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  1. Article ; Online: Establishment and evaluation of targeted molecular screening model for the ryanodine receptor or sarco/endoplasmic reticulum calcium ATPase.

    Lu, Xiaopeng / Jiang, Linlin / Chen, Li / Ding, Wenwei / Wu, Hua / Ma, Zhiqing

    Pest management science

    2024  

    Abstract: Backgroud: Endoplasmic reticulum/sarcoplasmic reticulum (ER/SR) is crucial for maintaining intracellular calcium homeostasis due to the calcium-signaling-related proteins on its membrane. While ryanodine receptors (RyR) on insect ER/SR membranes are ... ...

    Abstract Backgroud: Endoplasmic reticulum/sarcoplasmic reticulum (ER/SR) is crucial for maintaining intracellular calcium homeostasis due to the calcium-signaling-related proteins on its membrane. While ryanodine receptors (RyR) on insect ER/SR membranes are well-known as targets for diamide insecticides, little is known about other calcium channels. Given the resistance of diamide insecticides, the establishment of molecular screening models targeting RyR or sarco/endoplasmic reticulum calcium ATPase (SERCA) is conducive to the discovery of new insecticidal molecules.
    Results: The morphological features of Mythimna separata SR have closed vesicles with integrity and high density. The 282 proteins in the SR component contained RyR and SERCA. A measurement model for the release and uptake of calcium was successfully established by detecting calcium ions outside the SR membrane using a fluorescence spectrophotometer. In vitro testing systems using SR vesicles found that diamide insecticides could activate dose-dependently RyR, with EC
    Conclusions: SR vesicles can be used to study the function of unknown proteins on the SR membranes, as well as for high-throughput screening of highly active compounds targeting RyR or SERCA. © 2024 Society of Chemical Industry.
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001705-4
    ISSN 1526-4998 ; 1526-498X
    ISSN (online) 1526-4998
    ISSN 1526-498X
    DOI 10.1002/ps.8040
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  2. Article ; Online: Isolation of anthraquinone derivatives from Rubia cordifolia (Rubiaceae) and their bioactivities against plant pathogenic microorganisms.

    Wang, Wenhao / Guo, Yifei / Xu, Jialu / Zhang, Hao / Ma, Zhiqing / Wu, Hua

    Pest management science

    2024  

    Abstract: Background: The discovery of antimicrobial ingredients from natural products could be an effective way to create novel fungicides. Rubia cordifolia L., a traditional Chinese herb, may have antimicrobial effects on plant pathogens according to our ... ...

    Abstract Background: The discovery of antimicrobial ingredients from natural products could be an effective way to create novel fungicides. Rubia cordifolia L., a traditional Chinese herb, may have antimicrobial effects on plant pathogens according to our previous screening study.
    Results: Rubia cordifolia L. extracts had moderate inhibitory effects on apple Valsa canker (Valsa mali) and tomato grey mould (Botrytis cinerea) at a concentration of 10 mg mL
    Conclusion: Mollugin and 1,3,6-trihydroxy-2-methylanthraquinone are potentially valuable active compounds that lay a foundation for research on botanical fungicide products derived from R. cordifolia L. and provide lead structures for quinone derivative synthesis and structural modification. © 2024 Society of Chemical Industry.
    Language English
    Publishing date 2024-05-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001705-4
    ISSN 1526-4998 ; 1526-498X
    ISSN (online) 1526-4998
    ISSN 1526-498X
    DOI 10.1002/ps.8177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Incorporating

    Fan, Xiaojing / Zhang, Bin / Zhang, Xing / Ma, Zhiqing / Feng, Xianchao

    Food chemistry: X

    2023  Volume 18, Page(s) 100662

    Abstract: This study aimed to investigate the application potential ... ...

    Abstract This study aimed to investigate the application potential of
    Language English
    Publishing date 2023-03-27
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-1575
    ISSN (online) 2590-1575
    DOI 10.1016/j.fochx.2023.100662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chitosan-thymol nanoparticle with pH responsiveness as a potential intelligent botanical fungicide against Botrytis cinerea.

    Zhao, Xiaomin / Zhang, Yunfei / Chen, Li / Ma, Zhiqing / Zhang, Bin

    Pesticide biochemistry and physiology

    2023  Volume 195, Page(s) 105571

    Abstract: The practical application of essential oils (EOs) as an alternative for synthetic pesticides in agricultural production is severely limited because of their instability, high volatility, and water insolubility. Nanoencapsulation of EOs is an important ... ...

