 16S rRNA gene and metabolomics) of 161 CAD patients and 40 healthy controls, we found that the composition of both the gut microbiota and metabolites changed significantly with CAD severity. We identified 29 metabolite modules that were separately classified as being positively or negatively correlated with CAD phenotypes, and the bacterial co-abundance group (CAG) with characteristic changes at different stages of CAD was represented by Roseburia, Klebsiella, Clostridium IV and Ruminococcaceae. The result revealed that certain bacteria might affect atherosclerosis by modulating the metabolic pathways of the host, such as taurine, sphingolipid and ceramide, and benzene metabolism. Moreover, a disease classifier based on differential levels of microbes and metabolites was constructed to discriminate cases from controls and was even able to distinguish stable coronary artery disease from acute coronary syndrome accurately. Conclusion: Overall, the composition and functions of the gut microbial community differed from healthy controls to diverse coronary artery disease subtypes. Our study identified the relationships between the features of the gut microbiota and circulating metabolites, providing a new direction for future studies aiming to understand the host-gut microbiota interplay in atherosclerotic pathogenesis.
MeSH term(s)	Adult ; Aged ; Bacteria/classification ; Biomarkers/metabolism ; Coronary Artery Disease/metabolism ; Coronary Artery Disease/microbiology ; Coronary Artery Disease/physiopathology ; Feces/microbiology ; Female ; Gastrointestinal Microbiome ; Genomics ; Humans ; Male ; Metabolomics ; Middle Aged ; RNA, Ribosomal, 16S/genetics ; Severity of Illness Index
Chemical Substances	Biomarkers ; RNA, Ribosomal, 16S
Language	English
Publishing date	2019-04-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2697425-3
ISSN	2049-2618 ; 2049-2618
ISSN (online)	2049-2618
ISSN	2049-2618
DOI	10.1186/s40168-019-0683-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

Search results

Search options

Article ; Online: Disease-associated immune cell endotypes in anti-MDA5-positive dermatomyositis using unbiased hierarchical clustering.

More links

Kategorien

Order via subito

Article ; Online: Causality of Opportunistic Pathogen

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Article ; Online: Anti-synthetase syndrome is associated with a higher risk of hospitalization among patients with idiopathic inflammatory myopathy and COVID-19.

More links

Kategorien

Order via subito

Article ; Online: Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus.

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Article ; Online: Applications of Next-generation Sequencing in Systemic Autoimmune Diseases.

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Article ; Online: Lupus gut microbiota transplants cause autoimmunity and inflammation.

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Article: Applications of Next-generation Sequencing in Systemic Autoimmune Diseases

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Article ; Online: Alterations in the gut microbiome and metabolism with coronary artery disease severity.

More links

Kategorien

Order via subito