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  1. AU="Maarten Jacquemyn"
  2. AU="Gilboa, Eli"
  3. AU="Matthew Collins"
  4. AU="Buttar, Irvind"
  5. AU="F Leslie, Katie"
  6. AU="Zafar, Mohammad A"
  7. AU=Owens Michael D
  8. AU="Kuveždić, D."
  9. AU="John, Shannon"
  10. AU="O'Shaughnessy, R F L"
  11. AU="AlHarfoush, Enmar"
  12. AU="Savill, Edward"
  13. AU="Pavel P. Polyakov"
  14. AU="Robert Haennel"
  15. AU="Robert W. Crawford"
  16. AU="Figueroa, Andres V"
  17. AU="Racca, C."
  18. AU="Slavu, Diana-Maria"
  19. AU="Talbert, Emily"
  20. AU=Abdelnour Loay H
  21. AU=Meisburger Steve P.
  22. AU="Silveira, Fernando A. O."
  23. AU="Toru Nabika"
  24. AU="Vojkovic, Marina"
  25. AU="Gaier, Eric D"
  26. AU="Chandler Crews"
  27. AU="Comte, Marie-Hélène"
  28. AU="Cohen, Or"
  29. AU="Abdellatifi, Mohamed"
  30. AU="Luebbe, Elizabeth"
  31. AU="Emidio, Adriana"
  32. AU=Masmejan Sophie
  33. AU="Samantha Ridley"
  34. AU="Moghaddam-Alvandi, Arash"
  35. AU="Khanolkar, Amey R."
  36. AU="Vasquez Martinez, Rodolfo"
  37. AU="Morgan, E"

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  1. Artikel ; Online: Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes

    Jasper Edgar Neggers / Bert Kwanten / Tim Dierckx / Hiroki Noguchi / Arnout Voet / Lotte Bral / Kristien Minner / Bob Massant / Nicolas Kint / Michel Delforge / Thomas Vercruysse / Erkan Baloglu / William Senapedis / Maarten Jacquemyn / Dirk Daelemans

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Band 14

    Abstract: Cancer therapy drugs are designed to target genetic vulnerabilities, but loss-of-function screens often fail to identify essential genes in drug mechanism studies. Here the authors demonstrate CRISPRres, which exploits in-frame variation generated by ... ...

    Abstract Cancer therapy drugs are designed to target genetic vulnerabilities, but loss-of-function screens often fail to identify essential genes in drug mechanism studies. Here the authors demonstrate CRISPRres, which exploits in-frame variation generated by indel formation to discover gene-drug interactions.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-02-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes

    Jasper Edgar Neggers / Bert Kwanten / Tim Dierckx / Hiroki Noguchi / Arnout Voet / Lotte Bral / Kristien Minner / Bob Massant / Nicolas Kint / Michel Delforge / Thomas Vercruysse / Erkan Baloglu / William Senapedis / Maarten Jacquemyn / Dirk Daelemans

    Nature Communications, Vol 9, Iss 1, Pp 1-

    2018  Band 14

    Abstract: Cancer therapy drugs are designed to target genetic vulnerabilities, but loss-of-function screens often fail to identify essential genes in drug mechanism studies. Here the authors demonstrate CRISPRres, which exploits in-frame variation generated by ... ...

    Abstract Cancer therapy drugs are designed to target genetic vulnerabilities, but loss-of-function screens often fail to identify essential genes in drug mechanism studies. Here the authors demonstrate CRISPRres, which exploits in-frame variation generated by indel formation to discover gene-drug interactions.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma

    Eline Boons / Els Vanstreels / Maarten Jacquemyn / Tatiane C. Nogueira / Jasper E. Neggers / Thomas Vercruysse / Joost van den Oord / Sharon Tamir / Sharon Shacham / Yosef Landesman / Robert Snoeck / Christophe Pannecouque / Graciela Andrei / Dirk Daelemans

    EBioMedicine, Vol 2, Iss 9, Pp 1102-

    2015  Band 1113

    Abstract: Infection with HIV ultimately leads to advanced immunodeficiency resulting in an increased incidence of cancer. For example primary effusion lymphoma (PEL) is an aggressive non-Hodgkin lymphoma with very poor prognosis that typically affects HIV infected ...

    Abstract Infection with HIV ultimately leads to advanced immunodeficiency resulting in an increased incidence of cancer. For example primary effusion lymphoma (PEL) is an aggressive non-Hodgkin lymphoma with very poor prognosis that typically affects HIV infected individuals in advanced stages of immunodeficiency. Here we report on the dual anti-HIV and anti-PEL effect of targeting a single process common in both diseases. Inhibition of the exportin-1 (XPO1) mediated nuclear transport by clinical stage orally bioavailable small molecule inhibitors (SINE) prevented the nuclear export of the late intron-containing HIV RNA species and consequently potently suppressed viral replication. In contrast, in CRISPR-Cas9 genome edited cells expressing mutant C528S XPO1, viral replication was unaffected upon treatment, clearly demonstrating the anti-XPO1 mechanism of action. At the same time, SINE caused the nuclear accumulation of p53 tumor suppressor protein as well as inhibition of NF-κB activity in PEL cells resulting in cell cycle arrest and effective apoptosis induction. In vivo, oral administration arrested PEL tumor growth in engrafted mice. Our findings provide strong rationale for inhibiting XPO1 as an innovative strategy for the combined anti-retroviral and anti-neoplastic treatment of HIV and PEL and offer perspectives for the treatment of other AIDS-associated cancers and potentially other virus-related malignancies.
    Schlagwörter Exportin-1 ; CRM1 ; XPO1 ; Small-molecule inhibitors ; HIV ; AIDS-related lymphoma ; Primary effusion lymphoma ; Medicine ; R ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2015-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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