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Artikel ; Online: Morphology and DNA barcodes of two sympatric species of Filchneria Klapálek, 1908 (Plecoptera: Perlodidae): intraspecific variation and underestimated biodiversity of the genus

Chen, Zhi-Teng / Ma, Yun-Shu

Aquatic Insects. 2023 Apr. 3, v. 44, no. 2 p.87-105

2023

Abstract: A new perlodid species of Filchneria Klapálek, 1908, Filchneria tianshana sp. n., from the middle section of Tianshan Mountains, Xinjiang Uygur Autonomous Region, China is described and illustrated based on males, females, and eggs. Another species, ... ...

Abstract	A new perlodid species of Filchneria Klapálek, 1908, Filchneria tianshana sp. n., from the middle section of Tianshan Mountains, Xinjiang Uygur Autonomous Region, China is described and illustrated based on males, females, and eggs. Another species, Filchneria sp. CH-1, is described based on females and eggs from the same location. DNA barcodes of the two species are sequenced and analysed, revealing intraspecific variation of F. tianshana sp. n. and delimitation of the second species. http://www.zoobank.org/urn:lsid:zoobank.org:pub:F6314C6A-BCB0-40B8-81B8-F703D56F40AA
Schlagwörter	DNA barcoding ; Perlodidae ; intraspecific variation ; sympatry ; China ; Plecoptera ; Filchneria ; new species
Sprache	Englisch
Erscheinungsverlauf	2023-0403
Umfang	p. 87-105.
Erscheinungsort	Taylor & Francis
Dokumenttyp	Artikel ; Online
ISSN	1744-4152
DOI	10.1080/01650424.2022.2093378
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Description of a new brachypterous species of Filchneria Klapálek, 1908 (Plecoptera: Perlodidae) from northwestern China

Chen, Zhi-Teng / Ma, Yun-Shu

Aquatic insects. 2022 Jan. 2, v. 43, no. 1

2022

Abstract: A new brachypterous species of Perlodidae, Filchneria urumqiensis sp. n., from Xinjiang Uygur Autonomous Region of northwestern China is described and illustrated based on male, female and eggs. Morphological comparisons with the related taxa and habitat ...

Abstract	A new brachypterous species of Perlodidae, Filchneria urumqiensis sp. n., from Xinjiang Uygur Autonomous Region of northwestern China is described and illustrated based on male, female and eggs. Morphological comparisons with the related taxa and habitat information of the new species are provided. http://zoobank.org/urn:lsid:zoobank.org:pub:ACA7D22F-A02C-4127-96D6-649FC65ECE2E
Schlagwörter	Perlodidae ; females ; habitats ; males ; new species ; China
Sprache	Englisch
Erscheinungsverlauf	2022-0102
Umfang	p. 18-29.
Erscheinungsort	Taylor & Francis
Dokumenttyp	Artikel
ISSN	1744-4152
DOI	10.1080/01650424.2021.1942921
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: The anti-inflammatory and analgesic activities of 2Br-Crebanine and Stephanine from Stephania yunnanenses H. S.Lo.

Cui, Lili / Peng, Chaorui / Li, Jun / Cheng, Xin / Fan, Xiao / Li, Jingyu / Yang, Zixian / Zhao, Yuancui / Ma, Yunshu

Frontiers in pharmacology

2023 Band 13, Seite(n) 1092583

Abstract: Ethnopharmacological relevance: ...

Abstract	Ethnopharmacological relevance:
Sprache	Englisch
Erscheinungsdatum	2023-01-04
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.1092583
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Network pharmacology-based study of the molecular mechanisms of Qixuekang in treating COVID-19 during the recovery period.

Tian, Jing / Sun, Daolei / Xie, Yuke / Liu, Kun / Ma, Yunshu

International journal of clinical and experimental pathology

2020 Band 13, Heft 10, Seite(n) 2677–2690

Abstract: Objective: In this research, the analytical method of network pharmacology was used to explore Qixuekang molecular mechanism in treating Coronavirus 2019 (COVID-19) during the recovery period.: Methods: Traditional Chinese Medicine Systems ... ...

