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  1. Article: Mechanical Properties of Lattice Structures with a Central Cube: Experiments and Simulations.

    Guo, Shuai / Ma, Yuwei / Liu, Peng / Chen, Yang

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 6

    Abstract: In this study, a new structure is proposed based on the body-centered cubic (BCC) lattice structure by adding a cubic truss in the center of the BCC structure and denoting it TLC (truss-lattice-cube). The different dimensions of the central cube can ... ...

    Abstract In this study, a new structure is proposed based on the body-centered cubic (BCC) lattice structure by adding a cubic truss in the center of the BCC structure and denoting it TLC (truss-lattice-cube). The different dimensions of the central cube can notably affect the mechanical properties of the lattice structure. With a fixed length (15 mm) of a unit cell, the optimal size for the central cube is determined to be 5 mm. Quasi-static compressive tests are performed on specimens made of polylactic acid (PLA) using additive manufacturing technology. The deformation characteristics of the new structure are analyzed in detail by experiments and numerical simulations. Compared to the BCC structure, the mechanical properties of the TLC structure were significantly improved. The initial flow stress of the TLC increased by 122% at a strain of 0.1; the specific strength enhanced by 293% at a strain of 0.5; and the specific energy absorption improved by 312% at a strain of 0.6. Printing defects in the lattice structure may remarkably damage its mechanical properties. In this work, incorporation of microcracks into the finite element model allows the simulation to capture the influence of printing defects and significantly improve the predictive accuracy of the simulation.
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17061329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Numerical Investigation on Precipitation Hardening of Mg-Gd Alloys.

    Ge, Yulong / Yang, Chunyan / Ma, Yuwei / Chen, Yang / Gupta, Manoj

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 6

    Abstract: The second-phase particles in magnesium alloys could affect the mechanical properties of the material significantly. In this work, 3D finite element models with explicit incorporation of second-phase particles are established. The simulations are ... ...

    Abstract The second-phase particles in magnesium alloys could affect the mechanical properties of the material significantly. In this work, 3D finite element models with explicit incorporation of second-phase particles are established. The simulations are calibrated with the experimental results of the Mg-1Gd alloy. The influences of factors, such as the particle distribution, size, and orientation of cylindrical particles, on precipitation hardening are investigated in detail. Three interface conditions between particles and the matrix-perfect bonding and high- and low-strength bonding-are studied at the same time. The interface conditions are shown to exert a stronger influence on precipitation hardening compared to the factors of particle distribution and size. In contrast, the influence of the orientation of cylindrical particles at grain boundaries outweighs the effect of interface property. When second-phase particles are relatively large and all located at grain boundaries, the hardening effect can be improved, and the magnesium alloy shows relatively high flow stress. However, the high hardening effect from the second-phase particles could result in high local stress concentration and possible early failure or low ductility of Mg alloys.
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17061393
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  3. Article: Silicon balance in the South China Sea

    Ma, Yuwei / Zhang, Lanlan / Liu, Sumei / Zhu, Dongdong

    Biogeochemistry. 2022 Feb., v. 157, no. 3

    2022  

    Abstract: The South China Sea (SCS) is one of the largest marginal seas in the world, but the processes that control the silicon cycle are not well understood. Here, we analyse the factors that affect the distribution of biogenic silica (bSi) in SCS sediments and ... ...

    Abstract The South China Sea (SCS) is one of the largest marginal seas in the world, but the processes that control the silicon cycle are not well understood. Here, we analyse the factors that affect the distribution of biogenic silica (bSi) in SCS sediments and discuss the silicon cycle based on a box model. Our results show that the bSi content (~ 1.2%) in the shelf-slope (< 2000 m) sediments is lower overall than that (~ 2%) in the basin (> 2000 m) sediments. The dilution by terrestrial input, degradation rate of biogenic materials and lateral transport by current patterns are the main factors influencing the bSi content in SCS sediments. The bSi burial flux in the shelf-slope region (161 ± 156 Gmol-Si yr⁻¹) is six times greater than that in the basin region (27 ± 18 Gmol-Si yr⁻¹) due to higher burial rates, larger sea area, and coarser sediments. The estimated bSi burial efficiency (ratio of the bSi burial rate divided by the sum of the benthic silicic acid (dSi) diffusion rate and the burial rate) in SCS sediments is 27%, comparable to those of other marginal seas. Therefore, at the sediment–water interface, 73% of Si is recycled back to the water column. From compiled datasets of water fluxes and dSi concentrations over the past decades, we calculate a total output silicon flux of dSi of 2259 ± 397 Gmol-Si yr⁻¹ for the SCS, which is not significantly different from the total input flux (2196 ± 458 Gmol-Si yr⁻¹), suggesting that the Si cycle of this marginal sea is in a steady state. Interestingly, the submarine groundwater discharge (SGD) flux (477 ± 140 Gmol-Si yr⁻¹) in the SCS is 2.5 times higher than the riverine dSi and dissolvable amorphous silica input (194 ± 40 Gmol-Si yr⁻¹).
    Keywords basins ; biogeochemistry ; data collection ; groundwater ; models ; riparian areas ; sediment-water interface ; silica ; silicic acid ; silicon ; South China Sea
    Language English
    Dates of publication 2022-02
    Size p. 327-353.
    Publishing place Springer International Publishing
    Document type Article
    ZDB-ID 1478541-9
    ISSN 1573-515X ; 0168-2563
    ISSN (online) 1573-515X
    ISSN 0168-2563
    DOI 10.1007/s10533-021-00879-4
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Recent advances in primary cilia in bone metabolism.