    Abstract The practical application of essential oils (EOs) as an alternative for synthetic pesticides in agricultural production is severely limited because of their instability, high volatility, and water insolubility. Nanoencapsulation of EOs is an important strategy to overcome these limitations. In view of this, this study aimed to develop chitosan-thymol nanoparticle (NCS-Thy) with pH-responsive which can be used as an intelligent botanical fungicide to control Botrytis cinerea. The NCS-Thy nanoparticle was prepared by ionic crosslinking method with the loading capacity and encapsulation efficiency of 29.87% and 41.92%, respectively. The synthesized NCS-Thy nanoparticle was further characterized by Fourier transform infrared spectroscopy analysis, transmission electron microscopy observation, and dynamic lights scattering. The results of release kinetics and antifungal activity of NCS-Thy under different pH conditions were determined. The results showed that the NCS-Thy nanoparticle had excellent pH-responsiveness and can release more thymol under acidic conditions formed by B. cinerea, thereby achieving higher antifungal effects. Therefore, compared with unencapsulated thymol, the NCS-Thy nanoparticle had higher antifungal activity against B. cinerea in vitro. In addition, both the protective and curative efficacies of detached leaf test and pot experiment were significantly higher than those of unencapsulated thymol. Among them, the protective efficacy of NCS-Thy in the pot experiment was 78.73%, which was significantly higher than that of unencapsulated thymol with 61.13%. Therefore, the pH-responsive chitosan-thymol nano-preparation had a promising prospect of application in practical management of gray mold as an intelligent botanical fungicide.
    MeSH term(s) Thymol ; Fungicides, Industrial/pharmacology ; Antifungal Agents/pharmacology ; Chitosan/pharmacology ; Nanoparticles ; Hydrogen-Ion Concentration
    Chemical Substances Thymol (3J50XA376E) ; Fungicides, Industrial ; Antifungal Agents ; Chitosan (9012-76-4)
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 184819-7
    ISSN 1095-9939 ; 0048-3583 ; 0048-3575
    ISSN (online) 1095-9939
    ISSN 0048-3583 ; 0048-3575
    DOI 10.1016/j.pestbp.2023.105571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Matrine can be absorbed and transmitted bidirectionally to defend against aphids (Hemiptera: Aphididae) on wheat and pepper

    Sun, Zheng / Zhang, Bin / Li, Wenkui / Zhou, Yiwan / Zhang, Jing / Wang, Jun / Ma, Zhiqing

    Pest Management Science. 2023 June, v. 79, no. 6 p.2098-2106

    2023  

    Abstract: BACKGROUND: Although matrine is widely used, its absorption and transport mechanisms in crops remain unexplored. In this study, three methods including foliar application, hydroponics and seed immersion were used to investigate whether matrine molecules ... ...

    Abstract BACKGROUND: Although matrine is widely used, its absorption and transport mechanisms in crops remain unexplored. In this study, three methods including foliar application, hydroponics and seed immersion were used to investigate whether matrine molecules could enter into plants through different channels, and to further resolve its transport characteristics. The systemic activity of matrine also was evaluated. RESULT: Matrine was quickly absorbed and transported downwards after the leaves of wheat or peppers were treated, and also accumulated and transmitted upwards by roots. It was not only absorbed by seeds, but also appeared continuously in young roots and leaves in both plants for nearly 20 days. There were some differences in the uptake and conduction of matrine between pepper and wheat: matrine concentrated in pepper upper leaves with less delivered downwards to roots than in wheat, and also transduction of matrine in pepper lower leaves upwards to upper leaves was less than in wheat. Matrine had systemic activity, with LC₅₀ of 361.99 and 904.24 μg·mL⁻¹ against Rhopalosiphum padib on wheat and Myzus persicae (Sulzer) on pepper plants at 48 h, separately. CONCLUSION: Matrine can be absorbed by the roots, seeds and leaves of plants, and transmitted bidirectionally to any organs, presenting satisfactory systemic poisoning activity against aphids. It is of great significance to develop new formulation products of matrine and promote its commercialized value. © 2023 Society of Chemical Industry.
    Keywords Myzus persicae ; Rhopalosiphum ; absorption ; commercialization ; foliar application ; hydroponics ; pepper ; pest management ; wheat
    Language English
    Dates of publication 2023-06
    Size p. 2098-2106.
    Publishing place John Wiley & Sons, Ltd.
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 2001705-4
    ISSN 1526-4998 ; 1526-498X
    ISSN (online) 1526-4998
    ISSN 1526-498X
    DOI 10.1002/ps.7376
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Chitosan-thymol nanoparticle with pH responsiveness as a potential intelligent botanical fungicide against Botrytis cinerea