Abstract	Objective: In this research, the analytical method of network pharmacology was used to explore Qixuekang molecular mechanism in treating Coronavirus 2019 (COVID-19) during the recovery period. Methods: Traditional Chinese Medicine Systems Pharmacology (TCMSP) database was used to collect the active components and corresponding targets of Qixuekang. Disease targets, related to COVID-19 during the recovery period, were collected from the GeneCards database. Protein-Protein interaction (PPI) network was built by using the String database, and analyzing and using Cytoscape 3.7.0 software to screen out hub genes. GO enrichment and KEGG pathway enrichment analysis were analyzed by R 3.6.1 software. Results: 34 active components of Qixuekang were screened out, and 161 common targets of drug and disease were identified. GO enrichment suggested 141 biologic processes, mainly involving nuclear receptor activity, transcription factor activity, and direct ligand regulated sequence-specific DNA binding. KEGG pathway enrichment suggests 96 signaling pathways, mainly including TNF signaling pathway, IL-17 signal pathway, and C-type lectin receptor signal pathway. The hub genes, screened in the PPI network, were mainly inclusive of CXCL8, CXCL2, CXCL10, ADRA2A, and ADRA2C. Conclusion: Qixuekang has numerous components and targets in treating COVID-19 during the recovery period. It is mainly applied in anti-inflammatory action and regulating immune defense, which may guide clinical trials in the later stage.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-10-01
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2418306-4
ISSN	1936-2625 ; 1936-2625
ISSN (online)	1936-2625
ISSN	1936-2625
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats.

Zhu, Liyuan / Mei, Jiahua / Peng, Chaorui / Zhao, Yuancui / Liu, Yunkuan / Cui, Lili / Zhang, Kun / Ma, Yunshu

Xenobiotica; the fate of foreign compounds in biological systems

2022 Band 52, Heft 1, Seite(n) 91–98

Abstract: Sinoacutine is a natural isoquinoline alkaloid isolated from traditional Chinese ... ...

Abstract	Sinoacutine is a natural isoquinoline alkaloid isolated from traditional Chinese medicine
Mesh-Begriff(e)	Administration, Intravenous ; Animals ; Chromatography, High Pressure Liquid ; Female ; Injections, Intravenous ; Male ; Morphinans ; Protein Binding ; Rats ; Rats, Sprague-Dawley ; Tissue Distribution
Chemische Substanzen	Morphinans ; salutaridine (7X10PRH74D)
Sprache	Englisch
Erscheinungsdatum	2022-02-16
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	120287-x
ISSN	1366-5928 ; 0049-8254
ISSN (online)	1366-5928
ISSN	0049-8254
DOI	10.1080/00498254.2022.2036390
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: [Preparation of Cangai oil transfersomes patches and its in vitro evaluation].

Zhang, Kun / Xiong, Lei / Li, Dan-Ye / Gao, Jia-Ju / Liu, Yun-Kuan / Ma, Yun-Shu

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2020 Band 45, Heft 4, Seite(n) 854–860

Abstract: L_9(3~4) orthogonal experiment design was used to optimize the preparation of the patches,and investigate its affecting factors and skin irritation. Eugenol was taken as the index component to study the release behavior in vitro and percutaneous ... ...

Abstract	L_9(3~4) orthogonal experiment design was used to optimize the preparation of the patches,and investigate its affecting factors and skin irritation. Eugenol was taken as the index component to study the release behavior in vitro and percutaneous penetration of Cangai oil transfersomes patches by HPLC.The results showed that the optimal prescription for preparing Cangai oil transfersomes patches were Eudragit E100 0.6 g, succinic acid 0.08 g,triethyl citrate 0.25 g,glycerol 0.2 g.Patches prepared by the preferred preparation had a flat appearance without obvious bubbles.The initial adhesion was 18.33±2.52, the stickiness was(30.01±2.45) min,and the peel strength was(5.62±0.95) kN·m~(-1).The results of affecting factors experiment showed the order of factors affecting its adhesion was humidity>temperature>lighting,and the skin irritation test results showed no significant skin irritation after 24 h of single administration. The results of drug release behavior in vitro showed that the release and the percutaneous penetration of both Cangai oil patches and Cangai oil transfersomes patches conformed to the Higuchi equation.The release amount of eugenol were 80.66% and 82.25% at 72 h, with no significant difference. The cumulative permeation area of eugenol per unit area reached(0.195 6±0.065 9),(0.131 0±0.045 5) mg·cm~(-2) at 72 h, with significant differences(P<0.05).The experiment results proved that the preparation process of Cangai oil transfersomes patches was stable,and the prepared patches had a good adhesion. At the same time,the preparation of transfersomes patches could alleviate and control the release of the drug to a certain extent, and provide a certain experimental basis for clinical pediatric drug safety.
Mesh-Begriff(e)	Administration, Cutaneous ; Drug Carriers ; Drug Liberation ; Humans ; Plant Oils/pharmacology ; Polymethacrylic Acids ; Skin/drug effects ; Skin Absorption ; Transdermal Patch
Chemische Substanzen	Drug Carriers ; Plant Oils ; Polymethacrylic Acids ; methylmethacrylate-methacrylic acid copolymer (25086-15-1)
Sprache	Chinesisch
Erscheinungsdatum	2020-03-31
Erscheinungsland	China
Dokumenttyp	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20191217.304
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Synthesis and In Vivo Antiarrhythmic Activity Evaluation of Novel Scutellarein Analogues as Voltage-Gated Nav1.5 and Cav1.2 Channels Blockers.

