Article ; Online: Analysis of high risk factors of pathological escalation after LEEP in CIN2 diagnosed by colposcopic biopsy
Xin yixue, Vol 54, Iss 12, Pp 895-
2023 Volume 901
Abstract: Objective To investigate the risk factors associated with pathological escalation to cervical intraepithelial neoplasia grade 2 （CIN2） or above （CIN2+） in patients with CIN2 confirmed by colposcopic biopsy， aiming to provide evidence for the stratified ... ...
| Abstract | Objective To investigate the risk factors associated with pathological escalation to cervical intraepithelial neoplasia grade 2 （CIN2） or above （CIN2+） in patients with CIN2 confirmed by colposcopic biopsy， aiming to provide evidence for the stratified management of CIN2 patients. Methods Clinical data of 210 patients who underwent LEEP surgery after pathological diagnosis of cervical CIN2 by colposcopic biopsy were retrospectively analyzed. Pathological diagnosis of patients before and after LEEP surgery was observed. The relationship between pathological escalation after LEEP， and age，results of primary liquid-based thin-layer cytology （TCT）， typing of high-risk human papillomavirus （HPV）， the number of affected quadrants of lesions under colposcopy， the proportion of visible lesion area to cervical surface area， the longest linear length of the lesion， the type of transformation zone （TZ）， whether the lesion was involved with glands and the characteristics of colposcopic images was assessed by univariate and multivariate Logistic regression analyses. Results Among 210 cases of cervical CIN2 diagnosed by colposcopic biopsy， 37 cases （17.6%） were pathologically diagnosed with CIN2+ after LEEP， and 1 case was diagnosed with cervical squamous cell carcinoma stage IB1. Univariate analysis showed that pathological escalation after LEEP was associated with the age of patients， the number of affected quadrants of lesions under colposcopy， the proportion of visible lesion area to cervical surface area， the longest linear length of visible lesions， the type of transformation zone，and the characteristics of colposcoic images （all P < 0.05）. Multivariate analysis showed that the number （>1） of affected quadrants of lesions under colposcopy，the proportion （≥1/3） of visible lesion area to cervical surface area， TZ3 type and the characteristics （≥2） of colposcopic images were the high-risk factors for pathological escalation after LEEP （all P < 0.05）. For patients aged 26-50 years， the proportion （≥1/3） of lesion ... |
|---|---|
| Keywords | colposcopy|cervical intraepithelial neoplasia|loop resection of the cervix|pathological escalation|influencing factor|thin-prep cytology test ; Medicine ; R |
| Subject code | 610 |
| Language | Chinese |
| Publishing date | 2023-12-01T00:00:00Z |
| Publisher | Editorial Office of Journal of New Medicine |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Full text online
More links
Kategorien
Inter-library loan at ZB MED
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.