    Zhao, Xiaomin / Zhang, Yunfei / Chen, Li / Ma, Zhiqing / Zhang, Bin

    Pesticide Biochemistry and Physiology. 2023 Aug. 08, p.105571-

    2023  , Page(s) 105571–

    Abstract: The practical application of essential oils (EOs) as an alternative for synthetic pesticides in agricultural production is severely limited because of their instability, high volatility, and water insolubility. Nanoencapsulation of EOs is an important ... ...

    Abstract The practical application of essential oils (EOs) as an alternative for synthetic pesticides in agricultural production is severely limited because of their instability, high volatility, and water insolubility. Nanoencapsulation of EOs is an important strategy to overcome these limitations. In view of this, this study aimed to develop chitosan-thymol nanoparticle (NCS-Thy) with pH-responsive which can be used as an intelligent botanical fungicide to control Botrytis cinerea. The NCS-Thy nanoparticle was prepared by ionic crosslinking method with the loading capacity and encapsulation efficiency of 29.87% and 41.92%, respectively. The synthesized NCS-Thy nanoparticle was further characterized by Fourier transform infrared spectroscopy analysis, transmission electron microscopy observation, and dynamic lights scattering. The results of release kinetics and antifungal activity of NCS-Thy under different pH conditions were determined. The results showed that the NCS-Thy nanoparticle had excellent pH-responsiveness and can release more thymol under acidic conditions formed by B. cinerea, thereby achieving higher antifungal effects. Therefore, compared with unencapsulated thymol, the NCS-Thy nanoparticle had higher antifungal activity against B. cinerea in vitro. In addition, both the protective and curative efficacies of detached leaf test and pot experiment were significantly higher than those of unencapsulated thymol. Among them, the protective efficacy of NCS-Thy in the pot experiment was 78.73%, which was significantly higher than that of unencapsulated thymol with 61.13%. Therefore, the pH-responsive chitosan-thymol nano-preparation had a promising prospect of application in practical management of gray mold as an intelligent botanical fungicide.
    Keywords Botrytis cinerea ; Fourier transform infrared spectroscopy ; antifungal properties ; crosslinking ; encapsulation ; fungicides ; gray mold ; leaves ; nanocapsules ; nanoparticles ; pH ; physiology ; thymol ; transmission electron microscopy ; water solubility ; Essential oils ; Nano-fungicide ; pH-responsive ; Controlled release
    Language English
    Dates of publication 2023-0808
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 184819-7
    ISSN 1095-9939 ; 0048-3583 ; 0048-3575
    ISSN (online) 1095-9939
    ISSN 0048-3583 ; 0048-3575
    DOI 10.1016/j.pestbp.2023.105571
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Pd-NHC (NHC = N-Heterocyclic Carbene)-Catalyzed B-Alkyl Suzuki Cross-Coupling of 2-Pyridyl Ammonium Salts by N-C Activation: Application to the Discovery of Agrochemical Molecular Hybrids.

    Gao, Yanqing / Hu, Yuge / Ye, Jiuhui / Ma, Zhiqing / Feng, Juntao / Liu, Xili / Lei, Peng / Szostak, Michal

    Organic letters

    2024  Volume 26, Issue 11, Page(s) 2309–2314

    Abstract: 2-Alkylpyridines are a privileged scaffold throughout the realm of organic synthesis and play a key role in natural products, pharmaceuticals, and agrochemicals. Herein, we report the first B-alkyl Suzuki cross-coupling of 2-pyridyl ammonium salts to ... ...

    Abstract 2-Alkylpyridines are a privileged scaffold throughout the realm of organic synthesis and play a key role in natural products, pharmaceuticals, and agrochemicals. Herein, we report the first B-alkyl Suzuki cross-coupling of 2-pyridyl ammonium salts to access functionalized 2-alkylpyridines. The use of well-defined, operationally simple Pd-NHCs permits for an exceptionally broad scope of the challenging B-alkyl C-N cross-coupling with organoboranes containing β-hydrogen, representing a novel method for the discovery of highly sought-after molecules for plant protection.
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.4c00549
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  8. Article ; Online: Discovery of Novel Cinnamic Acid Derivatives as Fungicide Candidates.