Yang, Wei / Wang, Wenping / Cai, Song / Li, Peng / Zhang, Die / Ning, Jinhua / Ke, Jin / Hou, Anguo / Chen, Linyun / Ma, Yunshu / Jin, Wenbin

Molecules (Basel, Switzerland)

2023 Band 28, Heft 21

Abstract: Malignant cardiac arrhythmias with high morbidity and mortality have posed a significant threat to our human health. Scutellarein, a metabolite of Scutellarin which is isolated ... ...

Abstract	Malignant cardiac arrhythmias with high morbidity and mortality have posed a significant threat to our human health. Scutellarein, a metabolite of Scutellarin which is isolated from
Mesh-Begriff(e)	Rats ; Humans ; Animals ; Aconitine/pharmacology ; Anti-Arrhythmia Agents/adverse effects ; Arrhythmias, Cardiac/chemically induced ; Arrhythmias, Cardiac/drug therapy
Chemische Substanzen	barium chloride (0VK51DA1T2) ; scutellarin (16IGP0ML9A) ; scutellarein (P460GTI853) ; Aconitine (X8YN71D5WC) ; Anti-Arrhythmia Agents
Sprache	Englisch
Erscheinungsdatum	2023-11-03
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28217417
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Network pharmacology-based study of the molecular mechanisms of Qixuekang in treating COVID-19 during the recovery period

Tian, Jing / Sun, Daolei / Xie, Yuke / Liu, Kun / Ma, Yunshu

Int J Clin Exp Pathol

Abstract: OBJECTIVE: In this research, the analytical method of network pharmacology was used to explore Qixuekang molecular mechanism in treating Coronavirus 2019 (COVID-19) during the recovery period. METHODS: Traditional Chinese Medicine Systems Pharmacology ( ... ...

Abstract	OBJECTIVE: In this research, the analytical method of network pharmacology was used to explore Qixuekang molecular mechanism in treating Coronavirus 2019 (COVID-19) during the recovery period. METHODS: Traditional Chinese Medicine Systems Pharmacology (TCMSP) database was used to collect the active components and corresponding targets of Qixuekang. Disease targets, related to COVID-19 during the recovery period, were collected from the GeneCards database. Protein-Protein interaction (PPI) network was built by using the String database, and analyzing and using Cytoscape 3.7.0 software to screen out hub genes. GO enrichment and KEGG pathway enrichment analysis were analyzed by R 3.6.1 software. RESULTS: 34 active components of Qixuekang were screened out, and 161 common targets of drug and disease were identified. GO enrichment suggested 141 biologic processes, mainly involving nuclear receptor activity, transcription factor activity, and direct ligand regulated sequence-specific DNA binding. KEGG pathway enrichment suggests 96 signaling pathways, mainly including TNF signaling pathway, IL-17 signal pathway, and C-type lectin receptor signal pathway. The hub genes, screened in the PPI network, were mainly inclusive of CXCL8, CXCL2, CXCL10, ADRA2A, and ADRA2C. CONCLUSION: Qixuekang has numerous components and targets in treating COVID-19 during the recovery period. It is mainly applied in anti-inflammatory action and regulating immune defense, which may guide clinical trials in the later stage.
Schlagwörter	covid19
Verlag	WHO
Dokumenttyp	Artikel
Anmerkung	WHO #Covidence: #915077
Datenquelle	COVID19

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Artikel: Sinoacutine inhibits inflammatory responses to attenuates acute lung injury by regulating NF-κB and JNK signaling pathways

Zhao, Yuancui / Cui, Lili / Yang, Xing Xin / Sun, Xingqian / Liu, Yunkuan / Yang, Zixian / Zhu, Liyuan / Peng, Chaorui / Li, Danye / Cai, Junfei / Ma, Yunshu

BMC complementary medicine and therapies. 2021 Dec., v. 21, no. 1

2021

Abstract: BACKGROUND: Stephania yunnanensis H. S. Lo is widely used as an antipyretic, analgesic and anti-inflammatory herbal medicine in SouthWest China. In this study, we investigated the anti-inflammatory activity and mechanism of sinoacutine (sino), one of the ...

