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  1. Article ; Online: Some OPA once told me "LKB1 is going to rule me": The OPA1-LKB1 axis in immune response.

    Contreras, Nuria / Macías-Camero, Andrea / Delgado-Dolset, María Isabel

    Allergy

    2023  Volume 78, Issue 5, Page(s) 1400–1402

    MeSH term(s) Humans ; GTP Phosphohydrolases ; Immunity ; Protein Serine-Threonine Kinases ; AMP-Activated Protein Kinase Kinases/metabolism
    Chemical Substances GTP Phosphohydrolases (EC 3.6.1.-) ; OPA1 protein, human (EC 3.6.1.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; AMP-Activated Protein Kinase Kinases (EC 2.7.11.3)
    Language English
    Publishing date 2023-02-22
    Publishing country Denmark
    Document type News ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.150: Show issues Location:
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    Zs.MO 125: Show issues

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  2. Article ; Online: Effects of pectin methyl-esterification on intestinal microbiota and its immunomodulatory properties in naive mice.

    Steigerwald, Hanna / Blanco-Pérez, Frank / Macías-Camero, Andrea / Albrecht, Melanie / Huch, Melanie / Bender, Caroline / Schülke, Stefan / Keller, Judith / Krause, Maren / Barbas, Coral / Gonzalez-Menendez, Irene / Quintanilla-Martinez, Leticia / Toda, Masako / Barber, Domingo / Kulling, Sabine / Bunzel, Mirko / Vieths, Stefan / Villaseñor, Alma / Stoll, Dominic /
    Scheurer, Stephan

    Carbohydrate polymers

    2024  Volume 334, Page(s) 122007

    Abstract: Pectins are dietary fibers that are attributed with several beneficial immunomodulatory effects. Depending on the degree of esterification (DE), pectins can be classified as high methoxyl pectin (HMP) or low methoxyl pectin (LMP). The aim of this study ... ...

    Abstract Pectins are dietary fibers that are attributed with several beneficial immunomodulatory effects. Depending on the degree of esterification (DE), pectins can be classified as high methoxyl pectin (HMP) or low methoxyl pectin (LMP). The aim of this study was to investigate the effects of pectin methyl-esterification on intestinal microbiota and its immunomodulatory properties in naive mice. Supplementation of the diet with LMP or HMP induced changes in the composition of the intestinal microbiota in mice toward Bacteroides, which was mainly promoted by HMP. Metabolome analysis of stool samples from pectin-fed mice showed a different effect of the two types of pectin on the levels of short-chain fatty acids and bile acids, which was consistent with highly efficient in vivo fermentation of LMP. Analysis of serum antibody levels showed a significant increase in IgG and IgA levels by both pectins, while FACS analysis revealed a decrease of infiltrating inflammatory cells in the intestinal lamina propria by HMP. Our study revealed that the structural properties of the investigated pectins determine fermentability, effects on microbial composition, metabolite production, and modulation of immune responses. Consumption of HMP preferentially altered the gut microbiota and suppressed pro-inflammatory immune responses, suggesting a beneficial role in inflammatory diseases.
    MeSH term(s) Mice ; Animals ; Pectins/chemistry ; Gastrointestinal Microbiome ; Esterification ; Dietary Fiber/pharmacology ; Dietary Fiber/metabolism ; Fermentation
    Chemical Substances Pectins (89NA02M4RX) ; Dietary Fiber
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2024.122007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach.

    Barker-Tejeda, Tomás Clive / Zubeldia-Varela, Elisa / Macías-Camero, Andrea / Alonso, Lola / Martín-Antoniano, Isabel Adoración / Rey-Stolle, María Fernanda / Mera-Berriatua, Leticia / Bazire, Raphaëlle / Cabrera-Freitag, Paula / Shanmuganathan, Meera / Britz-McKibbin, Philip / Ubeda, Carles / Francino, M Pilar / Barber, Domingo / Ibáñez-Sandín, María Dolores / Barbas, Coral / Pérez-Gordo, Marina / Villaseñor, Alma

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 3004

    Abstract: The human gut microbiome establishes and matures during infancy, and dysregulation at this stage may lead to pathologies later in life. We conducted a multi-omics study comprising three generations of family members to investigate the early development ... ...

    Abstract The human gut microbiome establishes and matures during infancy, and dysregulation at this stage may lead to pathologies later in life. We conducted a multi-omics study comprising three generations of family members to investigate the early development of the gut microbiota. Fecal samples from 200 individuals, including infants (0-12 months old; 55% females, 45% males) and their respective mothers and grandmothers, were analyzed using two independent metabolomics platforms and metagenomics. For metabolomics, gas chromatography and capillary electrophoresis coupled to mass spectrometry were applied. For metagenomics, both 16S rRNA gene and shotgun sequencing were performed. Here we show that infants greatly vary from their elders in fecal microbiota populations, function, and metabolome. Infants have a less diverse microbiota than adults and present differences in several metabolite classes, such as short- and branched-chain fatty acids, which are associated with shifts in bacterial populations. These findings provide innovative biochemical insights into the shaping of the gut microbiome within the same generational line that could be beneficial in improving childhood health outcomes.
    MeSH term(s) Infant ; Male ; Adult ; Female ; Humans ; Child ; Aged ; Infant, Newborn ; Gastrointestinal Microbiome/genetics ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 16S/metabolism ; Multiomics ; Metabolome ; Feces/microbiology ; Mothers
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47182-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Control of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43.

    Maroto, Irene B / Costas-Insua, Carlos / Berthoux, Coralie / Moreno, Estefanía / Ruiz-Calvo, Andrea / Montero-Fernández, Carlos / Macías-Camero, Andrea / Martín, Ricardo / García-Font, Nuria / Sánchez-Prieto, José / Marsicano, Giovanni / Bellocchio, Luigi / Canela, Enric I / Casadó, Vicent / Galve-Roperh, Ismael / Núñez, Ángel / Fernández de Sevilla, David / Rodríguez-Crespo, Ignacio / Castillo, Pablo E /
    Guzmán, Manuel

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 2303

    Abstract: The type-1 cannabinoid receptor ( ... ...

    Abstract The type-1 cannabinoid receptor (CB
    MeSH term(s) Mice ; Animals ; Cannabinoids/pharmacology ; Cannabinoids/metabolism ; Proteomics ; Hippocampus/metabolism ; Synaptic Transmission ; Synapses/metabolism ; Receptors, Cannabinoid/metabolism ; Receptor, Cannabinoid, CB1/genetics ; Receptor, Cannabinoid, CB1/metabolism
    Chemical Substances Cannabinoids ; Receptors, Cannabinoid ; Receptor, Cannabinoid, CB1
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38026-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of pectin methyl-esterification on intestinal microbiota and its immunomodulatory properties in naive mice

    Steigerwald, Hanna / Blanco-Pérez, Frank / Macías-Camero, Andrea / Albrecht, Melanie / Huch, Melanie / Bender, Caroline / Schülke, Stefan / Keller, Judith / Krause, Maren / Barbas, Coral / Gonzalez-Menendez, Irene / Quintanilla-Martinez, Leticia / Toda, Masako / Barber, Domingo / Kulling, Sabine / Bunzel, Mirko / Vieths, Stefan / Villaseñor, Alma / Stoll, Dominic /
    Scheurer, Stephan

    2024  

    Keywords article ; Text ; ddc:540
    Language English
    Publishing date 2024-03-18
    Publisher Elsevier BV
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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