    Lian, Fenfen / Li, Hui / Ma, Yuwei / Zhou, Rui / Wu, Wei

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1259650

    Abstract: Primary cilia are microtubule-based organelles that are widespread on the cell surface and play a key role in tissue development and homeostasis by sensing and transducing various signaling pathways. The process of intraflagellar transport (IFT), which ... ...

    Abstract Primary cilia are microtubule-based organelles that are widespread on the cell surface and play a key role in tissue development and homeostasis by sensing and transducing various signaling pathways. The process of intraflagellar transport (IFT), which is propelled by kinesin and dynein motors, plays a crucial role in the formation and functionality of cilia. Abnormalities in the cilia or ciliary transport system often cause a range of clinical conditions collectively known as ciliopathies, which include polydactyly, short ribs, scoliosis, thoracic stenosis and many abnormalities in the bones and cartilage. In this review, we summarize recent findings on the role of primary cilia and ciliary transport systems in bone development, we describe the role of cilia in bone formation, cartilage development and bone resorption, and we summarize advances in the study of primary cilia in fracture healing. In addition, the recent discovery of crosstalk between integrins and primary cilia provides new insights into how primary cilia affect bone.
    MeSH term(s) Cilia/metabolism ; Flagella/metabolism ; Biological Transport ; Kinesins/metabolism ; Dyneins
    Chemical Substances Kinesins (EC 3.6.4.4) ; Dyneins (EC 3.6.4.2)
    Language English
    Publishing date 2023-10-10
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1259650
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  5. Article ; Online: The role of graphene/graphene oxide in cement hydration

    Meng Shaoqiang / Ouyang Xiaowei / Fu Jiyang / Niu Yanfei / Ma Yuwei

    Nanotechnology Reviews, Vol 10, Iss 1, Pp 768-

    2021  Volume 778

    Abstract: 1) GO has a strong interaction with Ca2+. (2) G/GO accelerates C–S–H growth. (3) High mobility ions derived by G/GO facilitate hydration. ...

    Abstract (1) GO has a strong interaction with Ca2+. (2) G/GO accelerates C–S–H growth. (3) High mobility ions derived by G/GO facilitate hydration.
    Keywords graphene ; graphene oxide ; cement paste ; hydration ; c–s–h ; calcium ion ; Technology ; T ; Chemical technology ; TP1-1185 ; Physical and theoretical chemistry ; QD450-801
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Advances in the study of protein folding and endoplasmic reticulum-associated degradation in mammal cells.

    Cao, Hong / Zhou, Xuchang / Xu, Bowen / Hu, Han / Guo, Jianming / Ma, Yuwei / Wang, Miao / Li, Nan / Jun, Zou

    Journal of Zhejiang University. Science. B

    2024  Volume 25, Issue 3, Page(s) 212–232

    Abstract: The endoplasmic reticulum is a key site for protein production and quality control. More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulum. However, during protein folding, ... ...

    Title translation 哺乳动物细胞蛋白质折叠和内质网相关降解的研究进展.
    Abstract The endoplasmic reticulum is a key site for protein production and quality control. More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulum. However, during protein folding, unfolded and/or misfolded proteins are prone to occur, which may lead to endoplasmic reticulum stress. Organisms can monitor the quality of the proteins produced by endoplasmic reticulum quality control (ERQC) and endoplasmic reticulum-associated degradation (ERAD), which maintain endoplasmic reticulum protein homeostasis by degrading abnormally folded proteins. The underlying mechanisms of protein folding and ERAD in mammals have not yet been fully explored. Therefore, this paper reviews the process and function of protein folding and ERAD in mammalian cells, in order to help clinicians better understand the mechanism of ERAD and to provide a scientific reference for the treatment of diseases caused by abnormal ERAD.
    MeSH term(s) Animals ; Endoplasmic Reticulum-Associated Degradation ; Protein Folding ; Proteins ; Endoplasmic Reticulum Stress ; Mammals/metabolism
    Chemical Substances Proteins
    Language Chinese
    Publishing date 2024-03-07
    Publishing country China
    Document type Review ; Journal Article
    ZDB-ID 2247290-3
    ISSN 1862-1783 ; 1673-1581
    ISSN (online) 1862-1783
    ISSN 1673-1581
    DOI 10.1631/jzus.B2300403
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  7. Article ; Online: Author Correction: Study on the preparation and mechanical properties of purple ceramics.