Abstract	BACKGROUND: Stephania yunnanensis H. S. Lo is widely used as an antipyretic, analgesic and anti-inflammatory herbal medicine in SouthWest China. In this study, we investigated the anti-inflammatory activity and mechanism of sinoacutine (sino), one of the primary components extracted from this plant. METHODS: A RAW264.7 cell model was established using lipopolysaccharide (LPS) induced for estimation of cytokines in vitro, qPCR was used to estimate gene expression, western blot analysis was used to estimate protein level and investigate the regulation of NF- κB, JNK and MAPK signal pathway. In addition, an acute lung injury model was established to determine lung index and levels of influencing factors. RESULTS: Using the RAW264.7 model, we found that sino reduced levels of nitric oxide (NO), tumour necrosis factor-α (TNF-α), interleukin (IL)-1β and prostaglandin E₂ (PGE₂) but increased levels of IL-6. qPCR analysis revealed that sino (50, 25 μg/ml) inhibited gene expression of nitric oxide synthase (iNOS). western blot analysis showed that sino significantly inhibited protein levels of both iNOS and COX-2. Further signalling pathway analysis validated that sino also inhibited phosphorylation of p65 in the NF-κB and c-Jun NH2 terminal kinase (JNK) signalling pathways but promoted the phosphorylation of extracellular signal regulated kinase (ERK) and p38 in the MAPK signalling pathway. In addition, in a mouse model induced by LPS, we determined that sino reduced the lung index and the levels of myeloperoxidase (MPO), NO, IL-6 and TNF-α in lung tissues and bronchoalveolar lavage fluid (BALF) in acute lung injury (ALI). CONCLUSION: Taken together, our results demonstrate that sino is a promising drug to alleviate LPS-induced inflammatory reactions.
Schlagwörter	Stephania ; Western blotting ; alternative medicine ; analgesics ; anti-inflammatory activity ; gene expression ; herbal medicines ; interleukin-6 ; lipopolysaccharides ; lungs ; mice ; myeloperoxidase ; necrosis ; neoplasms ; nitric oxide ; phosphorylation inhibition ; prostaglandins ; protein content ; signal transduction ; China
Sprache	Englisch
Erscheinungsverlauf	2021-12
Umfang	p. 284.
Erscheinungsort	BioMed Central
Dokumenttyp	Artikel
ISSN	2662-7671
DOI	10.1186/s12906-021-03458-0
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: [Determination of 5 nucleosides components in culture of Paecilomyces hepialid by HPLC].

Yang, Dan / Ma, Yun-shu / Huang, Ting-ting / Chen, Cheng

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2015 Band 40, Heft 15, Seite(n) 3022–3026

Abstract: The concentration of 5 nucleosides, uracil, uridine, guanidine, adenine and adenosine in culture of Paecilomyces hepialid was determined by the developed method of HPLC. The HPLC method was performed on a Waters SunFire C18 (4.6 mm x 250 mm, 5 μm) column ...

Abstract	The concentration of 5 nucleosides, uracil, uridine, guanidine, adenine and adenosine in culture of Paecilomyces hepialid was determined by the developed method of HPLC. The HPLC method was performed on a Waters SunFire C18 (4.6 mm x 250 mm, 5 μm) column with methanol-water gradient elution as the mobile phase. The detection wavelength was 260 nm and the colunmn temperature was controlled at 30 °C. The linear range was 10.00-200.00 mg · L(-1) (r = 0.9994) for uracil, 10.10-202.00 mg · L(-1) (r = 0.9992) for uridine, 10.00-200.00 mg · L(-1) (r = 0.9991) for guanidine, 10.30-206.00 mg · L(-1) (r = 0.9992) for adenine and 10.45-209.00 mg · L(-1) (r = 0.9991) for adenosine, respectively. The RSD of precision was 0.032%, 0.035%, 0.039%, 0.049%, 0.00080%, respectively. The average recoveries of uracil, guanidine, adenine, and adenosine were 97.34%, 99.10%, 101.6%, 98.61% and 100.2% with RSD of 1.3%, 2.1%, 0.96%, 0.95%, and 1.3% respectively. The method showed high sensitivity, good selectivity, linearity and repeatability, which was suitable for the content analysis of 5 nucleosides components in P. hepialid and its extracts.
Mesh-Begriff(e)	Chromatography, High Pressure Liquid/methods ; Nucleosides/analysis ; Paecilomyces/chemistry
Chemische Substanzen	Nucleosides
Sprache	Chinesisch
Erscheinungsdatum	2015-08
Erscheinungsland	China
Dokumenttyp	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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