    Liu, Hanru / Cai, Chonglin / Zhang, Xingjia / Li, Wenkui / Ma, Zhiqing / Feng, Juntao / Liu, Xili / Lei, Peng

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 5, Page(s) 2492–2500

    Abstract: Structural diversity derivatization from natural products is an important and effective method of discovering novel green pesticides. Cinnamic acids are abundant in plants, and their unparalleled structures endow them with various excellent biological ... ...

    Abstract Structural diversity derivatization from natural products is an important and effective method of discovering novel green pesticides. Cinnamic acids are abundant in plants, and their unparalleled structures endow them with various excellent biological activities. A series of novel cinnamic oxime esters were designed and synthesized to develop high antifungal agrochemicals. The antifungal activity, structure-activity relationship, and action mechanism were systematically studied. Compounds
    MeSH term(s) Fungicides, Industrial/chemistry ; Antifungal Agents/pharmacology ; Structure-Activity Relationship ; Quantitative Structure-Activity Relationship ; Oximes/pharmacology ; Botrytis ; Ascomycota ; Cinnamates
    Chemical Substances Fungicides, Industrial ; Antifungal Agents ; cinnamic acid (140-10-3) ; Oximes ; Cinnamates
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c05655
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  9. Article: Exogenous phthalanilic acid induces resistance to drought stress in pepper seedlings (

    Lu, Xiaopeng / Wu, Qiong / Nie, Keyi / Wu, Hua / Chen, Guangyou / Wang, Jun / Ma, Zhiqing

    Frontiers in plant science

    2023  Volume 14, Page(s) 1156276

    Abstract: Drought stress (DS) is one of the main abiotic negative factors for plants. Phthalanilic acid (PPA), as a plant growth regulator, can promote the growth and development of crops. In order to evaluate the ideal application concentration and frequency of ... ...

    Abstract Drought stress (DS) is one of the main abiotic negative factors for plants. Phthalanilic acid (PPA), as a plant growth regulator, can promote the growth and development of crops. In order to evaluate the ideal application concentration and frequency of PPA-induced drought resistance in pepper (
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1156276
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  10. Article ; Online: Matrine can be absorbed and transmitted bidirectionally to defend against aphids (Hemiptera: Aphididae) on wheat and pepper.

    Sun, Zheng / Zhang, Bin / Li, Wenkui / Zhou, Yiwan / Zhang, Jing / Wang, Jun / Ma, Zhiqing

    Pest management science

    2023  Volume 79, Issue 6, Page(s) 2098–2106

    Abstract: Background: Although matrine is widely used, its absorption and transport mechanisms in crops remain unexplored. In this study, three methods including foliar application, hydroponics and seed immersion were used to investigate whether matrine molecules ...

    Abstract Background: Although matrine is widely used, its absorption and transport mechanisms in crops remain unexplored. In this study, three methods including foliar application, hydroponics and seed immersion were used to investigate whether matrine molecules could enter into plants through different channels, and to further resolve its transport characteristics. The systemic activity of matrine also was evaluated.
    Result: Matrine was quickly absorbed and transported downwards after the leaves of wheat or peppers were treated, and also accumulated and transmitted upwards by roots. It was not only absorbed by seeds, but also appeared continuously in young roots and leaves in both plants for nearly 20 days. There were some differences in the uptake and conduction of matrine between pepper and wheat: matrine concentrated in pepper upper leaves with less delivered downwards to roots than in wheat, and also transduction of matrine in pepper lower leaves upwards to upper leaves was less than in wheat. Matrine had systemic activity, with LC
    Conclusion: Matrine can be absorbed by the roots, seeds and leaves of plants, and transmitted bidirectionally to any organs, presenting satisfactory systemic poisoning activity against aphids. It is of great significance to develop new formulation products of matrine and promote its commercialized value. © 2023 Society of Chemical Industry.
    MeSH term(s) Animals ; Aphids/physiology ; Capsicum ; Matrines/metabolism ; Seeds ; Triticum
    Chemical Substances Matrines
    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001705-4
    ISSN 1526-4998 ; 1526-498X
    ISSN (online) 1526-4998
    ISSN 1526-498X
    DOI 10.1002/ps.7376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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