    Wang, Lihe / Wang, Yonghui / Wang, Qingchun / Ma, Yuwei / Ruan, Fei / Zhang, Yonghe / Lv, Haodong / Jing, Qiang / Bao, Jinxiao

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 12196

    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-38494-y
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  8. Article ; Online: Study on the preparation and mechanical properties of purple ceramics.

    Wang, Lihe / Wang, Yonghui / Wang, Qingchun / Ma, Yuwei / Ruan, Fei / Zhang, Yonghe / Lv, Haodong / Jing, Qiang / Bao, Jinxiao

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 8755

    Abstract: This paper aims at preparing a smart wearable purple ceramic that meet the color requirements of purple smart wear in the market after using zirconate neodymium as a chromogenic agent. However, the mechanical performance of zirconate neodymium purple ... ...

    Abstract This paper aims at preparing a smart wearable purple ceramic that meet the color requirements of purple smart wear in the market after using zirconate neodymium as a chromogenic agent. However, the mechanical performance of zirconate neodymium purple ceramic is not satisfactory, especially it has an extremely low fracture toughness. To solve this, a 3 mol% yttria-stabilized zirconia (3YSZ) is added to zirconate neodymium in the preparation of multiphase ceramics to improve its mechanical properties. In this experiment, a series of ceramic samples with addition of increasing amount of 3YSZ 0, 20, 40, 50, 60, 70 and 80% were prepared in the 1400-1500 °C sintering temperature range. It was found that at the same temperature, the mechanical properties of the ceramic samples gradually improved with the increase in the 3YSZ content. Moreover, with the same content, the mechanical properties of the ceramic samples gradually improved with the decrease in temperature. The results show that when 3YSZ has a mass fraction of 80% and is sintered at 1400 °C, the fracture toughness of the prepared ceramic samples reaches 8.15 MPa‧m
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-35957-0
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  9. Article ; Online: Simultaneous Delivery of Doxorubicin and EZH2-Targeting siRNA by Vortex Magnetic Nanorods Synergistically Improved Anti-Tumor Efficacy in Triple-Negative Breast Cancer.

    Lu, Yunshu / Gu, Fenfen / Ma, Yuwei / Li, Ruonan / Luo, Yi / Da, Xianhong / Jiang, Lan / Li, Xiang / Liu, Yan

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 43, Page(s) e2301307

    Abstract: Triple-negative breast cancer (TNBC), one of the most aggressive types of breast cancer, currently lacks a targeted therapy and has a high clinical recurrence rate. The present study reports an engineered magnetic nanodrug based on ... ...

    Abstract Triple-negative breast cancer (TNBC), one of the most aggressive types of breast cancer, currently lacks a targeted therapy and has a high clinical recurrence rate. The present study reports an engineered magnetic nanodrug based on Fe
    MeSH term(s) Humans ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; RNA, Small Interfering ; Enhancer of Zeste Homolog 2 Protein/genetics ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Magnetic Phenomena ; Cell Line, Tumor
    Chemical Substances RNA, Small Interfering ; Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43) ; Doxorubicin (80168379AG) ; EZH2 protein, human (EC 2.1.1.43)
    Language English
    Publishing date 2023-06-27
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202301307
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  10. Article ; Online: Graphene sandwich-based biological specimen preparation for cryo-EM analysis.

    Xu, Jie / Gao, Xiaoyin / Zheng, Liming / Jia, Xia / Xu, Kui / Ma, Yuwei / Wei, Xiaoding / Liu, Nan / Peng, Hailin / Wang, Hong-Wei

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 5, Page(s) e2309384121

    Abstract: High-quality specimen preparation plays a crucial role in cryo-electron microscopy (cryo-EM) structural analysis. In this study, we have developed a reliable and convenient technique called the graphene sandwich method for preparing cryo-EM specimens. ... ...

    Abstract High-quality specimen preparation plays a crucial role in cryo-electron microscopy (cryo-EM) structural analysis. In this study, we have developed a reliable and convenient technique called the graphene sandwich method for preparing cryo-EM specimens. This method involves using two layers of graphene films that enclose macromolecules on both sides, allowing for an appropriate ice thickness for cryo-EM analysis. The graphene sandwich helps to mitigate beam-induced charging effect and reduce particle motion compared to specimens prepared using the traditional method with graphene support on only one side, therefore improving the cryo-EM data quality. These advancements may open new opportunities to expand the use of graphene in the field of biological electron microscopy.
    MeSH term(s) Cryoelectron Microscopy ; Data Accuracy ; Graphite ; Motion
    Chemical Substances Graphite (7782-42-5)
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2309384121
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